Mutagenetix > Incidental Mutation

Incidental Mutation 'R0798:Cyp3a25'

76484

Institutional Source

Beutler Lab

Gene Symbol

Cyp3a25

Ensembl Gene

ENSMUSG00000029630

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 25

Synonyms

MMRRC Submission

038978-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R0798 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

145914004-145946428 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 145928343 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 234 (E234G)

Ref Sequence

ENSEMBL: ENSMUSP00000065585 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]

AlphaFold

O09158

Predicted Effect

probably damaging
Transcript: ENSMUST00000068317
AA Change: E234G

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: E234G

Domain	Start	End	E-Value	Type
Pfam:p450	38	493	9.4e-129	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138870

SMART Domains

Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	126	2e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000145062

SMART Domains

Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	148	3.9e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153808

Meta Mutation Damage Score

0.5315

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.4%
20x: 95.2%

Validation Efficiency

100% (30/30)

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010315B03Rik	T	C	9: 124,057,789 (GRCm39)		probably benign	Het
4930579C12Rik	T	A	9: 89,034,880 (GRCm39)		noncoding transcript	Het
Baz2a	T	A	10: 127,962,192 (GRCm39)		probably benign	Het
Bcar3	T	C	3: 122,318,948 (GRCm39)	V695A	probably benign	Het
C130074G19Rik	G	A	1: 184,614,873 (GRCm39)		probably benign	Het
Cmas	T	C	6: 142,710,382 (GRCm39)	V167A	probably damaging	Het
Crppa	G	A	12: 36,571,998 (GRCm39)	R302H	probably benign	Het
Gopc	C	T	10: 52,234,907 (GRCm39)	G79S	probably damaging	Het
Herc2	T	A	7: 55,785,431 (GRCm39)		probably null	Het
Iqca1	C	A	1: 90,070,453 (GRCm39)	G133V	probably null	Het
Kcnq5	A	G	1: 22,031,399 (GRCm39)		probably null	Het
Lpp	G	T	16: 24,790,622 (GRCm39)	G29*	probably null	Het
Ly6g6e	T	C	17: 35,297,017 (GRCm39)	F86S	probably benign	Het
Myo5c	T	C	9: 75,165,266 (GRCm39)	F358S	probably damaging	Het
Nlgn1	A	G	3: 25,488,410 (GRCm39)	Y613H	probably benign	Het
Or4k38	T	C	2: 111,165,689 (GRCm39)	I245V	probably benign	Het
Or7e178	A	T	9: 20,225,495 (GRCm39)	Y232*	probably null	Het
Plekhn1	T	A	4: 156,312,720 (GRCm39)	D46V	probably damaging	Het
Ptp4a1	A	T	1: 30,984,005 (GRCm39)		probably benign	Het
Rab23	A	T	1: 33,773,908 (GRCm39)	I123F	probably damaging	Het
Samd4b	G	A	7: 28,101,048 (GRCm39)		probably benign	Het
Shisa4	G	A	1: 135,300,886 (GRCm39)		probably benign	Het
Slc39a11	C	T	11: 113,414,330 (GRCm39)	A90T	probably benign	Het
Tas1r2	T	C	4: 139,397,024 (GRCm39)	Y788H	probably damaging	Het
Tasor	T	A	14: 27,198,593 (GRCm39)	F1308L	probably damaging	Het
Tial1	C	T	7: 128,045,602 (GRCm39)	M327I	probably benign	Het
Ubr2	C	T	17: 47,280,102 (GRCm39)		probably benign	Het
Utp4	T	C	8: 107,648,858 (GRCm39)	S630P	probably benign	Het
Vmn1r212	T	C	13: 23,067,868 (GRCm39)	N155S	probably damaging	Het
Zmym6	C	T	4: 126,997,316 (GRCm39)	P312S	probably benign	Het

Other mutations in Cyp3a25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Cyp3a25	APN	5	145,938,273 (GRCm39)	nonsense	probably null
IGL00430:Cyp3a25	APN	5	145,930,170 (GRCm39)	missense	probably damaging	1.00
IGL00803:Cyp3a25	APN	5	145,938,253 (GRCm39)	splice site	probably benign
IGL00928:Cyp3a25	APN	5	145,923,764 (GRCm39)	missense	possibly damaging	0.94
IGL01557:Cyp3a25	APN	5	145,921,711 (GRCm39)	missense	probably damaging	1.00
IGL01997:Cyp3a25	APN	5	145,931,766 (GRCm39)	missense	possibly damaging	0.92
IGL02140:Cyp3a25	APN	5	145,946,273 (GRCm39)	splice site	probably benign
IGL02267:Cyp3a25	APN	5	145,935,362 (GRCm39)	missense	possibly damaging	0.48
IGL02272:Cyp3a25	APN	5	145,930,075 (GRCm39)	intron	probably benign
IGL02327:Cyp3a25	APN	5	145,923,731 (GRCm39)	missense	possibly damaging	0.50
IGL02411:Cyp3a25	APN	5	145,938,257 (GRCm39)	critical splice donor site	probably benign
IGL02504:Cyp3a25	APN	5	145,930,141 (GRCm39)	missense	probably benign	0.03
IGL02653:Cyp3a25	APN	5	145,939,920 (GRCm39)	missense	possibly damaging	0.95
R0378:Cyp3a25	UTSW	5	145,923,652 (GRCm39)	missense	probably damaging	1.00
R0403:Cyp3a25	UTSW	5	145,935,323 (GRCm39)	missense	probably damaging	1.00
R0685:Cyp3a25	UTSW	5	145,935,356 (GRCm39)	missense	probably damaging	1.00
R0725:Cyp3a25	UTSW	5	145,931,746 (GRCm39)	missense	probably damaging	1.00
R1061:Cyp3a25	UTSW	5	145,923,643 (GRCm39)	missense	probably benign
R1519:Cyp3a25	UTSW	5	145,938,257 (GRCm39)	critical splice donor site	probably null
R1628:Cyp3a25	UTSW	5	145,938,273 (GRCm39)	nonsense	probably null
R1822:Cyp3a25	UTSW	5	145,921,763 (GRCm39)	missense	probably damaging	1.00
R1824:Cyp3a25	UTSW	5	145,921,763 (GRCm39)	missense	probably damaging	1.00
R1864:Cyp3a25	UTSW	5	145,931,739 (GRCm39)	missense	probably damaging	0.98
R2062:Cyp3a25	UTSW	5	145,923,779 (GRCm39)	splice site	probably benign
R2401:Cyp3a25	UTSW	5	145,923,778 (GRCm39)	critical splice acceptor site	probably null
R2516:Cyp3a25	UTSW	5	145,939,837 (GRCm39)	splice site	probably null
R3080:Cyp3a25	UTSW	5	145,935,341 (GRCm39)	missense	probably benign	0.33
R3236:Cyp3a25	UTSW	5	145,939,938 (GRCm39)	splice site	probably benign
R3694:Cyp3a25	UTSW	5	145,926,786 (GRCm39)	splice site	probably null
R3730:Cyp3a25	UTSW	5	145,939,891 (GRCm39)	missense	probably damaging	1.00
R4112:Cyp3a25	UTSW	5	145,939,841 (GRCm39)	missense	probably benign	0.18
R4258:Cyp3a25	UTSW	5	145,928,248 (GRCm39)	missense	probably damaging	1.00
R4651:Cyp3a25	UTSW	5	145,931,701 (GRCm39)	missense	probably benign	0.01
R4788:Cyp3a25	UTSW	5	145,921,892 (GRCm39)	nonsense	probably null
R4899:Cyp3a25	UTSW	5	145,914,481 (GRCm39)	missense	possibly damaging	0.59
R4926:Cyp3a25	UTSW	5	145,928,266 (GRCm39)	missense	probably damaging	1.00
R4952:Cyp3a25	UTSW	5	145,928,334 (GRCm39)	missense	probably benign	0.01
R5270:Cyp3a25	UTSW	5	145,918,312 (GRCm39)	missense	probably benign	0.36
R5595:Cyp3a25	UTSW	5	145,931,673 (GRCm39)	critical splice donor site	probably null
R5659:Cyp3a25	UTSW	5	145,928,356 (GRCm39)	missense	possibly damaging	0.69
R5787:Cyp3a25	UTSW	5	145,935,313 (GRCm39)	missense	probably benign	0.14
R6307:Cyp3a25	UTSW	5	145,931,766 (GRCm39)	missense	possibly damaging	0.92
R6380:Cyp3a25	UTSW	5	145,935,357 (GRCm39)	missense	probably damaging	0.99
R7055:Cyp3a25	UTSW	5	145,929,801 (GRCm39)	missense	probably benign	0.00
R7140:Cyp3a25	UTSW	5	145,939,855 (GRCm39)	missense	probably benign
R7189:Cyp3a25	UTSW	5	145,939,870 (GRCm39)	missense	probably benign	0.37
R7201:Cyp3a25	UTSW	5	145,939,868 (GRCm39)	missense	probably benign	0.00
R7201:Cyp3a25	UTSW	5	145,928,257 (GRCm39)	missense	probably benign	0.22
R7332:Cyp3a25	UTSW	5	145,929,817 (GRCm39)	missense	probably damaging	1.00
R7404:Cyp3a25	UTSW	5	145,923,635 (GRCm39)	missense	probably damaging	1.00
R7548:Cyp3a25	UTSW	5	145,923,735 (GRCm39)	missense	probably damaging	0.98
R7607:Cyp3a25	UTSW	5	145,921,791 (GRCm39)	missense	possibly damaging	0.87
R8022:Cyp3a25	UTSW	5	145,914,478 (GRCm39)	missense	probably benign	0.33
R8266:Cyp3a25	UTSW	5	145,929,796 (GRCm39)	missense	probably damaging	1.00
R8894:Cyp3a25	UTSW	5	145,931,670 (GRCm39)	splice site	probably benign
R9249:Cyp3a25	UTSW	5	145,928,356 (GRCm39)	missense	possibly damaging	0.69
R9588:Cyp3a25	UTSW	5	145,921,699 (GRCm39)	missense	probably benign
R9691:Cyp3a25	UTSW	5	145,931,732 (GRCm39)	missense	probably benign	0.41
R9694:Cyp3a25	UTSW	5	145,923,685 (GRCm39)	nonsense	probably null

Predicted Primers

Posted On

2013-10-16