Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01410:Prr36'

79948

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prr36

Ensembl Gene

ENSMUSG00000064125

Gene Name

proline rich 36

Synonyms

BC068157

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL01410

Quality Score

Status

Chromosome

Chromosomal Location

4259543-4267459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 4266230 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 107 (I107F)

Ref Sequence

ENSEMBL: ENSMUSP00000135130 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168386] [ENSMUST00000175906] [ENSMUST00000176227] [ENSMUST00000177491]

AlphaFold

E9PV26

Predicted Effect

unknown
Transcript: ENSMUST00000168386
AA Change: I107F

SMART Domains

Protein: ENSMUSP00000133114
Gene: ENSMUSG00000064125
AA Change: I107F

Domain	Start	End	E-Value	Type
low complexity region	26	38	N/A	INTRINSIC
internal_repeat_1	63	82	5.9e-10	PROSPERO
internal_repeat_1	87	106	5.9e-10	PROSPERO
low complexity region	109	123	N/A	INTRINSIC
low complexity region	358	388	N/A	INTRINSIC
low complexity region	390	425	N/A	INTRINSIC
low complexity region	466	497	N/A	INTRINSIC
low complexity region	543	567	N/A	INTRINSIC
low complexity region	571	612	N/A	INTRINSIC
low complexity region	647	726	N/A	INTRINSIC
low complexity region	733	751	N/A	INTRINSIC
low complexity region	755	780	N/A	INTRINSIC
low complexity region	783	867	N/A	INTRINSIC
low complexity region	1020	1045	N/A	INTRINSIC
Pfam:DUF4596	1053	1098	4.1e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000175906
AA Change: I107F

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135713
Gene: ENSMUSG00000064125
AA Change: I107F

Domain	Start	End	E-Value	Type
low complexity region	26	38	N/A	INTRINSIC
internal_repeat_1	63	82	5.38e-8	PROSPERO
internal_repeat_1	87	106	5.38e-8	PROSPERO
low complexity region	109	123	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000176227

Predicted Effect

probably benign
Transcript: ENSMUST00000176645

Predicted Effect

probably benign
Transcript: ENSMUST00000177491
AA Change: I107F

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135130
Gene: ENSMUSG00000064125
AA Change: I107F

Domain	Start	End	E-Value	Type
low complexity region	26	38	N/A	INTRINSIC
internal_repeat_1	63	82	1.65e-6	PROSPERO
internal_repeat_1	87	106	1.65e-6	PROSPERO
low complexity region	109	123	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	A	1: 58,145,184 (GRCm39)		probably null	Het
Aspm	C	T	1: 139,410,182 (GRCm39)	T1359I	probably benign	Het
Atp13a2	A	G	4: 140,719,509 (GRCm39)	D26G	probably benign	Het
Atrnl1	G	A	19: 58,119,536 (GRCm39)	A1343T	probably damaging	Het
Ccsap	A	C	8: 124,585,969 (GRCm39)	S61A	probably damaging	Het
Cdh1	A	T	8: 107,384,485 (GRCm39)	M318L	probably benign	Het
Cfap69	G	A	5: 5,696,979 (GRCm39)	P106S	probably damaging	Het
Cfp	G	A	X: 20,795,963 (GRCm39)	T88I	probably damaging	Het
Chst1	A	T	2: 92,444,475 (GRCm39)	I316F	probably damaging	Het
Col7a1	A	T	9: 108,793,686 (GRCm39)	D1382V	unknown	Het
Cr2	T	A	1: 194,845,542 (GRCm39)	M514L	possibly damaging	Het
Cubn	G	A	2: 13,470,719 (GRCm39)	H558Y	probably benign	Het
Cul9	A	T	17: 46,839,572 (GRCm39)	M802K	probably damaging	Het
Dennd2d	A	T	3: 106,398,542 (GRCm39)	I169L	probably damaging	Het
Dnah11	T	A	12: 118,010,991 (GRCm39)	K162*	probably null	Het
Dnah3	T	A	7: 119,566,943 (GRCm39)	T2428S	possibly damaging	Het
Dock11	T	A	X: 35,301,296 (GRCm39)	H1284Q	probably damaging	Het
Flrt2	T	A	12: 95,745,966 (GRCm39)	D101E	probably damaging	Het
Gabrr2	G	A	4: 33,085,626 (GRCm39)	V349M	probably damaging	Het
Gli2	C	A	1: 118,764,621 (GRCm39)	V1177L	probably benign	Het
Gm16506	A	G	14: 43,961,630 (GRCm39)	Y206H	probably benign	Het
Gm5612	C	T	9: 18,338,869 (GRCm39)		probably benign	Het
Gvin3	C	T	7: 106,202,258 (GRCm39)		noncoding transcript	Het
Heg1	C	T	16: 33,545,936 (GRCm39)	T460I	possibly damaging	Het
Lgals9	T	G	11: 78,863,977 (GRCm39)	D56A	probably damaging	Het
Lpgat1	A	T	1: 191,508,544 (GRCm39)		probably null	Het
Megf6	T	A	4: 154,337,020 (GRCm39)		probably null	Het
Megf8	G	A	7: 25,059,296 (GRCm39)	M2265I	probably benign	Het
Memo1	G	A	17: 74,548,976 (GRCm39)	R121*	probably null	Het
Morc1	T	C	16: 48,432,677 (GRCm39)	V715A	probably benign	Het
Mycbp2	A	T	14: 103,466,928 (GRCm39)		probably null	Het
Ncapg2	T	A	12: 116,388,270 (GRCm39)	V318D	possibly damaging	Het
Ndst1	T	C	18: 60,833,517 (GRCm39)	Y498C	probably damaging	Het
Nod1	C	T	6: 54,921,341 (GRCm39)	A326T	probably damaging	Het
Or2ag15	A	G	7: 106,340,706 (GRCm39)	V145A	probably benign	Het
Or4c11	T	A	2: 88,695,864 (GRCm39)	M305K	probably benign	Het
Peg3	T	C	7: 6,710,624 (GRCm39)	S1533G	probably benign	Het
Pgc	G	T	17: 48,045,165 (GRCm39)	G361V	probably damaging	Het
Phka1	C	T	X: 101,629,712 (GRCm39)	R477H	probably damaging	Het
Plagl2	C	T	2: 153,074,574 (GRCm39)	R109Q	probably damaging	Het
Ptpdc1	T	A	13: 48,740,080 (GRCm39)	R450S	probably damaging	Het
Ptprb	A	T	10: 116,138,179 (GRCm39)	D361V	possibly damaging	Het
Rbm44	A	G	1: 91,096,551 (GRCm39)	D970G	probably benign	Het
Scrn2	T	G	11: 96,921,396 (GRCm39)	V52G	probably benign	Het
Sdk1	C	T	5: 142,197,875 (GRCm39)	T2176I	probably benign	Het
Serpina1d	T	A	12: 103,729,993 (GRCm39)	E396D	probably benign	Het
Slc38a5	A	C	X: 8,146,070 (GRCm39)	Q465P	probably benign	Het
Slc38a5	G	T	X: 8,146,071 (GRCm39)	Q465H	probably benign	Het
Smarca1	T	C	X: 46,981,255 (GRCm39)	T48A	possibly damaging	Het
Trak2	A	T	1: 58,962,766 (GRCm39)	I132N	probably damaging	Het
Trank1	A	G	9: 111,194,117 (GRCm39)	T714A	probably benign	Het
Trank1	T	C	9: 111,194,327 (GRCm39)	S784P	probably benign	Het
Trp53i13	G	A	11: 77,399,083 (GRCm39)		probably benign	Het
Trrap	A	C	5: 144,767,831 (GRCm39)	D2596A	probably benign	Het
Ttyh1	A	T	7: 4,127,656 (GRCm39)	T19S	probably damaging	Het
Tyk2	C	T	9: 21,020,660 (GRCm39)	V947M	probably damaging	Het
Ugt2b34	G	A	5: 87,040,689 (GRCm39)	A411V	possibly damaging	Het
Virma	T	A	4: 11,518,929 (GRCm39)	Y725*	probably null	Het
Vmn1r192	A	G	13: 22,372,079 (GRCm39)	L47P	probably damaging	Het
Vmn2r74	T	C	7: 85,610,500 (GRCm39)	D64G	possibly damaging	Het

Other mutations in Prr36

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01535:Prr36	APN	8	4,264,043 (GRCm39)	unclassified	probably benign
IGL01658:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL01710:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL01712:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL01713:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL01892:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL01893:Prr36	APN	8	4,265,243 (GRCm39)	missense	probably damaging	1.00
IGL02496:Prr36	APN	8	4,266,407 (GRCm39)	nonsense	probably null
IGL02829:Prr36	APN	8	4,265,278 (GRCm39)	missense	possibly damaging	0.55
R0479:Prr36	UTSW	8	4,263,930 (GRCm39)	nonsense	probably null
R0667:Prr36	UTSW	8	4,266,311 (GRCm39)	unclassified	probably benign
R0784:Prr36	UTSW	8	4,263,771 (GRCm39)	unclassified	probably benign
R1737:Prr36	UTSW	8	4,264,370 (GRCm39)	unclassified	probably benign
R2017:Prr36	UTSW	8	4,265,205 (GRCm39)	missense	probably benign	0.02
R2032:Prr36	UTSW	8	4,264,304 (GRCm39)	unclassified	probably benign
R2430:Prr36	UTSW	8	4,263,488 (GRCm39)	unclassified	probably benign
R4160:Prr36	UTSW	8	4,262,910 (GRCm39)	missense	probably benign	0.10
R4184:Prr36	UTSW	8	4,263,409 (GRCm39)	unclassified	probably benign
R4393:Prr36	UTSW	8	4,264,901 (GRCm39)	unclassified	probably benign
R4887:Prr36	UTSW	8	4,260,881 (GRCm39)	missense	probably benign	0.01
R5508:Prr36	UTSW	8	4,266,488 (GRCm39)	missense	probably damaging	0.99
R5628:Prr36	UTSW	8	4,266,273 (GRCm39)	small deletion	probably benign
R6189:Prr36	UTSW	8	4,264,177 (GRCm39)	unclassified	probably benign
R6277:Prr36	UTSW	8	4,264,746 (GRCm39)	unclassified	probably benign
R7185:Prr36	UTSW	8	4,266,458 (GRCm39)	missense	probably damaging	1.00
R7286:Prr36	UTSW	8	4,265,163 (GRCm39)	critical splice donor site	probably benign
R7338:Prr36	UTSW	8	4,266,212 (GRCm39)	missense	probably damaging	1.00
R7604:Prr36	UTSW	8	4,264,836 (GRCm39)	missense	unknown
R7621:Prr36	UTSW	8	4,263,150 (GRCm39)	missense	unknown
R7699:Prr36	UTSW	8	4,263,989 (GRCm39)	missense	unknown
R7703:Prr36	UTSW	8	4,262,982 (GRCm39)	missense	probably benign	0.03
R7842:Prr36	UTSW	8	4,260,953 (GRCm39)	missense	probably benign	0.09
R7853:Prr36	UTSW	8	4,263,905 (GRCm39)	missense	unknown
R8325:Prr36	UTSW	8	4,262,982 (GRCm39)	missense	probably benign	0.03
R8340:Prr36	UTSW	8	4,264,224 (GRCm39)	missense	unknown
R8353:Prr36	UTSW	8	4,263,831 (GRCm39)	unclassified	probably benign
R8777-TAIL:Prr36	UTSW	8	4,266,273 (GRCm39)	small deletion	probably benign
R9498:Prr36	UTSW	8	4,263,291 (GRCm39)	missense	unknown
R9502:Prr36	UTSW	8	4,264,775 (GRCm39)	missense	unknown
R9757:Prr36	UTSW	8	4,260,998 (GRCm39)	missense	probably damaging	1.00
RF044:Prr36	UTSW	8	4,266,273 (GRCm39)	small deletion	probably benign

Posted On

2013-11-05