Incidental Mutation 'IGL01405:Zfp961'
| ID |
79789 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp961
|
| Ensembl Gene |
ENSMUSG00000052446 |
| Gene Name |
zinc finger protein 961 |
| Synonyms |
A230105L22Rik, BC049349 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01405
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
72704910-72724177 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72721778 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 78
(N78S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122942
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109997]
[ENSMUST00000131237]
[ENSMUST00000132848]
[ENSMUST00000136516]
[ENSMUST00000138304]
[ENSMUST00000145256]
|
| AlphaFold |
E9Q4R5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109997
AA Change: N97S
PolyPhen 2
Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: N97S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
226 |
248 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
4.61e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131237
AA Change: N78S
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: N78S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
63 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
125 |
147 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
153 |
175 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
207 |
229 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
235 |
257 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
263 |
285 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
291 |
313 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
319 |
341 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
347 |
369 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
375 |
397 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
4.61e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132848
AA Change: N97S
PolyPhen 2
Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: N97S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136516
|
| SMART Domains |
Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136878
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138304
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139781
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144807
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151168
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145256
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147033
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf1 |
G |
A |
17: 36,274,902 (GRCm39) |
R82W |
probably damaging |
Het |
| Atxn7 |
T |
C |
14: 14,100,105 (GRCm38) |
V597A |
probably benign |
Het |
| Bsg |
T |
A |
10: 79,547,348 (GRCm39) |
M205K |
probably benign |
Het |
| Ccdc18 |
T |
C |
5: 108,350,052 (GRCm39) |
|
probably benign |
Het |
| Cdh1 |
T |
C |
8: 107,375,633 (GRCm39) |
V57A |
probably damaging |
Het |
| Ddost |
A |
G |
4: 138,039,014 (GRCm39) |
D378G |
probably damaging |
Het |
| Depdc5 |
A |
G |
5: 33,095,033 (GRCm39) |
E779G |
possibly damaging |
Het |
| Elp5 |
T |
C |
11: 69,859,962 (GRCm39) |
R250G |
probably damaging |
Het |
| Gnb1 |
A |
G |
4: 155,627,645 (GRCm39) |
H142R |
probably damaging |
Het |
| Ift172 |
G |
T |
5: 31,419,196 (GRCm39) |
Y1148* |
probably null |
Het |
| Kif5a |
T |
C |
10: 127,081,859 (GRCm39) |
N153S |
probably damaging |
Het |
| Malrd1 |
G |
A |
2: 16,106,768 (GRCm39) |
|
probably null |
Het |
| Man2a2 |
T |
A |
7: 80,010,682 (GRCm39) |
M770L |
probably benign |
Het |
| Msh2 |
T |
C |
17: 87,985,663 (GRCm39) |
L80P |
probably damaging |
Het |
| Naip5 |
A |
T |
13: 100,358,453 (GRCm39) |
S928T |
probably benign |
Het |
| Or7g35 |
T |
A |
9: 19,496,501 (GRCm39) |
S223T |
probably benign |
Het |
| Pla2g4d |
T |
C |
2: 120,097,304 (GRCm39) |
N765S |
probably benign |
Het |
| Plcb4 |
C |
T |
2: 135,792,267 (GRCm39) |
T330I |
probably damaging |
Het |
| Ppp3ca |
A |
G |
3: 136,574,482 (GRCm39) |
I127V |
probably benign |
Het |
| Rapgef5 |
C |
A |
12: 117,685,115 (GRCm39) |
T320K |
probably benign |
Het |
| Rbfa |
A |
G |
18: 80,236,080 (GRCm39) |
V223A |
probably benign |
Het |
| Rfx7 |
A |
G |
9: 72,517,626 (GRCm39) |
M187V |
probably benign |
Het |
| Ric1 |
T |
C |
19: 29,544,770 (GRCm39) |
|
probably benign |
Het |
| Slc22a16 |
C |
T |
10: 40,461,191 (GRCm39) |
T331M |
probably benign |
Het |
| Slc34a1 |
T |
C |
13: 55,559,941 (GRCm39) |
S303P |
probably damaging |
Het |
| Slfn3 |
T |
C |
11: 83,105,542 (GRCm39) |
V513A |
possibly damaging |
Het |
| Tbce |
A |
T |
13: 14,178,280 (GRCm39) |
I370N |
probably damaging |
Het |
| Zfp358 |
G |
A |
8: 3,545,663 (GRCm39) |
D109N |
probably benign |
Het |
| Zfp523 |
T |
C |
17: 28,423,480 (GRCm39) |
S152P |
probably damaging |
Het |
|
| Other mutations in Zfp961 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Zfp961
|
APN |
8 |
72,722,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00801:Zfp961
|
APN |
8 |
72,719,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00825:Zfp961
|
APN |
8 |
72,721,888 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03100:Zfp961
|
APN |
8 |
72,721,754 (GRCm39) |
makesense |
probably null |
|
|
R0969:Zfp961
|
UTSW |
8 |
72,722,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Zfp961
|
UTSW |
8 |
72,722,847 (GRCm39) |
unclassified |
probably benign |
|
|
R5502:Zfp961
|
UTSW |
8 |
72,721,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5813:Zfp961
|
UTSW |
8 |
72,722,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Zfp961
|
UTSW |
8 |
72,719,958 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6902:Zfp961
|
UTSW |
8 |
72,722,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7858:Zfp961
|
UTSW |
8 |
72,704,949 (GRCm39) |
missense |
unknown |
|
|
R8749:Zfp961
|
UTSW |
8 |
72,719,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9718:Zfp961
|
UTSW |
8 |
72,721,933 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
X0027:Zfp961
|
UTSW |
8 |
72,721,793 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2013-11-05 |
Incidental Mutation