Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01403:Ly6g'

79691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ly6g

Ensembl Gene

ENSMUSG00000022582

Gene Name

lymphocyte antigen 6 family member G

Synonyms

Gr-1, Ly-6G, Gr1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01403

Quality Score

Status

Chromosome

Chromosomal Location

75027110-75030977 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 75030497 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 82 (N82S)

Ref Sequence

ENSEMBL: ENSMUSP00000023246 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023246] [ENSMUST00000190262]

AlphaFold

P35461

Predicted Effect

probably damaging
Transcript: ENSMUST00000023246
AA Change: N82S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023246
Gene: ENSMUSG00000022582
AA Change: N82S

Domain	Start	End	E-Value	Type
LU	4	95	1.64e-33	SMART
low complexity region	97	107	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000190262
AA Change: N105S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000140173
Gene: ENSMUSG00000022582
AA Change: N105S

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
LU	27	118	8.2e-36	SMART
low complexity region	120	130	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	T	12: 118,836,602 (GRCm39)	L1103Q	probably damaging	Het
Adam12	T	A	7: 133,521,339 (GRCm39)	Q605L	probably benign	Het
Adk	A	G	14: 21,284,983 (GRCm39)	K102R	probably damaging	Het
Afdn	C	T	17: 14,124,132 (GRCm39)	P1761S	probably damaging	Het
Ascc1	A	G	10: 59,848,280 (GRCm39)		probably benign	Het
Aspdh	A	G	7: 44,115,983 (GRCm39)		probably null	Het
Bbx	T	C	16: 50,022,876 (GRCm39)	I753V	probably benign	Het
Ccdc33	T	C	9: 58,024,668 (GRCm39)	Y186C	probably damaging	Het
Ccdc78	T	A	17: 26,007,218 (GRCm39)		probably null	Het
Ckmt1	T	C	2: 121,193,447 (GRCm39)		probably benign	Het
Csf1r	A	G	18: 61,247,897 (GRCm39)	T322A	probably benign	Het
Dnah7b	T	C	1: 46,155,460 (GRCm39)		probably benign	Het
Dr1	A	G	5: 108,417,576 (GRCm39)	N41D	possibly damaging	Het
Ehmt1	G	A	2: 24,729,638 (GRCm39)	T633I	possibly damaging	Het
Fgf7	T	A	2: 125,877,860 (GRCm39)	Y76N	probably damaging	Het
Hmcn1	A	T	1: 150,468,848 (GRCm39)	W5038R	probably damaging	Het
Ighv14-1	A	G	12: 113,895,862 (GRCm39)	V21A	probably damaging	Het
Igkv5-37	T	A	6: 69,940,420 (GRCm39)	I75F	probably damaging	Het
Inhbc	T	A	10: 127,205,968 (GRCm39)	I100F	probably damaging	Het
Irs3	A	G	5: 137,643,581 (GRCm39)	F68L	probably damaging	Het
Itpr3	T	A	17: 27,337,569 (GRCm39)	C2460S	probably damaging	Het
Krt34	A	G	11: 99,929,116 (GRCm39)	C365R	possibly damaging	Het
Krt81	G	A	15: 101,361,269 (GRCm39)	H104Y	probably benign	Het
Mrpl58	A	T	11: 115,297,404 (GRCm39)	I72F	probably damaging	Het
Myo9a	G	A	9: 59,778,846 (GRCm39)	R1534H	probably damaging	Het
Npat	T	A	9: 53,466,429 (GRCm39)	F239L	probably benign	Het
Nsd2	A	G	5: 34,042,722 (GRCm39)		probably benign	Het
Nuggc	T	C	14: 65,860,635 (GRCm39)	V427A	probably benign	Het
Or52b1	G	A	7: 104,978,605 (GRCm39)	R265C	probably benign	Het
Or5p55	A	G	7: 107,566,828 (GRCm39)	T75A	possibly damaging	Het
Pde4a	A	T	9: 21,116,412 (GRCm39)	I467F	probably damaging	Het
Pkhd1l1	T	A	15: 44,347,229 (GRCm39)	C198*	probably null	Het
Pla2r1	A	G	2: 60,254,632 (GRCm39)	V1312A	probably damaging	Het
Pola2	T	C	19: 6,009,121 (GRCm39)	H79R	probably benign	Het
Potefam1	T	C	2: 111,059,515 (GRCm39)		probably benign	Het
Pramel15	A	T	4: 144,103,703 (GRCm39)	M141K	probably benign	Het
Psen2	A	T	1: 180,062,548 (GRCm39)		probably benign	Het
Rnf213	A	G	11: 119,334,126 (GRCm39)	K3112E	probably damaging	Het
Slc6a4	G	T	11: 76,922,498 (GRCm39)	V630L	probably benign	Het
Smg1	A	T	7: 117,757,355 (GRCm39)		probably benign	Het
Tmc8	A	G	11: 117,681,900 (GRCm39)	T510A	possibly damaging	Het
Usp18	T	A	6: 121,245,627 (GRCm39)	H334Q	possibly damaging	Het
Vmn2r103	T	C	17: 20,013,229 (GRCm39)	Y117H	probably benign	Het
Vps13b	T	A	15: 35,709,625 (GRCm39)	D1857E	probably benign	Het

Other mutations in Ly6g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02294:Ly6g	APN	15	75,030,413 (GRCm39)	missense	possibly damaging	0.87
R1389:Ly6g	UTSW	15	75,028,615 (GRCm39)	missense	probably benign	0.10
R1450:Ly6g	UTSW	15	75,030,482 (GRCm39)	missense	probably benign	0.16
R4179:Ly6g	UTSW	15	75,027,567 (GRCm39)	splice site	probably null
R5746:Ly6g	UTSW	15	75,028,596 (GRCm39)	missense	possibly damaging	0.92
R6514:Ly6g	UTSW	15	75,028,581 (GRCm39)	missense	probably benign	0.00
R6777:Ly6g	UTSW	15	75,030,431 (GRCm39)	missense	probably benign	0.04
R6967:Ly6g	UTSW	15	75,030,398 (GRCm39)	missense	possibly damaging	0.81
R7574:Ly6g	UTSW	15	75,030,413 (GRCm39)	missense	probably benign	0.39
R8744:Ly6g	UTSW	15	75,027,518 (GRCm39)	missense	probably benign	0.02
R9261:Ly6g	UTSW	15	75,030,529 (GRCm39)	missense	probably damaging	0.99
R9746:Ly6g	UTSW	15	75,030,458 (GRCm39)	missense	probably benign	0.13

Posted On

2013-11-05