Incidental Mutation 'IGL01402:Frk'
ID 79681
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Frk
Ensembl Gene ENSMUSG00000019779
Gene Name fyn-related kinase
Synonyms BSK/IYK, GTK
Accession Numbers
Essential gene? Probably non essential (E-score: 0.190) question?
Stock # IGL01402
Quality Score
Status
Chromosome 10
Chromosomal Location 34359395-34487274 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 34423381 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Alanine at position 153 (E153A)
Ref Sequence ENSEMBL: ENSMUSP00000130289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019913] [ENSMUST00000170771]
AlphaFold Q922K9
Predicted Effect probably damaging
Transcript: ENSMUST00000019913
AA Change: E153A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000019913
Gene: ENSMUSG00000019779
AA Change: E153A

DomainStartEndE-ValueType
SH3 52 116 2.76e-19 SMART
SH2 121 206 4.97e-37 SMART
TyrKc 241 494 8.58e-137 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170771
AA Change: E153A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000130289
Gene: ENSMUSG00000019779
AA Change: E153A

DomainStartEndE-ValueType
SH3 52 116 2.76e-19 SMART
SH2 121 206 4.97e-37 SMART
TyrKc 241 494 8.58e-137 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215594
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit increased susceptibility to spontaneous tumors nor increased sensitivity to inoizing radiation. Epithelial tissues appear similar to controls, but circulating levels of T3 were significantly reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,638,653 (GRCm39) S351P possibly damaging Het
Abca2 T C 2: 25,332,015 (GRCm39) S1376P probably damaging Het
Ablim3 A G 18: 62,004,754 (GRCm39) Y12H probably damaging Het
Akr1b7 A G 6: 34,398,052 (GRCm39) R294G possibly damaging Het
Aldh3b1 A C 19: 3,971,205 (GRCm39) V153G probably benign Het
Alk A T 17: 72,181,173 (GRCm39) H1372Q probably damaging Het
Ano9 A C 7: 140,681,955 (GRCm39) Y731* probably null Het
Apol11b G A 15: 77,522,219 (GRCm39) T26M probably damaging Het
Asl T C 5: 130,048,645 (GRCm39) E43G probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Cfap43 T C 19: 47,784,105 (GRCm39) D476G probably benign Het
Cpa1 A G 6: 30,645,275 (GRCm39) H417R possibly damaging Het
Cpeb3 T C 19: 37,065,948 (GRCm39) D407G probably benign Het
Dcaf15 A T 8: 84,825,026 (GRCm39) C469S probably damaging Het
Dpy19l4 C A 4: 11,273,006 (GRCm39) probably null Het
E4f1 A T 17: 24,663,208 (GRCm39) L699Q probably damaging Het
Eif4g2 A G 7: 110,676,234 (GRCm39) F349S possibly damaging Het
Ermap T C 4: 119,044,355 (GRCm39) Y147C probably damaging Het
Fubp3 G A 2: 31,494,733 (GRCm39) probably null Het
Gdi2 A G 13: 3,614,611 (GRCm39) T319A probably benign Het
Gjc3 A G 5: 137,956,120 (GRCm39) F55S probably damaging Het
Gm10762 C T 2: 128,809,005 (GRCm39) probably benign Het
Got1 A G 19: 43,493,048 (GRCm39) I291T possibly damaging Het
Gpr179 C A 11: 97,229,012 (GRCm39) G1048* probably null Het
Hectd3 G T 4: 116,853,262 (GRCm39) R163L probably damaging Het
Hectd4 T C 5: 121,477,480 (GRCm39) probably benign Het
Ifnb1 T C 4: 88,440,480 (GRCm39) R178G probably benign Het
Ino80 T A 2: 119,287,199 (GRCm39) D56V possibly damaging Het
Kctd1 T A 18: 15,102,610 (GRCm39) Q857L probably damaging Het
Kdm5a T A 6: 120,367,640 (GRCm39) L445* probably null Het
Lins1 G A 7: 66,363,676 (GRCm39) V524I probably damaging Het
Lrp1 A T 10: 127,430,901 (GRCm39) Y383N probably damaging Het
Malrd1 G A 2: 16,106,768 (GRCm39) probably null Het
Mgam A C 6: 40,621,879 (GRCm39) K84Q probably benign Het
Mlh3 A T 12: 85,314,703 (GRCm39) F494L probably benign Het
Mpped1 T C 15: 83,676,414 (GRCm39) F60S possibly damaging Het
Myo1e A G 9: 70,245,048 (GRCm39) Y382C probably benign Het
Ncor1 C A 11: 62,231,300 (GRCm39) V836F probably damaging Het
Nktr G A 9: 121,570,218 (GRCm39) probably null Het
Or10al4 A G 17: 38,037,193 (GRCm39) T93A probably benign Het
Or4d5 A G 9: 40,012,558 (GRCm39) I76T probably benign Het
Or5k8 G A 16: 58,644,958 (GRCm39) T38I probably damaging Het
Rnf144a T A 12: 26,377,300 (GRCm39) Y93F probably benign Het
Rubcn G A 16: 32,647,666 (GRCm39) T636M probably damaging Het
Scn5a A C 9: 119,315,536 (GRCm39) L1724R probably damaging Het
Sel1l A G 12: 91,808,607 (GRCm39) S45P possibly damaging Het
Serpina3k A G 12: 104,306,882 (GRCm39) D38G probably benign Het
Sh3bgr A C 16: 96,007,690 (GRCm39) K18N probably damaging Het
Slc28a2 T G 2: 122,282,538 (GRCm39) I287M probably damaging Het
St8sia6 T C 2: 13,670,318 (GRCm39) N214S probably damaging Het
Syt11 A G 3: 88,669,523 (GRCm39) I123T probably benign Het
Tcerg1l A T 7: 137,861,568 (GRCm39) I387N probably damaging Het
Tfg C A 16: 56,514,856 (GRCm39) probably benign Het
Tgm4 A G 9: 122,880,519 (GRCm39) K307E possibly damaging Het
Tmem177 T C 1: 119,837,791 (GRCm39) D296G probably damaging Het
Tmem270 C T 5: 134,930,763 (GRCm39) probably benign Het
Tnrc6b G T 15: 80,764,745 (GRCm39) G749V possibly damaging Het
Trp63 C A 16: 25,639,135 (GRCm39) probably benign Het
Ugt1a8 T C 1: 88,015,617 (GRCm39) L10P probably benign Het
Vmn2r107 A T 17: 20,596,009 (GRCm39) K854M probably damaging Het
Vmn2r45 T C 7: 8,484,467 (GRCm39) N446S probably damaging Het
Vps13c A T 9: 67,820,486 (GRCm39) probably null Het
Wdr91 G A 6: 34,865,998 (GRCm39) P518L probably benign Het
Yap1 G A 9: 7,934,742 (GRCm39) probably benign Het
Zfp282 A C 6: 47,874,770 (GRCm39) D325A probably damaging Het
Other mutations in Frk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Frk APN 10 34,360,239 (GRCm39) missense probably damaging 0.98
IGL02197:Frk APN 10 34,360,330 (GRCm39) missense probably damaging 1.00
IGL02289:Frk APN 10 34,360,362 (GRCm39) missense probably damaging 0.99
IGL02618:Frk APN 10 34,459,960 (GRCm39) missense possibly damaging 0.88
IGL02885:Frk APN 10 34,360,067 (GRCm39) missense probably benign 0.03
IGL03256:Frk APN 10 34,483,838 (GRCm39) missense probably benign 0.00
R0299:Frk UTSW 10 34,360,367 (GRCm39) critical splice donor site probably null
R0697:Frk UTSW 10 34,483,833 (GRCm39) missense probably benign 0.12
R1033:Frk UTSW 10 34,484,454 (GRCm39) missense probably damaging 1.00
R1583:Frk UTSW 10 34,467,806 (GRCm39) critical splice acceptor site probably null
R1793:Frk UTSW 10 34,483,878 (GRCm39) missense probably benign 0.05
R2248:Frk UTSW 10 34,484,527 (GRCm39) missense probably benign 0.10
R3084:Frk UTSW 10 34,483,950 (GRCm39) missense probably damaging 1.00
R3086:Frk UTSW 10 34,483,950 (GRCm39) missense probably damaging 1.00
R3765:Frk UTSW 10 34,360,001 (GRCm39) start codon destroyed probably null 0.98
R3766:Frk UTSW 10 34,360,001 (GRCm39) start codon destroyed probably null 0.98
R3906:Frk UTSW 10 34,460,052 (GRCm39) missense probably benign 0.00
R4163:Frk UTSW 10 34,467,868 (GRCm39) missense probably damaging 0.98
R4486:Frk UTSW 10 34,484,377 (GRCm39) missense probably benign 0.10
R4591:Frk UTSW 10 34,481,829 (GRCm39) missense probably benign 0.03
R4821:Frk UTSW 10 34,360,233 (GRCm39) missense probably benign 0.01
R5070:Frk UTSW 10 34,360,280 (GRCm39) nonsense probably null
R6172:Frk UTSW 10 34,467,961 (GRCm39) missense probably damaging 1.00
R6572:Frk UTSW 10 34,459,963 (GRCm39) missense probably benign 0.00
R6619:Frk UTSW 10 34,481,835 (GRCm39) missense probably benign 0.22
R7307:Frk UTSW 10 34,467,934 (GRCm39) missense probably damaging 1.00
R7486:Frk UTSW 10 34,423,292 (GRCm39) nonsense probably null
R7916:Frk UTSW 10 34,360,021 (GRCm39) missense possibly damaging 0.74
R8341:Frk UTSW 10 34,462,279 (GRCm39) missense probably damaging 1.00
R8675:Frk UTSW 10 34,484,493 (GRCm39) missense probably benign 0.00
R8801:Frk UTSW 10 34,423,402 (GRCm39) missense possibly damaging 0.78
R9608:Frk UTSW 10 34,481,873 (GRCm39) critical splice donor site probably null
Z1177:Frk UTSW 10 34,460,001 (GRCm39) missense probably benign
Posted On 2013-11-05