Incidental Mutation 'R0782:Cdc14a'
ID 76675
Institutional Source Beutler Lab
Gene Symbol Cdc14a
Ensembl Gene ENSMUSG00000033502
Gene Name CDC14 cell division cycle 14A
Synonyms A830059A17Rik, CDC14a1, CDC14A2, Cdc14
MMRRC Submission 038962-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R0782 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 116066202-116222390 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116115785 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 259 (I259T)
Ref Sequence ENSEMBL: ENSMUSP00000102100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090464] [ENSMUST00000106491] [ENSMUST00000197830]
AlphaFold Q6GQT0
Predicted Effect possibly damaging
Transcript: ENSMUST00000090464
AA Change: I308T

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000087950
Gene: ENSMUSG00000033502
AA Change: I308T

DomainStartEndE-ValueType
Pfam:DSPn 13 153 1.6e-66 PFAM
Pfam:Y_phosphatase 210 324 1.1e-7 PFAM
Pfam:DSPc 214 328 1.8e-14 PFAM
low complexity region 539 558 N/A INTRINSIC
low complexity region 573 595 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106491
AA Change: I259T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102100
Gene: ENSMUSG00000033502
AA Change: I259T

DomainStartEndE-ValueType
Pfam:DSPn 12 121 9.5e-44 PFAM
Pfam:Y_phosphatase 160 274 6.4e-8 PFAM
Pfam:DSPc 160 280 2.8e-14 PFAM
low complexity region 490 509 N/A INTRINSIC
low complexity region 524 546 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127704
Predicted Effect probably benign
Transcript: ENSMUST00000197830
Meta Mutation Damage Score 0.2936 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap23 C T 11: 97,391,380 (GRCm39) P1299L possibly damaging Het
B3glct C T 5: 149,650,275 (GRCm39) T126M probably damaging Het
Baz1a A T 12: 54,941,273 (GRCm39) D1492E probably damaging Het
Cog7 C A 7: 121,543,020 (GRCm39) A464S possibly damaging Het
Csf2rb2 C A 15: 78,170,951 (GRCm39) K368N probably damaging Het
Cspp1 T A 1: 10,200,199 (GRCm39) probably benign Het
Cyp2c37 A G 19: 39,982,269 (GRCm39) H90R probably benign Het
Dcst1 A G 3: 89,264,807 (GRCm39) F314L possibly damaging Het
Dhx36 A T 3: 62,414,135 (GRCm39) probably benign Het
Efr3b G A 12: 4,034,686 (GRCm39) probably benign Het
Faap100 A G 11: 120,267,530 (GRCm39) probably null Het
Hmcn1 A G 1: 150,629,416 (GRCm39) I947T possibly damaging Het
Ilkap C T 1: 91,306,272 (GRCm39) R103H probably damaging Het
Impa1 A T 3: 10,387,956 (GRCm39) probably benign Het
Kbtbd8 C T 6: 95,099,213 (GRCm39) R164C probably damaging Het
Lactb2 T G 1: 13,717,675 (GRCm39) N116T probably benign Het
Myh8 T A 11: 67,180,580 (GRCm39) N605K probably benign Het
Mylk G C 16: 34,699,845 (GRCm39) E403Q possibly damaging Het
Napa T C 7: 15,849,192 (GRCm39) M244T probably benign Het
Nckap5 G A 1: 125,909,278 (GRCm39) S1719F probably damaging Het
Nfe2l2 T C 2: 75,507,177 (GRCm39) I308V probably benign Het
Or51af1 C A 7: 103,141,722 (GRCm39) R121L probably damaging Het
Ppfia2 C T 10: 106,763,592 (GRCm39) S1195L probably benign Het
Rasa4 A G 5: 136,133,386 (GRCm39) K615R possibly damaging Het
Rnf216 T C 5: 143,054,647 (GRCm39) K634E possibly damaging Het
Samd3 A G 10: 26,146,138 (GRCm39) T388A probably damaging Het
Serping1 G A 2: 84,597,790 (GRCm39) P364S probably damaging Het
Slc39a10 T C 1: 46,875,156 (GRCm39) S49G probably damaging Het
Smc2 C A 4: 52,469,799 (GRCm39) T762K probably benign Het
Smpd1 T A 7: 105,204,550 (GRCm39) V143E possibly damaging Het
Synj2bp A T 12: 81,579,507 (GRCm39) L16Q probably damaging Het
Tcof1 G A 18: 60,949,352 (GRCm39) R1188W probably damaging Het
Unc80 A G 1: 66,661,740 (GRCm39) R1722G possibly damaging Het
Vamp5 T C 6: 72,346,453 (GRCm39) S48G probably damaging Het
Vps13d G A 4: 144,853,195 (GRCm39) probably benign Het
Zfp292 T C 4: 34,839,382 (GRCm39) N161S possibly damaging Het
Zfp831 A G 2: 174,488,423 (GRCm39) T1033A probably benign Het
Other mutations in Cdc14a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Cdc14a APN 3 116,088,493 (GRCm39) nonsense probably null
IGL01062:Cdc14a APN 3 116,068,361 (GRCm39) splice site probably benign
IGL01584:Cdc14a APN 3 116,186,474 (GRCm39) nonsense probably null
IGL03084:Cdc14a APN 3 116,142,101 (GRCm39) critical splice donor site probably null
IGL03237:Cdc14a APN 3 116,198,275 (GRCm39) intron probably benign
IGL03296:Cdc14a APN 3 116,090,807 (GRCm39) missense probably benign 0.02
PIT4131001:Cdc14a UTSW 3 116,122,310 (GRCm39) missense possibly damaging 0.66
R0707:Cdc14a UTSW 3 116,087,362 (GRCm39) splice site probably benign
R0835:Cdc14a UTSW 3 116,122,171 (GRCm39) missense probably benign 0.12
R1363:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R1507:Cdc14a UTSW 3 116,087,646 (GRCm39) missense possibly damaging 0.47
R1545:Cdc14a UTSW 3 116,087,373 (GRCm39) critical splice donor site probably null
R1795:Cdc14a UTSW 3 116,092,122 (GRCm39) missense possibly damaging 0.81
R1797:Cdc14a UTSW 3 116,115,843 (GRCm39) missense probably damaging 1.00
R1830:Cdc14a UTSW 3 116,216,296 (GRCm39) nonsense probably null
R4229:Cdc14a UTSW 3 116,087,413 (GRCm39) missense probably damaging 0.99
R4655:Cdc14a UTSW 3 116,122,136 (GRCm39) missense probably damaging 1.00
R4769:Cdc14a UTSW 3 116,088,399 (GRCm39) critical splice donor site probably null
R4870:Cdc14a UTSW 3 116,217,109 (GRCm39) missense probably benign 0.30
R4980:Cdc14a UTSW 3 116,186,506 (GRCm39) nonsense probably null
R6228:Cdc14a UTSW 3 116,144,862 (GRCm39) missense probably damaging 1.00
R6248:Cdc14a UTSW 3 116,101,843 (GRCm39) missense probably benign 0.01
R6402:Cdc14a UTSW 3 116,142,108 (GRCm39) missense probably damaging 1.00
R6749:Cdc14a UTSW 3 116,090,807 (GRCm39) missense possibly damaging 0.68
R6852:Cdc14a UTSW 3 116,122,325 (GRCm39) missense possibly damaging 0.94
R6996:Cdc14a UTSW 3 116,122,355 (GRCm39) missense probably damaging 1.00
R7185:Cdc14a UTSW 3 116,087,676 (GRCm39) missense probably benign
R7783:Cdc14a UTSW 3 116,198,236 (GRCm39) missense probably damaging 1.00
R7896:Cdc14a UTSW 3 116,088,482 (GRCm39) missense probably benign 0.00
R7991:Cdc14a UTSW 3 116,101,887 (GRCm39) missense probably benign 0.01
R8049:Cdc14a UTSW 3 116,087,577 (GRCm39) missense probably benign 0.33
R9163:Cdc14a UTSW 3 116,122,213 (GRCm39) missense possibly damaging 0.95
R9434:Cdc14a UTSW 3 116,217,092 (GRCm39) missense probably benign
R9526:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R9662:Cdc14a UTSW 3 116,088,484 (GRCm39) missense probably damaging 0.99
R9781:Cdc14a UTSW 3 116,122,274 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGTGACTGTCCCCAGTGAATGACC -3'
(R):5'- ACACGAGAGACACTGCGTGAAC -3'

Sequencing Primer
(F):5'- cccagtgaatgacccagtg -3'
(R):5'- GTCTTAGCCCTAGAATCCAGTG -3'
Posted On 2013-10-16