Incidental Mutation 'R0842:Socs4'
ID 77232
Institutional Source Beutler Lab
Gene Symbol Socs4
Ensembl Gene ENSMUSG00000048379
Gene Name suppressor of cytokine signaling 4
Synonyms Socs7, 3110032M18Rik, A730004F22Rik
MMRRC Submission 039021-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.368) question?
Stock # R0842 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 47514388-47533559 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 47527426 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 107 (H107Q)
Ref Sequence ENSEMBL: ENSMUSP00000154000 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065562] [ENSMUST00000227413]
AlphaFold Q91ZA6
Predicted Effect probably damaging
Transcript: ENSMUST00000065562
AA Change: H120Q

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000066031
Gene: ENSMUSG00000048379
AA Change: H120Q

DomainStartEndE-ValueType
low complexity region 30 47 N/A INTRINSIC
Pfam:SOCS 55 108 6.8e-23 PFAM
low complexity region 219 232 N/A INTRINSIC
SH2 281 367 1.11e-16 SMART
SOCS 377 420 1.69e-16 SMART
SOCS_box 383 419 1.13e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000227413
AA Change: H107Q

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angptl8 C A 9: 21,746,972 (GRCm39) Y53* probably null Het
Apbb1ip G A 2: 22,757,678 (GRCm39) R432Q possibly damaging Het
Catsperb A T 12: 101,429,307 (GRCm39) Q160L probably damaging Het
Cdhr18 G A 14: 13,856,686 (GRCm38) S475L probably benign Het
Cilp2 T C 8: 70,335,768 (GRCm39) Y410C probably damaging Het
Cntnap5a G A 1: 116,369,953 (GRCm39) G857S probably damaging Het
D630045J12Rik A T 6: 38,125,400 (GRCm39) V1538E probably damaging Het
Dnah7a A G 1: 53,540,833 (GRCm39) S2514P possibly damaging Het
Eme1 C T 11: 94,541,700 (GRCm39) A41T probably benign Het
F11 T C 8: 45,705,196 (GRCm39) Y115C probably damaging Het
Fap A T 2: 62,367,345 (GRCm39) W313R probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Ggt6 T A 11: 72,328,088 (GRCm39) L158* probably null Het
Herc2 A C 7: 55,771,453 (GRCm39) I1072L probably benign Het
Hhat T C 1: 192,408,639 (GRCm39) N164S probably benign Het
Klrb1 A G 6: 128,687,008 (GRCm39) probably null Het
L3mbtl4 T A 17: 68,793,957 (GRCm39) D320E probably benign Het
Lyst C A 13: 13,852,826 (GRCm39) Y2275* probably null Het
Map4k3 T C 17: 80,913,412 (GRCm39) N611S probably benign Het
Morc3 T C 16: 93,670,284 (GRCm39) probably null Het
Mtr A C 13: 12,215,133 (GRCm39) Y864D probably damaging Het
Myh2 C T 11: 67,070,350 (GRCm39) A431V possibly damaging Het
Myo9a C A 9: 59,778,350 (GRCm39) Q1369K probably benign Het
Nalf1 T A 8: 9,820,114 (GRCm39) D302V probably benign Het
Nat3 T C 8: 68,000,649 (GRCm39) I176T probably benign Het
Ncapd3 C T 9: 26,948,380 (GRCm39) T54I probably benign Het
Nfyc C A 4: 120,616,574 (GRCm39) E281D probably benign Het
Nlrp14 A G 7: 106,782,342 (GRCm39) D513G probably benign Het
Pacsin2 T C 15: 83,263,382 (GRCm39) E83G probably damaging Het
Plagl1 G T 10: 13,004,298 (GRCm39) probably benign Het
Pmpcb T C 5: 21,953,772 (GRCm39) L340P possibly damaging Het
Pou2af3 T C 9: 51,183,668 (GRCm39) E102G probably benign Het
Pou2f2 A T 7: 24,796,355 (GRCm39) L364Q probably damaging Het
Rab1b A T 19: 5,154,697 (GRCm39) I84N probably damaging Het
Ric3 T C 7: 108,638,087 (GRCm39) Y222C probably damaging Het
Samhd1 A G 2: 156,965,251 (GRCm39) V188A probably damaging Het
Tex15 T A 8: 34,061,575 (GRCm39) I335K possibly damaging Het
Thoc2l T A 5: 104,667,066 (GRCm39) N529K possibly damaging Het
Thop1 C A 10: 80,911,411 (GRCm39) T99K probably damaging Het
Tnik A G 3: 28,648,235 (GRCm39) E429G possibly damaging Het
Vmn2r106 T A 17: 20,488,465 (GRCm39) I645F probably damaging Het
Zscan29 T A 2: 120,991,960 (GRCm39) R609S possibly damaging Het
Other mutations in Socs4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Socs4 APN 14 47,527,709 (GRCm39) missense probably benign
IGL01942:Socs4 APN 14 47,528,107 (GRCm39) nonsense probably null
IGL02039:Socs4 APN 14 47,527,650 (GRCm39) missense probably benign
IGL02117:Socs4 APN 14 47,528,264 (GRCm39) missense probably damaging 1.00
R0281:Socs4 UTSW 14 47,527,325 (GRCm39) missense probably benign 0.25
R0703:Socs4 UTSW 14 47,527,505 (GRCm39) missense probably damaging 1.00
R0763:Socs4 UTSW 14 47,528,112 (GRCm39) missense probably damaging 1.00
R1133:Socs4 UTSW 14 47,527,651 (GRCm39) missense probably benign 0.01
R1280:Socs4 UTSW 14 47,528,370 (GRCm39) missense probably benign 0.23
R1619:Socs4 UTSW 14 47,527,740 (GRCm39) missense possibly damaging 0.87
R1632:Socs4 UTSW 14 47,527,034 (GRCm39) start gained probably benign
R5058:Socs4 UTSW 14 47,527,589 (GRCm39) nonsense probably null
R6008:Socs4 UTSW 14 47,527,618 (GRCm39) missense probably damaging 0.98
R6648:Socs4 UTSW 14 47,527,633 (GRCm39) missense probably benign 0.02
R6925:Socs4 UTSW 14 47,527,195 (GRCm39) nonsense probably null
R7408:Socs4 UTSW 14 47,527,296 (GRCm39) missense probably benign 0.00
R9162:Socs4 UTSW 14 47,528,301 (GRCm39) missense probably damaging 0.99
R9234:Socs4 UTSW 14 47,527,716 (GRCm39) missense probably benign 0.00
R9428:Socs4 UTSW 14 47,528,034 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCGTCCAGAAAGTGCCCAGAAG -3'
(R):5'- CCACCTGTACACGAAGCACTGTTG -3'

Sequencing Primer
(F):5'- CTGAATCTGAAGCCATAGGTACTG -3'
(R):5'- GTGAGAAACAGGGTATGTCATCTTC -3'
Posted On 2013-10-16