Incidental Mutation 'IGL01374:Fut4'
ID 78636
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fut4
Ensembl Gene ENSMUSG00000049307
Gene Name fucosyltransferase 4
Synonyms Ssea1, SSEA-1, LeX, FAL, 3-fucosyl-N-acetyl-lactosamine epitope, FucT-IV
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01374
Quality Score
Status
Chromosome 9
Chromosomal Location 14659755-14663418 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 14662786 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 169 (F169L)
Ref Sequence ENSEMBL: ENSMUSP00000053027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061498]
AlphaFold Q11127
Predicted Effect probably benign
Transcript: ENSMUST00000061498
AA Change: F169L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000053027
Gene: ENSMUSG00000049307
AA Change: F169L

DomainStartEndE-ValueType
Pfam:Glyco_tran_10_N 87 234 2.8e-40 PFAM
Pfam:Glyco_transf_10 256 431 9.2e-66 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
PHENOTYPE: Mice homozygous for a knock-out allele show a modest increase in blood neutrophils, monocytes and eosinophils, and increased leukocyte rolling velocities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik T C 7: 130,747,830 (GRCm39) H54R probably benign Het
Acsl6 T C 11: 54,229,245 (GRCm39) V359A probably damaging Het
Aldh3a2 C T 11: 61,139,828 (GRCm39) V435I probably benign Het
Atm A T 9: 53,443,024 (GRCm39) S80T possibly damaging Het
Atp8b4 A T 2: 126,225,577 (GRCm39) probably benign Het
Atxn1 T C 13: 45,721,903 (GRCm39) probably benign Het
Chd3 T C 11: 69,250,806 (GRCm39) E641G probably damaging Het
Clpb T C 7: 101,422,335 (GRCm39) V346A probably damaging Het
Ctnnbl1 T A 2: 157,678,613 (GRCm39) probably null Het
Cyp2b19 C T 7: 26,458,504 (GRCm39) P73L probably benign Het
Dcc T C 18: 71,507,624 (GRCm39) Y916C probably damaging Het
Fat4 A G 3: 38,941,647 (GRCm39) N180S probably damaging Het
Foxi1 A C 11: 34,157,984 (GRCm39) C14G probably damaging Het
Grip1 T C 10: 119,885,273 (GRCm39) S748P probably benign Het
Hnrnpr T C 4: 136,054,729 (GRCm39) probably benign Het
Ifnz G A 4: 88,701,578 (GRCm39) probably benign Het
Krt28 A G 11: 99,262,294 (GRCm39) V232A probably benign Het
Lyar C A 5: 38,385,391 (GRCm39) probably null Het
Manba G A 3: 135,260,541 (GRCm39) W575* probably null Het
Morc3 T A 16: 93,641,101 (GRCm39) D44E probably damaging Het
Mrc2 T A 11: 105,238,469 (GRCm39) Y1205* probably null Het
Myh2 A T 11: 67,068,250 (GRCm39) T293S probably benign Het
Nlrp10 T A 7: 108,523,788 (GRCm39) K564I possibly damaging Het
Nuak1 A G 10: 84,210,532 (GRCm39) S519P probably damaging Het
Or12k5 T C 2: 36,894,942 (GRCm39) H228R probably benign Het
Or9m2 T C 2: 87,820,892 (GRCm39) F146L probably benign Het
Padi2 T A 4: 140,660,496 (GRCm39) N325K probably damaging Het
Pcdhb19 A T 18: 37,631,042 (GRCm39) Y279F probably damaging Het
Phldb1 A G 9: 44,607,464 (GRCm39) L1247P probably damaging Het
Rmdn3 A G 2: 118,984,428 (GRCm39) V108A probably damaging Het
Slc22a5 A G 11: 53,758,490 (GRCm39) F437L probably benign Het
Slc3a2 C T 19: 8,690,701 (GRCm39) probably null Het
Slc5a3 T A 16: 91,874,006 (GRCm39) M21K probably benign Het
Spink5 T A 18: 44,122,471 (GRCm39) F312Y possibly damaging Het
Stab1 T C 14: 30,869,032 (GRCm39) Y1531C probably damaging Het
Tln2 C A 9: 67,169,205 (GRCm39) A433S probably damaging Het
Usp24 C T 4: 106,237,296 (GRCm39) L1076F possibly damaging Het
Vmn2r117 T C 17: 23,697,356 (GRCm39) Y112C possibly damaging Het
Vmn2r16 C T 5: 109,478,283 (GRCm39) L13F probably benign Het
Vmn2r76 T C 7: 85,874,857 (GRCm39) M707V probably benign Het
Zmym4 A T 4: 126,762,750 (GRCm39) F1358I probably damaging Het
Other mutations in Fut4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02576:Fut4 APN 9 14,662,701 (GRCm39) missense probably damaging 1.00
R0373:Fut4 UTSW 9 14,662,506 (GRCm39) missense probably damaging 1.00
R4426:Fut4 UTSW 9 14,662,677 (GRCm39) missense possibly damaging 0.57
R7100:Fut4 UTSW 9 14,662,689 (GRCm39) missense probably damaging 1.00
R7459:Fut4 UTSW 9 14,662,602 (GRCm39) missense possibly damaging 0.94
R8725:Fut4 UTSW 9 14,662,082 (GRCm39) missense probably damaging 1.00
R8727:Fut4 UTSW 9 14,662,082 (GRCm39) missense probably damaging 1.00
R9276:Fut4 UTSW 9 14,662,572 (GRCm39) missense probably benign 0.05
Posted On 2013-11-05