Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01407:Vmn2r19'

79828

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r19

Ensembl Gene

ENSMUSG00000091260

Gene Name

vomeronasal 2, receptor 19

Synonyms

EG232358

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01407

Quality Score

Status

Chromosome

Chromosomal Location

123285292-123313496 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123306826 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 445 (F445I)

Ref Sequence

ENSEMBL: ENSMUSP00000073604 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073948]

AlphaFold

G5E8G4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000073948
AA Change: F445I

PolyPhen 2 Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: F445I

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	476	2.9e-35	PFAM
Pfam:NCD3G	518	571	8.3e-23	PFAM
Pfam:7tm_3	603	839	7.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	A	2: 69,076,288 (GRCm39)	D1140V	probably damaging	Het
Ak1	G	T	2: 32,523,507 (GRCm39)		probably benign	Het
Ano1	A	T	7: 144,190,848 (GRCm39)	L411H	probably benign	Het
Atad2	A	T	15: 57,967,921 (GRCm39)	N569K	probably benign	Het
Bst2	C	A	8: 71,989,830 (GRCm39)	R81L	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Chrna5	C	T	9: 54,911,683 (GRCm39)	T57M	possibly damaging	Het
Cp	A	T	3: 20,031,369 (GRCm39)	D602V	possibly damaging	Het
Drd2	T	C	9: 49,312,115 (GRCm39)	I156T	probably damaging	Het
Elp4	G	A	2: 105,622,653 (GRCm39)	R349W	probably damaging	Het
Eml6	G	A	11: 29,705,021 (GRCm39)	R1508*	probably null	Het
Etl4	T	C	2: 20,748,667 (GRCm39)	L335S	probably damaging	Het
Fat3	A	T	9: 16,289,319 (GRCm39)	I68K	probably benign	Het
Fyco1	G	T	9: 123,657,944 (GRCm39)	A744D	probably damaging	Het
Gm22165	G	T	3: 64,012,886 (GRCm39)		probably benign	Het
Gse1	T	C	8: 121,280,326 (GRCm39)	M1T	probably null	Het
Hs3st5	A	T	10: 36,709,404 (GRCm39)	H313L	probably damaging	Het
Hsd17b3	T	C	13: 64,210,719 (GRCm39)	Y212C	probably damaging	Het
Hyal5	G	T	6: 24,876,406 (GRCm39)	S93I	probably benign	Het
Itgb1	T	C	8: 129,449,315 (GRCm39)	V578A	probably benign	Het
Klf12	A	T	14: 100,347,294 (GRCm39)	N12K	possibly damaging	Het
Krt40	C	T	11: 99,432,045 (GRCm39)	C222Y	probably damaging	Het
Lrrn2	T	C	1: 132,864,965 (GRCm39)	L10P	probably damaging	Het
Lrsam1	T	C	2: 32,837,915 (GRCm39)	Y213C	probably damaging	Het
Mitf	C	A	6: 97,994,892 (GRCm39)	T277K	possibly damaging	Het
Ncan	C	T	8: 70,554,607 (GRCm39)	R1070H	probably benign	Het
Nr4a3	A	G	4: 48,083,201 (GRCm39)	E578G	probably benign	Het
Patj	A	G	4: 98,301,287 (GRCm39)	T191A	possibly damaging	Het
Pign	A	G	1: 105,517,027 (GRCm39)	V533A	probably benign	Het
Smad5	G	A	13: 56,883,630 (GRCm39)	V339I	probably benign	Het
Spem2	T	A	11: 69,708,065 (GRCm39)	Y300F	possibly damaging	Het
Trank1	T	G	9: 111,193,790 (GRCm39)	S605A	probably damaging	Het
Treml4	T	A	17: 48,571,877 (GRCm39)	D93E	possibly damaging	Het
Tsc22d2	T	A	3: 58,323,924 (GRCm39)	V272E	probably damaging	Het
Zfp712	T	A	13: 67,190,230 (GRCm39)	Q99L	possibly damaging	Het
Zfp719	A	T	7: 43,233,611 (GRCm39)	K10I	probably benign	Het

Other mutations in Vmn2r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02294:Vmn2r19	APN	6	123,306,937 (GRCm39)	missense	probably benign	0.19
IGL02442:Vmn2r19	APN	6	123,286,621 (GRCm39)	missense	possibly damaging	0.94
IGL02871:Vmn2r19	APN	6	123,313,042 (GRCm39)	missense	probably damaging	1.00
H8562:Vmn2r19	UTSW	6	123,292,861 (GRCm39)	missense	possibly damaging	0.82
R0025:Vmn2r19	UTSW	6	123,308,506 (GRCm39)	missense	probably benign	0.01
R0389:Vmn2r19	UTSW	6	123,312,945 (GRCm39)	missense	possibly damaging	0.53
R0402:Vmn2r19	UTSW	6	123,313,141 (GRCm39)	missense	probably damaging	1.00
R0411:Vmn2r19	UTSW	6	123,286,703 (GRCm39)	missense	probably damaging	0.98
R0554:Vmn2r19	UTSW	6	123,313,102 (GRCm39)	missense	probably damaging	0.99
R0578:Vmn2r19	UTSW	6	123,312,931 (GRCm39)	missense	probably damaging	1.00
R1102:Vmn2r19	UTSW	6	123,313,132 (GRCm39)	missense	probably benign	0.28
R1652:Vmn2r19	UTSW	6	123,292,656 (GRCm39)	missense	possibly damaging	0.68
R1663:Vmn2r19	UTSW	6	123,313,411 (GRCm39)	missense	probably benign	0.11
R1817:Vmn2r19	UTSW	6	123,307,011 (GRCm39)	missense	possibly damaging	0.80
R1866:Vmn2r19	UTSW	6	123,308,597 (GRCm39)	critical splice donor site	probably null
R1928:Vmn2r19	UTSW	6	123,308,589 (GRCm39)	missense	probably damaging	1.00
R1997:Vmn2r19	UTSW	6	123,292,880 (GRCm39)	missense	probably damaging	0.98
R2013:Vmn2r19	UTSW	6	123,292,954 (GRCm39)	missense	probably benign	0.01
R2015:Vmn2r19	UTSW	6	123,292,954 (GRCm39)	missense	probably benign	0.01
R2088:Vmn2r19	UTSW	6	123,312,795 (GRCm39)	missense	probably damaging	1.00
R2126:Vmn2r19	UTSW	6	123,293,033 (GRCm39)	missense	possibly damaging	0.82
R2128:Vmn2r19	UTSW	6	123,285,289 (GRCm39)	splice site	probably null
R2256:Vmn2r19	UTSW	6	123,306,845 (GRCm39)	missense	probably benign	0.20
R2517:Vmn2r19	UTSW	6	123,306,937 (GRCm39)	missense	probably benign	0.19
R3753:Vmn2r19	UTSW	6	123,292,548 (GRCm39)	missense	possibly damaging	0.80
R3817:Vmn2r19	UTSW	6	123,286,601 (GRCm39)	missense	probably damaging	1.00
R3929:Vmn2r19	UTSW	6	123,292,587 (GRCm39)	missense	probably benign	0.01
R3934:Vmn2r19	UTSW	6	123,292,628 (GRCm39)	missense	probably damaging	1.00
R4232:Vmn2r19	UTSW	6	123,306,871 (GRCm39)	missense	probably benign
R4574:Vmn2r19	UTSW	6	123,292,939 (GRCm39)	missense	probably benign	0.01
R4886:Vmn2r19	UTSW	6	123,286,800 (GRCm39)	missense	probably benign	0.05
R4995:Vmn2r19	UTSW	6	123,306,869 (GRCm39)	missense	probably benign	0.00
R5107:Vmn2r19	UTSW	6	123,286,602 (GRCm39)	nonsense	probably null
R5232:Vmn2r19	UTSW	6	123,312,916 (GRCm39)	missense	probably benign
R6102:Vmn2r19	UTSW	6	123,306,907 (GRCm39)	missense	probably damaging	1.00
R6105:Vmn2r19	UTSW	6	123,293,054 (GRCm39)	missense	possibly damaging	0.70
R6280:Vmn2r19	UTSW	6	123,313,212 (GRCm39)	missense	probably benign
R6393:Vmn2r19	UTSW	6	123,293,112 (GRCm39)	missense	possibly damaging	0.80
R6502:Vmn2r19	UTSW	6	123,293,067 (GRCm39)	missense	possibly damaging	0.68
R6617:Vmn2r19	UTSW	6	123,313,494 (GRCm39)	makesense	probably null
R6742:Vmn2r19	UTSW	6	123,306,917 (GRCm39)	missense	possibly damaging	0.90
R7662:Vmn2r19	UTSW	6	123,308,521 (GRCm39)	missense	probably benign	0.33
R8041:Vmn2r19	UTSW	6	123,312,750 (GRCm39)	missense	possibly damaging	0.94
R8054:Vmn2r19	UTSW	6	123,292,998 (GRCm39)	missense	probably damaging	1.00
R8074:Vmn2r19	UTSW	6	123,312,904 (GRCm39)	missense	probably damaging	0.96
R8267:Vmn2r19	UTSW	6	123,313,221 (GRCm39)	missense	possibly damaging	0.50
R8287:Vmn2r19	UTSW	6	123,308,588 (GRCm39)	missense	probably damaging	1.00
R8937:Vmn2r19	UTSW	6	123,293,283 (GRCm39)	critical splice donor site	probably null
R9058:Vmn2r19	UTSW	6	123,313,021 (GRCm39)	missense	possibly damaging	0.53
R9119:Vmn2r19	UTSW	6	123,292,527 (GRCm39)	missense	possibly damaging	0.68
R9384:Vmn2r19	UTSW	6	123,292,923 (GRCm39)	missense	probably benign	0.00
X0058:Vmn2r19	UTSW	6	123,285,308 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r19	UTSW	6	123,285,298 (GRCm39)	missense	probably benign	0.02
Z1177:Vmn2r19	UTSW	6	123,313,036 (GRCm39)	missense	possibly damaging	0.89

Posted On

2013-11-05