Incidental Mutation 'R0785:Trappc1'
ID 76824
Institutional Source Beutler Lab
Gene Symbol Trappc1
Ensembl Gene ENSMUSG00000049299
Gene Name trafficking protein particle complex 1
Synonyms MUM2, BET5, D11Ertd172e
MMRRC Submission 038965-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0785 (G1)
Quality Score 144
Status Validated
Chromosome 11
Chromosomal Location 69214812-69216619 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 69215636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018614] [ENSMUST00000060956] [ENSMUST00000092973] [ENSMUST00000102601] [ENSMUST00000102602] [ENSMUST00000108662] [ENSMUST00000123176]
AlphaFold Q5NCF2
Predicted Effect probably benign
Transcript: ENSMUST00000018614
SMART Domains Protein: ENSMUSP00000018614
Gene: ENSMUSG00000018470

DomainStartEndE-ValueType
low complexity region 23 49 N/A INTRINSIC
low complexity region 54 65 N/A INTRINSIC
Pfam:Aldo_ket_red 92 396 1.6e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000060956
SMART Domains Protein: ENSMUSP00000050153
Gene: ENSMUSG00000049299

DomainStartEndE-ValueType
Pfam:Sybindin 3 109 2.2e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000092973
SMART Domains Protein: ENSMUSP00000090651
Gene: ENSMUSG00000032782

DomainStartEndE-ValueType
coiled coil region 191 218 N/A INTRINSIC
coiled coil region 249 557 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102601
SMART Domains Protein: ENSMUSP00000099661
Gene: ENSMUSG00000049299

DomainStartEndE-ValueType
Pfam:Sybindin 3 137 1.4e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102602
SMART Domains Protein: ENSMUSP00000099662
Gene: ENSMUSG00000049299

DomainStartEndE-ValueType
Pfam:Sybindin 3 137 1.4e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108662
SMART Domains Protein: ENSMUSP00000104302
Gene: ENSMUSG00000049299

DomainStartEndE-ValueType
Pfam:Sybindin 3 127 2.2e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123176
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140555
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125777
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142328
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.1%
  • 20x: 87.1%
Validation Efficiency 100% (36/36)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 G A 7: 119,893,380 (GRCm39) G1277R probably damaging Het
Adam10 A G 9: 70,675,170 (GRCm39) E593G possibly damaging Het
Adh6a T C 3: 138,034,829 (GRCm39) probably benign Het
Akap6 T A 12: 52,933,405 (GRCm39) I299N probably benign Het
Bltp1 T C 3: 37,013,483 (GRCm39) probably benign Het
Bod1l A T 5: 41,977,359 (GRCm39) N1318K probably benign Het
Ccdc121rt2 A G 5: 112,598,434 (GRCm39) D327G probably benign Het
Eif2b2 C A 12: 85,268,335 (GRCm39) T170K probably damaging Het
Ermard T A 17: 15,242,239 (GRCm39) H138Q probably damaging Het
Ern2 A T 7: 121,770,884 (GRCm39) probably null Het
Fkbp11 T C 15: 98,624,430 (GRCm39) K108R probably damaging Het
Golgb1 A G 16: 36,719,152 (GRCm39) K353E possibly damaging Het
Hipk1 G T 3: 103,661,641 (GRCm39) probably null Het
Itga4 A G 2: 79,119,649 (GRCm39) D485G possibly damaging Het
Krt1c C A 15: 101,726,356 (GRCm39) G61C unknown Het
Med12l T A 3: 59,168,253 (GRCm39) L1561Q probably damaging Het
Mtmr14 T C 6: 113,254,908 (GRCm39) probably null Het
Myorg A G 4: 41,497,539 (GRCm39) V697A probably benign Het
Naip1 A G 13: 100,559,584 (GRCm39) M1140T probably benign Het
Naip1 C T 13: 100,559,593 (GRCm39) R1137Q probably benign Het
Nav2 T A 7: 49,070,081 (GRCm39) H251Q probably benign Het
Nphp4 A G 4: 152,646,566 (GRCm39) D1366G possibly damaging Het
Or2b7 A G 13: 21,739,958 (GRCm39) V78A probably benign Het
Or6c75 A G 10: 129,336,750 (GRCm39) probably null Het
Pde6c A C 19: 38,121,628 (GRCm39) M79L probably benign Het
Pld5 C T 1: 175,803,018 (GRCm39) probably benign Het
Polr1g G C 7: 19,091,210 (GRCm39) S299C probably benign Het
Rps6kc1 A G 1: 190,541,142 (GRCm39) V387A probably damaging Het
Tas2r136 T C 6: 132,754,890 (GRCm39) D79G probably benign Het
Tmem243 A T 5: 9,168,488 (GRCm39) K90I probably damaging Het
Topbp1 A G 9: 103,192,289 (GRCm39) H260R probably damaging Het
Vmn2r125 C A 4: 156,703,396 (GRCm39) A258D probably benign Het
Zfp300 T C X: 20,949,164 (GRCm39) Y200C possibly damaging Het
Other mutations in Trappc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0362:Trappc1 UTSW 11 69,216,402 (GRCm39) missense probably benign 0.00
R2109:Trappc1 UTSW 11 69,215,243 (GRCm39) missense probably damaging 1.00
R3522:Trappc1 UTSW 11 69,215,248 (GRCm39) missense probably damaging 0.96
R4663:Trappc1 UTSW 11 69,216,337 (GRCm39) missense probably benign
R4676:Trappc1 UTSW 11 69,216,356 (GRCm39) missense probably damaging 1.00
R5165:Trappc1 UTSW 11 69,215,060 (GRCm39) missense probably benign 0.43
R5448:Trappc1 UTSW 11 69,216,361 (GRCm39) missense probably benign 0.15
R5817:Trappc1 UTSW 11 69,215,060 (GRCm39) missense possibly damaging 0.54
Predicted Primers PCR Primer
(F):5'- TTTGTCAGCAAGATGTCCCCGC -3'
(R):5'- GCACAAGCTCTCCCTTAGAGAAGC -3'

Sequencing Primer
(F):5'- TCTGGATCGAGAATCTTGAAGC -3'
(R):5'- AGCTCTCCCTTAGAGAAGCTATTAC -3'
Posted On 2013-10-16