Incidental Mutation 'IGL01374:Zmym4'
ID78663
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Namezinc finger, MYM-type 4
SynonymsZfp262, 6330503C17Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.632) question?
Stock #IGL01374
Quality Score
Status
Chromosome4
Chromosomal Location126861939-126968135 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 126868957 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 1358 (F1358I)
Ref Sequence ENSEMBL: ENSMUSP00000101714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102607] [ENSMUST00000102608] [ENSMUST00000106108]
Predicted Effect probably benign
Transcript: ENSMUST00000102607
SMART Domains Protein: ENSMUSP00000099667
Gene: ENSMUSG00000028830

DomainStartEndE-ValueType
low complexity region 83 97 N/A INTRINSIC
FN3 113 391 8.45e1 SMART
IG_like 305 398 3.57e1 SMART
PKD 309 400 3.1e-1 SMART
FN3 399 485 2.7e1 SMART
PKD 408 497 1.87e-4 SMART
FN3 502 676 4.47e1 SMART
PKD 503 593 3.22e-8 SMART
IG_like 508 591 1.17e1 SMART
IG_like 597 782 1.66e2 SMART
PKD 599 687 8.98e-7 SMART
PKD 693 784 1.05e-7 SMART
FN3 694 772 3.71e1 SMART
transmembrane domain 927 949 N/A INTRINSIC
low complexity region 995 1010 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102608
SMART Domains Protein: ENSMUSP00000099668
Gene: ENSMUSG00000028830

DomainStartEndE-ValueType
low complexity region 83 97 N/A INTRINSIC
FN3 113 391 8.45e1 SMART
IG_like 305 398 3.57e1 SMART
PKD 309 400 3.1e-1 SMART
FN3 399 485 2.7e1 SMART
PKD 408 497 1.87e-4 SMART
FN3 502 676 4.47e1 SMART
PKD 503 593 3.22e-8 SMART
IG_like 508 591 1.17e1 SMART
IG_like 597 782 1.66e2 SMART
PKD 599 687 8.98e-7 SMART
PKD 693 784 1.05e-7 SMART
FN3 694 772 3.71e1 SMART
transmembrane domain 927 949 N/A INTRINSIC
low complexity region 995 1010 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106108
AA Change: F1358I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: F1358I

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000135003
AA Change: F1017I
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: F1017I

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150467
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N03Rik T C 7: 131,146,101 H54R probably benign Het
Acsl6 T C 11: 54,338,419 V359A probably damaging Het
Aldh3a2 C T 11: 61,249,002 V435I probably benign Het
Atm A T 9: 53,531,724 S80T possibly damaging Het
Atp8b4 A T 2: 126,383,657 probably benign Het
Atxn1 T C 13: 45,568,427 probably benign Het
Chd3 T C 11: 69,359,980 E641G probably damaging Het
Clpb T C 7: 101,773,128 V346A probably damaging Het
Ctnnbl1 T A 2: 157,836,693 probably null Het
Cyp2b19 C T 7: 26,759,079 P73L probably benign Het
Dcc T C 18: 71,374,553 Y916C probably damaging Het
Fat4 A G 3: 38,887,498 N180S probably damaging Het
Foxi1 A C 11: 34,207,984 C14G probably damaging Het
Fut4 G T 9: 14,751,490 F169L probably benign Het
Grip1 T C 10: 120,049,368 S748P probably benign Het
Hnrnpr T C 4: 136,327,418 probably benign Het
Ifnz G A 4: 88,783,341 probably benign Het
Krt28 A G 11: 99,371,468 V232A probably benign Het
Lyar C A 5: 38,228,047 probably null Het
Manba G A 3: 135,554,780 W575* probably null Het
Morc3 T A 16: 93,844,213 D44E probably damaging Het
Mrc2 T A 11: 105,347,643 Y1205* probably null Het
Myh2 A T 11: 67,177,424 T293S probably benign Het
Nlrp10 T A 7: 108,924,581 K564I possibly damaging Het
Nuak1 A G 10: 84,374,668 S519P probably damaging Het
Olfr1158 T C 2: 87,990,548 F146L probably benign Het
Olfr358 T C 2: 37,004,930 H228R probably benign Het
Padi2 T A 4: 140,933,185 N325K probably damaging Het
Pcdhb19 A T 18: 37,497,989 Y279F probably damaging Het
Phldb1 A G 9: 44,696,167 L1247P probably damaging Het
Rmdn3 A G 2: 119,153,947 V108A probably damaging Het
Slc22a5 A G 11: 53,867,664 F437L probably benign Het
Slc3a2 C T 19: 8,713,337 probably null Het
Slc5a3 T A 16: 92,077,118 M21K probably benign Het
Spink5 T A 18: 43,989,404 F312Y possibly damaging Het
Stab1 T C 14: 31,147,075 Y1531C probably damaging Het
Tln2 C A 9: 67,261,923 A433S probably damaging Het
Usp24 C T 4: 106,380,099 L1076F possibly damaging Het
Vmn2r117 T C 17: 23,478,382 Y112C possibly damaging Het
Vmn2r16 C T 5: 109,330,417 L13F probably benign Het
Vmn2r76 T C 7: 86,225,649 M707V probably benign Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126890058 missense probably benign
IGL00845:Zmym4 APN 4 126900613 missense probably benign 0.28
IGL01122:Zmym4 APN 4 126864252 missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126911280 missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126900669 missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126870273 missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126948475 missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126915088 missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126923127 missense probably benign 0.12
R0149:Zmym4 UTSW 4 126911145 missense probably benign 0.00
R0361:Zmym4 UTSW 4 126911145 missense probably benign 0.00
R0423:Zmym4 UTSW 4 126882319 splice site probably benign
R0532:Zmym4 UTSW 4 126898401 nonsense probably null
R0745:Zmym4 UTSW 4 126902703 splice site probably benign
R1183:Zmym4 UTSW 4 126925839 missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126911169 missense probably benign 0.00
R1446:Zmym4 UTSW 4 126882482 missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126882312 critical splice acceptor site probably null
R1566:Zmym4 UTSW 4 126911147 missense possibly damaging 0.94
R1962:Zmym4 UTSW 4 126902670 missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126923136 missense probably damaging 1.00
R2930:Zmym4 UTSW 4 126925523 missense probably benign 0.00
R3891:Zmym4 UTSW 4 126904476 missense probably benign 0.04
R3892:Zmym4 UTSW 4 126904476 missense probably benign 0.04
R4659:Zmym4 UTSW 4 126948428 splice site probably null
R4702:Zmym4 UTSW 4 126923165 missense probably benign 0.01
R5160:Zmym4 UTSW 4 126870184 missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126910936 missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126905370 missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126895306 missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126915085 missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126868800 missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126882592 missense probably benign 0.09
U24488:Zmym4 UTSW 4 126925660 missense possibly damaging 0.69
Posted On2013-11-05