Incidental Mutation 'R0829:Or4l15'
ID 78441
Institutional Source Beutler Lab
Gene Symbol Or4l15
Ensembl Gene ENSMUSG00000096254
Gene Name olfactory receptor family 4 subfamily L member 15
Synonyms MOR247-2, Olfr724, GA_x6K02T2PMLR-5645801-5644872
MMRRC Submission 039009-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.220) question?
Stock # R0829 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50197548-50198553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50198503 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 9 (V9L)
Ref Sequence ENSEMBL: ENSMUSP00000149110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]
AlphaFold K7N5X7
Predicted Effect probably benign
Transcript: ENSMUST00000075030
AA Change: V9L

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254
AA Change: V9L

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7TM_GPCR_Srsx 34 302 3e-11 PFAM
Pfam:7tm_1 41 287 5.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213390
AA Change: V9L

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.1612 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 94.7%
Validation Efficiency 95% (37/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adprh C A 16: 38,266,150 (GRCm39) A331S probably benign Het
Atp4b T G 8: 13,440,098 (GRCm39) T83P probably damaging Het
Ccdc177 T C 12: 80,806,253 (GRCm39) E7G probably damaging Het
Cercam G T 2: 29,761,079 (GRCm39) R126L probably damaging Het
Cpb1 C T 3: 20,306,107 (GRCm39) probably benign Het
Dnah7a T C 1: 53,543,238 (GRCm39) M2311V probably benign Het
Dnah9 C A 11: 65,896,002 (GRCm39) V2458L probably benign Het
Dnajb6 T C 5: 29,990,020 (GRCm39) probably benign Het
Dst A G 1: 34,202,301 (GRCm39) T210A probably damaging Het
Gfpt1 T C 6: 87,030,847 (GRCm39) probably benign Het
Grin1 C T 2: 25,188,460 (GRCm39) D429N probably benign Het
Iqck T C 7: 118,499,111 (GRCm39) probably null Het
Itgb5 A G 16: 33,764,571 (GRCm39) I359V probably benign Het
Lemd3 T C 10: 120,814,988 (GRCm39) T82A probably benign Het
Lrrc74b A G 16: 17,376,254 (GRCm39) probably benign Het
Mitf A T 6: 97,980,869 (GRCm39) I246F possibly damaging Het
Msgn1 C T 12: 11,258,525 (GRCm39) R142Q probably damaging Het
Myh8 C A 11: 67,174,326 (GRCm39) probably benign Het
Nacad C A 11: 6,551,158 (GRCm39) V678L probably benign Het
Nomo1 A G 7: 45,725,596 (GRCm39) probably benign Het
Ofcc1 C T 13: 40,362,305 (GRCm39) G206R probably benign Het
Or1s2 T A 19: 13,758,556 (GRCm39) D191E probably damaging Het
Or4c100 A T 2: 88,356,572 (GRCm39) Y215F probably damaging Het
Or6d13 A G 6: 116,518,226 (GRCm39) T271A probably benign Het
Pcdh15 T A 10: 74,338,598 (GRCm39) V1068E probably damaging Het
Plat A G 8: 23,262,273 (GRCm39) Y99C probably damaging Het
Potefam1 G A 2: 111,028,450 (GRCm39) T42I possibly damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Rbm25 T C 12: 83,707,150 (GRCm39) probably benign Het
Scaf11 T C 15: 96,316,570 (GRCm39) D998G probably damaging Het
Serpinb6a A G 13: 34,119,684 (GRCm39) probably benign Het
Spef2 T C 15: 9,687,899 (GRCm39) I507M probably benign Het
Srebf2 T A 15: 82,061,790 (GRCm39) probably null Het
Stimate C T 14: 30,584,842 (GRCm39) R56C probably damaging Het
Tert T C 13: 73,792,504 (GRCm39) C924R probably damaging Het
Usp19 T C 9: 108,371,000 (GRCm39) S221P probably benign Het
Xkr4 C T 1: 3,741,469 (GRCm39) A35T possibly damaging Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Other mutations in Or4l15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02811:Or4l15 APN 14 50,197,590 (GRCm39) utr 3 prime probably benign
R1513:Or4l15 UTSW 14 50,198,558 (GRCm39) critical splice acceptor site probably null
R2016:Or4l15 UTSW 14 50,197,959 (GRCm39) missense probably benign 0.00
R2936:Or4l15 UTSW 14 50,197,611 (GRCm39) missense probably benign 0.03
R3082:Or4l15 UTSW 14 50,198,161 (GRCm39) missense probably damaging 1.00
R3738:Or4l15 UTSW 14 50,198,013 (GRCm39) missense possibly damaging 0.60
R4772:Or4l15 UTSW 14 50,198,452 (GRCm39) small deletion probably benign
R4830:Or4l15 UTSW 14 50,197,681 (GRCm39) missense probably damaging 1.00
R4839:Or4l15 UTSW 14 50,197,646 (GRCm39) missense probably benign 0.41
R5362:Or4l15 UTSW 14 50,197,986 (GRCm39) missense possibly damaging 0.95
R5695:Or4l15 UTSW 14 50,198,080 (GRCm39) missense probably benign 0.00
R6187:Or4l15 UTSW 14 50,198,526 (GRCm39) start codon destroyed probably null 0.99
R7371:Or4l15 UTSW 14 50,198,563 (GRCm39) splice site probably null
R7611:Or4l15 UTSW 14 50,198,368 (GRCm39) missense probably benign 0.03
R9243:Or4l15 UTSW 14 50,197,881 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- ACATGTCTAGGAAGGAGAGGTTTCCAA -3'
(R):5'- AGCATCTGAGGACAGAGGCTCAA -3'

Sequencing Primer
(F):5'- AGGTTTCCAAGAAGAAAATACATGG -3'
(R):5'- TGATTTCAAGCTATGCTCTGATATG -3'
Posted On 2013-10-16