Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00091:Vmn2r118'

777

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

Vmn2r119, EG668547, EG383258

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.121) question?

Stock #

IGL00091

Quality Score

Status

Chromosome

Chromosomal Location

55899341-55931672 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 55899708 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 732 (E732G)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably damaging
Transcript: ENSMUST00000168440
AA Change: E732G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: E732G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abraxas2	A	T	7: 132,485,157 (GRCm39)	Y400F	probably benign	Het
Adamts8	C	A	9: 30,864,796 (GRCm39)	T429K	probably damaging	Het
Adgrv1	C	T	13: 81,726,220 (GRCm39)	D602N	probably damaging	Het
Ano7	A	T	1: 93,329,888 (GRCm39)	H775L	probably benign	Het
Apoo-ps	A	T	13: 107,551,134 (GRCm39)		noncoding transcript	Het
Arid2	T	C	15: 96,270,183 (GRCm39)	V1432A	probably benign	Het
Atoh1	T	C	6: 64,706,568 (GRCm39)	S88P	possibly damaging	Het
C130050O18Rik	A	G	5: 139,400,601 (GRCm39)	E218G	probably damaging	Het
Cacna2d1	T	A	5: 16,417,942 (GRCm39)	F155L	probably damaging	Het
Car4	C	T	11: 84,856,593 (GRCm39)	P294S	probably damaging	Het
Cyp1a2	G	T	9: 57,589,352 (GRCm39)	S154*	probably null	Het
Cyp3a25	A	T	5: 145,938,273 (GRCm39)	Y68*	probably null	Het
Dmbt1	C	A	7: 130,681,270 (GRCm39)		probably benign	Het
Dnajc22	T	A	15: 98,999,059 (GRCm39)	F81L	possibly damaging	Het
Eml5	G	A	12: 98,839,468 (GRCm39)		probably benign	Het
Fpgs	A	T	2: 32,576,559 (GRCm39)		probably benign	Het
Gab2	T	C	7: 96,951,650 (GRCm39)	S537P	possibly damaging	Het
Gmds	G	A	13: 32,418,373 (GRCm39)	S37L	probably damaging	Het
Ipo13	T	C	4: 117,760,602 (GRCm39)	E626G	probably benign	Het
Kcng1	T	C	2: 168,110,684 (GRCm39)	H160R	probably benign	Het
Lama3	A	G	18: 12,713,349 (GRCm39)	T1608A	probably benign	Het
Lama4	A	C	10: 38,948,801 (GRCm39)	S855R	probably damaging	Het
Ltbp1	C	T	17: 75,532,333 (GRCm39)	H454Y	probably damaging	Het
Map3k14	C	A	11: 103,118,405 (GRCm39)	G594C	probably damaging	Het
Mcph1	A	G	8: 18,682,636 (GRCm39)	N591S	possibly damaging	Het
Moxd1	G	A	10: 24,155,762 (GRCm39)	V289I	probably damaging	Het
Mptx2	T	G	1: 173,102,455 (GRCm39)	N78T	probably damaging	Het
Muc4	G	A	16: 32,754,086 (GRCm38)	G1321R	probably benign	Het
Muc6	A	C	7: 141,218,497 (GRCm39)	S2059A	probably benign	Het
Nup50	T	A	15: 84,819,605 (GRCm39)	F293Y	probably benign	Het
Ogn	A	G	13: 49,774,514 (GRCm39)	Y219C	probably damaging	Het
Pdia3	T	C	2: 121,244,659 (GRCm39)	L47P	probably damaging	Het
Piwil4	A	T	9: 14,614,393 (GRCm39)	D786E	probably damaging	Het
Pspc1	A	G	14: 57,009,168 (GRCm39)	L222P	probably damaging	Het
Ptchd3	T	A	11: 121,721,972 (GRCm39)	Y282N	probably damaging	Het
Reln	C	A	5: 22,244,563 (GRCm39)	G805V	possibly damaging	Het
Serpini2	T	C	3: 75,156,549 (GRCm39)	Y327C	probably damaging	Het
Spire2	A	G	8: 124,080,798 (GRCm39)	D14G	probably damaging	Het
Stab2	A	T	10: 86,705,070 (GRCm39)		probably null	Het
Timeless	T	C	10: 128,077,577 (GRCm39)	L219P	probably damaging	Het
Tmem63a	C	T	1: 180,790,653 (GRCm39)	T437M	probably damaging	Het
Tslp	A	G	18: 32,948,448 (GRCm39)		probably benign	Het
Ttbk2	C	A	2: 120,579,314 (GRCm39)	G534*	probably null	Het
Uggt1	T	C	1: 36,218,633 (GRCm39)		probably benign	Het
Zfhx2	G	A	14: 55,304,022 (GRCm39)	P1321S	possibly damaging	Het
Zfp58	A	G	13: 67,639,114 (GRCm39)	V459A	probably benign	Het
Zfp831	T	C	2: 174,487,451 (GRCm39)	S709P	possibly damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00976:Vmn2r118	APN	17	55,900,204 (GRCm39)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,900,000 (GRCm39)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,915,585 (GRCm39)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,899,990 (GRCm39)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,899,619 (GRCm39)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,917,517 (GRCm39)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,931,598 (GRCm39)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,917,870 (GRCm39)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,899,655 (GRCm39)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,914,996 (GRCm39)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,915,616 (GRCm39)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,917,717 (GRCm39)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,915,643 (GRCm39)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,918,021 (GRCm39)	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55,917,970 (GRCm39)	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55,917,772 (GRCm39)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,915,466 (GRCm39)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,915,620 (GRCm39)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,900,237 (GRCm39)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,917,935 (GRCm39)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,917,643 (GRCm39)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,915,083 (GRCm39)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,918,530 (GRCm39)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,899,456 (GRCm39)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,917,406 (GRCm39)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,918,556 (GRCm39)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,899,882 (GRCm39)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,899,925 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,931,650 (GRCm39)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,915,421 (GRCm39)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,917,347 (GRCm39)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,917,665 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,917,860 (GRCm39)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,899,581 (GRCm39)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,899,894 (GRCm39)	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55,918,565 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,899,765 (GRCm39)	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55,900,103 (GRCm39)	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55,931,494 (GRCm39)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,899,871 (GRCm39)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,915,093 (GRCm39)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,899,996 (GRCm39)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,899,714 (GRCm39)	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55,899,348 (GRCm39)	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55,917,440 (GRCm39)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,915,496 (GRCm39)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,899,853 (GRCm39)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,900,242 (GRCm39)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,915,484 (GRCm39)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,917,936 (GRCm39)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,917,423 (GRCm39)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,915,057 (GRCm39)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,915,642 (GRCm39)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,917,216 (GRCm39)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,917,835 (GRCm39)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,918,649 (GRCm39)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,917,207 (GRCm39)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,899,837 (GRCm39)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,918,009 (GRCm39)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,915,415 (GRCm39)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,899,496 (GRCm39)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,900,218 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,917,655 (GRCm39)	nonsense	probably null

Posted On

2011-07-12