Incidental Mutation 'R0849:Armc9'
ID 77041
Institutional Source Beutler Lab
Gene Symbol Armc9
Ensembl Gene ENSMUSG00000062590
Gene Name armadillo repeat containing 9
Synonyms 4831423D23Rik, 4930438O05Rik, 5730415N24Rik, 3830422A13Rik
MMRRC Submission 039028-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.660) question?
Stock # R0849 (G1)
Quality Score 224
Status Not validated
Chromosome 1
Chromosomal Location 86082502-86206006 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 86184992 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 681 (R681K)
Ref Sequence ENSEMBL: ENSMUSP00000108934 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027434] [ENSMUST00000113309] [ENSMUST00000126579] [ENSMUST00000131412] [ENSMUST00000150059] [ENSMUST00000156675]
AlphaFold Q9D2I5
Predicted Effect probably benign
Transcript: ENSMUST00000027434
AA Change: R681K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000027434
Gene: ENSMUSG00000062590
AA Change: R681K

DomainStartEndE-ValueType
LisH 7 39 1.8e-4 SMART
low complexity region 175 190 N/A INTRINSIC
coiled coil region 206 242 N/A INTRINSIC
SCOP:d1jdha_ 377 575 8e-14 SMART
low complexity region 793 807 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000113309
AA Change: R681K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000108934
Gene: ENSMUSG00000062590
AA Change: R681K

DomainStartEndE-ValueType
LisH 7 39 1.8e-4 SMART
low complexity region 175 190 N/A INTRINSIC
coiled coil region 206 242 N/A INTRINSIC
SCOP:d1jdha_ 377 575 8e-14 SMART
low complexity region 794 808 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000126579
Predicted Effect probably benign
Transcript: ENSMUST00000131412
SMART Domains Protein: ENSMUSP00000117267
Gene: ENSMUSG00000062590

DomainStartEndE-ValueType
LisH 7 39 1.8e-4 SMART
low complexity region 175 190 N/A INTRINSIC
coiled coil region 206 242 N/A INTRINSIC
SCOP:d1jdha_ 377 575 4e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135973
Predicted Effect probably benign
Transcript: ENSMUST00000150059
SMART Domains Protein: ENSMUSP00000116908
Gene: ENSMUSG00000062590

DomainStartEndE-ValueType
SCOP:d1qbkb_ 1 168 4e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156675
SMART Domains Protein: ENSMUSP00000119749
Gene: ENSMUSG00000062590

DomainStartEndE-ValueType
SCOP:d1qbkb_ 6 100 3e-3 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.5%
  • 20x: 92.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap5 T C 12: 52,566,406 (GRCm39) F1126L probably benign Het
Arhgef11 G T 3: 87,643,203 (GRCm39) A1472S probably benign Het
Atxn2 T A 5: 121,885,484 (GRCm39) probably null Het
B3gnt6 C A 7: 97,843,950 (GRCm39) L3F probably benign Het
Cand2 A G 6: 115,769,352 (GRCm39) T721A probably damaging Het
Cntn2 A T 1: 132,450,124 (GRCm39) M590K probably benign Het
Cntn4 A T 6: 106,644,418 (GRCm39) D622V probably damaging Het
Des T G 1: 75,337,272 (GRCm39) S71A probably benign Het
Dnah5 C A 15: 28,263,745 (GRCm39) R827S probably damaging Het
Dstn G A 2: 143,780,455 (GRCm39) G52S probably benign Het
Eln T A 5: 134,736,835 (GRCm39) R704* probably null Het
Fezf2 T A 14: 12,342,607 (GRCm38) K419N probably damaging Het
Gm2381 G A 7: 42,469,372 (GRCm39) Q251* probably null Het
Grin3a G A 4: 49,665,501 (GRCm39) R1045* probably null Het
Herc2 T A 7: 55,856,326 (GRCm39) H3921Q probably damaging Het
Hs3st2 A G 7: 121,100,255 (GRCm39) E367G possibly damaging Het
Hydin G A 8: 111,325,616 (GRCm39) R4675H probably damaging Het
Inhca A C 9: 103,140,256 (GRCm39) Y488D possibly damaging Het
Irf2bp1 T C 7: 18,738,659 (GRCm39) S100P possibly damaging Het
Itga10 A G 3: 96,559,846 (GRCm39) I500M possibly damaging Het
Kcnt2 T C 1: 140,435,500 (GRCm39) V496A probably damaging Het
Mansc1 T C 6: 134,587,670 (GRCm39) D169G probably benign Het
Mdn1 T A 4: 32,741,835 (GRCm39) S3869T probably damaging Het
Mrgprb4 G A 7: 47,848,868 (GRCm39) T20I probably benign Het
Nek4 A G 14: 30,679,253 (GRCm39) E198G probably damaging Het
Or12e8 G T 2: 87,188,609 (GRCm39) V274L probably benign Het
Or2y10 G A 11: 49,455,129 (GRCm39) C127Y probably damaging Het
Or5w11 C A 2: 87,459,626 (GRCm39) T273K possibly damaging Het
Ppfia4 A T 1: 134,247,110 (GRCm39) F537I probably benign Het
Rarb A G 14: 16,434,293 (GRCm38) V295A probably damaging Het
Ryr1 A G 7: 28,740,104 (GRCm39) S3941P probably damaging Het
Scnn1b A G 7: 121,511,698 (GRCm39) N370S probably damaging Het
Stard9 C A 2: 120,504,117 (GRCm39) S221R probably damaging Het
Sv2c C T 13: 96,126,319 (GRCm39) G311D probably damaging Het
Tas2r109 T C 6: 132,957,856 (GRCm39) I25V probably benign Het
Tbcel A C 9: 42,348,453 (GRCm39) I305S probably damaging Het
Tmem35b A G 4: 127,019,990 (GRCm39) probably null Het
Tmem38b T C 4: 53,840,765 (GRCm39) L60S probably damaging Het
Tmtc4 A G 14: 123,182,966 (GRCm39) I244T possibly damaging Het
Usp9y C A Y: 1,394,002 (GRCm39) C576F probably damaging Het
Vcan A T 13: 89,853,072 (GRCm39) N629K possibly damaging Het
Vmn2r22 T C 6: 123,614,363 (GRCm39) Y409C probably damaging Het
Vmn2r-ps158 A G 7: 42,674,142 (GRCm39) Y400C probably damaging Het
Other mutations in Armc9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00468:Armc9 APN 1 86,126,061 (GRCm39) missense probably damaging 1.00
IGL00771:Armc9 APN 1 86,127,557 (GRCm39) splice site probably null
IGL01689:Armc9 APN 1 86,202,140 (GRCm39) missense probably benign
IGL02143:Armc9 APN 1 86,104,587 (GRCm39) missense possibly damaging 0.58
IGL02680:Armc9 APN 1 86,180,000 (GRCm39) missense probably damaging 1.00
IGL02812:Armc9 APN 1 86,172,293 (GRCm39) missense probably damaging 0.99
IGL02887:Armc9 APN 1 86,092,557 (GRCm39) missense probably damaging 1.00
IGL03011:Armc9 APN 1 86,127,638 (GRCm39) critical splice donor site probably null
IGL03309:Armc9 APN 1 86,202,155 (GRCm39) missense possibly damaging 0.54
R0184:Armc9 UTSW 1 86,126,092 (GRCm39) missense probably damaging 1.00
R0440:Armc9 UTSW 1 86,121,984 (GRCm39) splice site probably null
R0787:Armc9 UTSW 1 86,130,227 (GRCm39) missense probably damaging 0.99
R1687:Armc9 UTSW 1 86,084,677 (GRCm39) start codon destroyed probably null 1.00
R1962:Armc9 UTSW 1 86,135,696 (GRCm39) missense probably damaging 1.00
R2176:Armc9 UTSW 1 86,127,614 (GRCm39) missense probably damaging 1.00
R3418:Armc9 UTSW 1 86,122,060 (GRCm39) missense probably damaging 1.00
R3419:Armc9 UTSW 1 86,122,060 (GRCm39) missense probably damaging 1.00
R4079:Armc9 UTSW 1 86,140,851 (GRCm39) intron probably benign
R4112:Armc9 UTSW 1 86,116,661 (GRCm39) missense possibly damaging 0.80
R4151:Armc9 UTSW 1 86,092,497 (GRCm39) missense probably damaging 1.00
R4675:Armc9 UTSW 1 86,130,240 (GRCm39) missense probably damaging 1.00
R4934:Armc9 UTSW 1 86,140,801 (GRCm39) missense probably damaging 1.00
R4944:Armc9 UTSW 1 86,202,256 (GRCm39) missense probably damaging 0.98
R5069:Armc9 UTSW 1 86,184,959 (GRCm39) missense probably benign 0.03
R5070:Armc9 UTSW 1 86,184,959 (GRCm39) missense probably benign 0.03
R5071:Armc9 UTSW 1 86,113,838 (GRCm39) missense probably benign 0.01
R5238:Armc9 UTSW 1 86,127,569 (GRCm39) missense probably benign 0.01
R5386:Armc9 UTSW 1 86,126,011 (GRCm39) missense probably null 1.00
R5459:Armc9 UTSW 1 86,135,694 (GRCm39) missense probably damaging 0.97
R6027:Armc9 UTSW 1 86,172,389 (GRCm39) missense probably damaging 1.00
R6144:Armc9 UTSW 1 86,172,301 (GRCm39) missense probably benign 0.06
R7111:Armc9 UTSW 1 86,087,717 (GRCm39) missense probably damaging 1.00
R7237:Armc9 UTSW 1 86,092,571 (GRCm39) missense possibly damaging 0.82
R7304:Armc9 UTSW 1 86,090,437 (GRCm39) missense probably benign
R7452:Armc9 UTSW 1 86,140,814 (GRCm39) missense possibly damaging 0.87
R7555:Armc9 UTSW 1 86,203,400 (GRCm39) missense probably damaging 1.00
R7805:Armc9 UTSW 1 86,124,041 (GRCm39) missense probably damaging 1.00
R8490:Armc9 UTSW 1 86,202,125 (GRCm39) missense probably benign 0.00
R8513:Armc9 UTSW 1 86,090,405 (GRCm39) missense probably damaging 1.00
R9378:Armc9 UTSW 1 86,189,766 (GRCm39) missense probably benign
R9439:Armc9 UTSW 1 86,084,687 (GRCm39) missense possibly damaging 0.46
Z1177:Armc9 UTSW 1 86,124,077 (GRCm39) missense probably benign 0.00
Z1177:Armc9 UTSW 1 86,104,547 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GAATCTCAGGCACAGTCACTTCCTC -3'
(R):5'- AGCTGTGAGCGGTAGACACATTG -3'

Sequencing Primer
(F):5'- AGTCACTTCCTCCATCTTCTTGTAG -3'
(R):5'- ATCTGGCAGCATGACTGG -3'
Posted On 2013-10-16