Incidental Mutation 'IGL01391:Zfp142'
ID 79218
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp142
Ensembl Gene ENSMUSG00000026135
Gene Name zinc finger protein 142
Synonyms 9330177B18Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01391
Quality Score
Status
Chromosome 1
Chromosomal Location 74605490-74627308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 74618699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 120 (V120A)
Ref Sequence ENSEMBL: ENSMUSP00000109366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027315] [ENSMUST00000066986] [ENSMUST00000113737] [ENSMUST00000127921] [ENSMUST00000156613]
AlphaFold G5E869
Predicted Effect probably damaging
Transcript: ENSMUST00000027315
AA Change: V223A

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: V223A

DomainStartEndE-ValueType
ZnF_C2H2 103 127 1.16e1 SMART
ZnF_C2H2 164 186 1.26e-2 SMART
ZnF_C2H2 193 218 7.78e-3 SMART
ZnF_C2H2 223 247 2.29e0 SMART
ZnF_C2H2 250 272 9.96e-1 SMART
low complexity region 317 329 N/A INTRINSIC
ZnF_C2H2 363 385 9.96e-1 SMART
ZnF_C2H2 391 411 1.26e1 SMART
ZnF_C2H2 419 442 1.47e-3 SMART
ZnF_C2H2 453 475 2.75e-3 SMART
ZnF_C2H2 486 511 3.34e-2 SMART
ZnF_C2H2 516 540 4.81e0 SMART
ZnF_C2H2 543 566 7.05e-1 SMART
ZnF_C2H2 572 595 2.17e-1 SMART
ZnF_C2H2 601 623 1.56e-2 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 657 679 1.38e-3 SMART
ZnF_C2H2 685 707 9.44e-2 SMART
ZnF_C2H2 712 735 1.26e-2 SMART
ZnF_C2H2 744 767 1.31e0 SMART
ZnF_C2H2 773 796 2.63e0 SMART
low complexity region 903 919 N/A INTRINSIC
low complexity region 953 969 N/A INTRINSIC
low complexity region 996 1007 N/A INTRINSIC
ZnF_C2H2 1039 1059 2.01e1 SMART
ZnF_C2H2 1069 1089 1.91e1 SMART
low complexity region 1147 1160 N/A INTRINSIC
ZnF_C2H2 1187 1207 2.7e2 SMART
low complexity region 1209 1222 N/A INTRINSIC
ZnF_C2H2 1265 1285 3.56e1 SMART
ZnF_C2H2 1295 1318 4.98e-1 SMART
ZnF_C2H2 1331 1354 2.49e-1 SMART
ZnF_C2H2 1360 1382 1.03e-2 SMART
ZnF_C2H2 1388 1411 5.72e-1 SMART
ZnF_C2H2 1417 1440 6.75e0 SMART
ZnF_C2H2 1446 1469 9.58e-3 SMART
ZnF_C2H2 1488 1511 1.64e-1 SMART
ZnF_C2H2 1514 1536 1.1e-2 SMART
ZnF_C2H2 1540 1563 4.05e-1 SMART
ZnF_C2H2 1580 1602 4.45e0 SMART
ZnF_C2H2 1608 1630 8.81e-2 SMART
ZnF_C2H2 1636 1658 1.18e-2 SMART
ZnF_C2H2 1664 1686 1.2e-3 SMART
ZnF_C2H2 1692 1715 3.89e-3 SMART
ZnF_C2H2 1721 1743 4.54e-4 SMART
ZnF_C2H2 1749 1771 1.18e-2 SMART
ZnF_C2H2 1777 1799 3.52e-1 SMART
low complexity region 1829 1838 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000066986
SMART Domains Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135

DomainStartEndE-ValueType
low complexity region 116 128 N/A INTRINSIC
ZnF_C2H2 162 184 9.96e-1 SMART
ZnF_C2H2 190 210 1.26e1 SMART
ZnF_C2H2 218 241 1.47e-3 SMART
ZnF_C2H2 252 274 2.75e-3 SMART
ZnF_C2H2 285 310 3.34e-2 SMART
ZnF_C2H2 315 339 4.81e0 SMART
ZnF_C2H2 342 365 7.05e-1 SMART
ZnF_C2H2 371 394 2.17e-1 SMART
ZnF_C2H2 400 422 1.56e-2 SMART
ZnF_C2H2 428 450 8.94e-3 SMART
ZnF_C2H2 456 478 1.38e-3 SMART
ZnF_C2H2 484 506 9.44e-2 SMART
ZnF_C2H2 511 534 1.26e-2 SMART
ZnF_C2H2 543 566 1.31e0 SMART
ZnF_C2H2 572 595 2.63e0 SMART
low complexity region 702 718 N/A INTRINSIC
low complexity region 752 768 N/A INTRINSIC
low complexity region 795 806 N/A INTRINSIC
ZnF_C2H2 838 858 2.01e1 SMART
ZnF_C2H2 868 888 1.91e1 SMART
low complexity region 946 959 N/A INTRINSIC
ZnF_C2H2 986 1006 2.7e2 SMART
low complexity region 1008 1021 N/A INTRINSIC
ZnF_C2H2 1064 1084 3.56e1 SMART
ZnF_C2H2 1094 1117 4.98e-1 SMART
ZnF_C2H2 1130 1153 2.49e-1 SMART
ZnF_C2H2 1159 1181 1.03e-2 SMART
ZnF_C2H2 1187 1210 5.72e-1 SMART
ZnF_C2H2 1216 1239 6.75e0 SMART
ZnF_C2H2 1245 1268 9.58e-3 SMART
ZnF_C2H2 1287 1310 1.64e-1 SMART
ZnF_C2H2 1313 1335 1.1e-2 SMART
ZnF_C2H2 1339 1362 4.05e-1 SMART
ZnF_C2H2 1379 1401 4.45e0 SMART
ZnF_C2H2 1407 1429 8.81e-2 SMART
ZnF_C2H2 1435 1457 1.18e-2 SMART
ZnF_C2H2 1463 1485 1.2e-3 SMART
ZnF_C2H2 1491 1514 3.89e-3 SMART
ZnF_C2H2 1520 1542 4.54e-4 SMART
ZnF_C2H2 1548 1570 1.18e-2 SMART
ZnF_C2H2 1576 1598 3.52e-1 SMART
low complexity region 1628 1637 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000113737
AA Change: V120A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: V120A

DomainStartEndE-ValueType
ZnF_C2H2 93 115 9.81e1 SMART
ZnF_C2H2 120 144 2.29e0 SMART
ZnF_C2H2 147 169 9.96e-1 SMART
low complexity region 214 226 N/A INTRINSIC
ZnF_C2H2 260 282 9.96e-1 SMART
ZnF_C2H2 288 308 1.26e1 SMART
ZnF_C2H2 316 339 1.47e-3 SMART
ZnF_C2H2 350 372 2.75e-3 SMART
ZnF_C2H2 383 408 3.34e-2 SMART
ZnF_C2H2 413 437 4.81e0 SMART
ZnF_C2H2 440 463 7.05e-1 SMART
ZnF_C2H2 469 492 2.17e-1 SMART
ZnF_C2H2 498 520 1.56e-2 SMART
ZnF_C2H2 526 548 8.94e-3 SMART
ZnF_C2H2 554 576 1.38e-3 SMART
ZnF_C2H2 582 604 9.44e-2 SMART
ZnF_C2H2 609 632 1.26e-2 SMART
ZnF_C2H2 641 664 1.31e0 SMART
ZnF_C2H2 670 693 2.63e0 SMART
low complexity region 800 816 N/A INTRINSIC
low complexity region 850 866 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
ZnF_C2H2 936 956 2.01e1 SMART
ZnF_C2H2 966 986 1.91e1 SMART
low complexity region 1044 1057 N/A INTRINSIC
ZnF_C2H2 1084 1104 2.7e2 SMART
low complexity region 1106 1119 N/A INTRINSIC
ZnF_C2H2 1162 1182 3.56e1 SMART
ZnF_C2H2 1192 1215 4.98e-1 SMART
ZnF_C2H2 1228 1251 2.49e-1 SMART
ZnF_C2H2 1257 1279 1.03e-2 SMART
ZnF_C2H2 1285 1308 5.72e-1 SMART
ZnF_C2H2 1314 1337 6.75e0 SMART
ZnF_C2H2 1343 1366 9.58e-3 SMART
ZnF_C2H2 1385 1408 1.64e-1 SMART
ZnF_C2H2 1411 1433 1.1e-2 SMART
ZnF_C2H2 1437 1460 4.05e-1 SMART
ZnF_C2H2 1477 1499 4.45e0 SMART
ZnF_C2H2 1505 1527 8.81e-2 SMART
ZnF_C2H2 1533 1555 1.18e-2 SMART
ZnF_C2H2 1561 1583 1.2e-3 SMART
ZnF_C2H2 1589 1612 3.89e-3 SMART
ZnF_C2H2 1618 1640 4.54e-4 SMART
ZnF_C2H2 1646 1668 1.18e-2 SMART
ZnF_C2H2 1674 1696 3.52e-1 SMART
low complexity region 1726 1735 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127921
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130112
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136865
Predicted Effect probably benign
Transcript: ENSMUST00000156613
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap3m2 T A 8: 23,289,663 (GRCm39) I147F probably benign Het
Areg T A 5: 91,288,954 (GRCm39) S87T probably damaging Het
Arid1b T A 17: 5,369,133 (GRCm39) probably benign Het
Arl6ip6 A G 2: 53,082,156 (GRCm39) R8G probably benign Het
Brms1 A G 19: 5,096,723 (GRCm39) E135G possibly damaging Het
Ccser1 A G 6: 61,615,505 (GRCm39) probably benign Het
Dock3 A T 9: 106,784,433 (GRCm39) M258K possibly damaging Het
Epb41l4a T G 18: 33,934,678 (GRCm39) D562A possibly damaging Het
Etaa1 G A 11: 17,896,005 (GRCm39) T704I probably damaging Het
Fer1l4 T A 2: 155,878,376 (GRCm39) H972L probably damaging Het
Foxn1 A G 11: 78,252,320 (GRCm39) M356T probably damaging Het
Gfral C A 9: 76,072,107 (GRCm39) G388* probably null Het
Gm12258 A G 11: 58,739,520 (GRCm39) T3A probably benign Het
Hoxa5 T C 6: 52,181,311 (GRCm39) N7S probably damaging Het
Itgb4 T C 11: 115,881,746 (GRCm39) L765P probably damaging Het
Jchain C T 5: 88,669,383 (GRCm39) C90Y probably damaging Het
Klhl40 A G 9: 121,607,983 (GRCm39) Y381C probably damaging Het
Lhx6 A T 2: 35,993,477 (GRCm39) C74S probably benign Het
Magel2 A G 7: 62,030,632 (GRCm39) S1179G unknown Het
Mapre3 T C 5: 31,022,241 (GRCm39) I236T probably damaging Het
Mcf2l A T 8: 13,064,010 (GRCm39) probably null Het
Med13 A T 11: 86,219,323 (GRCm39) H374Q probably benign Het
Meioc A G 11: 102,565,113 (GRCm39) Y187C probably benign Het
Myh1 G A 11: 67,108,689 (GRCm39) M1368I probably benign Het
Or14a258 A T 7: 86,035,208 (GRCm39) I220N possibly damaging Het
Or8b54 A G 9: 38,686,826 (GRCm39) I92V probably damaging Het
Phrf1 T C 7: 140,842,394 (GRCm39) Y1501H probably damaging Het
Pigb T C 9: 72,929,573 (GRCm39) T337A probably damaging Het
Pls1 T C 9: 95,655,751 (GRCm39) K334E probably benign Het
Pramel51 C T 12: 88,145,225 (GRCm39) V34I possibly damaging Het
Rab3b T C 4: 108,797,999 (GRCm39) C226R probably damaging Het
Ryr2 A T 13: 11,571,571 (GRCm39) I4889N possibly damaging Het
Serpinb1a G A 13: 33,029,398 (GRCm39) S210L probably benign Het
Slc52a3 A G 2: 151,849,522 (GRCm39) I390V probably benign Het
Slc6a7 C A 18: 61,136,382 (GRCm39) A340S probably damaging Het
Tcaf3 T C 6: 42,570,615 (GRCm39) Y379C probably damaging Het
Tex261 A G 6: 83,748,222 (GRCm39) V180A probably benign Het
Tnnt1 C T 7: 4,517,211 (GRCm39) probably null Het
Ttn T C 2: 76,798,847 (GRCm39) T476A possibly damaging Het
Vcan A G 13: 89,852,288 (GRCm39) S891P probably benign Het
Vmn2r16 T A 5: 109,511,627 (GRCm39) D611E possibly damaging Het
Vmn2r68 T C 7: 84,886,819 (GRCm39) T32A probably benign Het
Vwde T G 6: 13,190,526 (GRCm39) S522R probably benign Het
Wdr3 G A 3: 100,054,105 (GRCm39) probably benign Het
Wfs1 G T 5: 37,128,907 (GRCm39) Q288K probably benign Het
Zfp672 A G 11: 58,208,192 (GRCm39) F43S probably damaging Het
Znhit3 A T 11: 84,802,283 (GRCm39) probably benign Het
Other mutations in Zfp142
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00581:Zfp142 APN 1 74,606,131 (GRCm39) missense probably damaging 1.00
IGL00711:Zfp142 APN 1 74,611,593 (GRCm39) missense probably damaging 1.00
IGL01808:Zfp142 APN 1 74,615,184 (GRCm39) missense probably damaging 1.00
IGL02074:Zfp142 APN 1 74,609,022 (GRCm39) missense probably damaging 0.97
IGL02134:Zfp142 APN 1 74,609,022 (GRCm39) missense probably damaging 0.97
IGL02567:Zfp142 APN 1 74,617,309 (GRCm39) missense possibly damaging 0.92
IGL02567:Zfp142 APN 1 74,617,306 (GRCm39) missense possibly damaging 0.84
IGL02567:Zfp142 APN 1 74,617,308 (GRCm39) missense possibly damaging 0.92
IGL02669:Zfp142 APN 1 74,610,432 (GRCm39) missense probably benign 0.18
IGL02694:Zfp142 APN 1 74,609,307 (GRCm39) missense probably damaging 0.98
IGL02884:Zfp142 APN 1 74,611,142 (GRCm39) missense probably damaging 0.99
IGL03000:Zfp142 APN 1 74,612,777 (GRCm39) missense probably benign 0.01
IGL03080:Zfp142 APN 1 74,610,368 (GRCm39) missense probably benign 0.18
IGL03238:Zfp142 APN 1 74,615,437 (GRCm39) missense probably benign 0.37
IGL03277:Zfp142 APN 1 74,610,193 (GRCm39) missense probably damaging 1.00
PIT4402001:Zfp142 UTSW 1 74,618,687 (GRCm39) missense probably damaging 1.00
R0124:Zfp142 UTSW 1 74,607,782 (GRCm39) missense probably damaging 1.00
R0256:Zfp142 UTSW 1 74,617,317 (GRCm39) missense probably benign
R0267:Zfp142 UTSW 1 74,615,223 (GRCm39) missense probably benign 0.05
R0306:Zfp142 UTSW 1 74,609,341 (GRCm39) missense probably damaging 1.00
R0321:Zfp142 UTSW 1 74,608,873 (GRCm39) missense probably damaging 1.00
R0466:Zfp142 UTSW 1 74,624,570 (GRCm39) missense possibly damaging 0.95
R0513:Zfp142 UTSW 1 74,610,714 (GRCm39) missense probably damaging 1.00
R1084:Zfp142 UTSW 1 74,610,985 (GRCm39) missense probably benign
R1534:Zfp142 UTSW 1 74,611,247 (GRCm39) missense probably benign 0.00
R1548:Zfp142 UTSW 1 74,609,263 (GRCm39) missense probably damaging 1.00
R1623:Zfp142 UTSW 1 74,610,934 (GRCm39) missense possibly damaging 0.56
R1628:Zfp142 UTSW 1 74,611,047 (GRCm39) missense possibly damaging 0.94
R1710:Zfp142 UTSW 1 74,611,389 (GRCm39) missense probably damaging 1.00
R1722:Zfp142 UTSW 1 74,608,935 (GRCm39) missense probably damaging 1.00
R1770:Zfp142 UTSW 1 74,618,790 (GRCm39) missense probably damaging 0.99
R2042:Zfp142 UTSW 1 74,609,778 (GRCm39) missense probably benign 0.10
R2112:Zfp142 UTSW 1 74,612,795 (GRCm39) missense probably damaging 1.00
R2249:Zfp142 UTSW 1 74,606,191 (GRCm39) missense probably damaging 1.00
R4393:Zfp142 UTSW 1 74,611,219 (GRCm39) missense probably benign 0.00
R4700:Zfp142 UTSW 1 74,609,431 (GRCm39) missense probably damaging 1.00
R4750:Zfp142 UTSW 1 74,611,617 (GRCm39) missense probably damaging 1.00
R4763:Zfp142 UTSW 1 74,615,671 (GRCm39) missense probably damaging 1.00
R5208:Zfp142 UTSW 1 74,610,027 (GRCm39) missense probably benign 0.18
R5233:Zfp142 UTSW 1 74,624,608 (GRCm39) missense probably damaging 1.00
R5585:Zfp142 UTSW 1 74,617,404 (GRCm39) nonsense probably null
R6192:Zfp142 UTSW 1 74,609,667 (GRCm39) missense probably damaging 1.00
R6461:Zfp142 UTSW 1 74,606,344 (GRCm39) missense probably damaging 1.00
R6482:Zfp142 UTSW 1 74,609,376 (GRCm39) splice site probably null
R7320:Zfp142 UTSW 1 74,609,167 (GRCm39) nonsense probably null
R7438:Zfp142 UTSW 1 74,624,679 (GRCm39) missense probably benign
R7528:Zfp142 UTSW 1 74,610,061 (GRCm39) missense probably benign 0.00
R7600:Zfp142 UTSW 1 74,612,827 (GRCm39) missense probably damaging 1.00
R8007:Zfp142 UTSW 1 74,610,655 (GRCm39) missense probably benign 0.01
R8681:Zfp142 UTSW 1 74,610,747 (GRCm39) missense probably damaging 1.00
R8772:Zfp142 UTSW 1 74,610,825 (GRCm39) missense possibly damaging 0.87
R9058:Zfp142 UTSW 1 74,608,955 (GRCm39) nonsense probably null
R9233:Zfp142 UTSW 1 74,610,288 (GRCm39) missense probably benign
R9281:Zfp142 UTSW 1 74,607,731 (GRCm39) missense probably damaging 1.00
R9302:Zfp142 UTSW 1 74,606,302 (GRCm39) missense probably damaging 0.98
R9454:Zfp142 UTSW 1 74,609,016 (GRCm39) missense probably damaging 1.00
R9569:Zfp142 UTSW 1 74,615,386 (GRCm39) missense probably damaging 1.00
R9595:Zfp142 UTSW 1 74,611,462 (GRCm39) missense probably damaging 1.00
R9680:Zfp142 UTSW 1 74,610,933 (GRCm39) missense probably benign 0.16
Z1177:Zfp142 UTSW 1 74,609,325 (GRCm39) missense probably damaging 1.00
Posted On 2013-11-05