Incidental Mutation 'R0842:Morc3'
ID 77234
Institutional Source Beutler Lab
Gene Symbol Morc3
Ensembl Gene ENSMUSG00000039456
Gene Name microrchidia 3
Synonyms Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
MMRRC Submission 039021-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0842 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 93629009-93672961 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 93670284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044068] [ENSMUST00000201097] [ENSMUST00000202261]
AlphaFold F7BJB9
Predicted Effect probably null
Transcript: ENSMUST00000044068
SMART Domains Protein: ENSMUSP00000040152
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000201097
SMART Domains Protein: ENSMUSP00000144058
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Blast:HATPase_c 1 70 4e-39 BLAST
Pfam:zf-CW 340 383 1.2e-16 PFAM
low complexity region 392 403 N/A INTRINSIC
low complexity region 557 566 N/A INTRINSIC
coiled coil region 692 798 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000202261
SMART Domains Protein: ENSMUSP00000144369
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232425
Predicted Effect probably benign
Transcript: ENSMUST00000232639
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a null allele die at or within a day of birth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angptl8 C A 9: 21,746,972 (GRCm39) Y53* probably null Het
Apbb1ip G A 2: 22,757,678 (GRCm39) R432Q possibly damaging Het
Catsperb A T 12: 101,429,307 (GRCm39) Q160L probably damaging Het
Cdhr18 G A 14: 13,856,686 (GRCm38) S475L probably benign Het
Cilp2 T C 8: 70,335,768 (GRCm39) Y410C probably damaging Het
Cntnap5a G A 1: 116,369,953 (GRCm39) G857S probably damaging Het
D630045J12Rik A T 6: 38,125,400 (GRCm39) V1538E probably damaging Het
Dnah7a A G 1: 53,540,833 (GRCm39) S2514P possibly damaging Het
Eme1 C T 11: 94,541,700 (GRCm39) A41T probably benign Het
F11 T C 8: 45,705,196 (GRCm39) Y115C probably damaging Het
Fap A T 2: 62,367,345 (GRCm39) W313R probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Ggt6 T A 11: 72,328,088 (GRCm39) L158* probably null Het
Herc2 A C 7: 55,771,453 (GRCm39) I1072L probably benign Het
Hhat T C 1: 192,408,639 (GRCm39) N164S probably benign Het
Klrb1 A G 6: 128,687,008 (GRCm39) probably null Het
L3mbtl4 T A 17: 68,793,957 (GRCm39) D320E probably benign Het
Lyst C A 13: 13,852,826 (GRCm39) Y2275* probably null Het
Map4k3 T C 17: 80,913,412 (GRCm39) N611S probably benign Het
Mtr A C 13: 12,215,133 (GRCm39) Y864D probably damaging Het
Myh2 C T 11: 67,070,350 (GRCm39) A431V possibly damaging Het
Myo9a C A 9: 59,778,350 (GRCm39) Q1369K probably benign Het
Nalf1 T A 8: 9,820,114 (GRCm39) D302V probably benign Het
Nat3 T C 8: 68,000,649 (GRCm39) I176T probably benign Het
Ncapd3 C T 9: 26,948,380 (GRCm39) T54I probably benign Het
Nfyc C A 4: 120,616,574 (GRCm39) E281D probably benign Het
Nlrp14 A G 7: 106,782,342 (GRCm39) D513G probably benign Het
Pacsin2 T C 15: 83,263,382 (GRCm39) E83G probably damaging Het
Plagl1 G T 10: 13,004,298 (GRCm39) probably benign Het
Pmpcb T C 5: 21,953,772 (GRCm39) L340P possibly damaging Het
Pou2af3 T C 9: 51,183,668 (GRCm39) E102G probably benign Het
Pou2f2 A T 7: 24,796,355 (GRCm39) L364Q probably damaging Het
Rab1b A T 19: 5,154,697 (GRCm39) I84N probably damaging Het
Ric3 T C 7: 108,638,087 (GRCm39) Y222C probably damaging Het
Samhd1 A G 2: 156,965,251 (GRCm39) V188A probably damaging Het
Socs4 T A 14: 47,527,426 (GRCm39) H107Q probably damaging Het
Tex15 T A 8: 34,061,575 (GRCm39) I335K possibly damaging Het
Thoc2l T A 5: 104,667,066 (GRCm39) N529K possibly damaging Het
Thop1 C A 10: 80,911,411 (GRCm39) T99K probably damaging Het
Tnik A G 3: 28,648,235 (GRCm39) E429G possibly damaging Het
Vmn2r106 T A 17: 20,488,465 (GRCm39) I645F probably damaging Het
Zscan29 T A 2: 120,991,960 (GRCm39) R609S possibly damaging Het
Other mutations in Morc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Morc3 APN 16 93,670,283 (GRCm39) critical splice donor site probably null
IGL01015:Morc3 APN 16 93,659,534 (GRCm39) missense probably damaging 1.00
IGL01374:Morc3 APN 16 93,641,101 (GRCm39) missense probably damaging 1.00
IGL01634:Morc3 APN 16 93,670,125 (GRCm39) missense probably benign 0.02
IGL01845:Morc3 APN 16 93,657,455 (GRCm39) missense probably damaging 0.96
IGL02202:Morc3 APN 16 93,667,749 (GRCm39) missense probably benign 0.01
IGL02478:Morc3 APN 16 93,661,844 (GRCm39) splice site probably benign
IGL03026:Morc3 APN 16 93,659,612 (GRCm39) splice site probably benign
IGL03115:Morc3 APN 16 93,667,971 (GRCm39) missense probably damaging 0.99
Ballista UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
mindy UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
Pfaff UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
shield UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
sparkle UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
Stooges UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
Sword UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R0173:Morc3 UTSW 16 93,629,094 (GRCm39) splice site probably null
R0413:Morc3 UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
R0639:Morc3 UTSW 16 93,650,738 (GRCm39) missense probably damaging 1.00
R1134:Morc3 UTSW 16 93,667,557 (GRCm39) missense probably benign
R1162:Morc3 UTSW 16 93,649,996 (GRCm39) missense probably damaging 1.00
R1498:Morc3 UTSW 16 93,650,743 (GRCm39) missense probably damaging 1.00
R1520:Morc3 UTSW 16 93,641,129 (GRCm39) missense probably damaging 0.96
R1603:Morc3 UTSW 16 93,663,391 (GRCm39) missense probably benign
R1622:Morc3 UTSW 16 93,671,694 (GRCm39) missense probably benign 0.28
R1630:Morc3 UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
R1818:Morc3 UTSW 16 93,652,398 (GRCm39) missense probably damaging 1.00
R1902:Morc3 UTSW 16 93,667,385 (GRCm39) missense probably damaging 1.00
R2090:Morc3 UTSW 16 93,663,341 (GRCm39) missense probably benign 0.23
R2261:Morc3 UTSW 16 93,650,109 (GRCm39) splice site probably benign
R2360:Morc3 UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
R2407:Morc3 UTSW 16 93,641,215 (GRCm39) critical splice donor site probably null
R2519:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R3736:Morc3 UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
R3873:Morc3 UTSW 16 93,659,324 (GRCm39) missense probably damaging 0.99
R4114:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4115:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4116:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4472:Morc3 UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R4609:Morc3 UTSW 16 93,661,856 (GRCm39) missense probably benign 0.01
R4708:Morc3 UTSW 16 93,670,126 (GRCm39) missense probably benign 0.19
R4883:Morc3 UTSW 16 93,667,250 (GRCm39) critical splice acceptor site probably null
R4945:Morc3 UTSW 16 93,668,082 (GRCm39) missense probably damaging 1.00
R4965:Morc3 UTSW 16 93,657,475 (GRCm39) nonsense probably null
R5399:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R5481:Morc3 UTSW 16 93,659,543 (GRCm39) missense probably damaging 0.99
R5540:Morc3 UTSW 16 93,644,268 (GRCm39) missense probably benign
R5970:Morc3 UTSW 16 93,663,341 (GRCm39) missense possibly damaging 0.65
R6006:Morc3 UTSW 16 93,663,381 (GRCm39) missense possibly damaging 0.67
R6044:Morc3 UTSW 16 93,663,330 (GRCm39) missense probably benign 0.02
R6045:Morc3 UTSW 16 93,671,733 (GRCm39) missense probably damaging 1.00
R6155:Morc3 UTSW 16 93,659,313 (GRCm39) missense possibly damaging 0.94
R6165:Morc3 UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
R6225:Morc3 UTSW 16 93,642,082 (GRCm39) nonsense probably null
R6240:Morc3 UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
R6835:Morc3 UTSW 16 93,644,309 (GRCm39) missense probably damaging 1.00
R6918:Morc3 UTSW 16 93,650,023 (GRCm39) missense probably benign 0.36
R6944:Morc3 UTSW 16 93,667,460 (GRCm39) missense probably benign
R7311:Morc3 UTSW 16 93,646,061 (GRCm39) missense probably damaging 1.00
R7398:Morc3 UTSW 16 93,671,748 (GRCm39) missense probably damaging 1.00
R7553:Morc3 UTSW 16 93,667,824 (GRCm39) missense probably damaging 0.98
R8056:Morc3 UTSW 16 93,642,064 (GRCm39) missense probably benign 0.07
R8299:Morc3 UTSW 16 93,650,088 (GRCm39) missense probably damaging 1.00
R8317:Morc3 UTSW 16 93,659,417 (GRCm39) missense probably benign 0.25
R8542:Morc3 UTSW 16 93,644,319 (GRCm39) critical splice donor site probably null
R8697:Morc3 UTSW 16 93,667,908 (GRCm39) missense probably benign 0.00
R8739:Morc3 UTSW 16 93,657,398 (GRCm39) missense probably damaging 1.00
R9072:Morc3 UTSW 16 93,667,482 (GRCm39) missense probably benign 0.00
R9235:Morc3 UTSW 16 93,659,321 (GRCm39) missense probably damaging 1.00
R9305:Morc3 UTSW 16 93,667,302 (GRCm39) missense probably benign 0.00
R9405:Morc3 UTSW 16 93,642,036 (GRCm39) missense probably damaging 1.00
R9431:Morc3 UTSW 16 93,667,771 (GRCm39) nonsense probably null
R9440:Morc3 UTSW 16 93,649,975 (GRCm39) critical splice acceptor site probably null
R9524:Morc3 UTSW 16 93,667,401 (GRCm39) missense probably benign 0.09
R9571:Morc3 UTSW 16 93,641,107 (GRCm39) missense possibly damaging 0.89
X0023:Morc3 UTSW 16 93,644,287 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATTCAATGTGTCTTGGAAGCCG -3'
(R):5'- GGCTTACGTTCCAGCATCCACATAG -3'

Sequencing Primer
(F):5'- CCGAAAACTTTATCAGGGTAGGTC -3'
(R):5'- Tacacacacacacacacacac -3'
Posted On 2013-10-16