Incidental Mutation 'R0800:Sell'
ID 76214
Institutional Source Beutler Lab
Gene Symbol Sell
Ensembl Gene ENSMUSG00000026581
Gene Name selectin, lymphocyte
Synonyms CD62L, Ly-22, Lyam1, LECAM-1, Lyam-1, Ly-m22, Lnhr, L-selectin
MMRRC Submission 038980-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0800 (G1)
Quality Score 213
Status Validated
Chromosome 1
Chromosomal Location 163889556-163908354 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 163893770 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141365 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027871] [ENSMUST00000097491] [ENSMUST00000192047] [ENSMUST00000195358]
AlphaFold P18337
Predicted Effect probably null
Transcript: ENSMUST00000027871
SMART Domains Protein: ENSMUSP00000027871
Gene: ENSMUSG00000026581

DomainStartEndE-ValueType
CLECT 27 156 1.14e-19 SMART
EGF 159 192 6.55e-1 SMART
CCP 197 254 1.09e-11 SMART
CCP 259 316 1.09e-11 SMART
transmembrane domain 333 355 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000097491
SMART Domains Protein: ENSMUSP00000095099
Gene: ENSMUSG00000026581

DomainStartEndE-ValueType
CLECT 27 156 1.14e-19 SMART
CCP 161 218 1.09e-11 SMART
CCP 223 280 1.09e-11 SMART
transmembrane domain 297 319 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000192047
SMART Domains Protein: ENSMUSP00000142237
Gene: ENSMUSG00000026581

DomainStartEndE-ValueType
CLECT 27 156 1.14e-19 SMART
CCP 161 218 1.09e-11 SMART
CCP 223 280 1.09e-11 SMART
transmembrane domain 297 319 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000195358
SMART Domains Protein: ENSMUSP00000141365
Gene: ENSMUSG00000026581

DomainStartEndE-ValueType
Pfam:Sushi 1 31 1.3e-4 PFAM
transmembrane domain 48 70 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 93.7%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cellsurvival is also reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
B230217C12Rik T C 11: 97,732,086 (GRCm39) probably benign Het
Cacna1g T C 11: 94,317,265 (GRCm39) D1498G probably damaging Het
Ces3b T A 8: 105,811,901 (GRCm39) D103E possibly damaging Het
Chd5 A G 4: 152,440,614 (GRCm39) Y158C probably damaging Het
Cic A G 7: 24,984,662 (GRCm39) T1033A probably benign Het
Cst13 A T 2: 148,672,247 (GRCm39) I141F possibly damaging Het
Dnah7a A G 1: 53,604,855 (GRCm39) L1301P probably damaging Het
Dnah8 T A 17: 30,923,636 (GRCm39) F1201L probably benign Het
Dok7 T C 5: 35,232,633 (GRCm39) probably benign Het
Dzip3 A G 16: 48,774,171 (GRCm39) probably benign Het
Eml6 A G 11: 29,699,877 (GRCm39) V1753A probably benign Het
Fer1l4 A G 2: 155,887,583 (GRCm39) F538L possibly damaging Het
Fmo2 C T 1: 162,704,383 (GRCm39) D508N probably benign Het
Gabpb1 A T 2: 126,472,248 (GRCm39) Y351N probably damaging Het
Gnaq T A 19: 16,312,428 (GRCm39) V230E probably damaging Het
Gprc5c A C 11: 114,757,537 (GRCm39) K48Q probably damaging Het
Gzmd A G 14: 56,369,948 (GRCm39) L11P unknown Het
Hbq1b A C 11: 32,237,581 (GRCm39) H123P probably damaging Het
Hibadh T A 6: 52,533,490 (GRCm39) I209F probably damaging Het
Il17f G T 1: 20,848,177 (GRCm39) C100* probably null Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Itga8 A T 2: 12,198,362 (GRCm39) V541E possibly damaging Het
Kifc5b T A 17: 27,142,158 (GRCm39) V212D probably benign Het
Klra2 A T 6: 131,207,137 (GRCm39) Y157* probably null Het
Kprp T C 3: 92,732,342 (GRCm39) Y236C unknown Het
Mmp12 A T 9: 7,357,827 (GRCm39) M414L possibly damaging Het
Myh6 A G 14: 55,190,735 (GRCm39) probably benign Het
Nlgn2 A G 11: 69,716,823 (GRCm39) F573L possibly damaging Het
Or10j7 C T 1: 173,011,627 (GRCm39) A125T probably damaging Het
Or4c124 A G 2: 89,156,008 (GRCm39) V172A probably benign Het
Pakap T A 4: 57,709,650 (GRCm39) D198E probably benign Het
Papss1 T A 3: 131,305,615 (GRCm39) probably benign Het
Parp4 A G 14: 56,827,408 (GRCm39) T181A probably benign Het
Piwil2 A T 14: 70,646,486 (GRCm39) probably benign Het
Pla2g12b A G 10: 59,239,642 (GRCm39) N17S probably benign Het
Polr3c C A 3: 96,626,627 (GRCm39) V266L probably damaging Het
Pou3f3 A G 1: 42,737,527 (GRCm39) T408A probably damaging Het
Pskh1 A G 8: 106,640,238 (GRCm39) Y306C probably damaging Het
Rom1 T A 19: 8,906,272 (GRCm39) D89V probably damaging Het
Sox6 A G 7: 115,178,249 (GRCm39) probably null Het
Speg T C 1: 75,400,133 (GRCm39) S2527P probably damaging Het
Stat3 A G 11: 100,784,981 (GRCm39) probably benign Het
Stra6l A G 4: 45,882,797 (GRCm39) T503A probably benign Het
Tapbp A G 17: 34,145,227 (GRCm39) T375A probably benign Het
Tgm6 G A 2: 129,985,342 (GRCm39) V382M possibly damaging Het
Trappc9 A T 15: 72,824,981 (GRCm39) probably benign Het
Txlnb A G 10: 17,675,240 (GRCm39) N131S possibly damaging Het
Usp19 A G 9: 108,372,353 (GRCm39) E469G probably damaging Het
Vmn2r17 T A 5: 109,575,192 (GRCm39) probably benign Het
Zfp750 T C 11: 121,402,838 (GRCm39) T637A probably benign Het
Zhx2 A C 15: 57,686,124 (GRCm39) I498L probably damaging Het
Other mutations in Sell
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01981:Sell APN 1 163,893,195 (GRCm39) missense probably benign 0.04
IGL02466:Sell APN 1 163,896,632 (GRCm39) splice site probably null
IGL02578:Sell APN 1 163,893,165 (GRCm39) missense probably damaging 1.00
IGL03243:Sell APN 1 163,892,911 (GRCm39) missense possibly damaging 0.94
dim_sum UTSW 1 163,893,770 (GRCm39) splice site probably null
dim_sum2 UTSW 1 163,893,230 (GRCm39) nonsense probably null
Duct UTSW 1 163,893,122 (GRCm39) missense probably damaging 1.00
Postit UTSW 1 163,893,176 (GRCm39) missense possibly damaging 0.85
R0125:Sell UTSW 1 163,899,674 (GRCm39) splice site probably benign
R1900:Sell UTSW 1 163,892,907 (GRCm39) missense probably damaging 1.00
R3848:Sell UTSW 1 163,893,230 (GRCm39) nonsense probably null
R4553:Sell UTSW 1 163,899,685 (GRCm39) missense probably benign 0.08
R4671:Sell UTSW 1 163,893,042 (GRCm39) missense probably damaging 1.00
R4685:Sell UTSW 1 163,893,829 (GRCm39) missense probably damaging 1.00
R4896:Sell UTSW 1 163,890,631 (GRCm39) missense probably benign 0.02
R4970:Sell UTSW 1 163,892,887 (GRCm39) missense possibly damaging 0.75
R5112:Sell UTSW 1 163,892,887 (GRCm39) missense possibly damaging 0.75
R6549:Sell UTSW 1 163,893,198 (GRCm39) missense probably damaging 1.00
R7148:Sell UTSW 1 163,893,176 (GRCm39) missense possibly damaging 0.85
R7545:Sell UTSW 1 163,892,903 (GRCm39) missense probably benign 0.21
R8010:Sell UTSW 1 163,893,081 (GRCm39) missense possibly damaging 0.92
R9026:Sell UTSW 1 163,893,042 (GRCm39) missense probably damaging 1.00
R9239:Sell UTSW 1 163,893,176 (GRCm39) missense possibly damaging 0.85
R9329:Sell UTSW 1 163,893,122 (GRCm39) missense probably damaging 1.00
R9336:Sell UTSW 1 163,893,177 (GRCm39) missense probably damaging 1.00
R9455:Sell UTSW 1 163,894,218 (GRCm39) missense probably benign 0.02
R9699:Sell UTSW 1 163,893,114 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCATAGCACCTCTGGGCAATC -3'
(R):5'- GGGTCTAATGAACACCAGCAGGAAC -3'

Sequencing Primer
(F):5'- TGGACAGACTGTGCCTCAAG -3'
(R):5'- GGAACAAACAAACAAACAAATGAAG -3'
Posted On 2013-10-16