Mutagenetix > Incidental Mutation

Incidental Mutation 'R0840:Or10al7'

77144

Institutional Source

Beutler Lab

Gene Symbol

Or10al7

Ensembl Gene

ENSMUSG00000081724

Gene Name

olfactory receptor family 10 subfamily AL member 7

Synonyms

MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129

MMRRC Submission

039019-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

R0840 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38365490-38370675 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38366463 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 7 (F7S)

Ref Sequence

ENSEMBL: ENSMUSP00000113564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000122318] [ENSMUST00000174675] [ENSMUST00000216476]

AlphaFold

Q8VEY1

Predicted Effect

probably benign
Transcript: ENSMUST00000122318
AA Change: F7S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000113564
Gene: ENSMUSG00000081724
AA Change: F7S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	46	323	4.6e-56	PFAM
Pfam:7TM_GPCR_Srsx	50	319	1.1e-5	PFAM
Pfam:7tm_1	56	305	3.2e-21	PFAM

Predicted Effect

SMART Domains

Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000216476

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.1%
20x: 94.1%

Validation Efficiency

100% (51/51)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	C	G	12: 71,205,657 (GRCm39)	Q434E	probably benign	Het
A930011G23Rik	T	C	5: 99,382,547 (GRCm39)	T234A	probably benign	Het
Acot5	G	A	12: 84,122,614 (GRCm39)	W399*	probably null	Het
Adra1a	A	G	14: 66,965,159 (GRCm39)	E383G	possibly damaging	Het
Ahnak	T	A	19: 8,982,427 (GRCm39)	I1237N	probably damaging	Het
Bsg	A	G	10: 79,545,519 (GRCm39)	T28A	probably damaging	Het
Cacna1i	A	T	15: 80,243,150 (GRCm39)	I436F	possibly damaging	Het
Cd109	T	C	9: 78,571,612 (GRCm39)	I417T	probably benign	Het
Cep295	A	T	9: 15,245,611 (GRCm39)	D948E	probably benign	Het
Cfap92	G	T	6: 87,657,260 (GRCm39)		noncoding transcript	Het
Clcn3	C	A	8: 61,382,188 (GRCm39)	V467F	probably benign	Het
Cntnap3	T	C	13: 64,935,724 (GRCm39)	S380G	possibly damaging	Het
Dab1	C	T	4: 104,588,948 (GRCm39)	A524V	probably benign	Het
Dll4	T	A	2: 119,156,966 (GRCm39)	N79K	probably benign	Het
Ep300	A	T	15: 81,529,134 (GRCm39)	N1558I	unknown	Het
Fblim1	A	G	4: 141,308,320 (GRCm39)	F330L	possibly damaging	Het
Fbxo46	T	A	7: 18,871,073 (GRCm39)	M564K	possibly damaging	Het
Fnip1	T	A	11: 54,384,007 (GRCm39)		probably benign	Het
Foxl2	A	T	9: 98,837,984 (GRCm39)	K91*	probably null	Het
Gapvd1	C	A	2: 34,619,125 (GRCm39)	V83F	probably benign	Het
Guk1	G	A	11: 59,075,921 (GRCm39)	R146C	probably damaging	Het
Irf8	G	A	8: 121,480,220 (GRCm39)	G153S	probably benign	Het
Kcnu1	T	A	8: 26,403,712 (GRCm39)	M1K	probably null	Het
Krt32	G	A	11: 99,972,068 (GRCm39)	P427S	probably benign	Het
Lrp12	A	G	15: 39,739,554 (GRCm39)	S529P	probably damaging	Het
Mettl22	T	C	16: 8,300,021 (GRCm39)	V134A	probably damaging	Het
Morc2b	G	T	17: 33,355,086 (GRCm39)	H895Q	probably benign	Het
Nrros	T	C	16: 31,962,241 (GRCm39)	D556G	probably damaging	Het
Nrxn3	A	G	12: 90,298,567 (GRCm39)	S1367G	possibly damaging	Het
Or56b1b	A	T	7: 108,164,823 (GRCm39)	S60T	probably benign	Het
Pcnx3	T	A	19: 5,735,729 (GRCm39)		probably null	Het
Pgap2	A	T	7: 101,886,655 (GRCm39)	M226L	probably damaging	Het
Pik3c2g	A	G	6: 139,841,798 (GRCm39)	I616M	probably damaging	Het
Pisd	A	G	5: 32,894,656 (GRCm39)	I380T	probably damaging	Het
Pkhd1	T	C	1: 20,420,745 (GRCm39)	I2454V	probably damaging	Het
Plpp2	A	G	10: 79,363,378 (GRCm39)	I151T	probably benign	Het
Polr3a	G	A	14: 24,502,268 (GRCm39)	T1295I	possibly damaging	Het
Pot1a	T	C	6: 25,748,283 (GRCm39)		probably benign	Het
Prpf39	T	G	12: 65,094,980 (GRCm39)	N219K	probably benign	Het
Rnf17	T	A	14: 56,712,904 (GRCm39)	N790K	probably damaging	Het
Slit3	C	T	11: 35,514,263 (GRCm39)		probably benign	Het
Stx1a	T	A	5: 135,070,088 (GRCm39)		probably benign	Het
Tenm3	C	A	8: 48,788,777 (GRCm39)	V690F	probably damaging	Het
Tmcc3	A	G	10: 94,414,633 (GRCm39)	I143V	probably benign	Het
Tmem41b	G	A	7: 109,580,256 (GRCm39)	S36F	probably damaging	Het
Trim5	A	T	7: 103,914,978 (GRCm39)	W364R	probably damaging	Het
Ttn	T	C	2: 76,617,155 (GRCm39)	Y16403C	probably damaging	Het
Vps8	T	C	16: 21,275,071 (GRCm39)	S210P	probably damaging	Het
Zbtb3	T	A	19: 8,780,821 (GRCm39)	S145T	possibly damaging	Het
Zfp882	T	A	8: 72,668,530 (GRCm39)	C452*	probably null	Het

Other mutations in Or10al7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Or10al7	APN	17	38,366,481 (GRCm39)	start codon destroyed	probably null	0.15
IGL02163:Or10al7	APN	17	38,365,641 (GRCm39)	missense	probably benign	0.06
IGL02374:Or10al7	APN	17	38,366,412 (GRCm39)	missense	probably damaging	1.00
R1774:Or10al7	UTSW	17	38,366,328 (GRCm39)	missense	probably benign	0.00
R3720:Or10al7	UTSW	17	38,366,259 (GRCm39)	missense	probably damaging	1.00
R3794:Or10al7	UTSW	17	38,365,786 (GRCm39)	missense	probably damaging	1.00
R3840:Or10al7	UTSW	17	38,366,239 (GRCm39)	missense	probably damaging	1.00
R4002:Or10al7	UTSW	17	38,365,879 (GRCm39)	missense	probably damaging	1.00
R4273:Or10al7	UTSW	17	38,366,163 (GRCm39)	missense	probably damaging	1.00
R4872:Or10al7	UTSW	17	38,366,467 (GRCm39)	missense	probably benign
R5606:Or10al7	UTSW	17	38,365,693 (GRCm39)	missense	probably damaging	0.98
R6309:Or10al7	UTSW	17	38,366,043 (GRCm39)	missense	probably damaging	1.00
R7269:Or10al7	UTSW	17	38,366,442 (GRCm39)	missense	probably damaging	1.00
R7450:Or10al7	UTSW	17	38,366,000 (GRCm39)	missense	probably benign	0.00
R7829:Or10al7	UTSW	17	38,366,220 (GRCm39)	missense	possibly damaging	0.64
R8103:Or10al7	UTSW	17	38,365,903 (GRCm39)	missense	probably damaging	1.00
R8994:Or10al7	UTSW	17	38,366,220 (GRCm39)	missense	possibly damaging	0.64
R9388:Or10al7	UTSW	17	38,366,148 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCTCTGCAACATCTTCGGTATGAC -3'
(R):5'- TGCCAGGACTGCAAGTTTCCAC -3'

Sequencing Primer
(F):5'- AAGTGTAGCCAATCTCCAGG -3'
(R):5'- GGTCAGTACACTTTGGAAAATCCC -3'

Posted On

2013-10-16