Incidental Mutation 'R0840:Zbtb3'
ID 77146
Institutional Source Beutler Lab
Gene Symbol Zbtb3
Ensembl Gene ENSMUSG00000071661
Gene Name zinc finger and BTB domain containing 3
Synonyms 4930563M09Rik
MMRRC Submission 039019-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.443) question?
Stock # R0840 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 8779919-8782210 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 8780821 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 145 (S145T)
Ref Sequence ENSEMBL: ENSMUSP00000127746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096261] [ENSMUST00000172175]
AlphaFold Q91X45
Predicted Effect probably benign
Transcript: ENSMUST00000096261
SMART Domains Protein: ENSMUSP00000093980
Gene: ENSMUSG00000071662

DomainStartEndE-ValueType
Pfam:SHS2_Rpb7-N 8 77 1e-18 PFAM
S1 80 162 1.75e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000172175
AA Change: S145T

PolyPhen 2 Score 0.505 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000127746
Gene: ENSMUSG00000071661
AA Change: S145T

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
BTB 24 123 4.37e-21 SMART
low complexity region 207 225 N/A INTRINSIC
low complexity region 273 292 N/A INTRINSIC
low complexity region 386 406 N/A INTRINSIC
ZnF_C2H2 418 440 7.55e-1 SMART
ZnF_C2H2 446 469 3.11e-2 SMART
Meta Mutation Damage Score 0.0632 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.1%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik C G 12: 71,205,657 (GRCm39) Q434E probably benign Het
A930011G23Rik T C 5: 99,382,547 (GRCm39) T234A probably benign Het
Acot5 G A 12: 84,122,614 (GRCm39) W399* probably null Het
Adra1a A G 14: 66,965,159 (GRCm39) E383G possibly damaging Het
Ahnak T A 19: 8,982,427 (GRCm39) I1237N probably damaging Het
Bsg A G 10: 79,545,519 (GRCm39) T28A probably damaging Het
Cacna1i A T 15: 80,243,150 (GRCm39) I436F possibly damaging Het
Cd109 T C 9: 78,571,612 (GRCm39) I417T probably benign Het
Cep295 A T 9: 15,245,611 (GRCm39) D948E probably benign Het
Cfap92 G T 6: 87,657,260 (GRCm39) noncoding transcript Het
Clcn3 C A 8: 61,382,188 (GRCm39) V467F probably benign Het
Cntnap3 T C 13: 64,935,724 (GRCm39) S380G possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dll4 T A 2: 119,156,966 (GRCm39) N79K probably benign Het
Ep300 A T 15: 81,529,134 (GRCm39) N1558I unknown Het
Fblim1 A G 4: 141,308,320 (GRCm39) F330L possibly damaging Het
Fbxo46 T A 7: 18,871,073 (GRCm39) M564K possibly damaging Het
Fnip1 T A 11: 54,384,007 (GRCm39) probably benign Het
Foxl2 A T 9: 98,837,984 (GRCm39) K91* probably null Het
Gapvd1 C A 2: 34,619,125 (GRCm39) V83F probably benign Het
Guk1 G A 11: 59,075,921 (GRCm39) R146C probably damaging Het
Irf8 G A 8: 121,480,220 (GRCm39) G153S probably benign Het
Kcnu1 T A 8: 26,403,712 (GRCm39) M1K probably null Het
Krt32 G A 11: 99,972,068 (GRCm39) P427S probably benign Het
Lrp12 A G 15: 39,739,554 (GRCm39) S529P probably damaging Het
Mettl22 T C 16: 8,300,021 (GRCm39) V134A probably damaging Het
Morc2b G T 17: 33,355,086 (GRCm39) H895Q probably benign Het
Nrros T C 16: 31,962,241 (GRCm39) D556G probably damaging Het
Nrxn3 A G 12: 90,298,567 (GRCm39) S1367G possibly damaging Het
Or10al7 A G 17: 38,366,463 (GRCm39) F7S probably benign Het
Or56b1b A T 7: 108,164,823 (GRCm39) S60T probably benign Het
Pcnx3 T A 19: 5,735,729 (GRCm39) probably null Het
Pgap2 A T 7: 101,886,655 (GRCm39) M226L probably damaging Het
Pik3c2g A G 6: 139,841,798 (GRCm39) I616M probably damaging Het
Pisd A G 5: 32,894,656 (GRCm39) I380T probably damaging Het
Pkhd1 T C 1: 20,420,745 (GRCm39) I2454V probably damaging Het
Plpp2 A G 10: 79,363,378 (GRCm39) I151T probably benign Het
Polr3a G A 14: 24,502,268 (GRCm39) T1295I possibly damaging Het
Pot1a T C 6: 25,748,283 (GRCm39) probably benign Het
Prpf39 T G 12: 65,094,980 (GRCm39) N219K probably benign Het
Rnf17 T A 14: 56,712,904 (GRCm39) N790K probably damaging Het
Slit3 C T 11: 35,514,263 (GRCm39) probably benign Het
Stx1a T A 5: 135,070,088 (GRCm39) probably benign Het
Tenm3 C A 8: 48,788,777 (GRCm39) V690F probably damaging Het
Tmcc3 A G 10: 94,414,633 (GRCm39) I143V probably benign Het
Tmem41b G A 7: 109,580,256 (GRCm39) S36F probably damaging Het
Trim5 A T 7: 103,914,978 (GRCm39) W364R probably damaging Het
Ttn T C 2: 76,617,155 (GRCm39) Y16403C probably damaging Het
Vps8 T C 16: 21,275,071 (GRCm39) S210P probably damaging Het
Zfp882 T A 8: 72,668,530 (GRCm39) C452* probably null Het
Other mutations in Zbtb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zbtb3 APN 19 8,781,029 (GRCm39) missense possibly damaging 0.72
IGL01399:Zbtb3 APN 19 8,780,819 (GRCm39) missense probably damaging 0.97
IGL01447:Zbtb3 APN 19 8,781,680 (GRCm39) missense probably damaging 1.00
IGL02016:Zbtb3 APN 19 8,780,579 (GRCm39) missense probably damaging 1.00
IGL02264:Zbtb3 APN 19 8,780,729 (GRCm39) missense probably damaging 1.00
IGL02720:Zbtb3 APN 19 8,781,578 (GRCm39) splice site probably null
R0456:Zbtb3 UTSW 19 8,780,564 (GRCm39) missense probably damaging 1.00
R1496:Zbtb3 UTSW 19 8,780,714 (GRCm39) missense probably damaging 1.00
R1509:Zbtb3 UTSW 19 8,780,771 (GRCm39) missense probably damaging 1.00
R4110:Zbtb3 UTSW 19 8,780,384 (GRCm39) start gained probably benign
R4902:Zbtb3 UTSW 19 8,781,331 (GRCm39) missense probably benign 0.40
R6148:Zbtb3 UTSW 19 8,781,560 (GRCm39) missense probably benign 0.15
R7121:Zbtb3 UTSW 19 8,780,771 (GRCm39) missense probably damaging 1.00
R8780:Zbtb3 UTSW 19 8,781,173 (GRCm39) missense possibly damaging 0.94
R9803:Zbtb3 UTSW 19 8,781,833 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCTACAAGGAGCGGGAATTGGAC -3'
(R):5'- TGCCCGAAGATGTGATGAGTCAAC -3'

Sequencing Primer
(F):5'- TCACAATGAGATTGTCACGGC -3'
(R):5'- GTGATGAGTCAACTTCCATGC -3'
Posted On 2013-10-16