Incidental Mutation 'R0843:Fgf11'
ID 77259
Institutional Source Beutler Lab
Gene Symbol Fgf11
Ensembl Gene ENSMUSG00000042826
Gene Name fibroblast growth factor 11
Synonyms Fhf3
MMRRC Submission 039022-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.590) question?
Stock # R0843 (G1)
Quality Score 112
Status Validated
Chromosome 11
Chromosomal Location 69686894-69692683 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 69689602 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000099645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011285] [ENSMUST00000045971] [ENSMUST00000051025] [ENSMUST00000102585]
AlphaFold P70378
Predicted Effect probably benign
Transcript: ENSMUST00000011285
SMART Domains Protein: ENSMUSP00000011285
Gene: ENSMUSG00000042826

DomainStartEndE-ValueType
FGF 69 172 6.95e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000045971
SMART Domains Protein: ENSMUSP00000047270
Gene: ENSMUSG00000041189

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
Pfam:Neur_chan_LBD 27 245 3.6e-65 PFAM
Pfam:Neur_chan_memb 252 487 3.5e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000051025
SMART Domains Protein: ENSMUSP00000132164
Gene: ENSMUSG00000089876

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
Mab-21 191 494 3.31e-43 SMART
low complexity region 498 507 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102585
SMART Domains Protein: ENSMUSP00000099645
Gene: ENSMUSG00000042826

DomainStartEndE-ValueType
FGF 69 200 3.43e-66 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129381
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147791
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154816
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.5%
  • 20x: 92.6%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb2 T C 18: 62,312,142 (GRCm39) R228G probably benign Het
Arrdc3 T C 13: 81,038,922 (GRCm39) probably benign Het
Cacna1d T C 14: 29,846,828 (GRCm39) Y526C probably damaging Het
Cenpn T C 8: 117,660,045 (GRCm39) V125A probably benign Het
Cyfip1 A T 7: 55,572,568 (GRCm39) H963L probably benign Het
Dnah8 T C 17: 31,032,069 (GRCm39) Y4130H probably damaging Het
Dnmt3a T C 12: 3,922,886 (GRCm39) probably benign Het
Dync1h1 C T 12: 110,631,647 (GRCm39) T4448M possibly damaging Het
Efr3a T A 15: 65,709,272 (GRCm39) probably benign Het
Gabrr1 T A 4: 33,161,717 (GRCm39) I347N possibly damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Hspa1b T A 17: 35,176,524 (GRCm39) N487I possibly damaging Het
Ifi207 A T 1: 173,555,143 (GRCm39) N853K probably damaging Het
Iqgap3 A G 3: 88,015,738 (GRCm39) D40G possibly damaging Het
Iyd T C 10: 3,495,663 (GRCm39) V107A possibly damaging Het
Kctd3 A T 1: 188,729,170 (GRCm39) L129* probably null Het
Myo7b A G 18: 32,107,137 (GRCm39) F1286S possibly damaging Het
Or4a47 C T 2: 89,665,960 (GRCm39) V110I probably benign Het
Or52s1b T A 7: 102,822,326 (GRCm39) T173S possibly damaging Het
Or8c15 T A 9: 38,120,579 (GRCm39) F77I possibly damaging Het
Pcsk5 T A 19: 17,632,182 (GRCm39) Y328F probably damaging Het
Plxnb1 T C 9: 108,942,769 (GRCm39) L1810P probably benign Het
Polr2h T A 16: 20,537,649 (GRCm39) V50E probably damaging Het
Ppm1g T C 5: 31,364,895 (GRCm39) probably benign Het
Ptpru T A 4: 131,525,259 (GRCm39) R741S probably benign Het
Pyroxd2 T C 19: 42,735,986 (GRCm39) E64G probably damaging Het
Rad54b T C 4: 11,609,471 (GRCm39) probably null Het
Rangap1 A T 15: 81,594,703 (GRCm39) D375E probably benign Het
Rhbdf1 G A 11: 32,165,053 (GRCm39) R107C probably damaging Het
Scaf11 T C 15: 96,329,706 (GRCm39) E140G probably damaging Het
Slitrk6 G T 14: 110,987,530 (GRCm39) H726N probably benign Het
Spry2 A G 14: 106,130,524 (GRCm39) C221R probably damaging Het
Stx2 C T 5: 129,076,612 (GRCm39) V24M probably damaging Het
Tent5b T C 4: 133,213,842 (GRCm39) S238P probably damaging Het
Tll2 T A 19: 41,116,902 (GRCm39) probably null Het
Ttyh3 C A 5: 140,612,201 (GRCm39) probably null Het
Vmn2r116 T C 17: 23,619,934 (GRCm39) V556A probably benign Het
Xpo5 T C 17: 46,533,576 (GRCm39) probably benign Het
Zc3h3 A G 15: 75,709,328 (GRCm39) S514P probably benign Het
Zfp277 A C 12: 40,370,599 (GRCm39) probably null Het
Other mutations in Fgf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02867:Fgf11 APN 11 69,690,498 (GRCm39) missense possibly damaging 0.94
R1899:Fgf11 UTSW 11 69,692,279 (GRCm39) missense probably benign 0.03
R1900:Fgf11 UTSW 11 69,692,279 (GRCm39) missense probably benign 0.03
R3619:Fgf11 UTSW 11 69,690,234 (GRCm39) missense probably benign 0.00
R4995:Fgf11 UTSW 11 69,689,585 (GRCm39) missense probably damaging 1.00
R5466:Fgf11 UTSW 11 69,690,267 (GRCm39) missense probably damaging 0.97
R6589:Fgf11 UTSW 11 69,690,261 (GRCm39) missense probably damaging 1.00
R9312:Fgf11 UTSW 11 69,689,412 (GRCm39) missense probably damaging 1.00
X0018:Fgf11 UTSW 11 69,692,421 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATGTCAAGGTCAATGCCCTCCCAC -3'
(R):5'- TGGCACCTCTCAGCCTTCAAAC -3'

Sequencing Primer
(F):5'- CTTGGGCACAAAGTGGGC -3'
(R):5'- AAATTTAGATCCTGCCCCTGG -3'
Posted On 2013-10-16