Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01402:Tcerg1l'

79668

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tcerg1l

Ensembl Gene

ENSMUSG00000091002

Gene Name

transcription elongation regulator 1-like

Synonyms

5730476P14Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01402

Quality Score

Status

Chromosome

Chromosomal Location

137810703-137999459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 137861568 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 387 (I387N)

Ref Sequence

ENSEMBL: ENSMUSP00000124476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000160436]

AlphaFold

Q3B807

Predicted Effect

probably damaging
Transcript: ENSMUST00000160436
AA Change: I387N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000124476
Gene: ENSMUSG00000091002
AA Change: I387N

Domain	Start	End	E-Value	Type
low complexity region	6	44	N/A	INTRINSIC
low complexity region	52	97	N/A	INTRINSIC
WW	146	178	2.11e1	SMART
low complexity region	235	249	N/A	INTRINSIC
WW	344	376	3.29e-4	SMART
low complexity region	402	415	N/A	INTRINSIC
FF	454	507	4.57e-12	SMART
FF	520	574	1.53e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161213

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162222

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	C	18: 6,638,653 (GRCm39)	S351P	possibly damaging	Het
Abca2	T	C	2: 25,332,015 (GRCm39)	S1376P	probably damaging	Het
Ablim3	A	G	18: 62,004,754 (GRCm39)	Y12H	probably damaging	Het
Akr1b7	A	G	6: 34,398,052 (GRCm39)	R294G	possibly damaging	Het
Aldh3b1	A	C	19: 3,971,205 (GRCm39)	V153G	probably benign	Het
Alk	A	T	17: 72,181,173 (GRCm39)	H1372Q	probably damaging	Het
Ano9	A	C	7: 140,681,955 (GRCm39)	Y731*	probably null	Het
Apol11b	G	A	15: 77,522,219 (GRCm39)	T26M	probably damaging	Het
Asl	T	C	5: 130,048,645 (GRCm39)	E43G	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Cfap43	T	C	19: 47,784,105 (GRCm39)	D476G	probably benign	Het
Cpa1	A	G	6: 30,645,275 (GRCm39)	H417R	possibly damaging	Het
Cpeb3	T	C	19: 37,065,948 (GRCm39)	D407G	probably benign	Het
Dcaf15	A	T	8: 84,825,026 (GRCm39)	C469S	probably damaging	Het
Dpy19l4	C	A	4: 11,273,006 (GRCm39)		probably null	Het
E4f1	A	T	17: 24,663,208 (GRCm39)	L699Q	probably damaging	Het
Eif4g2	A	G	7: 110,676,234 (GRCm39)	F349S	possibly damaging	Het
Ermap	T	C	4: 119,044,355 (GRCm39)	Y147C	probably damaging	Het
Frk	A	C	10: 34,423,381 (GRCm39)	E153A	probably damaging	Het
Fubp3	G	A	2: 31,494,733 (GRCm39)		probably null	Het
Gdi2	A	G	13: 3,614,611 (GRCm39)	T319A	probably benign	Het
Gjc3	A	G	5: 137,956,120 (GRCm39)	F55S	probably damaging	Het
Gm10762	C	T	2: 128,809,005 (GRCm39)		probably benign	Het
Got1	A	G	19: 43,493,048 (GRCm39)	I291T	possibly damaging	Het
Gpr179	C	A	11: 97,229,012 (GRCm39)	G1048*	probably null	Het
Hectd3	G	T	4: 116,853,262 (GRCm39)	R163L	probably damaging	Het
Hectd4	T	C	5: 121,477,480 (GRCm39)		probably benign	Het
Ifnb1	T	C	4: 88,440,480 (GRCm39)	R178G	probably benign	Het
Ino80	T	A	2: 119,287,199 (GRCm39)	D56V	possibly damaging	Het
Kctd1	T	A	18: 15,102,610 (GRCm39)	Q857L	probably damaging	Het
Kdm5a	T	A	6: 120,367,640 (GRCm39)	L445*	probably null	Het
Lins1	G	A	7: 66,363,676 (GRCm39)	V524I	probably damaging	Het
Lrp1	A	T	10: 127,430,901 (GRCm39)	Y383N	probably damaging	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Mgam	A	C	6: 40,621,879 (GRCm39)	K84Q	probably benign	Het
Mlh3	A	T	12: 85,314,703 (GRCm39)	F494L	probably benign	Het
Mpped1	T	C	15: 83,676,414 (GRCm39)	F60S	possibly damaging	Het
Myo1e	A	G	9: 70,245,048 (GRCm39)	Y382C	probably benign	Het
Ncor1	C	A	11: 62,231,300 (GRCm39)	V836F	probably damaging	Het
Nktr	G	A	9: 121,570,218 (GRCm39)		probably null	Het
Or10al4	A	G	17: 38,037,193 (GRCm39)	T93A	probably benign	Het
Or4d5	A	G	9: 40,012,558 (GRCm39)	I76T	probably benign	Het
Or5k8	G	A	16: 58,644,958 (GRCm39)	T38I	probably damaging	Het
Rnf144a	T	A	12: 26,377,300 (GRCm39)	Y93F	probably benign	Het
Rubcn	G	A	16: 32,647,666 (GRCm39)	T636M	probably damaging	Het
Scn5a	A	C	9: 119,315,536 (GRCm39)	L1724R	probably damaging	Het
Sel1l	A	G	12: 91,808,607 (GRCm39)	S45P	possibly damaging	Het
Serpina3k	A	G	12: 104,306,882 (GRCm39)	D38G	probably benign	Het
Sh3bgr	A	C	16: 96,007,690 (GRCm39)	K18N	probably damaging	Het
Slc28a2	T	G	2: 122,282,538 (GRCm39)	I287M	probably damaging	Het
St8sia6	T	C	2: 13,670,318 (GRCm39)	N214S	probably damaging	Het
Syt11	A	G	3: 88,669,523 (GRCm39)	I123T	probably benign	Het
Tfg	C	A	16: 56,514,856 (GRCm39)		probably benign	Het
Tgm4	A	G	9: 122,880,519 (GRCm39)	K307E	possibly damaging	Het
Tmem177	T	C	1: 119,837,791 (GRCm39)	D296G	probably damaging	Het
Tmem270	C	T	5: 134,930,763 (GRCm39)		probably benign	Het
Tnrc6b	G	T	15: 80,764,745 (GRCm39)	G749V	possibly damaging	Het
Trp63	C	A	16: 25,639,135 (GRCm39)		probably benign	Het
Ugt1a8	T	C	1: 88,015,617 (GRCm39)	L10P	probably benign	Het
Vmn2r107	A	T	17: 20,596,009 (GRCm39)	K854M	probably damaging	Het
Vmn2r45	T	C	7: 8,484,467 (GRCm39)	N446S	probably damaging	Het
Vps13c	A	T	9: 67,820,486 (GRCm39)		probably null	Het
Wdr91	G	A	6: 34,865,998 (GRCm39)	P518L	probably benign	Het
Yap1	G	A	9: 7,934,742 (GRCm39)		probably benign	Het
Zfp282	A	C	6: 47,874,770 (GRCm39)	D325A	probably damaging	Het

Other mutations in Tcerg1l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00504:Tcerg1l	APN	7	137,811,533 (GRCm39)	missense	probably damaging	0.99
IGL01510:Tcerg1l	APN	7	137,996,034 (GRCm39)	splice site	probably benign
IGL01638:Tcerg1l	APN	7	137,881,805 (GRCm39)	missense	probably damaging	1.00
IGL01710:Tcerg1l	APN	7	137,996,789 (GRCm39)	missense	possibly damaging	0.81
IGL02547:Tcerg1l	APN	7	137,850,100 (GRCm39)	critical splice donor site	probably null
IGL02887:Tcerg1l	APN	7	137,831,619 (GRCm39)	missense	probably damaging	1.00
IGL03105:Tcerg1l	APN	7	137,850,173 (GRCm39)	splice site	probably benign
IGL03348:Tcerg1l	APN	7	137,815,100 (GRCm39)	missense	probably damaging	0.97
R0378:Tcerg1l	UTSW	7	137,878,384 (GRCm39)	missense	probably benign	0.01
R1474:Tcerg1l	UTSW	7	137,881,804 (GRCm39)	missense	probably damaging	0.99
R1589:Tcerg1l	UTSW	7	137,963,496 (GRCm39)	missense	probably damaging	0.99
R1658:Tcerg1l	UTSW	7	137,995,909 (GRCm39)	missense	probably damaging	0.98
R1792:Tcerg1l	UTSW	7	137,963,595 (GRCm39)	missense	probably benign	0.07
R1807:Tcerg1l	UTSW	7	137,996,826 (GRCm39)	missense	probably benign	0.34
R2920:Tcerg1l	UTSW	7	137,850,108 (GRCm39)	missense	probably damaging	0.99
R3148:Tcerg1l	UTSW	7	137,861,596 (GRCm39)	missense	probably benign
R4106:Tcerg1l	UTSW	7	137,861,673 (GRCm39)	missense	probably damaging	0.99
R4180:Tcerg1l	UTSW	7	137,878,405 (GRCm39)	critical splice acceptor site	probably null
R4241:Tcerg1l	UTSW	7	137,999,361 (GRCm39)	missense	unknown
R4898:Tcerg1l	UTSW	7	137,819,786 (GRCm39)	missense	probably damaging	0.99
R5652:Tcerg1l	UTSW	7	137,881,775 (GRCm39)	missense	probably damaging	0.97
R6646:Tcerg1l	UTSW	7	137,996,912 (GRCm39)	splice site	probably null
R6824:Tcerg1l	UTSW	7	137,995,844 (GRCm39)	critical splice donor site	probably null
R7414:Tcerg1l	UTSW	7	137,819,786 (GRCm39)	missense	probably damaging	0.97
R7490:Tcerg1l	UTSW	7	137,861,557 (GRCm39)	missense	probably damaging	1.00
R8810:Tcerg1l	UTSW	7	137,811,526 (GRCm39)	missense	possibly damaging	0.79
R8889:Tcerg1l	UTSW	7	137,999,260 (GRCm39)	nonsense	probably null
R8892:Tcerg1l	UTSW	7	137,999,260 (GRCm39)	nonsense	probably null
R9146:Tcerg1l	UTSW	7	137,831,588 (GRCm39)	missense	probably damaging	1.00
R9374:Tcerg1l	UTSW	7	137,995,998 (GRCm39)	missense	possibly damaging	0.95
R9392:Tcerg1l	UTSW	7	137,815,164 (GRCm39)	missense	probably damaging	0.98
R9402:Tcerg1l	UTSW	7	137,811,551 (GRCm39)	missense	probably damaging	0.99
R9428:Tcerg1l	UTSW	7	137,811,490 (GRCm39)	missense	probably damaging	0.99
R9551:Tcerg1l	UTSW	7	137,995,998 (GRCm39)	missense	possibly damaging	0.95
R9552:Tcerg1l	UTSW	7	137,995,998 (GRCm39)	missense	possibly damaging	0.95
R9572:Tcerg1l	UTSW	7	137,881,787 (GRCm39)	missense	probably benign	0.07
R9624:Tcerg1l	UTSW	7	137,995,923 (GRCm39)	missense	possibly damaging	0.71

Posted On

2013-11-05