Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01398:Grm3'

79547

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Grm3

Ensembl Gene

ENSMUSG00000003974

Gene Name

glutamate receptor, metabotropic 3

Synonyms

mGluR3, mGlu3, 0710001G23Rik, Gprc1c

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01398

Quality Score

Status

Chromosome

Chromosomal Location

9535541-9775170 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 9535762 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000111005 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004076] [ENSMUST00000115348]

AlphaFold

Q9QYS2

Predicted Effect

probably benign
Transcript: ENSMUST00000004076

SMART Domains

Protein: ENSMUSP00000004076
Gene: ENSMUSG00000003974

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	67	473	4.8e-102	PFAM
Pfam:NCD3G	505	555	2.4e-14	PFAM
Pfam:7tm_3	588	825	4.7e-62	PFAM
low complexity region	849	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115348

SMART Domains

Protein: ENSMUSP00000111005
Gene: ENSMUSG00000056004

Domain	Start	End	E-Value	Type
signal peptide	1	47	N/A	INTRINSIC
low complexity region	213	224	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap1	T	C	11: 69,772,548 (GRCm39)	D521G	probably damaging	Het
Apol11b	G	A	15: 77,522,219 (GRCm39)	T26M	probably damaging	Het
Best2	T	A	8: 85,735,956 (GRCm39)	Y326F	probably damaging	Het
Clca3a1	T	C	3: 144,722,512 (GRCm39)	T287A	possibly damaging	Het
Cyp26a1	C	T	19: 37,686,395 (GRCm39)	T13I	probably damaging	Het
Dhcr7	T	C	7: 143,395,056 (GRCm39)	S188P	probably damaging	Het
Eml3	T	G	19: 8,911,598 (GRCm39)		probably benign	Het
Faf1	A	T	4: 109,593,793 (GRCm39)	I124F	probably damaging	Het
Fkbp9	T	A	6: 56,837,790 (GRCm39)		probably benign	Het
Foxq1	G	A	13: 31,743,434 (GRCm39)	D179N	probably damaging	Het
Frem1	C	T	4: 82,868,599 (GRCm39)	V1443M	possibly damaging	Het
Gpnmb	T	A	6: 49,027,365 (GRCm39)	M363K	probably benign	Het
Ints3	A	G	3: 90,300,130 (GRCm39)	L929P	probably damaging	Het
Myh11	T	A	16: 14,019,964 (GRCm39)	I1823F	probably damaging	Het
Nudt9	T	C	5: 104,212,979 (GRCm39)	*351Q	probably null	Het
Or2ak6	A	T	11: 58,592,593 (GRCm39)	H22L	probably benign	Het
Or4c107	C	T	2: 88,789,193 (GRCm39)	P128S	probably damaging	Het
Or8k38	A	T	2: 86,488,032 (GRCm39)	F257I	probably damaging	Het
Pgr15l	C	T	X: 96,121,785 (GRCm39)	T392I	probably benign	Het
Sdk1	C	A	5: 141,923,332 (GRCm39)	L318I	probably benign	Het
Sult1c2	C	A	17: 54,269,180 (GRCm39)	V279L	possibly damaging	Het
Tek	T	C	4: 94,738,014 (GRCm39)	I688T	probably damaging	Het
Telo2	A	T	17: 25,324,748 (GRCm39)	D477E	probably benign	Het
Ubr3	T	A	2: 69,789,997 (GRCm39)	Y884N	probably damaging	Het
Upf3a	C	A	8: 13,836,221 (GRCm39)	H92Q	probably damaging	Het
Vmn2r51	C	T	7: 9,836,341 (GRCm39)	E147K	probably benign	Het
Vps54	A	G	11: 21,245,403 (GRCm39)		probably benign	Het
Zdhhc14	T	C	17: 5,762,738 (GRCm39)	I214T	possibly damaging	Het

Other mutations in Grm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00495:Grm3	APN	5	9,562,290 (GRCm39)	missense	probably benign
IGL01393:Grm3	APN	5	9,639,856 (GRCm39)	missense	probably benign	0.00
IGL01825:Grm3	APN	5	9,561,600 (GRCm39)	missense	probably damaging	1.00
IGL01966:Grm3	APN	5	9,561,486 (GRCm39)	missense	probably damaging	0.98
IGL02367:Grm3	APN	5	9,561,660 (GRCm39)	missense	probably damaging	1.00
IGL02526:Grm3	APN	5	9,639,847 (GRCm39)	missense	probably damaging	1.00
IGL02972:Grm3	APN	5	9,562,410 (GRCm39)	missense	probably damaging	1.00
IGL03356:Grm3	APN	5	9,562,206 (GRCm39)	missense	possibly damaging	0.89
BB002:Grm3	UTSW	5	9,639,880 (GRCm39)	missense	probably benign	0.09
BB012:Grm3	UTSW	5	9,639,880 (GRCm39)	missense	probably benign	0.09
R0032:Grm3	UTSW	5	9,561,452 (GRCm39)	splice site	probably null
R0032:Grm3	UTSW	5	9,561,452 (GRCm39)	splice site	probably null
R0389:Grm3	UTSW	5	9,554,794 (GRCm39)	missense	probably damaging	1.00
R0455:Grm3	UTSW	5	9,562,477 (GRCm39)	missense	probably benign
R0538:Grm3	UTSW	5	9,562,446 (GRCm39)	missense	possibly damaging	0.95
R0553:Grm3	UTSW	5	9,620,048 (GRCm39)	missense	probably benign	0.16
R1124:Grm3	UTSW	5	9,620,297 (GRCm39)	missense	probably benign
R1163:Grm3	UTSW	5	9,620,738 (GRCm39)	missense	probably benign	0.34
R1440:Grm3	UTSW	5	9,639,958 (GRCm39)	missense	probably benign
R1635:Grm3	UTSW	5	9,561,520 (GRCm39)	missense	probably damaging	1.00
R1734:Grm3	UTSW	5	9,639,742 (GRCm39)	missense	probably benign	0.00
R1895:Grm3	UTSW	5	9,562,123 (GRCm39)	missense	probably damaging	1.00
R1926:Grm3	UTSW	5	9,554,881 (GRCm39)	missense	probably damaging	0.98
R1940:Grm3	UTSW	5	9,561,682 (GRCm39)	missense	probably damaging	1.00
R1946:Grm3	UTSW	5	9,562,123 (GRCm39)	missense	probably damaging	1.00
R2004:Grm3	UTSW	5	9,639,793 (GRCm39)	missense	possibly damaging	0.57
R2005:Grm3	UTSW	5	9,639,793 (GRCm39)	missense	possibly damaging	0.57
R2006:Grm3	UTSW	5	9,639,793 (GRCm39)	missense	possibly damaging	0.57
R3116:Grm3	UTSW	5	9,620,752 (GRCm39)	missense	probably damaging	1.00
R4083:Grm3	UTSW	5	9,562,054 (GRCm39)	missense	probably benign
R4537:Grm3	UTSW	5	9,562,083 (GRCm39)	missense	probably benign	0.02
R4855:Grm3	UTSW	5	9,620,047 (GRCm39)	missense	probably damaging	0.98
R5060:Grm3	UTSW	5	9,620,167 (GRCm39)	missense	probably damaging	0.99
R5093:Grm3	UTSW	5	9,639,766 (GRCm39)	missense	probably benign	0.01
R5419:Grm3	UTSW	5	9,620,233 (GRCm39)	missense	probably damaging	1.00
R5525:Grm3	UTSW	5	9,554,872 (GRCm39)	missense	probably damaging	1.00
R5642:Grm3	UTSW	5	9,620,536 (GRCm39)	missense	probably benign	0.21
R5804:Grm3	UTSW	5	9,620,155 (GRCm39)	missense	probably benign	0.33
R5915:Grm3	UTSW	5	9,561,927 (GRCm39)	missense	probably damaging	1.00
R5966:Grm3	UTSW	5	9,561,930 (GRCm39)	missense	probably damaging	0.98
R6151:Grm3	UTSW	5	9,561,556 (GRCm39)	missense	probably damaging	1.00
R6419:Grm3	UTSW	5	9,620,201 (GRCm39)	missense	probably damaging	1.00
R7267:Grm3	UTSW	5	9,639,581 (GRCm39)	missense	probably benign	0.00
R7555:Grm3	UTSW	5	9,620,000 (GRCm39)	missense	probably benign	0.00
R7657:Grm3	UTSW	5	9,561,452 (GRCm39)	splice site	probably null
R7925:Grm3	UTSW	5	9,639,880 (GRCm39)	missense	probably benign	0.09
R8032:Grm3	UTSW	5	9,562,272 (GRCm39)	missense	probably benign	0.11
R8227:Grm3	UTSW	5	9,620,242 (GRCm39)	missense	possibly damaging	0.65
R8462:Grm3	UTSW	5	9,562,365 (GRCm39)	missense	probably benign
R8500:Grm3	UTSW	5	9,561,726 (GRCm39)	missense	probably benign	0.21
R8696:Grm3	UTSW	5	9,562,311 (GRCm39)	missense	probably damaging	1.00
R8807:Grm3	UTSW	5	9,561,499 (GRCm39)	missense	probably damaging	1.00
R8828:Grm3	UTSW	5	9,554,725 (GRCm39)	missense	probably benign	0.00
R8876:Grm3	UTSW	5	9,561,580 (GRCm39)	missense	probably damaging	1.00
R8896:Grm3	UTSW	5	9,562,483 (GRCm39)	missense	possibly damaging	0.91
R9035:Grm3	UTSW	5	9,620,464 (GRCm39)	missense	probably damaging	0.99
R9779:Grm3	UTSW	5	9,561,656 (GRCm39)	missense	possibly damaging	0.74
X0020:Grm3	UTSW	5	9,562,195 (GRCm39)	missense	probably damaging	1.00
X0025:Grm3	UTSW	5	9,535,790 (GRCm39)	missense	probably damaging	1.00
X0026:Grm3	UTSW	5	9,562,238 (GRCm39)	nonsense	probably null
Z1088:Grm3	UTSW	5	9,620,183 (GRCm39)	missense	probably damaging	0.97

Posted On

2013-11-05