Mutagenetix > Incidental Mutation

Incidental Mutation 'R0817:Vmn1r215'

78614

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r215

Ensembl Gene

ENSMUSG00000099917

Gene Name

vomeronasal 1 receptor 215

Synonyms

V1ri2

MMRRC Submission

038997-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R0817 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23259962-23260864 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23260124 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 55 (M55V)

Ref Sequence

ENSEMBL: ENSMUSP00000154763 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072972] [ENSMUST00000228092]

AlphaFold

Q8R264

Predicted Effect

probably benign
Transcript: ENSMUST00000072972
AA Change: M55V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000072739
Gene: ENSMUSG00000099917
AA Change: M55V

Domain	Start	End	E-Value	Type
Pfam:V1R	35	298	2.4e-37	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228092
AA Change: M55V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 96.9%
20x: 93.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 4 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccdc106	G	A	7: 5,062,539 (GRCm39)	D11N	possibly damaging	Het
Mycbp2	C	T	14: 103,466,854 (GRCm39)	R1303Q	probably damaging	Het
Polr3a	G	A	14: 24,534,232 (GRCm39)	P91L	probably damaging	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het

Other mutations in Vmn1r215

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00923:Vmn1r215	APN	13	23,260,419 (GRCm39)	missense	probably damaging	0.98
IGL02515:Vmn1r215	APN	13	23,259,990 (GRCm39)	missense	probably benign	0.21
IGL03061:Vmn1r215	APN	13	23,260,088 (GRCm39)	missense	probably damaging	0.97
PIT4651001:Vmn1r215	UTSW	13	23,260,530 (GRCm39)	missense	probably damaging	0.97
R0196:Vmn1r215	UTSW	13	23,260,254 (GRCm39)	missense	probably damaging	1.00
R0816:Vmn1r215	UTSW	13	23,260,124 (GRCm39)	missense	probably benign	0.00
R0820:Vmn1r215	UTSW	13	23,260,124 (GRCm39)	missense	probably benign	0.00
R1104:Vmn1r215	UTSW	13	23,260,758 (GRCm39)	missense	possibly damaging	0.50
R1733:Vmn1r215	UTSW	13	23,260,848 (GRCm39)	missense	probably benign	0.43
R1912:Vmn1r215	UTSW	13	23,260,673 (GRCm39)	missense	possibly damaging	0.94
R2010:Vmn1r215	UTSW	13	23,260,378 (GRCm39)	missense	probably damaging	1.00
R2510:Vmn1r215	UTSW	13	23,260,343 (GRCm39)	missense	probably benign	0.00
R2511:Vmn1r215	UTSW	13	23,260,343 (GRCm39)	missense	probably benign	0.00
R2877:Vmn1r215	UTSW	13	23,260,731 (GRCm39)	missense	probably benign	0.01
R3429:Vmn1r215	UTSW	13	23,260,378 (GRCm39)	missense	probably damaging	1.00
R3854:Vmn1r215	UTSW	13	23,260,058 (GRCm39)	missense	probably benign
R4124:Vmn1r215	UTSW	13	23,260,163 (GRCm39)	missense	probably benign	0.42
R4235:Vmn1r215	UTSW	13	23,260,101 (GRCm39)	missense	probably benign	0.31
R4979:Vmn1r215	UTSW	13	23,260,064 (GRCm39)	missense	probably benign	0.04
R4991:Vmn1r215	UTSW	13	23,260,697 (GRCm39)	missense	probably damaging	1.00
R5011:Vmn1r215	UTSW	13	23,260,721 (GRCm39)	missense	probably damaging	1.00
R5026:Vmn1r215	UTSW	13	23,260,449 (GRCm39)	missense	probably benign	0.30
R5070:Vmn1r215	UTSW	13	23,260,666 (GRCm39)	missense	probably benign	0.03
R5589:Vmn1r215	UTSW	13	23,260,190 (GRCm39)	missense	probably damaging	1.00
R5589:Vmn1r215	UTSW	13	23,260,189 (GRCm39)	missense	probably damaging	1.00
R5651:Vmn1r215	UTSW	13	23,259,981 (GRCm39)	missense	possibly damaging	0.93
R5928:Vmn1r215	UTSW	13	23,260,487 (GRCm39)	missense	possibly damaging	0.50
R6176:Vmn1r215	UTSW	13	23,260,528 (GRCm39)	missense	probably damaging	1.00
R6228:Vmn1r215	UTSW	13	23,260,633 (GRCm39)	missense	probably benign	0.19
R7270:Vmn1r215	UTSW	13	23,260,089 (GRCm39)	missense	possibly damaging	0.77
R7313:Vmn1r215	UTSW	13	23,260,484 (GRCm39)	missense	probably benign	0.01
R7820:Vmn1r215	UTSW	13	23,260,715 (GRCm39)	missense	probably damaging	1.00
R8492:Vmn1r215	UTSW	13	23,260,056 (GRCm39)	missense	possibly damaging	0.79
R8515:Vmn1r215	UTSW	13	23,260,037 (GRCm39)	missense	probably benign	0.00
R8835:Vmn1r215	UTSW	13	23,260,409 (GRCm39)	missense	possibly damaging	0.68
R9428:Vmn1r215	UTSW	13	23,260,749 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- TGTGACCAGGCATCCTCAAAGAAAG -3'
(R):5'- AGACCTGTTCAAGCTACTGCCTCC -3'

Sequencing Primer
(F):5'- CCTAGTGTTGTGCTTAAAGTCAGAAG -3'
(R):5'- CCTCCTTTGATGTAGGAGAGCAAG -3'

Posted On

2013-10-16