Incidental Mutation 'IGL01377:Fbxw21'
ID 78754
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw21
Ensembl Gene ENSMUSG00000047237
Gene Name F-box and WD-40 domain protein 21
Synonyms E330009P21Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL01377
Quality Score
Status
Chromosome 9
Chromosomal Location 108968522-108991090 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 108975713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 228 (R228*)
Ref Sequence ENSEMBL: ENSMUSP00000143095 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054925] [ENSMUST00000198076] [ENSMUST00000199540]
AlphaFold Q8BI38
Predicted Effect probably null
Transcript: ENSMUST00000054925
AA Change: R228*
SMART Domains Protein: ENSMUSP00000056358
Gene: ENSMUSG00000047237
AA Change: R228*

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 1e-7 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197401
Predicted Effect probably null
Transcript: ENSMUST00000198076
AA Change: R228*
SMART Domains Protein: ENSMUSP00000143095
Gene: ENSMUSG00000047237
AA Change: R228*

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 9e-8 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000199540
SMART Domains Protein: ENSMUSP00000143200
Gene: ENSMUSG00000047237

DomainStartEndE-ValueType
FBOX 5 45 9e-9 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,460,108 (GRCm39) V196D probably damaging Het
Ago1 C T 4: 126,353,610 (GRCm39) V279M probably damaging Het
Bltp1 T C 3: 37,027,601 (GRCm39) probably null Het
Ccdc170 A G 10: 4,510,966 (GRCm39) D675G probably damaging Het
Cdc42bpa T A 1: 179,892,708 (GRCm39) Y291N probably damaging Het
Cdca5 T C 19: 6,140,312 (GRCm39) S158P probably damaging Het
Cdh8 A G 8: 99,760,021 (GRCm39) I576T probably damaging Het
Cpsf2 T A 12: 101,953,640 (GRCm39) probably null Het
Cyc1 C T 15: 76,229,162 (GRCm39) R143* probably null Het
Dcaf6 A T 1: 165,216,293 (GRCm39) S437T probably benign Het
Eif5b A G 1: 38,075,179 (GRCm39) D552G probably benign Het
Epor T C 9: 21,870,593 (GRCm39) D429G probably damaging Het
Farp2 A G 1: 93,531,181 (GRCm39) I560V possibly damaging Het
Fyb1 T C 15: 6,609,801 (GRCm39) S125P probably benign Het
Gfm1 A T 3: 67,382,086 (GRCm39) Y720F probably damaging Het
Hspbap1 T A 16: 35,645,681 (GRCm39) D455E possibly damaging Het
Katnal2 T C 18: 77,090,153 (GRCm39) R285G probably damaging Het
Kif12 G A 4: 63,088,962 (GRCm39) T153I probably damaging Het
Klhl31 T C 9: 77,558,013 (GRCm39) F243S probably benign Het
Large2 A G 2: 92,199,676 (GRCm39) Y208H probably damaging Het
Lrp1b A G 2: 40,491,550 (GRCm39) V239A probably damaging Het
Mblac2 G A 13: 81,898,266 (GRCm39) R214H probably damaging Het
Mlf2 A G 6: 124,911,654 (GRCm39) N168D probably damaging Het
Mtmr6 T A 14: 60,519,483 (GRCm39) Y134* probably null Het
Mtus1 T C 8: 41,536,172 (GRCm39) K515E possibly damaging Het
Nek1 A G 8: 61,542,490 (GRCm39) T718A probably benign Het
Nfx1 A G 4: 40,977,241 (GRCm39) N305S probably benign Het
Nrxn3 T A 12: 89,499,782 (GRCm39) probably null Het
Nsf T C 11: 103,763,473 (GRCm39) D377G probably damaging Het
Pde4b A G 4: 102,344,599 (GRCm39) E102G probably damaging Het
Pdlim4 G T 11: 53,947,130 (GRCm39) S56R probably benign Het
Poc5 T C 13: 96,538,139 (GRCm39) V268A probably benign Het
Sec23b A C 2: 144,401,157 (GRCm39) E6A probably damaging Het
Sgsm1 A T 5: 113,424,048 (GRCm39) probably benign Het
Slc16a12 T A 19: 34,650,084 (GRCm39) N317I possibly damaging Het
Slc1a7 A T 4: 107,850,162 (GRCm39) D91V probably damaging Het
Slc30a9 T G 5: 67,473,173 (GRCm39) S86A probably benign Het
Stxbp4 A G 11: 90,512,475 (GRCm39) probably benign Het
Tacr1 T C 6: 82,380,636 (GRCm39) S16P probably benign Het
Tmtc1 A C 6: 148,147,285 (GRCm39) V804G possibly damaging Het
Ttc7b A G 12: 100,321,371 (GRCm39) F587L probably benign Het
Vmn2r86 A T 10: 130,288,855 (GRCm39) D215E probably damaging Het
Other mutations in Fbxw21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00679:Fbxw21 APN 9 108,991,032 (GRCm39) missense probably damaging 1.00
IGL00901:Fbxw21 APN 9 108,985,467 (GRCm39) missense probably benign 0.00
IGL01941:Fbxw21 APN 9 108,977,224 (GRCm39) missense probably benign 0.07
IGL02491:Fbxw21 APN 9 108,972,887 (GRCm39) missense probably benign
IGL03163:Fbxw21 APN 9 108,974,552 (GRCm39) missense probably benign 0.01
IGL03377:Fbxw21 APN 9 108,968,597 (GRCm39) missense probably benign 0.01
R0148:Fbxw21 UTSW 9 108,977,085 (GRCm39) critical splice donor site probably null
R0328:Fbxw21 UTSW 9 108,975,653 (GRCm39) missense possibly damaging 0.52
R0909:Fbxw21 UTSW 9 108,985,476 (GRCm39) missense possibly damaging 0.84
R1506:Fbxw21 UTSW 9 108,977,257 (GRCm39) missense probably damaging 1.00
R1575:Fbxw21 UTSW 9 108,990,984 (GRCm39) missense probably benign 0.00
R1615:Fbxw21 UTSW 9 108,972,794 (GRCm39) missense probably damaging 1.00
R1719:Fbxw21 UTSW 9 108,977,242 (GRCm39) missense possibly damaging 0.85
R2415:Fbxw21 UTSW 9 108,985,469 (GRCm39) missense possibly damaging 0.71
R2424:Fbxw21 UTSW 9 108,986,587 (GRCm39) nonsense probably null
R2508:Fbxw21 UTSW 9 108,974,553 (GRCm39) missense probably benign 0.31
R2898:Fbxw21 UTSW 9 108,985,404 (GRCm39) missense possibly damaging 0.52
R2964:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2965:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2966:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R4809:Fbxw21 UTSW 9 108,972,458 (GRCm39) missense probably damaging 1.00
R4911:Fbxw21 UTSW 9 108,974,731 (GRCm39) missense probably damaging 1.00
R5669:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.12
R5928:Fbxw21 UTSW 9 108,972,893 (GRCm39) missense possibly damaging 0.55
R6043:Fbxw21 UTSW 9 108,974,607 (GRCm39) missense possibly damaging 0.69
R6277:Fbxw21 UTSW 9 108,974,623 (GRCm39) missense possibly damaging 0.95
R6805:Fbxw21 UTSW 9 108,986,633 (GRCm39) missense probably damaging 1.00
R6944:Fbxw21 UTSW 9 108,986,603 (GRCm39) missense probably damaging 1.00
R7079:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R7081:Fbxw21 UTSW 9 108,990,990 (GRCm39) missense probably damaging 1.00
R7744:Fbxw21 UTSW 9 108,986,720 (GRCm39) missense possibly damaging 0.81
R7774:Fbxw21 UTSW 9 108,972,908 (GRCm39) missense probably benign 0.00
R7980:Fbxw21 UTSW 9 108,985,639 (GRCm39) splice site probably null
R8043:Fbxw21 UTSW 9 108,975,694 (GRCm39) missense probably benign 0.01
R8260:Fbxw21 UTSW 9 108,975,614 (GRCm39) critical splice donor site probably null
R9142:Fbxw21 UTSW 9 108,985,413 (GRCm39) missense probably damaging 1.00
R9172:Fbxw21 UTSW 9 108,975,764 (GRCm39) missense probably benign 0.00
R9250:Fbxw21 UTSW 9 108,972,846 (GRCm39) missense probably benign 0.31
R9251:Fbxw21 UTSW 9 108,974,687 (GRCm39) missense probably damaging 1.00
R9294:Fbxw21 UTSW 9 108,972,830 (GRCm39) missense probably damaging 0.99
R9303:Fbxw21 UTSW 9 108,986,727 (GRCm39) missense probably benign
R9479:Fbxw21 UTSW 9 108,968,612 (GRCm39) missense probably benign 0.00
R9509:Fbxw21 UTSW 9 108,977,217 (GRCm39) missense possibly damaging 0.90
R9765:Fbxw21 UTSW 9 108,975,625 (GRCm39) missense possibly damaging 0.71
R9773:Fbxw21 UTSW 9 108,977,128 (GRCm39) missense possibly damaging 0.89
R9774:Fbxw21 UTSW 9 108,991,057 (GRCm39) start codon destroyed probably null 0.98
Z1088:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1176:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1177:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Posted On 2013-11-05