Incidental Mutation 'R0784:Or2z2'
ID 76782
Institutional Source Beutler Lab
Gene Symbol Or2z2
Ensembl Gene ENSMUSG00000043314
Gene Name olfactory receptor family 2 subfamily Z member 2
Synonyms MOR281-1, MTPCR07, GA_x6K02T2NKPP-957001-957948, Olfr30
MMRRC Submission 038964-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0784 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 58345741-58346806 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58346131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 215 (I215F)
Ref Sequence ENSEMBL: ENSMUSP00000148907 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055204] [ENSMUST00000064614] [ENSMUST00000215691]
AlphaFold Q8VGD8
Predicted Effect possibly damaging
Transcript: ENSMUST00000055204
AA Change: I215F

PolyPhen 2 Score 0.625 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055961
Gene: ENSMUSG00000043314
AA Change: I215F

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 1.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 36 252 1.7e-6 PFAM
Pfam:7tm_1 42 291 8.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000064614
SMART Domains Protein: ENSMUSP00000063665
Gene: ENSMUSG00000052642

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:UPAR_LY6 47 124 1.3e-6 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215691
AA Change: I215F

PolyPhen 2 Score 0.625 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.5236 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.9%
  • 10x: 96.9%
  • 20x: 92.1%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 T C 14: 54,890,985 (GRCm39) probably benign Het
Adamts2 C T 11: 50,558,830 (GRCm39) R182W probably damaging Het
Ahr C T 12: 35,558,141 (GRCm39) G293D possibly damaging Het
Akna G T 4: 63,295,125 (GRCm39) T1028K probably benign Het
Akp3 G A 1: 87,055,593 (GRCm39) G547R unknown Het
Aoc1l3 T A 6: 48,964,235 (GRCm39) M81K possibly damaging Het
Asic2 T A 11: 80,784,815 (GRCm39) M324L possibly damaging Het
Atf6 A G 1: 170,537,516 (GRCm39) F635L probably benign Het
Atp8b2 A T 3: 89,864,380 (GRCm39) V195E probably damaging Het
Bicd1 T A 6: 149,414,861 (GRCm39) C525S probably damaging Het
Cbfa2t3 A G 8: 123,377,226 (GRCm39) probably benign Het
Cd46 G A 1: 194,774,502 (GRCm39) T11M possibly damaging Het
Cecr2 A G 6: 120,735,110 (GRCm39) H754R possibly damaging Het
Clcn3 G T 8: 61,382,237 (GRCm39) D450E probably benign Het
Cobl T G 11: 12,216,843 (GRCm39) probably benign Het
Cyba T A 8: 123,154,422 (GRCm39) T34S probably benign Het
Dennd1a A G 2: 37,911,426 (GRCm39) L187P probably damaging Het
Dennd4c A T 4: 86,763,145 (GRCm39) Q1817L probably benign Het
Drosha T C 15: 12,867,764 (GRCm39) probably benign Het
Dync1li2 A G 8: 105,169,130 (GRCm39) S34P probably damaging Het
Emilin2 T A 17: 71,582,282 (GRCm39) D148V possibly damaging Het
Galnt11 A G 5: 25,463,907 (GRCm39) D393G probably damaging Het
Gm5435 T A 12: 82,542,954 (GRCm39) noncoding transcript Het
Gpr176 C T 2: 118,203,533 (GRCm39) V46M possibly damaging Het
Gpr85 T A 6: 13,836,748 (GRCm39) H52L probably benign Het
Grn T C 11: 102,325,328 (GRCm39) M246T possibly damaging Het
Hnrnpul2 T C 19: 8,802,416 (GRCm39) F428L possibly damaging Het
Hoxa13 G C 6: 52,236,917 (GRCm39) N278K probably damaging Het
Irx5 A G 8: 93,087,118 (GRCm39) D350G probably benign Het
Kat2a C T 11: 100,601,667 (GRCm39) M249I probably benign Het
Klhl29 T C 12: 5,131,251 (GRCm39) Y782C probably damaging Het
Kmt2c A T 5: 25,515,893 (GRCm39) F2650Y probably benign Het
Lrp2 A G 2: 69,348,709 (GRCm39) I754T probably benign Het
LTO1 A T 7: 144,473,014 (GRCm39) Y108F probably benign Het
Mpl G A 4: 118,303,603 (GRCm39) P472S possibly damaging Het
Mtnr1b A G 9: 15,774,081 (GRCm39) I326T probably benign Het
Myh9 A G 15: 77,661,209 (GRCm39) probably benign Het
Mylk G C 16: 34,699,845 (GRCm39) E403Q possibly damaging Het
Myo9a A G 9: 59,803,828 (GRCm39) probably benign Het
Or4ac1-ps1 T A 2: 88,370,511 (GRCm39) noncoding transcript Het
Pcsk5 T C 19: 17,692,133 (GRCm39) M184V probably benign Het
Piezo2 T A 18: 63,216,306 (GRCm39) D1143V probably damaging Het
Prr36 G T 8: 4,263,771 (GRCm39) probably benign Het
Rnf220 C A 4: 117,135,195 (GRCm39) probably benign Het
Senp3 A G 11: 69,571,274 (GRCm39) L131P probably damaging Het
Shc4 A C 2: 125,499,416 (GRCm39) W354G probably benign Het
Slc6a15 A G 10: 103,252,661 (GRCm39) probably benign Het
Smtnl2 T C 11: 72,290,763 (GRCm39) D394G probably damaging Het
Sry G T Y: 2,662,731 (GRCm39) Q310K unknown Het
St7l A G 3: 104,778,240 (GRCm39) M126V probably benign Het
St8sia3 T C 18: 64,404,772 (GRCm39) W350R probably damaging Het
Stk35 A T 2: 129,652,722 (GRCm39) K408* probably null Het
Thsd7b T C 1: 129,523,096 (GRCm39) probably benign Het
Tmem106b T C 6: 13,084,252 (GRCm39) V252A probably damaging Het
Trpm7 A G 2: 126,687,992 (GRCm39) probably null Het
Ttf2 T C 3: 100,870,026 (GRCm39) D349G probably benign Het
Zfp386 T A 12: 116,023,540 (GRCm39) C419* probably null Het
Zfp541 A G 7: 15,816,917 (GRCm39) probably benign Het
Other mutations in Or2z2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01305:Or2z2 APN 11 58,346,088 (GRCm39) missense probably damaging 1.00
IGL02001:Or2z2 APN 11 58,346,335 (GRCm39) missense probably benign 0.33
IGL02170:Or2z2 APN 11 58,345,906 (GRCm39) missense probably damaging 1.00
IGL02638:Or2z2 APN 11 58,345,873 (GRCm39) missense probably damaging 1.00
ANU22:Or2z2 UTSW 11 58,346,088 (GRCm39) missense probably damaging 1.00
R0502:Or2z2 UTSW 11 58,346,140 (GRCm39) missense possibly damaging 0.54
R1300:Or2z2 UTSW 11 58,346,667 (GRCm39) missense probably damaging 1.00
R1451:Or2z2 UTSW 11 58,346,358 (GRCm39) missense probably benign 0.00
R1642:Or2z2 UTSW 11 58,346,664 (GRCm39) missense probably benign
R1754:Or2z2 UTSW 11 58,346,088 (GRCm39) missense probably damaging 1.00
R1854:Or2z2 UTSW 11 58,346,257 (GRCm39) missense probably damaging 1.00
R2920:Or2z2 UTSW 11 58,346,403 (GRCm39) missense probably damaging 1.00
R3160:Or2z2 UTSW 11 58,346,053 (GRCm39) missense probably damaging 1.00
R3162:Or2z2 UTSW 11 58,346,053 (GRCm39) missense probably damaging 1.00
R4791:Or2z2 UTSW 11 58,346,370 (GRCm39) missense possibly damaging 0.83
R4964:Or2z2 UTSW 11 58,346,733 (GRCm39) missense probably benign 0.05
R5433:Or2z2 UTSW 11 58,346,680 (GRCm39) missense probably damaging 0.99
R5543:Or2z2 UTSW 11 58,345,993 (GRCm39) missense probably damaging 1.00
R6649:Or2z2 UTSW 11 58,346,394 (GRCm39) missense probably damaging 0.98
R6653:Or2z2 UTSW 11 58,346,394 (GRCm39) missense probably damaging 0.98
R7388:Or2z2 UTSW 11 58,346,481 (GRCm39) missense probably damaging 1.00
R7492:Or2z2 UTSW 11 58,346,715 (GRCm39) missense probably benign 0.28
R7566:Or2z2 UTSW 11 58,346,489 (GRCm39) missense probably benign 0.02
R7567:Or2z2 UTSW 11 58,345,992 (GRCm39) missense probably damaging 1.00
R8557:Or2z2 UTSW 11 58,346,562 (GRCm39) missense probably damaging 1.00
R8777:Or2z2 UTSW 11 58,346,757 (GRCm39) nonsense probably null
R8777-TAIL:Or2z2 UTSW 11 58,346,757 (GRCm39) nonsense probably null
R8810:Or2z2 UTSW 11 58,345,936 (GRCm39) missense possibly damaging 0.54
R9139:Or2z2 UTSW 11 58,345,999 (GRCm39) missense possibly damaging 0.92
Z1177:Or2z2 UTSW 11 58,346,363 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCATTTCTATTGACGCCACACC -3'
(R):5'- GCTATCTGCAACCCTCTGCGATAC -3'

Sequencing Primer
(F):5'- GACAGATACTACATCGTCTTGGC -3'
(R):5'- CCTCTGCGATACCCAGTG -3'
Posted On 2013-10-16