Mutagenetix > Incidental Mutation

Incidental Mutation 'P0038:Fstl5'

7798

Institutional Source

Beutler Lab

Gene Symbol

Fstl5

Ensembl Gene

ENSMUSG00000034098

Gene Name

follistatin-like 5

Synonyms

9130207J01Rik

MMRRC Submission

038287-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

P0038 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

75981582-76617317 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 76052369 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 33 (Y33C)

Ref Sequence

ENSEMBL: ENSMUSP00000125393 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038364] [ENSMUST00000160261]

AlphaFold

Q8BFR2

Predicted Effect

probably damaging
Transcript: ENSMUST00000038364
AA Change: Y33C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000038506
Gene: ENSMUSG00000034098
AA Change: Y33C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
KAZAL	88	133	2.16e-9	SMART
IGc2	261	328	1.11e-5	SMART
IGc2	353	420	3.85e-14	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159686

Predicted Effect

probably damaging
Transcript: ENSMUST00000160261
AA Change: Y33C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000125393
Gene: ENSMUSG00000034098
AA Change: Y33C

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
KAZAL	88	133	2.16e-9	SMART
IGc2	261	328	1.11e-5	SMART
IGc2	353	420	3.85e-14	SMART

Meta Mutation Damage Score

0.2287

Coding Region Coverage

1x: 79.6%
3x: 69.7%
10x: 40.2%
20x: 18.1%

Validation Efficiency

86% (80/93)

Allele List at MGI

Other mutations in this stock

Total: 16 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atad2b	C	A	12: 5,004,536 (GRCm39)		probably benign	Het
Atmin	T	A	8: 117,683,775 (GRCm39)	C478*	probably null	Het
Cdh13	G	A	8: 119,401,843 (GRCm39)	V82M	probably damaging	Het
Dip2c	A	C	13: 9,697,018 (GRCm39)	T1310P	probably damaging	Het
Eral1	A	T	11: 77,966,847 (GRCm39)	D189E	probably damaging	Het
Gjb4	A	T	4: 127,245,293 (GRCm39)	V216D	probably benign	Het
Lars2	T	C	9: 123,206,842 (GRCm39)	V103A	probably damaging	Het
Mfsd12	C	T	10: 81,198,052 (GRCm39)	T311I	probably benign	Het
Mtrex	A	C	13: 113,047,513 (GRCm39)	Y277*	probably null	Het
Paf1	T	C	7: 28,096,350 (GRCm39)		probably null	Het
Rfc1	T	C	5: 65,445,304 (GRCm39)	T435A	probably damaging	Het
Siglec1	T	C	2: 130,923,359 (GRCm39)	N462S	probably benign	Het
Tnks1bp1	C	T	2: 84,892,755 (GRCm39)	T232I	probably benign	Het
Trpc6	A	T	9: 8,649,512 (GRCm39)	N574I	possibly damaging	Het
Ttll7	T	C	3: 146,650,939 (GRCm39)	F700L	possibly damaging	Het
Zc3hav1	G	A	6: 38,309,469 (GRCm39)	T451M	probably damaging	Het

Other mutations in Fstl5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01632:Fstl5	APN	3	76,615,135 (GRCm39)	missense	probably benign	0.30
IGL01658:Fstl5	APN	3	76,389,562 (GRCm39)	missense	possibly damaging	0.70
IGL01917:Fstl5	APN	3	76,615,153 (GRCm39)	missense	probably damaging	1.00
IGL02073:Fstl5	APN	3	76,566,959 (GRCm39)	splice site	probably benign
IGL02329:Fstl5	APN	3	76,496,302 (GRCm39)	missense	probably damaging	1.00
IGL02651:Fstl5	APN	3	76,500,841 (GRCm39)	missense	probably damaging	1.00
IGL02967:Fstl5	APN	3	76,229,498 (GRCm39)	missense	probably damaging	1.00
IGL03004:Fstl5	APN	3	76,555,738 (GRCm39)	splice site	probably benign
IGL03107:Fstl5	APN	3	76,443,618 (GRCm39)	missense	probably damaging	1.00
IGL03113:Fstl5	APN	3	76,337,099 (GRCm39)	nonsense	probably null
PIT4131001:Fstl5	UTSW	3	76,567,006 (GRCm39)	missense	probably damaging	0.99
R0015:Fstl5	UTSW	3	76,229,498 (GRCm39)	missense	probably damaging	1.00
R0015:Fstl5	UTSW	3	76,229,498 (GRCm39)	missense	probably damaging	1.00
R0032:Fstl5	UTSW	3	76,555,742 (GRCm39)	splice site	probably benign
R0032:Fstl5	UTSW	3	76,555,742 (GRCm39)	splice site	probably benign
R0078:Fstl5	UTSW	3	76,566,952 (GRCm39)	splice site	probably benign
R0137:Fstl5	UTSW	3	76,614,786 (GRCm39)	missense	probably damaging	1.00
R0183:Fstl5	UTSW	3	76,229,579 (GRCm39)	missense	possibly damaging	0.86
R0330:Fstl5	UTSW	3	76,615,060 (GRCm39)	missense	possibly damaging	0.80
R0427:Fstl5	UTSW	3	76,615,034 (GRCm39)	nonsense	probably null
R0687:Fstl5	UTSW	3	76,615,119 (GRCm39)	missense	possibly damaging	0.62
R1642:Fstl5	UTSW	3	76,317,929 (GRCm39)	missense	possibly damaging	0.80
R1765:Fstl5	UTSW	3	76,500,783 (GRCm39)	missense	possibly damaging	0.90
R1900:Fstl5	UTSW	3	76,615,467 (GRCm39)	missense	probably damaging	1.00
R1996:Fstl5	UTSW	3	76,615,141 (GRCm39)	missense	probably benign	0.19
R2157:Fstl5	UTSW	3	76,615,372 (GRCm39)	missense	possibly damaging	0.46
R2228:Fstl5	UTSW	3	76,389,659 (GRCm39)	missense	probably damaging	1.00
R2851:Fstl5	UTSW	3	76,337,045 (GRCm39)	splice site	probably benign
R4021:Fstl5	UTSW	3	76,536,282 (GRCm39)	missense	probably benign	0.00
R4086:Fstl5	UTSW	3	76,555,593 (GRCm39)	missense	probably damaging	1.00
R4777:Fstl5	UTSW	3	76,500,807 (GRCm39)	missense	probably damaging	1.00
R4829:Fstl5	UTSW	3	76,229,489 (GRCm39)	missense	probably damaging	1.00
R4934:Fstl5	UTSW	3	76,496,272 (GRCm39)	missense	probably damaging	1.00
R4955:Fstl5	UTSW	3	76,131,183 (GRCm39)	critical splice donor site	probably null
R4977:Fstl5	UTSW	3	76,317,801 (GRCm39)	nonsense	probably null
R5166:Fstl5	UTSW	3	76,536,267 (GRCm39)	missense	possibly damaging	0.86
R5232:Fstl5	UTSW	3	76,052,284 (GRCm39)	missense	possibly damaging	0.89
R5313:Fstl5	UTSW	3	76,500,812 (GRCm39)	missense	possibly damaging	0.90
R5584:Fstl5	UTSW	3	76,229,574 (GRCm39)	missense	probably damaging	1.00
R5647:Fstl5	UTSW	3	76,496,399 (GRCm39)	missense	probably damaging	1.00
R5842:Fstl5	UTSW	3	76,229,590 (GRCm39)	missense	possibly damaging	0.94
R5978:Fstl5	UTSW	3	76,052,392 (GRCm39)	missense	probably damaging	1.00
R6007:Fstl5	UTSW	3	76,317,899 (GRCm39)	missense	probably damaging	1.00
R6064:Fstl5	UTSW	3	76,229,605 (GRCm39)	missense	probably benign	0.13
R6327:Fstl5	UTSW	3	76,615,108 (GRCm39)	missense	probably benign	0.31
R6386:Fstl5	UTSW	3	76,229,373 (GRCm39)	missense	probably benign	0.13
R6523:Fstl5	UTSW	3	76,443,641 (GRCm39)	missense	probably benign	0.00
R6852:Fstl5	UTSW	3	76,615,162 (GRCm39)	missense	probably damaging	1.00
R6861:Fstl5	UTSW	3	76,229,523 (GRCm39)	missense	probably damaging	1.00
R6866:Fstl5	UTSW	3	76,229,532 (GRCm39)	missense	probably damaging	0.99
R7100:Fstl5	UTSW	3	76,443,600 (GRCm39)	missense	probably benign	0.11
R7341:Fstl5	UTSW	3	76,389,704 (GRCm39)	splice site	probably null
R7495:Fstl5	UTSW	3	76,615,099 (GRCm39)	missense	possibly damaging	0.85
R7558:Fstl5	UTSW	3	76,337,092 (GRCm39)	missense	possibly damaging	0.95
R7731:Fstl5	UTSW	3	76,569,069 (GRCm39)	missense	probably damaging	1.00
R7787:Fstl5	UTSW	3	76,337,131 (GRCm39)	missense	probably damaging	1.00
R7852:Fstl5	UTSW	3	76,615,275 (GRCm39)	missense	probably benign	0.00
R7874:Fstl5	UTSW	3	76,569,093 (GRCm39)	missense	probably benign	0.10
R7881:Fstl5	UTSW	3	76,443,605 (GRCm39)	missense	probably damaging	1.00
R7986:Fstl5	UTSW	3	76,337,097 (GRCm39)	missense	probably damaging	0.98
R8039:Fstl5	UTSW	3	76,555,725 (GRCm39)	missense	possibly damaging	0.69
R8050:Fstl5	UTSW	3	76,614,810 (GRCm39)	missense	probably benign	0.00
R8844:Fstl5	UTSW	3	76,337,154 (GRCm39)	missense	possibly damaging	0.71
R8929:Fstl5	UTSW	3	76,615,138 (GRCm39)	missense	probably damaging	0.98
R9012:Fstl5	UTSW	3	76,567,027 (GRCm39)	missense	probably damaging	1.00
R9069:Fstl5	UTSW	3	76,615,416 (GRCm39)	missense	probably damaging	0.99
R9221:Fstl5	UTSW	3	76,569,114 (GRCm39)	missense	probably damaging	0.98
R9373:Fstl5	UTSW	3	76,555,669 (GRCm39)	nonsense	probably null
R9427:Fstl5	UTSW	3	76,229,583 (GRCm39)	missense
R9490:Fstl5	UTSW	3	76,615,060 (GRCm39)	missense	possibly damaging	0.80
R9603:Fstl5	UTSW	3	76,496,260 (GRCm39)	missense	probably damaging	1.00
Z1176:Fstl5	UTSW	3	76,615,289 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-10-29