Incidental Mutation 'R0782:Cyp2c37'
ID 76698
Institutional Source Beutler Lab
Gene Symbol Cyp2c37
Ensembl Gene ENSMUSG00000042248
Gene Name cytochrome P450, family 2. subfamily c, polypeptide 37
Synonyms
MMRRC Submission 038962-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R0782 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 39980868-40000687 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39982269 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 90 (H90R)
Ref Sequence ENSEMBL: ENSMUSP00000045362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049178]
AlphaFold P56654
Predicted Effect probably benign
Transcript: ENSMUST00000049178
AA Change: H90R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: H90R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:p450 30 487 5e-160 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 93.3%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap23 C T 11: 97,391,380 (GRCm39) P1299L possibly damaging Het
B3glct C T 5: 149,650,275 (GRCm39) T126M probably damaging Het
Baz1a A T 12: 54,941,273 (GRCm39) D1492E probably damaging Het
Cdc14a A G 3: 116,115,785 (GRCm39) I259T probably damaging Het
Cog7 C A 7: 121,543,020 (GRCm39) A464S possibly damaging Het
Csf2rb2 C A 15: 78,170,951 (GRCm39) K368N probably damaging Het
Cspp1 T A 1: 10,200,199 (GRCm39) probably benign Het
Dcst1 A G 3: 89,264,807 (GRCm39) F314L possibly damaging Het
Dhx36 A T 3: 62,414,135 (GRCm39) probably benign Het
Efr3b G A 12: 4,034,686 (GRCm39) probably benign Het
Faap100 A G 11: 120,267,530 (GRCm39) probably null Het
Hmcn1 A G 1: 150,629,416 (GRCm39) I947T possibly damaging Het
Ilkap C T 1: 91,306,272 (GRCm39) R103H probably damaging Het
Impa1 A T 3: 10,387,956 (GRCm39) probably benign Het
Kbtbd8 C T 6: 95,099,213 (GRCm39) R164C probably damaging Het
Lactb2 T G 1: 13,717,675 (GRCm39) N116T probably benign Het
Myh8 T A 11: 67,180,580 (GRCm39) N605K probably benign Het
Mylk G C 16: 34,699,845 (GRCm39) E403Q possibly damaging Het
Napa T C 7: 15,849,192 (GRCm39) M244T probably benign Het
Nckap5 G A 1: 125,909,278 (GRCm39) S1719F probably damaging Het
Nfe2l2 T C 2: 75,507,177 (GRCm39) I308V probably benign Het
Or51af1 C A 7: 103,141,722 (GRCm39) R121L probably damaging Het
Ppfia2 C T 10: 106,763,592 (GRCm39) S1195L probably benign Het
Rasa4 A G 5: 136,133,386 (GRCm39) K615R possibly damaging Het
Rnf216 T C 5: 143,054,647 (GRCm39) K634E possibly damaging Het
Samd3 A G 10: 26,146,138 (GRCm39) T388A probably damaging Het
Serping1 G A 2: 84,597,790 (GRCm39) P364S probably damaging Het
Slc39a10 T C 1: 46,875,156 (GRCm39) S49G probably damaging Het
Smc2 C A 4: 52,469,799 (GRCm39) T762K probably benign Het
Smpd1 T A 7: 105,204,550 (GRCm39) V143E possibly damaging Het
Synj2bp A T 12: 81,579,507 (GRCm39) L16Q probably damaging Het
Tcof1 G A 18: 60,949,352 (GRCm39) R1188W probably damaging Het
Unc80 A G 1: 66,661,740 (GRCm39) R1722G possibly damaging Het
Vamp5 T C 6: 72,346,453 (GRCm39) S48G probably damaging Het
Vps13d G A 4: 144,853,195 (GRCm39) probably benign Het
Zfp292 T C 4: 34,839,382 (GRCm39) N161S possibly damaging Het
Zfp831 A G 2: 174,488,423 (GRCm39) T1033A probably benign Het
Other mutations in Cyp2c37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Cyp2c37 APN 19 39,990,441 (GRCm39) missense probably benign 0.00
IGL01307:Cyp2c37 APN 19 39,981,023 (GRCm39) missense probably benign 0.00
IGL01959:Cyp2c37 APN 19 39,984,277 (GRCm39) nonsense probably null
IGL02580:Cyp2c37 APN 19 39,982,942 (GRCm39) missense probably damaging 1.00
IGL02611:Cyp2c37 APN 19 39,982,309 (GRCm39) missense probably benign 0.00
R0124:Cyp2c37 UTSW 19 39,982,546 (GRCm39) missense probably damaging 1.00
R0391:Cyp2c37 UTSW 19 39,982,950 (GRCm39) missense probably damaging 1.00
R0420:Cyp2c37 UTSW 19 39,984,238 (GRCm39) missense probably benign 0.00
R1413:Cyp2c37 UTSW 19 39,982,542 (GRCm39) missense probably benign 0.21
R1637:Cyp2c37 UTSW 19 39,990,426 (GRCm39) nonsense probably null
R1688:Cyp2c37 UTSW 19 39,982,887 (GRCm39) splice site probably null
R2258:Cyp2c37 UTSW 19 39,984,303 (GRCm39) missense possibly damaging 0.49
R4353:Cyp2c37 UTSW 19 39,988,989 (GRCm39) missense possibly damaging 0.66
R4640:Cyp2c37 UTSW 19 40,000,276 (GRCm39) missense possibly damaging 0.67
R4965:Cyp2c37 UTSW 19 40,000,206 (GRCm39) missense possibly damaging 0.79
R5053:Cyp2c37 UTSW 19 39,990,331 (GRCm39) missense probably benign 0.00
R5645:Cyp2c37 UTSW 19 39,982,596 (GRCm39) missense probably benign 0.04
R5847:Cyp2c37 UTSW 19 40,000,176 (GRCm39) missense probably damaging 0.98
R6487:Cyp2c37 UTSW 19 39,983,025 (GRCm39) missense probably benign
R6631:Cyp2c37 UTSW 19 39,998,287 (GRCm39) missense probably damaging 1.00
R7062:Cyp2c37 UTSW 19 39,983,990 (GRCm39) splice site probably null
R7937:Cyp2c37 UTSW 19 39,982,202 (GRCm39) missense probably damaging 1.00
R9640:Cyp2c37 UTSW 19 40,000,180 (GRCm39) missense probably benign 0.01
R9779:Cyp2c37 UTSW 19 39,998,323 (GRCm39) missense probably benign 0.09
R9784:Cyp2c37 UTSW 19 39,988,943 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TGTGTGAAGTGAGCATGAGCATCC -3'
(R):5'- AGCGTCATGAGTGAGAAACGCC -3'

Sequencing Primer
(F):5'- TTTGCAATAGTGCCCTAGAAATG -3'
(R):5'- CACTCAGTAGAGAGTACATCCTG -3'
Posted On 2013-10-16