Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01387:Vmn2r124'

79076

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r124

Ensembl Gene

ENSMUSG00000094396

Gene Name

vomeronasal 2, receptor 124

Synonyms

Vmn2r-ps113, Gm7196

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.308) question?

Stock #

IGL01387

Quality Score

Status

Chromosome

Chromosomal Location

18269746-18294482 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 18283188 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 294 (T294K)

Ref Sequence

ENSEMBL: ENSMUSP00000135613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176802] [ENSMUST00000231546]

AlphaFold

K7N789

Predicted Effect

probably damaging
Transcript: ENSMUST00000176802
AA Change: T294K

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000135613
Gene: ENSMUSG00000094396
AA Change: T294K

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	84	449	2.2e-37	PFAM
Pfam:NCD3G	510	563	9.3e-21	PFAM
Pfam:7tm_3	596	831	1.6e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231546

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	C	10: 79,835,596 (GRCm39)	I288T	possibly damaging	Het
Akr1c13	T	A	13: 4,247,794 (GRCm39)		probably null	Het
Ano2	T	C	6: 125,990,240 (GRCm39)	L787P	probably damaging	Het
Arf4	A	T	14: 26,374,300 (GRCm39)	I73F	possibly damaging	Het
Atp6v1e1	A	G	6: 120,772,732 (GRCm39)		probably null	Het
Ccdc9	A	C	7: 16,018,424 (GRCm39)	M1R	probably null	Het
Cep162	A	G	9: 87,093,864 (GRCm39)	L838S	probably benign	Het
Cfap251	T	A	5: 123,421,609 (GRCm39)	I654N	probably damaging	Het
Cfi	T	A	3: 129,668,562 (GRCm39)		probably benign	Het
Creb3l3	T	C	10: 80,927,110 (GRCm39)	T107A	probably benign	Het
Erlin2	T	C	8: 27,526,576 (GRCm39)	L312P	probably benign	Het
Etv1	T	G	12: 38,911,326 (GRCm39)	M384R	probably damaging	Het
Exph5	G	T	9: 53,285,265 (GRCm39)	S782I	possibly damaging	Het
Fsd1	C	T	17: 56,303,733 (GRCm39)	S491F	probably damaging	Het
Fsip2	A	G	2: 82,823,326 (GRCm39)	N6353S	possibly damaging	Het
Gk5	T	C	9: 96,059,607 (GRCm39)		probably null	Het
Gm11168	T	G	9: 3,005,128 (GRCm39)	S202R	possibly damaging	Het
Hdlbp	T	C	1: 93,341,310 (GRCm39)	D1016G	possibly damaging	Het
Kpna4	A	G	3: 69,009,590 (GRCm39)		probably benign	Het
Lrrn2	T	C	1: 132,866,096 (GRCm39)	V387A	possibly damaging	Het
Or4a76	T	A	2: 89,460,964 (GRCm39)	R93*	probably null	Het
Or5bw2	A	G	7: 6,573,854 (GRCm39)	Y288C	probably damaging	Het
Or6c33	T	A	10: 129,853,710 (GRCm39)	M160K	probably damaging	Het
Or8g23	A	G	9: 38,971,617 (GRCm39)	L115S	probably damaging	Het
Or8k37	T	C	2: 86,469,594 (GRCm39)	T153A	probably benign	Het
Plekhs1	A	G	19: 56,459,403 (GRCm39)	Q51R	probably benign	Het
Rab27b	T	A	18: 70,118,380 (GRCm39)	D179V	possibly damaging	Het
Rprd2	C	T	3: 95,672,631 (GRCm39)	R924H	probably benign	Het
Shprh	T	C	10: 11,045,998 (GRCm39)	I905T	probably damaging	Het
Trpm8	T	C	1: 88,271,009 (GRCm39)	L433P	probably damaging	Het
Urb1	A	G	16: 90,554,649 (GRCm39)	L1861S	possibly damaging	Het
Znrf3	A	T	11: 5,288,656 (GRCm39)	C37*	probably null	Het

Other mutations in Vmn2r124

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00988:Vmn2r124	APN	17	18,282,932 (GRCm39)	missense	probably benign	0.04
IGL01356:Vmn2r124	APN	17	18,293,733 (GRCm39)	missense	probably benign	0.08
IGL01413:Vmn2r124	APN	17	18,282,827 (GRCm39)	missense	probably benign	0.41
IGL01550:Vmn2r124	APN	17	18,283,617 (GRCm39)	critical splice donor site	probably null
IGL01759:Vmn2r124	APN	17	18,284,330 (GRCm39)	missense	probably benign	0.00
IGL01762:Vmn2r124	APN	17	18,283,434 (GRCm39)	missense	possibly damaging	0.51
IGL02132:Vmn2r124	APN	17	18,284,491 (GRCm39)	splice site	probably benign
IGL02290:Vmn2r124	APN	17	18,293,597 (GRCm39)	missense	probably benign	0.09
IGL02370:Vmn2r124	APN	17	18,284,453 (GRCm39)	missense	probably benign	0.14
IGL02527:Vmn2r124	APN	17	18,286,764 (GRCm39)	critical splice acceptor site	probably null
PIT4280001:Vmn2r124	UTSW	17	18,283,487 (GRCm39)	missense	probably benign	0.22
PIT4514001:Vmn2r124	UTSW	17	18,293,974 (GRCm39)	missense	probably benign	0.01
R0362:Vmn2r124	UTSW	17	18,284,486 (GRCm39)	critical splice donor site	probably null
R0401:Vmn2r124	UTSW	17	18,284,407 (GRCm39)	missense	probably damaging	0.99
R0513:Vmn2r124	UTSW	17	18,293,991 (GRCm39)	missense	possibly damaging	0.89
R1139:Vmn2r124	UTSW	17	18,294,052 (GRCm39)	missense	possibly damaging	0.56
R1513:Vmn2r124	UTSW	17	18,283,535 (GRCm39)	missense	probably damaging	1.00
R1669:Vmn2r124	UTSW	17	18,283,206 (GRCm39)	missense	possibly damaging	0.94
R1710:Vmn2r124	UTSW	17	18,282,187 (GRCm39)	splice site	probably benign
R1852:Vmn2r124	UTSW	17	18,283,436 (GRCm39)	missense	probably benign
R1860:Vmn2r124	UTSW	17	18,269,759 (GRCm39)	missense	probably benign	0.11
R1953:Vmn2r124	UTSW	17	18,283,122 (GRCm39)	missense	probably benign	0.08
R2233:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2234:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2235:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2397:Vmn2r124	UTSW	17	18,269,859 (GRCm39)	missense	possibly damaging	0.95
R2519:Vmn2r124	UTSW	17	18,294,280 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R3846:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R4594:Vmn2r124	UTSW	17	18,294,231 (GRCm39)	missense	probably damaging	1.00
R4612:Vmn2r124	UTSW	17	18,283,284 (GRCm39)	missense	probably benign	0.12
R4790:Vmn2r124	UTSW	17	18,269,855 (GRCm39)	missense	probably damaging	1.00
R4809:Vmn2r124	UTSW	17	18,294,007 (GRCm39)	missense	probably benign	0.00
R5227:Vmn2r124	UTSW	17	18,269,819 (GRCm39)	missense	possibly damaging	0.95
R5254:Vmn2r124	UTSW	17	18,283,339 (GRCm39)	missense	probably benign	0.00
R5609:Vmn2r124	UTSW	17	18,294,102 (GRCm39)	missense	probably benign
R6145:Vmn2r124	UTSW	17	18,283,113 (GRCm39)	missense	probably benign	0.05
R6181:Vmn2r124	UTSW	17	18,294,019 (GRCm39)	missense	possibly damaging	0.93
R6271:Vmn2r124	UTSW	17	18,283,145 (GRCm39)	missense	probably benign	0.01
R7297:Vmn2r124	UTSW	17	18,293,835 (GRCm39)	missense	probably damaging	1.00
R7397:Vmn2r124	UTSW	17	18,282,947 (GRCm39)	missense	probably damaging	1.00
R7406:Vmn2r124	UTSW	17	18,282,306 (GRCm39)	missense	unknown
R7699:Vmn2r124	UTSW	17	18,293,985 (GRCm39)	missense	probably benign	0.00
R7859:Vmn2r124	UTSW	17	18,282,212 (GRCm39)	missense	probably damaging	1.00
R8121:Vmn2r124	UTSW	17	18,282,433 (GRCm39)	missense	probably benign
R8138:Vmn2r124	UTSW	17	18,283,610 (GRCm39)	missense	probably damaging	0.99
R8756:Vmn2r124	UTSW	17	18,294,094 (GRCm39)	missense	probably benign	0.08
R8796:Vmn2r124	UTSW	17	18,282,933 (GRCm39)	missense	possibly damaging	0.95
R8841:Vmn2r124	UTSW	17	18,283,299 (GRCm39)	missense
R8960:Vmn2r124	UTSW	17	18,283,291 (GRCm39)	nonsense	probably null
R8970:Vmn2r124	UTSW	17	18,294,439 (GRCm39)	missense	probably benign
R9128:Vmn2r124	UTSW	17	18,294,439 (GRCm39)	missense	probably benign
R9566:Vmn2r124	UTSW	17	18,293,581 (GRCm39)	missense	probably benign	0.14
R9680:Vmn2r124	UTSW	17	18,293,758 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-05