Incidental Mutation 'R0834:Trim10'
ID 77772
Institutional Source Beutler Lab
Gene Symbol Trim10
Ensembl Gene ENSMUSG00000073400
Gene Name tripartite motif-containing 10
Synonyms Rnf9, Herf1
MMRRC Submission 039013-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R0834 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37180466-37188725 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37183283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 193 (S193N)
Ref Sequence ENSEMBL: ENSMUSP00000057928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060524]
AlphaFold Q9WUH5
Predicted Effect probably benign
Transcript: ENSMUST00000060524
AA Change: S193N

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000057928
Gene: ENSMUSG00000073400
AA Change: S193N

DomainStartEndE-ValueType
RING 16 60 1.2e-7 SMART
BBOX 94 135 5.38e-10 SMART
coiled coil region 152 175 N/A INTRINSIC
low complexity region 187 207 N/A INTRINSIC
PRY 309 361 1.04e-25 SMART
SPRY 362 485 1.51e-23 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.7%
Validation Efficiency 100% (86/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add2 A T 6: 86,063,899 (GRCm39) E66V probably damaging Het
Aldh1a3 T C 7: 66,062,658 (GRCm39) I156V probably benign Het
Ang4 T A 14: 52,001,725 (GRCm39) K74N probably benign Het
Arcn1 A T 9: 44,670,172 (GRCm39) probably benign Het
Arhgef33 T A 17: 80,655,026 (GRCm39) probably benign Het
Atn1 A G 6: 124,720,188 (GRCm39) probably benign Het
Bmal2 A G 6: 146,724,185 (GRCm39) H359R probably damaging Het
Bmerb1 T C 16: 13,911,795 (GRCm39) L47P probably damaging Het
Brip1 T C 11: 86,083,653 (GRCm39) T123A probably benign Het
Camkv A G 9: 107,823,045 (GRCm39) Y95C probably damaging Het
Cdk12 T A 11: 98,095,211 (GRCm39) S340T probably benign Het
Ckap2l G A 2: 129,138,224 (GRCm39) probably benign Het
Clmn A T 12: 104,738,085 (GRCm39) L1042Q probably damaging Het
Clmn G T 12: 104,738,086 (GRCm39) L1042M probably damaging Het
Cluh T C 11: 74,554,631 (GRCm39) V737A probably benign Het
Cpne8 A G 15: 90,424,462 (GRCm39) V309A probably benign Het
Cpxm2 T A 7: 131,756,342 (GRCm39) probably benign Het
Csmd3 A T 15: 47,747,073 (GRCm39) probably benign Het
Ctr9 T A 7: 110,650,159 (GRCm39) S818T probably benign Het
Cyp26a1 C T 19: 37,688,405 (GRCm39) A309V probably damaging Het
Dbndd2 C T 2: 164,332,122 (GRCm39) T115I possibly damaging Het
Dhcr7 A G 7: 143,394,964 (GRCm39) N157S probably benign Het
Dlx2 C A 2: 71,375,859 (GRCm39) V155F probably damaging Het
Duox1 A T 2: 122,176,982 (GRCm39) I1470F probably damaging Het
Esrrb A T 12: 86,517,071 (GRCm39) I68F probably benign Het
Fhod3 T A 18: 25,248,862 (GRCm39) L1347* probably null Het
Fip1l1 T C 5: 74,755,721 (GRCm39) probably benign Het
Frem3 A G 8: 81,413,637 (GRCm39) Y1966C probably damaging Het
Gatd3a T C 10: 77,998,539 (GRCm39) D229G probably damaging Het
Ggt5 C T 10: 75,440,604 (GRCm39) R242C possibly damaging Het
Gm14496 G A 2: 181,637,480 (GRCm39) V185I probably benign Het
Gnptab T C 10: 88,265,814 (GRCm39) V409A probably damaging Het
Gramd1a A G 7: 30,837,589 (GRCm39) F390S possibly damaging Het
Helz2 A G 2: 180,872,570 (GRCm39) S2477P probably damaging Het
Hsd17b3 T C 13: 64,236,936 (GRCm39) K3E probably benign Het
Ift172 T C 5: 31,414,715 (GRCm39) H1395R probably benign Het
Jam2 T A 16: 84,609,855 (GRCm39) C180S probably damaging Het
Kalrn A C 16: 33,870,289 (GRCm39) S160A possibly damaging Het
Kcnk3 T C 5: 30,779,979 (GRCm39) I343T probably damaging Het
Kif13a T C 13: 46,967,712 (GRCm39) E334G probably damaging Het
Klhl41 A G 2: 69,508,491 (GRCm39) K482E possibly damaging Het
Lig3 A G 11: 82,689,113 (GRCm39) E794G probably damaging Het
Myh13 T C 11: 67,240,436 (GRCm39) M780T possibly damaging Het
Ndst2 A G 14: 20,779,761 (GRCm39) Y160H probably damaging Het
Ndufb10 T C 17: 24,941,648 (GRCm39) M90V probably damaging Het
Obscn T C 11: 59,024,104 (GRCm39) K522R probably benign Het
Olfml2b T C 1: 170,475,413 (GRCm39) S113P probably benign Het
Or14a257 T A 7: 86,138,698 (GRCm39) E20D probably benign Het
Or4a78 A G 2: 89,497,423 (GRCm39) I269T probably benign Het
Or4d10b T A 19: 12,036,979 (GRCm39) M46L probably benign Het
Or51v14 T C 7: 103,261,444 (GRCm39) T39A probably benign Het
Or6k2 T A 1: 173,986,930 (GRCm39) M197K possibly damaging Het
Parg T C 14: 31,936,511 (GRCm39) probably benign Het
Pde7a C T 3: 19,284,482 (GRCm39) C367Y probably damaging Het
Pigr T A 1: 130,772,281 (GRCm39) C166* probably null Het
Pip4k2c A T 10: 127,036,704 (GRCm39) probably benign Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Prkd2 A T 7: 16,599,602 (GRCm39) probably benign Het
Ptprt G T 2: 161,654,059 (GRCm39) probably null Het
Rapgef5 C T 12: 117,610,741 (GRCm39) probably benign Het
Retreg1 T C 15: 25,971,756 (GRCm39) L356P probably benign Het
Rigi T A 4: 40,239,596 (GRCm39) E34V possibly damaging Het
Rnf43 A G 11: 87,622,077 (GRCm39) T393A probably benign Het
Samd3 T C 10: 26,147,725 (GRCm39) S467P probably benign Het
Scarf1 C A 11: 75,405,229 (GRCm39) C89* probably null Het
Sdk1 T C 5: 141,227,779 (GRCm39) L59S probably benign Het
Sgca C T 11: 94,861,512 (GRCm39) W244* probably null Het
Sh3d21 T C 4: 126,045,065 (GRCm39) K538R probably benign Het
Smyd4 T A 11: 75,281,958 (GRCm39) L477Q possibly damaging Het
Sra1 A G 18: 36,801,829 (GRCm39) M87T probably benign Het
Ssh2 T C 11: 77,328,459 (GRCm39) Y336H possibly damaging Het
Steap1 T C 5: 5,790,357 (GRCm39) Y197C probably damaging Het
Strn3 A G 12: 51,673,879 (GRCm39) probably benign Het
Tgm3 A G 2: 129,868,677 (GRCm39) T205A probably benign Het
Tll2 G A 19: 41,101,512 (GRCm39) T374I probably damaging Het
Tmem63b C A 17: 45,971,870 (GRCm39) D782Y possibly damaging Het
Ttf1 A T 2: 28,963,962 (GRCm39) K613* probably null Het
Tube1 T A 10: 39,010,168 (GRCm39) probably null Het
Uimc1 T A 13: 55,224,222 (GRCm39) probably null Het
Wwp2 G T 8: 108,283,428 (GRCm39) probably benign Het
Zfp101 C T 17: 33,601,418 (GRCm39) V113I probably benign Het
Zfp292 T C 4: 34,809,114 (GRCm39) D1310G probably benign Het
Zfp575 A T 7: 24,285,245 (GRCm39) L132H probably damaging Het
Zmym2 T C 14: 57,194,420 (GRCm39) F1226S probably damaging Het
Zswim6 A C 13: 107,862,989 (GRCm39) noncoding transcript Het
Other mutations in Trim10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Trim10 APN 17 37,188,140 (GRCm39) missense probably benign 0.03
IGL00501:Trim10 APN 17 37,187,939 (GRCm39) missense probably benign 0.08
IGL00846:Trim10 APN 17 37,182,584 (GRCm39) missense probably damaging 1.00
IGL01536:Trim10 APN 17 37,188,180 (GRCm39) splice site probably null
IGL02814:Trim10 APN 17 37,188,228 (GRCm39) nonsense probably null
IGL03135:Trim10 APN 17 37,185,113 (GRCm39) missense possibly damaging 0.78
IGL03144:Trim10 APN 17 37,187,740 (GRCm39) missense probably damaging 1.00
IGL03298:Trim10 APN 17 37,187,917 (GRCm39) missense possibly damaging 0.87
PIT4378001:Trim10 UTSW 17 37,188,020 (GRCm39) missense probably damaging 0.98
R0102:Trim10 UTSW 17 37,181,074 (GRCm39) missense probably damaging 1.00
R0102:Trim10 UTSW 17 37,181,074 (GRCm39) missense probably damaging 1.00
R1517:Trim10 UTSW 17 37,183,346 (GRCm39) missense probably damaging 1.00
R1691:Trim10 UTSW 17 37,187,791 (GRCm39) missense probably damaging 1.00
R1696:Trim10 UTSW 17 37,188,073 (GRCm39) nonsense probably null
R2149:Trim10 UTSW 17 37,187,906 (GRCm39) missense probably benign 0.18
R3153:Trim10 UTSW 17 37,182,580 (GRCm39) missense probably damaging 1.00
R3154:Trim10 UTSW 17 37,182,580 (GRCm39) missense probably damaging 1.00
R5156:Trim10 UTSW 17 37,187,948 (GRCm39) missense probably damaging 0.99
R5327:Trim10 UTSW 17 37,181,081 (GRCm39) missense probably damaging 1.00
R5361:Trim10 UTSW 17 37,186,328 (GRCm39) missense probably benign 0.03
R5758:Trim10 UTSW 17 37,188,044 (GRCm39) missense possibly damaging 0.80
R5764:Trim10 UTSW 17 37,181,073 (GRCm39) missense probably damaging 0.97
R6032:Trim10 UTSW 17 37,182,606 (GRCm39) missense possibly damaging 0.87
R6032:Trim10 UTSW 17 37,182,606 (GRCm39) missense possibly damaging 0.87
R6179:Trim10 UTSW 17 37,187,923 (GRCm39) missense probably damaging 1.00
R6709:Trim10 UTSW 17 37,183,262 (GRCm39) missense probably damaging 0.99
R7172:Trim10 UTSW 17 37,180,955 (GRCm39) missense possibly damaging 0.78
R7197:Trim10 UTSW 17 37,187,846 (GRCm39) missense probably damaging 1.00
R7390:Trim10 UTSW 17 37,180,773 (GRCm39) start codon destroyed probably null 0.98
R7391:Trim10 UTSW 17 37,180,773 (GRCm39) start codon destroyed probably null 0.98
R7696:Trim10 UTSW 17 37,182,644 (GRCm39) missense probably damaging 1.00
R8830:Trim10 UTSW 17 37,180,846 (GRCm39) missense probably damaging 1.00
R8867:Trim10 UTSW 17 37,181,048 (GRCm39) missense probably benign 0.00
R8970:Trim10 UTSW 17 37,184,168 (GRCm39) missense probably benign 0.00
R9376:Trim10 UTSW 17 37,184,168 (GRCm39) missense probably benign 0.00
R9635:Trim10 UTSW 17 37,187,890 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCCCAGAAATGGAGTGACAAGCTG -3'
(R):5'- GATACGTCTCAGGAGCAACTTCCAC -3'

Sequencing Primer
(F):5'- ATTTTACTGCCTAACCTTGGGAG -3'
(R):5'- CTCTTGGGGAAGCACAGATTAC -3'
Posted On 2013-10-16