Incidental Mutation 'R0834:Parg'
ID 77761
Institutional Source Beutler Lab
Gene Symbol Parg
Ensembl Gene ENSMUSG00000021911
Gene Name poly (ADP-ribose) glycohydrolase
Synonyms
MMRRC Submission 039013-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0834 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 31923906-32019507 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 31936511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022470] [ENSMUST00000163350] [ENSMUST00000164137] [ENSMUST00000167699] [ENSMUST00000170129] [ENSMUST00000170840]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000022470
SMART Domains Protein: ENSMUSP00000022470
Gene: ENSMUSG00000021911

DomainStartEndE-ValueType
low complexity region 190 204 N/A INTRINSIC
low complexity region 286 298 N/A INTRINSIC
Pfam:PARG_cat 574 902 2.5e-135 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163350
SMART Domains Protein: ENSMUSP00000131566
Gene: ENSMUSG00000021911

DomainStartEndE-ValueType
low complexity region 190 204 N/A INTRINSIC
low complexity region 286 298 N/A INTRINSIC
Pfam:PARG_cat 570 905 5.1e-134 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164137
Predicted Effect probably benign
Transcript: ENSMUST00000167699
Predicted Effect probably benign
Transcript: ENSMUST00000170129
Predicted Effect probably benign
Transcript: ENSMUST00000170840
SMART Domains Protein: ENSMUSP00000132454
Gene: ENSMUSG00000021911

DomainStartEndE-ValueType
Pfam:PARG_cat 117 452 9.7e-135 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.7%
Validation Efficiency 100% (86/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
PHENOTYPE: Mice homozygous for one allele of this gene are hypersensitive to alkylating agents and ionizing radiation and susceptible to streptozotocin induced diabetes and endotoxic shock. Mice homozygous for a second allele display embryonic lethality and fail tohatch from the zona pellucida. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add2 A T 6: 86,063,899 (GRCm39) E66V probably damaging Het
Aldh1a3 T C 7: 66,062,658 (GRCm39) I156V probably benign Het
Ang4 T A 14: 52,001,725 (GRCm39) K74N probably benign Het
Arcn1 A T 9: 44,670,172 (GRCm39) probably benign Het
Arhgef33 T A 17: 80,655,026 (GRCm39) probably benign Het
Atn1 A G 6: 124,720,188 (GRCm39) probably benign Het
Bmal2 A G 6: 146,724,185 (GRCm39) H359R probably damaging Het
Bmerb1 T C 16: 13,911,795 (GRCm39) L47P probably damaging Het
Brip1 T C 11: 86,083,653 (GRCm39) T123A probably benign Het
Camkv A G 9: 107,823,045 (GRCm39) Y95C probably damaging Het
Cdk12 T A 11: 98,095,211 (GRCm39) S340T probably benign Het
Ckap2l G A 2: 129,138,224 (GRCm39) probably benign Het
Clmn A T 12: 104,738,085 (GRCm39) L1042Q probably damaging Het
Clmn G T 12: 104,738,086 (GRCm39) L1042M probably damaging Het
Cluh T C 11: 74,554,631 (GRCm39) V737A probably benign Het
Cpne8 A G 15: 90,424,462 (GRCm39) V309A probably benign Het
Cpxm2 T A 7: 131,756,342 (GRCm39) probably benign Het
Csmd3 A T 15: 47,747,073 (GRCm39) probably benign Het
Ctr9 T A 7: 110,650,159 (GRCm39) S818T probably benign Het
Cyp26a1 C T 19: 37,688,405 (GRCm39) A309V probably damaging Het
Dbndd2 C T 2: 164,332,122 (GRCm39) T115I possibly damaging Het
Dhcr7 A G 7: 143,394,964 (GRCm39) N157S probably benign Het
Dlx2 C A 2: 71,375,859 (GRCm39) V155F probably damaging Het
Duox1 A T 2: 122,176,982 (GRCm39) I1470F probably damaging Het
Esrrb A T 12: 86,517,071 (GRCm39) I68F probably benign Het
Fhod3 T A 18: 25,248,862 (GRCm39) L1347* probably null Het
Fip1l1 T C 5: 74,755,721 (GRCm39) probably benign Het
Frem3 A G 8: 81,413,637 (GRCm39) Y1966C probably damaging Het
Gatd3a T C 10: 77,998,539 (GRCm39) D229G probably damaging Het
Ggt5 C T 10: 75,440,604 (GRCm39) R242C possibly damaging Het
Gm14496 G A 2: 181,637,480 (GRCm39) V185I probably benign Het
Gnptab T C 10: 88,265,814 (GRCm39) V409A probably damaging Het
Gramd1a A G 7: 30,837,589 (GRCm39) F390S possibly damaging Het
Helz2 A G 2: 180,872,570 (GRCm39) S2477P probably damaging Het
Hsd17b3 T C 13: 64,236,936 (GRCm39) K3E probably benign Het
Ift172 T C 5: 31,414,715 (GRCm39) H1395R probably benign Het
Jam2 T A 16: 84,609,855 (GRCm39) C180S probably damaging Het
Kalrn A C 16: 33,870,289 (GRCm39) S160A possibly damaging Het
Kcnk3 T C 5: 30,779,979 (GRCm39) I343T probably damaging Het
Kif13a T C 13: 46,967,712 (GRCm39) E334G probably damaging Het
Klhl41 A G 2: 69,508,491 (GRCm39) K482E possibly damaging Het
Lig3 A G 11: 82,689,113 (GRCm39) E794G probably damaging Het
Myh13 T C 11: 67,240,436 (GRCm39) M780T possibly damaging Het
Ndst2 A G 14: 20,779,761 (GRCm39) Y160H probably damaging Het
Ndufb10 T C 17: 24,941,648 (GRCm39) M90V probably damaging Het
Obscn T C 11: 59,024,104 (GRCm39) K522R probably benign Het
Olfml2b T C 1: 170,475,413 (GRCm39) S113P probably benign Het
Or14a257 T A 7: 86,138,698 (GRCm39) E20D probably benign Het
Or4a78 A G 2: 89,497,423 (GRCm39) I269T probably benign Het
Or4d10b T A 19: 12,036,979 (GRCm39) M46L probably benign Het
Or51v14 T C 7: 103,261,444 (GRCm39) T39A probably benign Het
Or6k2 T A 1: 173,986,930 (GRCm39) M197K possibly damaging Het
Pde7a C T 3: 19,284,482 (GRCm39) C367Y probably damaging Het
Pigr T A 1: 130,772,281 (GRCm39) C166* probably null Het
Pip4k2c A T 10: 127,036,704 (GRCm39) probably benign Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Prkd2 A T 7: 16,599,602 (GRCm39) probably benign Het
Ptprt G T 2: 161,654,059 (GRCm39) probably null Het
Rapgef5 C T 12: 117,610,741 (GRCm39) probably benign Het
Retreg1 T C 15: 25,971,756 (GRCm39) L356P probably benign Het
Rigi T A 4: 40,239,596 (GRCm39) E34V possibly damaging Het
Rnf43 A G 11: 87,622,077 (GRCm39) T393A probably benign Het
Samd3 T C 10: 26,147,725 (GRCm39) S467P probably benign Het
Scarf1 C A 11: 75,405,229 (GRCm39) C89* probably null Het
Sdk1 T C 5: 141,227,779 (GRCm39) L59S probably benign Het
Sgca C T 11: 94,861,512 (GRCm39) W244* probably null Het
Sh3d21 T C 4: 126,045,065 (GRCm39) K538R probably benign Het
Smyd4 T A 11: 75,281,958 (GRCm39) L477Q possibly damaging Het
Sra1 A G 18: 36,801,829 (GRCm39) M87T probably benign Het
Ssh2 T C 11: 77,328,459 (GRCm39) Y336H possibly damaging Het
Steap1 T C 5: 5,790,357 (GRCm39) Y197C probably damaging Het
Strn3 A G 12: 51,673,879 (GRCm39) probably benign Het
Tgm3 A G 2: 129,868,677 (GRCm39) T205A probably benign Het
Tll2 G A 19: 41,101,512 (GRCm39) T374I probably damaging Het
Tmem63b C A 17: 45,971,870 (GRCm39) D782Y possibly damaging Het
Trim10 G A 17: 37,183,283 (GRCm39) S193N probably benign Het
Ttf1 A T 2: 28,963,962 (GRCm39) K613* probably null Het
Tube1 T A 10: 39,010,168 (GRCm39) probably null Het
Uimc1 T A 13: 55,224,222 (GRCm39) probably null Het
Wwp2 G T 8: 108,283,428 (GRCm39) probably benign Het
Zfp101 C T 17: 33,601,418 (GRCm39) V113I probably benign Het
Zfp292 T C 4: 34,809,114 (GRCm39) D1310G probably benign Het
Zfp575 A T 7: 24,285,245 (GRCm39) L132H probably damaging Het
Zmym2 T C 14: 57,194,420 (GRCm39) F1226S probably damaging Het
Zswim6 A C 13: 107,862,989 (GRCm39) noncoding transcript Het
Other mutations in Parg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Parg APN 14 32,018,142 (GRCm39) splice site probably benign
IGL01879:Parg APN 14 31,993,579 (GRCm39) splice site probably benign
IGL02391:Parg APN 14 31,984,638 (GRCm39) splice site probably null
IGL02451:Parg APN 14 31,964,186 (GRCm39) missense probably damaging 1.00
IGL02598:Parg APN 14 31,936,281 (GRCm39) missense probably damaging 1.00
IGL02899:Parg APN 14 31,960,531 (GRCm39) missense probably damaging 1.00
R0112:Parg UTSW 14 31,924,390 (GRCm39) missense probably damaging 1.00
R0167:Parg UTSW 14 31,939,693 (GRCm39) critical splice donor site probably null
R0514:Parg UTSW 14 31,976,517 (GRCm39) missense possibly damaging 0.69
R1140:Parg UTSW 14 32,018,200 (GRCm39) missense probably benign 0.01
R1480:Parg UTSW 14 31,931,585 (GRCm39) nonsense probably null
R1611:Parg UTSW 14 31,960,527 (GRCm39) missense probably damaging 1.00
R1912:Parg UTSW 14 31,932,497 (GRCm39) missense probably damaging 0.99
R1916:Parg UTSW 14 31,930,184 (GRCm39) splice site probably benign
R1983:Parg UTSW 14 31,939,653 (GRCm39) missense probably damaging 1.00
R2007:Parg UTSW 14 31,932,531 (GRCm39) missense possibly damaging 0.87
R2275:Parg UTSW 14 32,017,195 (GRCm39) missense probably damaging 0.98
R2942:Parg UTSW 14 31,931,294 (GRCm39) missense probably damaging 1.00
R4206:Parg UTSW 14 31,976,493 (GRCm39) missense probably benign 0.07
R4482:Parg UTSW 14 31,984,731 (GRCm39) missense probably damaging 1.00
R4512:Parg UTSW 14 31,984,693 (GRCm39) missense probably damaging 1.00
R4519:Parg UTSW 14 31,931,592 (GRCm39) missense probably damaging 1.00
R4611:Parg UTSW 14 31,996,821 (GRCm39) missense probably damaging 1.00
R4831:Parg UTSW 14 31,924,408 (GRCm39) missense probably benign 0.00
R4876:Parg UTSW 14 31,993,625 (GRCm39) missense probably damaging 0.98
R5298:Parg UTSW 14 31,924,210 (GRCm39) missense probably damaging 1.00
R5606:Parg UTSW 14 31,984,693 (GRCm39) missense probably damaging 1.00
R5782:Parg UTSW 14 31,996,862 (GRCm39) nonsense probably null
R5878:Parg UTSW 14 31,939,619 (GRCm39) missense possibly damaging 0.85
R6373:Parg UTSW 14 31,931,454 (GRCm39) splice site probably null
R6436:Parg UTSW 14 31,993,634 (GRCm39) missense probably damaging 1.00
R6530:Parg UTSW 14 31,931,156 (GRCm39) missense probably damaging 1.00
R7285:Parg UTSW 14 31,932,465 (GRCm39) missense probably damaging 0.98
R7348:Parg UTSW 14 31,972,036 (GRCm39) missense possibly damaging 0.82
R7455:Parg UTSW 14 31,931,432 (GRCm39) missense probably benign
R7780:Parg UTSW 14 31,930,758 (GRCm39) missense possibly damaging 0.94
R7887:Parg UTSW 14 31,939,619 (GRCm39) missense possibly damaging 0.85
R7968:Parg UTSW 14 31,936,327 (GRCm39) missense possibly damaging 0.57
R8153:Parg UTSW 14 31,984,777 (GRCm39) missense probably damaging 1.00
R8494:Parg UTSW 14 31,930,978 (GRCm39) missense probably benign 0.04
R8717:Parg UTSW 14 31,932,492 (GRCm39) missense probably benign 0.00
R8781:Parg UTSW 14 31,936,400 (GRCm39) missense probably benign 0.33
R8826:Parg UTSW 14 31,931,175 (GRCm39) missense possibly damaging 0.70
R9357:Parg UTSW 14 31,996,874 (GRCm39) missense probably damaging 1.00
R9423:Parg UTSW 14 31,939,662 (GRCm39) missense probably damaging 1.00
R9617:Parg UTSW 14 31,960,569 (GRCm39) missense probably benign 0.01
R9662:Parg UTSW 14 31,971,976 (GRCm39) missense probably damaging 1.00
R9666:Parg UTSW 14 31,964,294 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCATTTGCCTGAGCTGCTTCC -3'
(R):5'- ACATTGCACATGAAGATTGCTGCC -3'

Sequencing Primer
(F):5'- TCAGGTAGACCTTCTGAGAGC -3'
(R):5'- ACCTCTCAGCTGGCTCTATA -3'
Posted On 2013-10-16