Incidental Mutation 'R0849:Vmn2r22'
ID 77062
Institutional Source Beutler Lab
Gene Symbol Vmn2r22
Ensembl Gene ENSMUSG00000095486
Gene Name vomeronasal 2, receptor 22
Synonyms EG546913
MMRRC Submission 039028-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0849 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 123586717-123627594 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123614363 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 409 (Y409C)
Ref Sequence ENSEMBL: ENSMUSP00000132043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170808]
AlphaFold E9Q7S8
Predicted Effect probably damaging
Transcript: ENSMUST00000170808
AA Change: Y409C

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: Y409C

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 473 1.4e-32 PFAM
Pfam:NCD3G 517 570 2.2e-23 PFAM
Pfam:7tm_3 601 838 1.2e-54 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.5%
  • 20x: 92.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap5 T C 12: 52,566,406 (GRCm39) F1126L probably benign Het
Arhgef11 G T 3: 87,643,203 (GRCm39) A1472S probably benign Het
Armc9 G A 1: 86,184,992 (GRCm39) R681K probably benign Het
Atxn2 T A 5: 121,885,484 (GRCm39) probably null Het
B3gnt6 C A 7: 97,843,950 (GRCm39) L3F probably benign Het
Cand2 A G 6: 115,769,352 (GRCm39) T721A probably damaging Het
Cntn2 A T 1: 132,450,124 (GRCm39) M590K probably benign Het
Cntn4 A T 6: 106,644,418 (GRCm39) D622V probably damaging Het
Des T G 1: 75,337,272 (GRCm39) S71A probably benign Het
Dnah5 C A 15: 28,263,745 (GRCm39) R827S probably damaging Het
Dstn G A 2: 143,780,455 (GRCm39) G52S probably benign Het
Eln T A 5: 134,736,835 (GRCm39) R704* probably null Het
Fezf2 T A 14: 12,342,607 (GRCm38) K419N probably damaging Het
Gm2381 G A 7: 42,469,372 (GRCm39) Q251* probably null Het
Grin3a G A 4: 49,665,501 (GRCm39) R1045* probably null Het
Herc2 T A 7: 55,856,326 (GRCm39) H3921Q probably damaging Het
Hs3st2 A G 7: 121,100,255 (GRCm39) E367G possibly damaging Het
Hydin G A 8: 111,325,616 (GRCm39) R4675H probably damaging Het
Inhca A C 9: 103,140,256 (GRCm39) Y488D possibly damaging Het
Irf2bp1 T C 7: 18,738,659 (GRCm39) S100P possibly damaging Het
Itga10 A G 3: 96,559,846 (GRCm39) I500M possibly damaging Het
Kcnt2 T C 1: 140,435,500 (GRCm39) V496A probably damaging Het
Mansc1 T C 6: 134,587,670 (GRCm39) D169G probably benign Het
Mdn1 T A 4: 32,741,835 (GRCm39) S3869T probably damaging Het
Mrgprb4 G A 7: 47,848,868 (GRCm39) T20I probably benign Het
Nek4 A G 14: 30,679,253 (GRCm39) E198G probably damaging Het
Or12e8 G T 2: 87,188,609 (GRCm39) V274L probably benign Het
Or2y10 G A 11: 49,455,129 (GRCm39) C127Y probably damaging Het
Or5w11 C A 2: 87,459,626 (GRCm39) T273K possibly damaging Het
Ppfia4 A T 1: 134,247,110 (GRCm39) F537I probably benign Het
Rarb A G 14: 16,434,293 (GRCm38) V295A probably damaging Het
Ryr1 A G 7: 28,740,104 (GRCm39) S3941P probably damaging Het
Scnn1b A G 7: 121,511,698 (GRCm39) N370S probably damaging Het
Stard9 C A 2: 120,504,117 (GRCm39) S221R probably damaging Het
Sv2c C T 13: 96,126,319 (GRCm39) G311D probably damaging Het
Tas2r109 T C 6: 132,957,856 (GRCm39) I25V probably benign Het
Tbcel A C 9: 42,348,453 (GRCm39) I305S probably damaging Het
Tmem35b A G 4: 127,019,990 (GRCm39) probably null Het
Tmem38b T C 4: 53,840,765 (GRCm39) L60S probably damaging Het
Tmtc4 A G 14: 123,182,966 (GRCm39) I244T possibly damaging Het
Usp9y C A Y: 1,394,002 (GRCm39) C576F probably damaging Het
Vcan A T 13: 89,853,072 (GRCm39) N629K possibly damaging Het
Vmn2r-ps158 A G 7: 42,674,142 (GRCm39) Y400C probably damaging Het
Other mutations in Vmn2r22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r22 APN 6 123,615,012 (GRCm39) missense probably damaging 1.00
IGL01764:Vmn2r22 APN 6 123,627,379 (GRCm39) critical splice donor site probably null
IGL02037:Vmn2r22 APN 6 123,626,026 (GRCm39) missense probably damaging 1.00
IGL02183:Vmn2r22 APN 6 123,614,963 (GRCm39) missense probably damaging 1.00
IGL02335:Vmn2r22 APN 6 123,615,051 (GRCm39) missense probably damaging 0.99
IGL02440:Vmn2r22 APN 6 123,614,364 (GRCm39) missense probably benign 0.00
IGL02663:Vmn2r22 APN 6 123,626,117 (GRCm39) missense probably benign 0.11
IGL03101:Vmn2r22 APN 6 123,614,295 (GRCm39) missense probably benign 0.09
R0266:Vmn2r22 UTSW 6 123,614,363 (GRCm39) missense probably damaging 0.99
R0348:Vmn2r22 UTSW 6 123,614,684 (GRCm39) missense probably damaging 1.00
R0780:Vmn2r22 UTSW 6 123,614,933 (GRCm39) missense probably damaging 1.00
R1074:Vmn2r22 UTSW 6 123,626,217 (GRCm39) missense probably benign 0.02
R1456:Vmn2r22 UTSW 6 123,614,624 (GRCm39) missense possibly damaging 0.86
R1719:Vmn2r22 UTSW 6 123,614,802 (GRCm39) missense possibly damaging 0.68
R1989:Vmn2r22 UTSW 6 123,614,500 (GRCm39) missense probably damaging 1.00
R2928:Vmn2r22 UTSW 6 123,614,402 (GRCm39) missense probably damaging 0.96
R2939:Vmn2r22 UTSW 6 123,614,594 (GRCm39) missense probably damaging 0.99
R3727:Vmn2r22 UTSW 6 123,627,584 (GRCm39) missense possibly damaging 0.70
R3782:Vmn2r22 UTSW 6 123,627,591 (GRCm39) nonsense probably null
R3873:Vmn2r22 UTSW 6 123,614,339 (GRCm39) missense possibly damaging 0.68
R4344:Vmn2r22 UTSW 6 123,614,756 (GRCm39) missense probably damaging 1.00
R4407:Vmn2r22 UTSW 6 123,614,913 (GRCm39) missense probably damaging 1.00
R4428:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4430:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4431:Vmn2r22 UTSW 6 123,614,817 (GRCm39) missense possibly damaging 0.47
R4701:Vmn2r22 UTSW 6 123,627,428 (GRCm39) missense probably benign 0.00
R5274:Vmn2r22 UTSW 6 123,627,593 (GRCm39) start codon destroyed probably null 0.93
R5668:Vmn2r22 UTSW 6 123,614,873 (GRCm39) missense probably benign 0.06
R5776:Vmn2r22 UTSW 6 123,614,673 (GRCm39) missense probably damaging 1.00
R6416:Vmn2r22 UTSW 6 123,614,697 (GRCm39) missense probably damaging 1.00
R7788:Vmn2r22 UTSW 6 123,614,559 (GRCm39) missense not run
R8208:Vmn2r22 UTSW 6 123,614,444 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r22 UTSW 6 123,615,000 (GRCm39) missense possibly damaging 0.81
R8400:Vmn2r22 UTSW 6 123,614,486 (GRCm39) nonsense probably null
R8814:Vmn2r22 UTSW 6 123,614,789 (GRCm39) missense probably damaging 0.96
R8850:Vmn2r22 UTSW 6 123,614,454 (GRCm39) missense probably damaging 1.00
R9613:Vmn2r22 UTSW 6 123,615,075 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGACATGACAATGTAAGGGCCTGAAAAT -3'
(R):5'- GGCACTTCCTGTTCACACCACTT -3'

Sequencing Primer
(F):5'- CAATTGTTTTTCAGCACCATGC -3'
(R):5'- CTGATCGCATGGATCAAATTCTGG -3'
Posted On 2013-10-16