Incidental Mutation 'IGL01380:Suv39h2'
ID 78842
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suv39h2
Ensembl Gene ENSMUSG00000026646
Gene Name suppressor of variegation 3-9 2
Synonyms 4930507K23Rik, D2Ertd544e, Suv39h histone methyltransferase, KMT1B
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01380
Quality Score
Status
Chromosome 2
Chromosomal Location 3456852-3476068 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 3465296 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125485 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027956] [ENSMUST00000060618] [ENSMUST00000061852] [ENSMUST00000100463] [ENSMUST00000115066] [ENSMUST00000127540]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000027956
SMART Domains Protein: ENSMUSP00000027956
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
CHROMO 117 169 2.44e-11 SMART
Pfam:Pre-SET 212 309 4.4e-18 PFAM
SET 317 446 4.05e-41 SMART
PostSET 461 477 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000060618
SMART Domains Protein: ENSMUSP00000054169
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
SET 70 226 6.61e-23 SMART
PostSET 241 257 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000061852
SMART Domains Protein: ENSMUSP00000054300
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Lactamase_B 10 193 7.78e0 SMART
Pfam:DRMBL 239 345 1.6e-22 PFAM
low complexity region 383 400 N/A INTRINSIC
low complexity region 463 477 N/A INTRINSIC
low complexity region 593 601 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100458
SMART Domains Protein: ENSMUSP00000098026
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
CHROMO 6 67 2e-7 SMART
Pfam:Pre-SET 110 207 1.3e-17 PFAM
SET 215 344 4.05e-41 SMART
PostSET 359 375 7.05e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100463
SMART Domains Protein: ENSMUSP00000098031
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Lactamase_B 10 193 7.78e0 SMART
Pfam:DRMBL 239 345 6.5e-23 PFAM
low complexity region 476 484 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115066
SMART Domains Protein: ENSMUSP00000110718
Gene: ENSMUSG00000026648

DomainStartEndE-ValueType
Blast:Lactamase_B 25 70 1e-19 BLAST
Pfam:DRMBL 109 215 1.1e-22 PFAM
low complexity region 253 270 N/A INTRINSIC
low complexity region 333 347 N/A INTRINSIC
low complexity region 463 471 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127540
SMART Domains Protein: ENSMUSP00000125485
Gene: ENSMUSG00000026646

DomainStartEndE-ValueType
low complexity region 2 47 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149932
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Less than 5% of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 A G 3: 59,840,053 (GRCm39) T42A probably benign Het
Abcc10 C A 17: 46,634,948 (GRCm39) V352L possibly damaging Het
Ankrd44 A T 1: 54,766,724 (GRCm39) M488K probably benign Het
Ano8 A G 8: 71,933,453 (GRCm39) probably benign Het
Atp2a1 T A 7: 126,047,942 (GRCm39) M623L possibly damaging Het
Atxn10 G T 15: 85,260,896 (GRCm39) E214* probably null Het
Btla A C 16: 45,070,716 (GRCm39) D225A probably benign Het
C030048H21Rik G A 2: 26,146,659 (GRCm39) Q1218* probably null Het
Cacna1a A G 8: 85,285,746 (GRCm39) Y750C probably damaging Het
Ccdc15 A T 9: 37,187,853 (GRCm39) probably benign Het
Ccdc18 T A 5: 108,328,753 (GRCm39) I724N probably damaging Het
Cluh T A 11: 74,556,772 (GRCm39) F937L probably benign Het
Clybl G T 14: 122,616,761 (GRCm39) A259S probably benign Het
Cyp4f39 T G 17: 32,700,832 (GRCm39) I167S probably damaging Het
Dchs1 T A 7: 105,411,418 (GRCm39) D1566V probably damaging Het
Dnah3 C T 7: 119,525,787 (GRCm39) A3867T probably damaging Het
Dtwd1 T A 2: 126,001,847 (GRCm39) L189Q probably benign Het
Dusp10 T C 1: 183,801,211 (GRCm39) I326T possibly damaging Het
Eaf1 T A 14: 31,219,767 (GRCm39) probably benign Het
Eif3c C T 7: 126,163,585 (GRCm39) probably benign Het
Fam169a C T 13: 97,228,459 (GRCm39) T44M probably damaging Het
Fam184a T C 10: 53,570,782 (GRCm39) probably benign Het
Fam25a C T 14: 34,075,655 (GRCm39) A46T probably null Het
Gckr A G 5: 31,456,977 (GRCm39) probably benign Het
Gfra2 G T 14: 71,204,586 (GRCm39) probably benign Het
Gm8237 A T 14: 5,863,703 (GRCm38) probably null Het
H2-Eb2 G T 17: 34,554,783 (GRCm39) L228F probably benign Het
Igf2r T C 17: 12,914,261 (GRCm39) N1736S probably benign Het
Izumo1 T G 7: 45,276,519 (GRCm39) S361A probably benign Het
Klri1 T C 6: 129,675,761 (GRCm39) I170V probably benign Het
L3mbtl2 C T 15: 81,555,326 (GRCm39) A193V possibly damaging Het
Lats1 T A 10: 7,567,544 (GRCm39) M105K possibly damaging Het
Lrpprc T C 17: 85,030,158 (GRCm39) D1080G probably benign Het
Lrrc74a A T 12: 86,808,496 (GRCm39) M425L possibly damaging Het
Mfsd13a G T 19: 46,356,347 (GRCm39) D151Y probably damaging Het
Mst1 G A 9: 107,961,787 (GRCm39) E640K probably damaging Het
Napsa T C 7: 44,236,098 (GRCm39) V379A probably damaging Het
Or1e16 A T 11: 73,286,017 (GRCm39) M277K probably damaging Het
Or55b4 C T 7: 102,133,592 (GRCm39) C245Y probably damaging Het
Or7c19 C A 8: 85,957,775 (GRCm39) S217Y probably damaging Het
Or7c19 A T 8: 85,957,958 (GRCm39) Y278F possibly damaging Het
Otop3 T C 11: 115,237,237 (GRCm39) V567A probably damaging Het
Oxsr1 A T 9: 119,089,167 (GRCm39) probably benign Het
Pak2 A T 16: 31,860,362 (GRCm39) V167E probably benign Het
Pcdhb16 A G 18: 37,612,498 (GRCm39) H486R probably benign Het
Plekha5 C T 6: 140,516,042 (GRCm39) probably benign Het
Rbm6 T C 9: 107,665,548 (GRCm39) D616G probably damaging Het
Sf3b1 T C 1: 55,027,108 (GRCm39) Y1249C probably damaging Het
Sipa1l3 T C 7: 29,030,797 (GRCm39) H534R possibly damaging Het
Slco1c1 T C 6: 141,485,777 (GRCm39) Y136H probably damaging Het
Smarca4 A G 9: 21,590,369 (GRCm39) M1333V probably benign Het
Smc4 A G 3: 68,933,161 (GRCm39) D54G probably damaging Het
Spag5 T A 11: 78,195,443 (GRCm39) V250E possibly damaging Het
Stxbp4 A G 11: 90,512,475 (GRCm39) probably benign Het
Taar8b T A 10: 23,968,005 (GRCm39) H63L probably damaging Het
Tex2 G A 11: 106,435,141 (GRCm39) Q264* probably null Het
Thnsl2 A C 6: 71,115,740 (GRCm39) S156A probably benign Het
Tmtc4 G T 14: 123,163,366 (GRCm39) probably benign Het
Usp25 T C 16: 76,890,566 (GRCm39) L758P probably benign Het
Zfyve1 G A 12: 83,599,281 (GRCm39) R144C probably damaging Het
Zpld1 A G 16: 55,072,133 (GRCm39) V42A probably damaging Het
Other mutations in Suv39h2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03408:Suv39h2 APN 2 3,460,913 (GRCm39) missense probably damaging 1.00
R0060:Suv39h2 UTSW 2 3,465,953 (GRCm39) missense probably damaging 1.00
R0060:Suv39h2 UTSW 2 3,465,953 (GRCm39) missense probably damaging 1.00
R0511:Suv39h2 UTSW 2 3,473,616 (GRCm39) missense probably damaging 0.99
R1892:Suv39h2 UTSW 2 3,460,805 (GRCm39) missense probably damaging 1.00
R1919:Suv39h2 UTSW 2 3,465,353 (GRCm39) missense probably damaging 1.00
R3888:Suv39h2 UTSW 2 3,465,845 (GRCm39) missense probably benign 0.09
R5583:Suv39h2 UTSW 2 3,475,890 (GRCm39) unclassified probably benign
R6770:Suv39h2 UTSW 2 3,473,588 (GRCm39) missense possibly damaging 0.52
R6801:Suv39h2 UTSW 2 3,465,458 (GRCm39) missense probably benign 0.16
R7607:Suv39h2 UTSW 2 3,475,866 (GRCm39) missense unknown
R7914:Suv39h2 UTSW 2 3,465,453 (GRCm39) nonsense probably null
R9557:Suv39h2 UTSW 2 3,475,451 (GRCm39) missense
R9781:Suv39h2 UTSW 2 3,463,631 (GRCm39) missense probably benign 0.01
X0062:Suv39h2 UTSW 2 3,465,822 (GRCm39) missense probably benign
Posted On 2013-11-05