Incidental Mutation 'IGL01385:Or10ak16'
ID 79002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ak16
Ensembl Gene ENSMUSG00000073768
Gene Name olfactory receptor family 10 subfamily AK member 16
Synonyms Olfr1330, MOR259-8, GA_x6K02T2QD9B-18644371-18643424
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL01385
Quality Score
Status
Chromosome 4
Chromosomal Location 118750282-118751229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118750748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 156 (L156S)
Ref Sequence ENSEMBL: ENSMUSP00000101968 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094830] [ENSMUST00000105035] [ENSMUST00000106361]
AlphaFold Q8VEY6
Predicted Effect probably benign
Transcript: ENSMUST00000094830
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000092425
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 1.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 1.4e-6 PFAM
Pfam:7tm_1 44 293 1.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105035
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000100652
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 307 6.4e-8 PFAM
Pfam:7tm_1 44 293 2.9e-31 PFAM
Pfam:7tm_4 142 286 6.7e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106361
AA Change: L156S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101968
Gene: ENSMUSG00000073768
AA Change: L156S

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.1e-56 PFAM
Pfam:7tm_1 43 292 3.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216386
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 A T 19: 57,057,346 (GRCm39) S292R probably damaging Het
Adamts19 A G 18: 59,105,851 (GRCm39) T749A probably damaging Het
Agap2 A T 10: 126,923,865 (GRCm39) I747F unknown Het
Arhgap35 T A 7: 16,298,399 (GRCm39) N222I probably damaging Het
Atp10b A G 11: 43,125,256 (GRCm39) E1074G probably damaging Het
Brd3 T C 2: 27,354,101 (GRCm39) T4A possibly damaging Het
Col6a6 A G 9: 105,660,865 (GRCm39) S415P probably damaging Het
Dennd2a A G 6: 39,500,070 (GRCm39) V165A probably damaging Het
Dnm1l T A 16: 16,159,317 (GRCm39) E95V probably damaging Het
Dock9 A G 14: 121,817,995 (GRCm39) Y1609H possibly damaging Het
Esm1 A C 13: 113,353,216 (GRCm39) E166A possibly damaging Het
F2rl2 A C 13: 95,837,836 (GRCm39) I294L probably benign Het
Gstt3 A G 10: 75,610,822 (GRCm39) S187P probably benign Het
Katna1 T C 10: 7,628,574 (GRCm39) C268R probably damaging Het
Mbd5 T A 2: 49,140,233 (GRCm39) C66S possibly damaging Het
Naa35 G A 13: 59,748,880 (GRCm39) E167K probably damaging Het
Osbpl2 A G 2: 179,778,873 (GRCm39) N2S probably benign Het
Parp6 T C 9: 59,537,895 (GRCm39) probably benign Het
Pcdhb5 T A 18: 37,455,267 (GRCm39) V549E probably benign Het
Pcnx4 T C 12: 72,620,520 (GRCm39) L780P probably damaging Het
Plcb3 A T 19: 6,935,276 (GRCm39) D851E probably benign Het
Ppfia2 A G 10: 106,749,560 (GRCm39) S1149G probably damaging Het
Prkca A G 11: 107,869,178 (GRCm39) V469A probably damaging Het
Ryr1 A T 7: 28,756,410 (GRCm39) V3468D probably damaging Het
Spmip3 G A 1: 177,568,640 (GRCm39) G46R probably benign Het
Stxbp4 A G 11: 90,431,074 (GRCm39) V412A possibly damaging Het
Vmn1r238 G T 18: 3,122,770 (GRCm39) Q215K possibly damaging Het
Wdr11 A G 7: 129,209,637 (GRCm39) M482V probably benign Het
Wdr72 T C 9: 74,086,788 (GRCm39) probably benign Het
Xirp2 T C 2: 67,340,021 (GRCm39) L754P probably damaging Het
Zmym6 G A 4: 127,017,899 (GRCm39) G1135S probably benign Het
Other mutations in Or10ak16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01642:Or10ak16 APN 4 118,750,658 (GRCm39) missense probably damaging 1.00
R0402:Or10ak16 UTSW 4 118,750,426 (GRCm39) missense possibly damaging 0.95
R0418:Or10ak16 UTSW 4 118,750,448 (GRCm39) missense possibly damaging 0.51
R0646:Or10ak16 UTSW 4 118,750,687 (GRCm39) missense probably damaging 0.96
R1075:Or10ak16 UTSW 4 118,750,402 (GRCm39) missense probably damaging 1.00
R1743:Or10ak16 UTSW 4 118,750,723 (GRCm39) missense probably benign
R1950:Or10ak16 UTSW 4 118,750,537 (GRCm39) missense probably benign 0.22
R2265:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2268:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R2269:Or10ak16 UTSW 4 118,751,071 (GRCm39) missense probably damaging 1.00
R4648:Or10ak16 UTSW 4 118,751,147 (GRCm39) missense possibly damaging 0.84
R5635:Or10ak16 UTSW 4 118,750,832 (GRCm39) missense probably benign 0.31
R6881:Or10ak16 UTSW 4 118,750,304 (GRCm39) missense probably damaging 1.00
R7351:Or10ak16 UTSW 4 118,751,033 (GRCm39) missense probably benign 0.05
R7412:Or10ak16 UTSW 4 118,750,327 (GRCm39) missense possibly damaging 0.83
R8402:Or10ak16 UTSW 4 118,750,716 (GRCm39) missense probably benign 0.01
R9355:Or10ak16 UTSW 4 118,750,784 (GRCm39) missense probably benign 0.00
Posted On 2013-11-05