Incidental Mutation 'IGL01386:Vmn1r31'
| ID |
79034 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r31
|
| Ensembl Gene |
ENSMUSG00000115404 |
| Gene Name |
vomeronasal 1 receptor 31 |
| Synonyms |
Gm6709 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.135)
|
| Stock # |
IGL01386
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
58448952-58449863 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 58449587 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 93
(T93A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153749
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176023]
[ENSMUST00000176147]
[ENSMUST00000176177]
[ENSMUST00000177318]
[ENSMUST00000226390]
[ENSMUST00000228586]
|
| AlphaFold |
H3BKW5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176023
AA Change: T44A
PolyPhen 2
Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000135252
Gene: ENSMUSG00000115404
AA Change: T44A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176147
AA Change: T44A
PolyPhen 2
Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000135282
Gene: ENSMUSG00000115404
AA Change: T44A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000135472
Gene: ENSMUSG00000093379
AA Change: T93A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
4.7e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177318
AA Change: T93A
PolyPhen 2
Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000135555
Gene: ENSMUSG00000115404
AA Change: T93A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
107 |
1.9e-18 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204999
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226390
AA Change: T93A
PolyPhen 2
Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228586
AA Change: T93A
PolyPhen 2
Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actn1 |
T |
C |
12: 80,240,446 (GRCm39) |
R214G |
probably benign |
Het |
| Cacna1e |
T |
A |
1: 154,348,123 (GRCm39) |
K817N |
probably benign |
Het |
| Cyp3a16 |
A |
G |
5: 145,377,244 (GRCm39) |
F448L |
probably damaging |
Het |
| Dpp6 |
T |
A |
5: 27,869,760 (GRCm39) |
|
probably null |
Het |
| Eif2ak3 |
C |
T |
6: 70,869,710 (GRCm39) |
T799M |
probably damaging |
Het |
| Erbb4 |
A |
T |
1: 68,383,090 (GRCm39) |
S302R |
probably damaging |
Het |
| Fam217a |
T |
A |
13: 35,099,632 (GRCm39) |
|
probably benign |
Het |
| Flt4 |
C |
A |
11: 49,528,162 (GRCm39) |
A995D |
probably benign |
Het |
| Fpr-rs7 |
G |
A |
17: 20,334,454 (GRCm39) |
S12L |
probably damaging |
Het |
| Fsd1 |
C |
T |
17: 56,303,733 (GRCm39) |
S491F |
probably damaging |
Het |
| Hpcal4 |
T |
C |
4: 123,083,035 (GRCm39) |
|
probably null |
Het |
| Intu |
A |
T |
3: 40,647,017 (GRCm39) |
D630V |
probably damaging |
Het |
| Jak3 |
A |
G |
8: 72,136,933 (GRCm39) |
D703G |
probably damaging |
Het |
| Lama4 |
A |
G |
10: 38,887,060 (GRCm39) |
I122V |
probably benign |
Het |
| Mrpl11 |
A |
C |
19: 5,013,409 (GRCm39) |
K92T |
probably null |
Het |
| Mtarc2 |
A |
G |
1: 184,551,413 (GRCm39) |
|
probably benign |
Het |
| Mylk |
A |
G |
16: 34,791,610 (GRCm39) |
|
probably null |
Het |
| Or52ab4 |
A |
T |
7: 102,987,974 (GRCm39) |
K238* |
probably null |
Het |
| Parpbp |
A |
C |
10: 87,975,848 (GRCm39) |
Y88* |
probably null |
Het |
| Plod2 |
G |
A |
9: 92,488,655 (GRCm39) |
R627Q |
probably damaging |
Het |
| Rapsn |
G |
T |
2: 90,867,144 (GRCm39) |
A149S |
probably damaging |
Het |
| Ripk3 |
T |
G |
14: 56,023,484 (GRCm39) |
Q109P |
probably damaging |
Het |
| Scaf11 |
T |
C |
15: 96,318,361 (GRCm39) |
D401G |
probably damaging |
Het |
| Serpine2 |
G |
A |
1: 79,779,268 (GRCm39) |
T150I |
probably damaging |
Het |
| Sh2d6 |
T |
A |
6: 72,495,945 (GRCm39) |
T98S |
probably benign |
Het |
| Slc28a1 |
G |
T |
7: 80,814,427 (GRCm39) |
A513S |
probably benign |
Het |
| Tanc2 |
T |
C |
11: 105,777,207 (GRCm39) |
F795S |
probably damaging |
Het |
| Tcim |
T |
A |
8: 24,928,705 (GRCm39) |
I70F |
probably benign |
Het |
| Thbd |
G |
A |
2: 148,249,602 (GRCm39) |
Q89* |
probably null |
Het |
| Tmem115 |
C |
T |
9: 107,411,859 (GRCm39) |
T61I |
probably damaging |
Het |
| Tsc2 |
A |
T |
17: 24,832,259 (GRCm39) |
V650E |
probably damaging |
Het |
| Tubgcp6 |
A |
T |
15: 88,992,199 (GRCm39) |
Y595* |
probably null |
Het |
| Uroc1 |
C |
T |
6: 90,323,747 (GRCm39) |
A398V |
probably damaging |
Het |
| Vmn2r113 |
A |
G |
17: 23,175,024 (GRCm39) |
E545G |
possibly damaging |
Het |
| Vps13a |
A |
G |
19: 16,678,516 (GRCm39) |
V1155A |
possibly damaging |
Het |
| Zfp667 |
A |
G |
7: 6,307,869 (GRCm39) |
H179R |
probably benign |
Het |
|
| Other mutations in Vmn1r31 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01326:Vmn1r31
|
APN |
6 |
58,449,784 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01785:Vmn1r31
|
APN |
6 |
58,449,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02527:Vmn1r31
|
APN |
6 |
58,449,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4791001:Vmn1r31
|
UTSW |
6 |
58,449,028 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0107:Vmn1r31
|
UTSW |
6 |
58,449,728 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1250:Vmn1r31
|
UTSW |
6 |
58,449,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1616:Vmn1r31
|
UTSW |
6 |
58,449,043 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1883:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1884:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2942:Vmn1r31
|
UTSW |
6 |
58,449,583 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn1r31
|
UTSW |
6 |
58,449,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4672:Vmn1r31
|
UTSW |
6 |
58,449,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4676:Vmn1r31
|
UTSW |
6 |
58,448,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4702:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4703:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4705:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R6341:Vmn1r31
|
UTSW |
6 |
58,448,995 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6549:Vmn1r31
|
UTSW |
6 |
58,449,648 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7238:Vmn1r31
|
UTSW |
6 |
58,449,858 (GRCm39) |
missense |
|
|
|
R7609:Vmn1r31
|
UTSW |
6 |
58,449,455 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8438:Vmn1r31
|
UTSW |
6 |
58,449,646 (GRCm39) |
missense |
|
|
|
R8936:Vmn1r31
|
UTSW |
6 |
58,449,083 (GRCm39) |
missense |
unknown |
|
|
R9103:Vmn1r31
|
UTSW |
6 |
58,449,073 (GRCm39) |
missense |
unknown |
|
|
Z1176:Vmn1r31
|
UTSW |
6 |
58,449,376 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2013-11-05 |
Incidental Mutation