Incidental Mutation 'R0787:Or6c201'
ID 76910
Institutional Source Beutler Lab
Gene Symbol Or6c201
Ensembl Gene ENSMUSG00000047868
Gene Name olfactory receptor family 6 subfamily C member 201
Synonyms MOR114-5, Olfr770, GA_x6K02T2PULF-10819232-10818297
MMRRC Submission 038967-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R0787 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 128968700-128969635 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 128969395 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 81 (N81D)
Ref Sequence ENSEMBL: ENSMUSP00000144960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062314] [ENSMUST00000203887] [ENSMUST00000204250] [ENSMUST00000204712]
AlphaFold Q8VGC2
Predicted Effect possibly damaging
Transcript: ENSMUST00000062314
AA Change: N81D

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000055193
Gene: ENSMUSG00000047868
AA Change: N81D

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.2e-43 PFAM
Pfam:7tm_1 38 286 5.5e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000203887
AA Change: N81D

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144950
Gene: ENSMUSG00000047868
AA Change: N81D

DomainStartEndE-ValueType
Pfam:7tm_4 28 107 1.5e-8 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204250
AA Change: N81D

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144892
Gene: ENSMUSG00000047868
AA Change: N81D

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.2e-43 PFAM
Pfam:7tm_1 38 286 5.5e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204712
AA Change: N81D

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144960
Gene: ENSMUSG00000047868
AA Change: N81D

DomainStartEndE-ValueType
Pfam:7tm_4 28 130 1.4e-17 PFAM
Pfam:7TM_GPCR_Srsx 32 130 2.4e-4 PFAM
Pfam:7tm_1 38 130 8.8e-16 PFAM
Meta Mutation Damage Score 0.1201 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 96.9%
  • 20x: 93.4%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001F09Rik A T 14: 43,202,950 (GRCm39) probably null Het
Abca8a T A 11: 109,933,814 (GRCm39) Y1197F possibly damaging Het
Abcc2 T C 19: 43,786,955 (GRCm39) probably null Het
Adamts16 A T 13: 70,886,948 (GRCm39) C979S probably damaging Het
Agap2 T A 10: 126,921,019 (GRCm39) D523E unknown Het
Ankfy1 T A 11: 72,651,122 (GRCm39) I1024N probably damaging Het
Ankrd13c A G 3: 157,700,315 (GRCm39) S379G probably null Het
Arhgap40 T C 2: 158,389,710 (GRCm39) S625P probably benign Het
Armc12 G C 17: 28,757,740 (GRCm39) A291P probably damaging Het
Armc9 A G 1: 86,130,227 (GRCm39) N524D probably damaging Het
Col12a1 G T 9: 79,545,767 (GRCm39) T2305K probably damaging Het
Cyp2c54 T C 19: 40,036,079 (GRCm39) N277S probably benign Het
Czib T A 4: 107,747,326 (GRCm39) L6Q probably damaging Het
Dennd2b G T 7: 109,124,827 (GRCm39) R1068S possibly damaging Het
E130311K13Rik A T 3: 63,827,719 (GRCm39) V129E probably benign Het
Ehbp1l1 T C 19: 5,772,696 (GRCm39) D79G possibly damaging Het
Epb41l1 A G 2: 156,336,010 (GRCm39) E58G probably damaging Het
Fam217b T A 2: 178,062,702 (GRCm39) V222E probably benign Het
Fat1 T A 8: 45,493,592 (GRCm39) Y3913N probably damaging Het
Fgd4 A G 16: 16,241,765 (GRCm39) probably benign Het
Hltf A T 3: 20,160,610 (GRCm39) D759V probably damaging Het
Hsp90ab1 ACTTCTT ACTT 17: 45,880,425 (GRCm39) probably benign Het
Isg15 C T 4: 156,284,396 (GRCm39) R44H probably benign Het
Itga4 C T 2: 79,109,497 (GRCm39) T232I probably benign Het
Kntc1 C A 5: 123,934,167 (GRCm39) H1399Q probably benign Het
Lig1 A C 7: 13,032,995 (GRCm39) K499Q probably benign Het
Lrrn3 C A 12: 41,504,230 (GRCm39) C29F probably damaging Het
Mtmr10 T C 7: 63,950,363 (GRCm39) I136T possibly damaging Het
Naip1 A G 13: 100,562,604 (GRCm39) Y854H probably benign Het
Pcdh9 G A 14: 94,124,193 (GRCm39) A659V possibly damaging Het
Phf20l1 T A 15: 66,487,479 (GRCm39) probably benign Het
Phgdh A G 3: 98,241,865 (GRCm39) V83A probably damaging Het
Pik3r1 A T 13: 101,827,031 (GRCm39) M326K probably benign Het
Pirb A T 7: 3,720,637 (GRCm39) L287Q probably benign Het
Pkd1l2 T C 8: 117,802,916 (GRCm39) D235G possibly damaging Het
Pkhd1l1 C A 15: 44,392,660 (GRCm39) P1665Q probably damaging Het
Ppp1r7 A G 1: 93,292,678 (GRCm39) T326A probably damaging Het
Prr22 A T 17: 57,078,072 (GRCm39) Y75F possibly damaging Het
Ptov1 A C 7: 44,514,894 (GRCm39) probably null Het
Rasal2 A G 1: 156,986,266 (GRCm39) S766P probably damaging Het
Shmt1 T C 11: 60,683,802 (GRCm39) T337A probably benign Het
Tbc1d4 A T 14: 101,686,645 (GRCm39) I1168N probably damaging Het
Tecpr2 T C 12: 110,912,777 (GRCm39) V1126A probably benign Het
Tep1 A T 14: 51,066,687 (GRCm39) S2304T possibly damaging Het
Tiam1 C A 16: 89,586,449 (GRCm39) R1446M probably damaging Het
Tmem87a T C 2: 120,200,965 (GRCm39) I425V probably benign Het
Ubr3 T C 2: 69,781,765 (GRCm39) probably benign Het
Ubxn7 T A 16: 32,200,581 (GRCm39) probably benign Het
Vmn2r13 A G 5: 109,304,713 (GRCm39) S573P probably damaging Het
Wdfy3 A T 5: 102,105,254 (GRCm39) V191E probably damaging Het
Zdhhc3 A T 9: 122,912,688 (GRCm39) C153* probably null Het
Zfp407 A T 18: 84,227,147 (GRCm39) V2154D probably damaging Het
Zfp407 A G 18: 84,227,471 (GRCm39) V2046A probably benign Het
Zfr T A 15: 12,140,634 (GRCm39) I227N unknown Het
Other mutations in Or6c201
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2141:Or6c201 UTSW 10 128,968,875 (GRCm39) missense probably benign 0.23
R4190:Or6c201 UTSW 10 128,968,836 (GRCm39) missense possibly damaging 0.86
R4397:Or6c201 UTSW 10 128,969,450 (GRCm39) missense possibly damaging 0.59
R5009:Or6c201 UTSW 10 128,969,484 (GRCm39) missense probably benign 0.06
R5781:Or6c201 UTSW 10 128,969,016 (GRCm39) missense probably damaging 1.00
R6343:Or6c201 UTSW 10 128,969,535 (GRCm39) nonsense probably null
R7492:Or6c201 UTSW 10 128,969,509 (GRCm39) missense probably damaging 0.99
R7530:Or6c201 UTSW 10 128,969,849 (GRCm39) splice site probably null
Z1088:Or6c201 UTSW 10 128,968,944 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- TCTTCAGGAAGGGAGACACATCACA -3'
(R):5'- TCCACAAATTCAAAGCCTGCTTTTGATT -3'

Sequencing Primer
(F):5'- TGGCAGTATGATGATCACCC -3'
(R):5'- AAAGCCTGCTTTTGATTTTTCTCC -3'
Posted On 2013-10-16