Incidental Mutation 'R0831:Adgra3'
ID 77531
Institutional Source Beutler Lab
Gene Symbol Adgra3
Ensembl Gene ENSMUSG00000029090
Gene Name adhesion G protein-coupled receptor A3
Synonyms Tem5-like, 3830613O22Rik, Gpr125
MMRRC Submission 039010-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0831 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 50117293-50216338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50128144 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 779 (I779N)
Ref Sequence ENSEMBL: ENSMUSP00000030971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030971]
AlphaFold Q7TT36
Predicted Effect probably damaging
Transcript: ENSMUST00000030971
AA Change: I779N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000030971
Gene: ENSMUSG00000029090
AA Change: I779N

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
LRR 68 92 1.71e1 SMART
LRR_TYP 93 116 2.27e-4 SMART
LRR_TYP 117 140 4.11e-2 SMART
LRR_TYP 141 164 3.89e-3 SMART
LRRCT 176 225 5.24e-5 SMART
IG 238 331 8.26e-5 SMART
GPS 686 738 4.81e-3 SMART
Pfam:7tm_2 746 1031 1.6e-16 PFAM
low complexity region 1251 1262 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196177
Meta Mutation Damage Score 0.5809 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.9%
  • 10x: 96.9%
  • 20x: 92.0%
Validation Efficiency 95% (82/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik C T 7: 12,284,523 (GRCm39) probably benign Het
3425401B19Rik T C 14: 32,384,228 (GRCm39) N579S probably benign Het
Adck1 G T 12: 88,335,118 (GRCm39) M1I probably null Het
Adgrf2 A G 17: 43,021,334 (GRCm39) S497P probably damaging Het
Afg3l2 A C 18: 67,554,297 (GRCm39) F468L probably damaging Het
Alms1 T A 6: 85,605,502 (GRCm39) I2384N probably benign Het
Ankrd13b A T 11: 77,363,585 (GRCm39) S244R probably damaging Het
Aox1 T A 1: 58,378,842 (GRCm39) H1030Q probably benign Het
Ap1b1 A G 11: 4,973,092 (GRCm39) probably benign Het
Atxn2l A G 7: 126,098,332 (GRCm39) S187P probably damaging Het
B4galt4 G T 16: 38,588,341 (GRCm39) E57D probably benign Het
Cad T C 5: 31,224,944 (GRCm39) V949A probably damaging Het
Cadps2 C T 6: 23,321,739 (GRCm39) S1051N possibly damaging Het
Ccdc66 C T 14: 27,219,313 (GRCm39) V148I probably benign Het
Ccser1 C T 6: 61,400,045 (GRCm39) P55S probably damaging Het
Cds2 T C 2: 132,127,887 (GRCm39) probably null Het
Cep95 A G 11: 106,705,530 (GRCm39) D548G probably benign Het
Chil3 A G 3: 106,057,063 (GRCm39) Y294H probably benign Het
Chmp5 A G 4: 40,949,500 (GRCm39) D39G probably damaging Het
Chrd T A 16: 20,560,059 (GRCm39) F887I probably damaging Het
Col24a1 G T 3: 145,034,520 (GRCm39) G580V probably damaging Het
Col6a2 A T 10: 76,439,939 (GRCm39) N655K probably damaging Het
Ctsf A T 19: 4,909,868 (GRCm39) Y416F possibly damaging Het
Dennd5a A C 7: 109,533,961 (GRCm39) V77G probably damaging Het
Dna2 A T 10: 62,795,108 (GRCm39) K460* probably null Het
Dnah17 A T 11: 117,951,097 (GRCm39) M2842K probably damaging Het
Dnajc13 C A 9: 104,049,811 (GRCm39) G1765V probably damaging Het
Donson A C 16: 91,480,651 (GRCm39) C243W probably damaging Het
Dpp8 A T 9: 64,985,961 (GRCm39) N817I possibly damaging Het
Eef1d G A 15: 75,768,655 (GRCm39) probably benign Het
Esf1 T A 2: 140,010,279 (GRCm39) D19V probably damaging Het
Gm21738 T A 14: 19,415,957 (GRCm38) Y194F probably benign Het
Gm21738 T C 14: 19,415,963 (GRCm38) K192R probably benign Het
Gm9867 C A 4: 140,049,799 (GRCm39) A128S unknown Het
Igsf23 G T 7: 19,675,662 (GRCm39) probably benign Het
Inhca T C 9: 103,146,978 (GRCm39) H292R possibly damaging Het
Kdm7a C A 6: 39,143,699 (GRCm39) probably benign Het
Kif14 G A 1: 136,453,609 (GRCm39) probably benign Het
Mroh7 T C 4: 106,537,990 (GRCm39) N1229D possibly damaging Het
Mrps11 C A 7: 78,441,611 (GRCm39) probably benign Het
Mtmr2 T A 9: 13,707,409 (GRCm39) D248E probably damaging Het
Myrfl C A 10: 116,619,114 (GRCm39) S748I probably benign Het
Nop14 T C 5: 34,807,864 (GRCm39) E366G possibly damaging Het
Or13c3 T G 4: 52,855,764 (GRCm39) I250L possibly damaging Het
Or2w25 C T 11: 59,504,480 (GRCm39) T230I possibly damaging Het
Or52z13 A G 7: 103,247,338 (GRCm39) I272V probably benign Het
Or7e177 T A 9: 20,211,861 (GRCm39) C123S probably benign Het
Or8g2b C T 9: 39,751,579 (GRCm39) P283L probably damaging Het
Phykpl G T 11: 51,476,366 (GRCm39) E29* probably null Het
Plppr4 A G 3: 117,125,295 (GRCm39) probably null Het
Prmt2 A C 10: 76,043,641 (GRCm39) probably benign Het
Prodh2 T A 7: 30,193,649 (GRCm39) Y114* probably null Het
Prr23a2 C A 9: 98,738,917 (GRCm39) H92N probably damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rdx C A 9: 51,977,117 (GRCm39) A122E probably damaging Het
Rspo3 T G 10: 29,330,253 (GRCm39) D236A unknown Het
Sdk2 A T 11: 113,723,084 (GRCm39) D1302E probably damaging Het
Sipa1 A T 19: 5,710,382 (GRCm39) D209E probably damaging Het
Sirpa T G 2: 129,469,856 (GRCm39) probably benign Het
Ska1 A C 18: 74,330,570 (GRCm39) probably benign Het
Slc4a9 T C 18: 36,668,331 (GRCm39) probably benign Het
Slco1b2 T C 6: 141,631,172 (GRCm39) V602A probably benign Het
Slco2a1 T C 9: 102,959,533 (GRCm39) V543A probably damaging Het
Sorcs3 A T 19: 48,682,433 (GRCm39) L489F probably damaging Het
Sorl1 T C 9: 41,982,365 (GRCm39) probably benign Het
Sp140l1 C G 1: 85,077,226 (GRCm39) K113N probably benign Het
Spindoc G T 19: 7,352,100 (GRCm39) N82K probably benign Het
Stk17b C A 1: 53,796,651 (GRCm39) C372F probably damaging Het
Tbck A G 3: 132,428,052 (GRCm39) probably benign Het
Thoc1 C T 18: 9,963,267 (GRCm39) T127I probably benign Het
Togaram2 G T 17: 72,023,439 (GRCm39) R765L probably damaging Het
Tprg1 A G 16: 25,136,219 (GRCm39) Y70C probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Umodl1 T C 17: 31,215,325 (GRCm39) Y1050H probably damaging Het
Vmn1r205 T A 13: 22,776,586 (GRCm39) D172V probably benign Het
Vmn1r79 A T 7: 11,910,990 (GRCm39) N291Y probably damaging Het
Vmn2r112 T A 17: 22,833,980 (GRCm39) N549K probably damaging Het
Vrk3 T A 7: 44,414,227 (GRCm39) L241Q probably damaging Het
Zc3h7a A G 16: 10,969,744 (GRCm39) S386P probably damaging Het
Other mutations in Adgra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Adgra3 APN 5 50,183,100 (GRCm39) missense probably damaging 1.00
IGL00848:Adgra3 APN 5 50,159,291 (GRCm39) missense probably damaging 1.00
IGL01455:Adgra3 APN 5 50,144,899 (GRCm39) nonsense probably null
IGL01665:Adgra3 APN 5 50,164,272 (GRCm39) missense possibly damaging 0.64
IGL02151:Adgra3 APN 5 50,136,484 (GRCm39) missense probably benign
IGL02239:Adgra3 APN 5 50,118,054 (GRCm39) missense probably damaging 1.00
IGL02351:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02358:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02938:Adgra3 APN 5 50,118,659 (GRCm39) missense probably benign 0.01
IGL03028:Adgra3 APN 5 50,174,194 (GRCm39) missense probably benign 0.30
aperture UTSW 5 50,156,487 (GRCm39) nonsense probably null
saltatory UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
ANU74:Adgra3 UTSW 5 50,118,380 (GRCm39) missense probably benign 0.16
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0121:Adgra3 UTSW 5 50,183,128 (GRCm39) splice site probably benign
R0125:Adgra3 UTSW 5 50,159,194 (GRCm39) splice site probably benign
R0137:Adgra3 UTSW 5 50,121,182 (GRCm39) splice site probably benign
R0415:Adgra3 UTSW 5 50,119,099 (GRCm39) splice site probably benign
R0479:Adgra3 UTSW 5 50,147,607 (GRCm39) missense probably benign 0.00
R0505:Adgra3 UTSW 5 50,166,676 (GRCm39) critical splice donor site probably null
R0883:Adgra3 UTSW 5 50,118,065 (GRCm39) missense probably damaging 1.00
R0920:Adgra3 UTSW 5 50,118,503 (GRCm39) missense probably benign 0.19
R1139:Adgra3 UTSW 5 50,119,097 (GRCm39) splice site probably null
R1211:Adgra3 UTSW 5 50,164,218 (GRCm39) missense possibly damaging 0.88
R1370:Adgra3 UTSW 5 50,118,129 (GRCm39) missense possibly damaging 0.56
R1530:Adgra3 UTSW 5 50,118,479 (GRCm39) missense probably benign 0.00
R1703:Adgra3 UTSW 5 50,164,117 (GRCm39) missense probably benign 0.00
R1782:Adgra3 UTSW 5 50,129,404 (GRCm39) missense probably benign 0.02
R1843:Adgra3 UTSW 5 50,118,834 (GRCm39) missense probably damaging 1.00
R2157:Adgra3 UTSW 5 50,159,283 (GRCm39) missense possibly damaging 0.87
R2281:Adgra3 UTSW 5 50,159,222 (GRCm39) missense probably benign 0.04
R2385:Adgra3 UTSW 5 50,136,908 (GRCm39) missense possibly damaging 0.95
R2426:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R3084:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3086:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3409:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3410:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3411:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R4301:Adgra3 UTSW 5 50,118,420 (GRCm39) missense possibly damaging 0.94
R4360:Adgra3 UTSW 5 50,147,552 (GRCm39) missense possibly damaging 0.92
R4475:Adgra3 UTSW 5 50,159,240 (GRCm39) missense probably damaging 1.00
R4569:Adgra3 UTSW 5 50,117,905 (GRCm39) missense probably damaging 1.00
R4607:Adgra3 UTSW 5 50,128,081 (GRCm39) missense probably damaging 0.98
R4667:Adgra3 UTSW 5 50,136,298 (GRCm39) missense possibly damaging 0.94
R4671:Adgra3 UTSW 5 50,136,710 (GRCm39) missense probably damaging 1.00
R4886:Adgra3 UTSW 5 50,156,537 (GRCm39) missense probably benign 0.07
R5197:Adgra3 UTSW 5 50,118,096 (GRCm39) missense probably benign 0.01
R5208:Adgra3 UTSW 5 50,168,857 (GRCm39) missense probably damaging 0.99
R5313:Adgra3 UTSW 5 50,118,651 (GRCm39) missense probably benign 0.24
R5435:Adgra3 UTSW 5 50,147,468 (GRCm39) missense probably damaging 0.99
R5663:Adgra3 UTSW 5 50,156,627 (GRCm39) missense probably benign 0.14
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6064:Adgra3 UTSW 5 50,117,667 (GRCm39) missense probably damaging 0.97
R6259:Adgra3 UTSW 5 50,156,483 (GRCm39) missense possibly damaging 0.63
R6272:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R6293:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6296:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6297:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6352:Adgra3 UTSW 5 50,147,592 (GRCm39) missense probably benign 0.01
R6352:Adgra3 UTSW 5 50,136,478 (GRCm39) missense probably benign
R6989:Adgra3 UTSW 5 50,164,226 (GRCm39) missense probably damaging 1.00
R7026:Adgra3 UTSW 5 50,118,083 (GRCm39) missense probably benign
R7147:Adgra3 UTSW 5 50,118,587 (GRCm39) missense probably damaging 1.00
R7206:Adgra3 UTSW 5 50,164,238 (GRCm39) missense probably damaging 1.00
R7381:Adgra3 UTSW 5 50,216,116 (GRCm39) start codon destroyed probably null
R7508:Adgra3 UTSW 5 50,174,209 (GRCm39) missense probably benign 0.10
R7538:Adgra3 UTSW 5 50,118,792 (GRCm39) missense probably benign 0.01
R7579:Adgra3 UTSW 5 50,144,977 (GRCm39) missense probably benign
R7951:Adgra3 UTSW 5 50,121,126 (GRCm39) missense probably damaging 1.00
R8269:Adgra3 UTSW 5 50,121,079 (GRCm39) missense probably damaging 0.98
R8458:Adgra3 UTSW 5 50,145,013 (GRCm39) missense probably damaging 0.99
R8486:Adgra3 UTSW 5 50,147,621 (GRCm39) missense probably damaging 0.98
R8912:Adgra3 UTSW 5 50,118,273 (GRCm39) missense possibly damaging 0.61
R8955:Adgra3 UTSW 5 50,118,731 (GRCm39) missense probably benign 0.05
R9108:Adgra3 UTSW 5 50,136,295 (GRCm39) missense probably damaging 1.00
R9112:Adgra3 UTSW 5 50,118,395 (GRCm39) missense probably damaging 1.00
R9191:Adgra3 UTSW 5 50,145,006 (GRCm39) missense possibly damaging 0.88
R9267:Adgra3 UTSW 5 50,155,618 (GRCm39) missense possibly damaging 0.87
R9312:Adgra3 UTSW 5 50,117,900 (GRCm39) missense probably damaging 1.00
R9537:Adgra3 UTSW 5 50,118,207 (GRCm39) missense possibly damaging 0.82
R9614:Adgra3 UTSW 5 50,164,250 (GRCm39) missense probably damaging 1.00
RF005:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF024:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF036:Adgra3 UTSW 5 50,215,983 (GRCm39) small deletion probably benign
X0065:Adgra3 UTSW 5 50,129,304 (GRCm39) missense probably benign
Z1187:Adgra3 UTSW 5 50,136,421 (GRCm39) missense probably damaging 1.00
Z1192:Adgra3 UTSW 5 50,156,623 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACTGTGAGACTGCTTAGTGGACAGG -3'
(R):5'- GCCACGCATGTAATTCAGGCTTC -3'

Sequencing Primer
(F):5'- TTAGTGGACAGGCACTGGG -3'
(R):5'- GCATGTAATTCAGGCTTCTTCAAC -3'
Posted On 2013-10-16