Incidental Mutation 'R0771:Zfp61'
| ID |
76951 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp61
|
| Ensembl Gene |
ENSMUSG00000050605 |
| Gene Name |
zinc finger protein 61 |
| Synonyms |
|
| MMRRC Submission |
038951-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.060)
|
| Stock # |
R0771 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
23990464-24000657 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23992779 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 71
(R71G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077780]
[ENSMUST00000145131]
[ENSMUST00000165241]
|
| AlphaFold |
Q923D1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077780
AA Change: R71G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000076954
Gene: ENSMUSG00000050605
AA Change: R71G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
63 |
2.28e-27 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
1.5e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128421
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137342
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138619
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138924
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139811
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145131
|
| SMART Domains |
Protein: ENSMUSP00000117077
Gene: ENSMUSG00000050605
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
4.63e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165241
AA Change: R71G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000132551
Gene: ENSMUSG00000050605
AA Change: R71G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
63 |
2.28e-27 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
1.5e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206535
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.2%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abr |
T |
C |
11: 76,346,509 (GRCm39) |
E434G |
probably damaging |
Het |
| Adam19 |
G |
A |
11: 46,012,280 (GRCm39) |
V259I |
possibly damaging |
Het |
| Adam5 |
A |
G |
8: 25,276,315 (GRCm39) |
S451P |
probably benign |
Het |
| Chd6 |
G |
A |
2: 160,861,500 (GRCm39) |
L516F |
probably damaging |
Het |
| Elovl4 |
A |
G |
9: 83,667,168 (GRCm39) |
V154A |
possibly damaging |
Het |
| Gadl1 |
G |
A |
9: 115,773,300 (GRCm39) |
R114Q |
probably damaging |
Het |
| Ipo13 |
T |
C |
4: 117,751,843 (GRCm39) |
N936S |
possibly damaging |
Het |
| Kcnd2 |
T |
A |
6: 21,216,441 (GRCm39) |
S48R |
probably damaging |
Het |
| Lgalsl2 |
A |
G |
7: 5,362,822 (GRCm39) |
D151G |
probably damaging |
Het |
| Lim2 |
C |
A |
7: 43,080,127 (GRCm39) |
A38E |
possibly damaging |
Het |
| Lrp2 |
A |
T |
2: 69,338,334 (GRCm39) |
D1177E |
probably damaging |
Het |
| Mdh1 |
C |
T |
11: 21,507,550 (GRCm39) |
V300I |
probably benign |
Het |
| Mfsd4b4 |
T |
C |
10: 39,768,407 (GRCm39) |
T275A |
probably benign |
Het |
| Myo10 |
A |
G |
15: 25,778,264 (GRCm39) |
Y114C |
probably damaging |
Het |
| Ncapg2 |
T |
A |
12: 116,376,779 (GRCm39) |
C122* |
probably null |
Het |
| Nod1 |
T |
G |
6: 54,921,254 (GRCm39) |
S355R |
probably damaging |
Het |
| Or52x1 |
T |
A |
7: 104,853,368 (GRCm39) |
M61L |
possibly damaging |
Het |
| Or5ap2 |
A |
T |
2: 85,680,338 (GRCm39) |
I181F |
possibly damaging |
Het |
| Pcsk1 |
A |
T |
13: 75,280,281 (GRCm39) |
E702V |
probably benign |
Het |
| Ptpn21 |
T |
C |
12: 98,655,339 (GRCm39) |
T543A |
probably damaging |
Het |
| Ranbp9 |
T |
C |
13: 43,615,249 (GRCm39) |
I190V |
possibly damaging |
Het |
| Sirpd |
T |
A |
3: 15,385,506 (GRCm39) |
Q132L |
probably benign |
Het |
| Slc1a4 |
C |
T |
11: 20,256,467 (GRCm39) |
V455M |
probably damaging |
Het |
| Srbd1 |
T |
A |
17: 86,437,682 (GRCm39) |
E220D |
probably benign |
Het |
| Thsd7a |
A |
G |
6: 12,327,576 (GRCm39) |
V1432A |
probably benign |
Het |
|
| Other mutations in Zfp61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00588:Zfp61
|
APN |
7 |
23,990,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1574:Zfp61
|
UTSW |
7 |
23,990,635 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Zfp61
|
UTSW |
7 |
23,990,635 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2029:Zfp61
|
UTSW |
7 |
23,991,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2443:Zfp61
|
UTSW |
7 |
23,991,194 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3771:Zfp61
|
UTSW |
7 |
23,995,406 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R3773:Zfp61
|
UTSW |
7 |
23,995,406 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R4093:Zfp61
|
UTSW |
7 |
23,990,700 (GRCm39) |
splice site |
probably null |
|
|
R4095:Zfp61
|
UTSW |
7 |
23,990,700 (GRCm39) |
splice site |
probably null |
|
|
R7533:Zfp61
|
UTSW |
7 |
23,990,504 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8423:Zfp61
|
UTSW |
7 |
23,991,459 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9057:Zfp61
|
UTSW |
7 |
23,990,702 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTTTCTAGGCACTACCCAGAACCA -3'
(R):5'- TTGGAAGGGTCACATCATAAATGCTGTT -3'
Sequencing Primer
(F):5'- ATGCCTGGCACACACTC -3'
(R):5'- atgaaggaggggaagggg -3'
|
| Posted On |
2013-10-16 |
Incidental Mutation