Incidental Mutation 'R0003:Ptgdr2'
ID 7933
Institutional Source Beutler Lab
Gene Symbol Ptgdr2
Ensembl Gene ENSMUSG00000034117
Gene Name prostaglandin D2 receptor 2
Synonyms PGD2 receptor, Gpr44, Crth2
MMRRC Submission 038299-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R0003 (G1)
Quality Score
Status Validated
Chromosome 19
Chromosomal Location 10914524-10919875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 10917792 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 103 (C103Y)
Ref Sequence ENSEMBL: ENSMUSP00000036159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025639] [ENSMUST00000037261]
AlphaFold Q9Z2J6
Predicted Effect probably benign
Transcript: ENSMUST00000025639
SMART Domains Protein: ENSMUSP00000025639
Gene: ENSMUSG00000024732

DomainStartEndE-ValueType
low complexity region 53 64 N/A INTRINSIC
low complexity region 67 84 N/A INTRINSIC
low complexity region 87 104 N/A INTRINSIC
low complexity region 107 124 N/A INTRINSIC
low complexity region 127 144 N/A INTRINSIC
low complexity region 187 201 N/A INTRINSIC
coiled coil region 338 389 N/A INTRINSIC
low complexity region 392 400 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000037261
AA Change: C103Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000036159
Gene: ENSMUSG00000034117
AA Change: C103Y

DomainStartEndE-ValueType
low complexity region 32 46 N/A INTRINSIC
Pfam:7tm_1 48 303 7.5e-39 PFAM
low complexity region 339 356 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133836
Meta Mutation Damage Score 0.9431 question?
Coding Region Coverage
  • 1x: 80.3%
  • 3x: 68.0%
  • 10x: 36.1%
  • 20x: 15.3%
Validation Efficiency 36% (21/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a knock-out allele show enhanced IL-5 production and eosinophil recruitment into the lung in an allergic airway inflammatory model. In contrast, mice homozygous for a second knock-out allele exhibit lower serum IgE levels and reduced IgE-mediated inflammatory responses in skin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp2 T C 18: 80,174,205 (GRCm39) Y68C probably damaging Het
Arsi C T 18: 61,050,058 (GRCm39) R314C probably benign Het
Cnnm3 T C 1: 36,563,124 (GRCm39) V696A probably benign Het
Decr2 A T 17: 26,302,027 (GRCm39) N234K probably benign Het
Eprs1 T C 1: 185,146,588 (GRCm39) V1206A probably damaging Het
Fmnl3 T C 15: 99,219,013 (GRCm39) T807A probably damaging Het
Ints3 C A 3: 90,315,818 (GRCm39) M315I probably benign Het
Lamc1 A C 1: 153,138,185 (GRCm39) L223R probably damaging Het
Loxhd1 T C 18: 77,427,196 (GRCm39) L398P probably damaging Het
Mx1 A G 16: 97,252,788 (GRCm39) probably benign Het
Myt1 G A 2: 181,443,664 (GRCm39) G497S probably damaging Het
Or5t17 T A 2: 86,832,710 (GRCm39) Y132* probably null Het
Or9q1 T C 19: 13,805,050 (GRCm39) T237A probably damaging Het
Spta1 A T 1: 174,032,839 (GRCm39) Q965H probably damaging Het
Tfg T C 16: 56,511,351 (GRCm39) Y326C possibly damaging Het
Ttn T C 2: 76,574,027 (GRCm39) D25622G probably damaging Het
Other mutations in Ptgdr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Ptgdr2 APN 19 10,918,274 (GRCm39) missense probably benign 0.39
IGL02301:Ptgdr2 APN 19 10,917,573 (GRCm39) missense possibly damaging 0.89
R0003:Ptgdr2 UTSW 19 10,917,792 (GRCm39) missense probably damaging 1.00
R1175:Ptgdr2 UTSW 19 10,918,292 (GRCm39) missense possibly damaging 0.53
R1405:Ptgdr2 UTSW 19 10,918,395 (GRCm39) missense probably benign 0.43
R1405:Ptgdr2 UTSW 19 10,918,395 (GRCm39) missense probably benign 0.43
R1448:Ptgdr2 UTSW 19 10,917,857 (GRCm39) missense probably damaging 1.00
R2014:Ptgdr2 UTSW 19 10,917,789 (GRCm39) missense probably damaging 0.98
R5900:Ptgdr2 UTSW 19 10,918,352 (GRCm39) splice site probably null
R6631:Ptgdr2 UTSW 19 10,918,233 (GRCm39) missense probably benign 0.07
R7350:Ptgdr2 UTSW 19 10,918,319 (GRCm39) missense probably benign 0.00
R8146:Ptgdr2 UTSW 19 10,918,361 (GRCm39) missense probably damaging 1.00
R8458:Ptgdr2 UTSW 19 10,917,785 (GRCm39) missense possibly damaging 0.50
R8683:Ptgdr2 UTSW 19 10,917,893 (GRCm39) missense possibly damaging 0.85
R8818:Ptgdr2 UTSW 19 10,918,380 (GRCm39) missense probably damaging 1.00
R8953:Ptgdr2 UTSW 19 10,917,786 (GRCm39) missense probably benign 0.16
Z1177:Ptgdr2 UTSW 19 10,917,751 (GRCm39) missense probably benign 0.29
Posted On 2012-11-20