Mutagenetix > Incidental Mutation

Incidental Mutation 'R0830:Vmn1r178'

77486

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r178

Ensembl Gene

ENSMUSG00000062598

Gene Name

vomeronasal 1 receptor 178

Synonyms

V1rd13, LOC232959

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R0830 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23592954-23593868 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23593452 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 167 (T167A)

Ref Sequence

ENSEMBL: ENSMUSP00000154244 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078593] [ENSMUST00000226450] [ENSMUST00000226489] [ENSMUST00000226640] [ENSMUST00000227993]

AlphaFold

Q8R2B6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000078593
AA Change: T167A

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000077666
Gene: ENSMUSG00000062598
AA Change: T167A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	7.9e-11	PFAM
Pfam:7tm_1	15	283	2.5e-7	PFAM
Pfam:V1R	41	296	7.8e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226450
AA Change: T167A

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226489
AA Change: T94A

PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226640
AA Change: T94A

PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227993
AA Change: T167A

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.0%
20x: 90.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700056E22Rik	C	T	1: 183,765,624 (GRCm39)	R145H	probably damaging	Het
Adam26a	C	T	8: 44,021,439 (GRCm39)	V684I	probably benign	Het
Alk	T	C	17: 72,910,195 (GRCm39)	I170M	probably benign	Het
Apc2	T	C	10: 80,151,239 (GRCm39)	Y2069H	probably damaging	Het
Aspm	A	G	1: 139,401,992 (GRCm39)	T1219A	probably damaging	Het
Bnip1	T	C	17: 27,008,679 (GRCm39)	S94P	probably benign	Het
Cftr	A	G	6: 18,270,224 (GRCm39)	I805V	probably benign	Het
Col25a1	T	A	3: 130,378,375 (GRCm39)	D609E	probably damaging	Het
Cplane1	T	A	15: 8,276,669 (GRCm39)	V2771E	unknown	Het
Cyp2g1	A	G	7: 26,514,216 (GRCm39)	K274R	probably benign	Het
D5Ertd579e	G	A	5: 36,771,101 (GRCm39)	T1098I	probably damaging	Het
Ddx39a	T	A	8: 84,446,452 (GRCm39)	C74S	possibly damaging	Het
E2f3	C	T	13: 30,169,543 (GRCm39)	A37T	probably benign	Het
Emilin2	A	G	17: 71,580,815 (GRCm39)	M637T	probably benign	Het
Exosc7	T	C	9: 122,948,358 (GRCm39)	L93P	probably benign	Het
F2	T	C	2: 91,460,545 (GRCm39)	E316G	probably benign	Het
Fat4	A	C	3: 39,053,258 (GRCm39)	Q4084P	probably benign	Het
Flywch1	T	C	17: 23,981,344 (GRCm39)	K160E	probably benign	Het
Foxi2	A	G	7: 135,013,459 (GRCm39)	T230A	probably benign	Het
Fthl17a	A	G	X: 84,313,679 (GRCm39)	N154S	possibly damaging	Het
Hykk	G	A	9: 54,844,601 (GRCm39)	R222Q	probably damaging	Het
Il18rap	T	A	1: 40,582,150 (GRCm39)	V357E	probably damaging	Het
Ing4	A	G	6: 125,020,923 (GRCm39)	E15G	probably damaging	Het
Irak1	T	C	X: 73,060,189 (GRCm39)	D679G	probably damaging	Het
Itga1	T	C	13: 115,143,568 (GRCm39)	E321G	probably benign	Het
Nudt1	T	A	5: 140,321,076 (GRCm39)		probably null	Het
Nup58	A	G	14: 60,480,931 (GRCm39)	F138S	probably damaging	Het
Or10al6	A	T	17: 38,082,804 (GRCm39)	M87L	probably damaging	Het
Or2a5	G	T	6: 42,873,532 (GRCm39)	W49L	probably benign	Het
Pllp	T	C	8: 95,406,103 (GRCm39)	Y60C	probably damaging	Het
Pnpla7	T	C	2: 24,887,267 (GRCm39)	V37A	probably damaging	Het
Poglut3	T	G	9: 53,302,011 (GRCm39)	L32R	probably damaging	Het
Psme4	A	G	11: 30,757,797 (GRCm39)	H310R	possibly damaging	Het
Rasl10b	G	A	11: 83,308,665 (GRCm39)		probably null	Het
Sash1	C	T	10: 8,605,673 (GRCm39)	V906M	probably benign	Het
Scn1a	A	T	2: 66,130,128 (GRCm39)	I1212K	probably damaging	Het
Stbd1	A	T	5: 92,752,989 (GRCm39)	S160C	probably benign	Het
Tex29	T	C	8: 11,904,157 (GRCm39)	V99A	probably benign	Het
Tg	A	T	15: 66,596,993 (GRCm39)	N79I	probably damaging	Het
Tie1	T	C	4: 118,339,860 (GRCm39)	D389G	probably damaging	Het
Xkr4	C	T	1: 3,740,968 (GRCm39)	G202S	possibly damaging	Het

Other mutations in Vmn1r178

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01697:Vmn1r178	APN	7	23,593,114 (GRCm39)	missense	probably damaging	0.99
IGL01781:Vmn1r178	APN	7	23,593,434 (GRCm39)	missense	probably damaging	1.00
IGL01934:Vmn1r178	APN	7	23,593,362 (GRCm39)	missense	probably damaging	1.00
IGL02571:Vmn1r178	APN	7	23,593,660 (GRCm39)	missense	probably damaging	0.99
IGL02727:Vmn1r178	APN	7	23,593,871 (GRCm39)	splice site	probably null
IGL03112:Vmn1r178	APN	7	23,593,086 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn1r178	UTSW	7	23,593,609 (GRCm39)	missense	possibly damaging	0.93
R1186:Vmn1r178	UTSW	7	23,593,317 (GRCm39)	nonsense	probably null
R1340:Vmn1r178	UTSW	7	23,593,281 (GRCm39)	missense	probably benign	0.34
R1640:Vmn1r178	UTSW	7	23,593,548 (GRCm39)	missense	possibly damaging	0.70
R1696:Vmn1r178	UTSW	7	23,593,625 (GRCm39)	missense	probably damaging	0.99
R1746:Vmn1r178	UTSW	7	23,593,329 (GRCm39)	missense	probably benign	0.00
R3084:Vmn1r178	UTSW	7	23,593,331 (GRCm39)	missense	possibly damaging	0.94
R4368:Vmn1r178	UTSW	7	23,593,447 (GRCm39)	missense	probably damaging	1.00
R5199:Vmn1r178	UTSW	7	23,593,814 (GRCm39)	missense	probably benign	0.11
R6380:Vmn1r178	UTSW	7	23,592,984 (GRCm39)	missense	possibly damaging	0.62
R7000:Vmn1r178	UTSW	7	23,593,762 (GRCm39)	missense	probably benign	0.21
R7142:Vmn1r178	UTSW	7	23,593,035 (GRCm39)	missense	probably damaging	1.00
R7268:Vmn1r178	UTSW	7	23,593,378 (GRCm39)	missense	probably benign	0.05
R8829:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R8832:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R9068:Vmn1r178	UTSW	7	23,593,404 (GRCm39)	missense	probably damaging	1.00
R9798:Vmn1r178	UTSW	7	23,593,733 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGGTTCTAAACAGAGGCCCAGACAG -3'
(R):5'- CCAGCATCAGGATAGTATGGGTTGC -3'

Sequencing Primer
(F):5'- GCCCAGACAGTTGATTTTAAGCC -3'
(R):5'- GGCCTCTGGCATCCTGATTG -3'

Posted On

2013-10-16