Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01386:Tmem115'

79032

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem115

Ensembl Gene

ENSMUSG00000010045

Gene Name

transmembrane protein 115

Synonyms

Pl6

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.256) question?

Stock #

IGL01386

Quality Score

Status

Chromosome

Chromosomal Location

107411144-107415855 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 107411859 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 61 (T61I)

Ref Sequence

ENSEMBL: ENSMUSP00000010189 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000010189] [ENSMUST00000041459] [ENSMUST00000195235]

AlphaFold

Q9WUH1

Predicted Effect

probably damaging
Transcript: ENSMUST00000010189
AA Change: T61I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000010189
Gene: ENSMUSG00000010045
AA Change: T61I

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
DUF1751	49	151	4.14e-41	SMART
transmembrane domain	164	183	N/A	INTRINSIC
transmembrane domain	190	208	N/A	INTRINSIC
transmembrane domain	223	245	N/A	INTRINSIC
Blast:DUF1751	304	347	2e-20	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000041459

SMART Domains

Protein: ENSMUSP00000044093
Gene: ENSMUSG00000037190

Domain	Start	End	E-Value	Type
transmembrane domain	20	37	N/A	INTRINSIC
B561	47	178	8.01e-42	SMART
transmembrane domain	189	211	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194344

Predicted Effect

probably benign
Transcript: ENSMUST00000195235

SMART Domains

Protein: ENSMUSP00000141723
Gene: ENSMUSG00000037190

Domain	Start	End	E-Value	Type
transmembrane domain	20	37	N/A	INTRINSIC
B561	47	178	8.01e-42	SMART
transmembrane domain	189	211	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	C	12: 80,240,446 (GRCm39)	R214G	probably benign	Het
Cacna1e	T	A	1: 154,348,123 (GRCm39)	K817N	probably benign	Het
Cyp3a16	A	G	5: 145,377,244 (GRCm39)	F448L	probably damaging	Het
Dpp6	T	A	5: 27,869,760 (GRCm39)		probably null	Het
Eif2ak3	C	T	6: 70,869,710 (GRCm39)	T799M	probably damaging	Het
Erbb4	A	T	1: 68,383,090 (GRCm39)	S302R	probably damaging	Het
Fam217a	T	A	13: 35,099,632 (GRCm39)		probably benign	Het
Flt4	C	A	11: 49,528,162 (GRCm39)	A995D	probably benign	Het
Fpr-rs7	G	A	17: 20,334,454 (GRCm39)	S12L	probably damaging	Het
Fsd1	C	T	17: 56,303,733 (GRCm39)	S491F	probably damaging	Het
Hpcal4	T	C	4: 123,083,035 (GRCm39)		probably null	Het
Intu	A	T	3: 40,647,017 (GRCm39)	D630V	probably damaging	Het
Jak3	A	G	8: 72,136,933 (GRCm39)	D703G	probably damaging	Het
Lama4	A	G	10: 38,887,060 (GRCm39)	I122V	probably benign	Het
Mrpl11	A	C	19: 5,013,409 (GRCm39)	K92T	probably null	Het
Mtarc2	A	G	1: 184,551,413 (GRCm39)		probably benign	Het
Mylk	A	G	16: 34,791,610 (GRCm39)		probably null	Het
Or52ab4	A	T	7: 102,987,974 (GRCm39)	K238*	probably null	Het
Parpbp	A	C	10: 87,975,848 (GRCm39)	Y88*	probably null	Het
Plod2	G	A	9: 92,488,655 (GRCm39)	R627Q	probably damaging	Het
Rapsn	G	T	2: 90,867,144 (GRCm39)	A149S	probably damaging	Het
Ripk3	T	G	14: 56,023,484 (GRCm39)	Q109P	probably damaging	Het
Scaf11	T	C	15: 96,318,361 (GRCm39)	D401G	probably damaging	Het
Serpine2	G	A	1: 79,779,268 (GRCm39)	T150I	probably damaging	Het
Sh2d6	T	A	6: 72,495,945 (GRCm39)	T98S	probably benign	Het
Slc28a1	G	T	7: 80,814,427 (GRCm39)	A513S	probably benign	Het
Tanc2	T	C	11: 105,777,207 (GRCm39)	F795S	probably damaging	Het
Tcim	T	A	8: 24,928,705 (GRCm39)	I70F	probably benign	Het
Thbd	G	A	2: 148,249,602 (GRCm39)	Q89*	probably null	Het
Tsc2	A	T	17: 24,832,259 (GRCm39)	V650E	probably damaging	Het
Tubgcp6	A	T	15: 88,992,199 (GRCm39)	Y595*	probably null	Het
Uroc1	C	T	6: 90,323,747 (GRCm39)	A398V	probably damaging	Het
Vmn1r31	T	C	6: 58,449,587 (GRCm39)	T93A	probably benign	Het
Vmn2r113	A	G	17: 23,175,024 (GRCm39)	E545G	possibly damaging	Het
Vps13a	A	G	19: 16,678,516 (GRCm39)	V1155A	possibly damaging	Het
Zfp667	A	G	7: 6,307,869 (GRCm39)	H179R	probably benign	Het

Other mutations in Tmem115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01115:Tmem115	APN	9	107,411,781 (GRCm39)	missense	probably damaging	1.00
IGL01142:Tmem115	APN	9	107,411,844 (GRCm39)	missense	possibly damaging	0.94
IGL01705:Tmem115	APN	9	107,412,403 (GRCm39)	missense	probably benign	0.44
Gooseneck	UTSW	9	107,411,993 (GRCm39)	unclassified	probably benign
R0746:Tmem115	UTSW	9	107,415,198 (GRCm39)	missense	probably benign	0.11
R1511:Tmem115	UTSW	9	107,412,174 (GRCm39)	missense	probably benign	0.04
R4182:Tmem115	UTSW	9	107,412,482 (GRCm39)	missense	probably damaging	1.00
R4770:Tmem115	UTSW	9	107,412,156 (GRCm39)	missense	probably benign	0.43
R5097:Tmem115	UTSW	9	107,412,059 (GRCm39)	missense	probably benign	0.03
R5141:Tmem115	UTSW	9	107,415,141 (GRCm39)	missense	probably benign	0.01
R5687:Tmem115	UTSW	9	107,412,054 (GRCm39)	missense	probably benign	0.17
R7145:Tmem115	UTSW	9	107,412,285 (GRCm39)	missense	probably benign	0.30
R8299:Tmem115	UTSW	9	107,411,745 (GRCm39)	missense	possibly damaging	0.94
R8353:Tmem115	UTSW	9	107,411,997 (GRCm39)	missense	probably benign	0.44
R8453:Tmem115	UTSW	9	107,411,997 (GRCm39)	missense	probably benign	0.44
R8717:Tmem115	UTSW	9	107,415,132 (GRCm39)	missense	possibly damaging	0.77
R8901:Tmem115	UTSW	9	107,411,993 (GRCm39)	unclassified	probably benign
R9017:Tmem115	UTSW	9	107,411,880 (GRCm39)	missense	probably benign	0.28
R9384:Tmem115	UTSW	9	107,411,742 (GRCm39)	missense	possibly damaging	0.94
X0067:Tmem115	UTSW	9	107,411,712 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-11-05