Incidental Mutation 'IGL01410:Vmn2r74'
| ID |
79966 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.105)
|
| Stock # |
IGL01410
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85610500 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 64
(D64G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166355
AA Change: D64G
PolyPhen 2
Score 0.834 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: D64G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aox1 |
T |
A |
1: 58,145,184 (GRCm39) |
|
probably null |
Het |
| Aspm |
C |
T |
1: 139,410,182 (GRCm39) |
T1359I |
probably benign |
Het |
| Atp13a2 |
A |
G |
4: 140,719,509 (GRCm39) |
D26G |
probably benign |
Het |
| Atrnl1 |
G |
A |
19: 58,119,536 (GRCm39) |
A1343T |
probably damaging |
Het |
| Ccsap |
A |
C |
8: 124,585,969 (GRCm39) |
S61A |
probably damaging |
Het |
| Cdh1 |
A |
T |
8: 107,384,485 (GRCm39) |
M318L |
probably benign |
Het |
| Cfap69 |
G |
A |
5: 5,696,979 (GRCm39) |
P106S |
probably damaging |
Het |
| Cfp |
G |
A |
X: 20,795,963 (GRCm39) |
T88I |
probably damaging |
Het |
| Chst1 |
A |
T |
2: 92,444,475 (GRCm39) |
I316F |
probably damaging |
Het |
| Col7a1 |
A |
T |
9: 108,793,686 (GRCm39) |
D1382V |
unknown |
Het |
| Cr2 |
T |
A |
1: 194,845,542 (GRCm39) |
M514L |
possibly damaging |
Het |
| Cubn |
G |
A |
2: 13,470,719 (GRCm39) |
H558Y |
probably benign |
Het |
| Cul9 |
A |
T |
17: 46,839,572 (GRCm39) |
M802K |
probably damaging |
Het |
| Dennd2d |
A |
T |
3: 106,398,542 (GRCm39) |
I169L |
probably damaging |
Het |
| Dnah11 |
T |
A |
12: 118,010,991 (GRCm39) |
K162* |
probably null |
Het |
| Dnah3 |
T |
A |
7: 119,566,943 (GRCm39) |
T2428S |
possibly damaging |
Het |
| Dock11 |
T |
A |
X: 35,301,296 (GRCm39) |
H1284Q |
probably damaging |
Het |
| Flrt2 |
T |
A |
12: 95,745,966 (GRCm39) |
D101E |
probably damaging |
Het |
| Gabrr2 |
G |
A |
4: 33,085,626 (GRCm39) |
V349M |
probably damaging |
Het |
| Gli2 |
C |
A |
1: 118,764,621 (GRCm39) |
V1177L |
probably benign |
Het |
| Gm16506 |
A |
G |
14: 43,961,630 (GRCm39) |
Y206H |
probably benign |
Het |
| Gm5612 |
C |
T |
9: 18,338,869 (GRCm39) |
|
probably benign |
Het |
| Gvin3 |
C |
T |
7: 106,202,258 (GRCm39) |
|
noncoding transcript |
Het |
| Heg1 |
C |
T |
16: 33,545,936 (GRCm39) |
T460I |
possibly damaging |
Het |
| Lgals9 |
T |
G |
11: 78,863,977 (GRCm39) |
D56A |
probably damaging |
Het |
| Lpgat1 |
A |
T |
1: 191,508,544 (GRCm39) |
|
probably null |
Het |
| Megf6 |
T |
A |
4: 154,337,020 (GRCm39) |
|
probably null |
Het |
| Megf8 |
G |
A |
7: 25,059,296 (GRCm39) |
M2265I |
probably benign |
Het |
| Memo1 |
G |
A |
17: 74,548,976 (GRCm39) |
R121* |
probably null |
Het |
| Morc1 |
T |
C |
16: 48,432,677 (GRCm39) |
V715A |
probably benign |
Het |
| Mycbp2 |
A |
T |
14: 103,466,928 (GRCm39) |
|
probably null |
Het |
| Ncapg2 |
T |
A |
12: 116,388,270 (GRCm39) |
V318D |
possibly damaging |
Het |
| Ndst1 |
T |
C |
18: 60,833,517 (GRCm39) |
Y498C |
probably damaging |
Het |
| Nod1 |
C |
T |
6: 54,921,341 (GRCm39) |
A326T |
probably damaging |
Het |
| Or2ag15 |
A |
G |
7: 106,340,706 (GRCm39) |
V145A |
probably benign |
Het |
| Or4c11 |
T |
A |
2: 88,695,864 (GRCm39) |
M305K |
probably benign |
Het |
| Peg3 |
T |
C |
7: 6,710,624 (GRCm39) |
S1533G |
probably benign |
Het |
| Pgc |
G |
T |
17: 48,045,165 (GRCm39) |
G361V |
probably damaging |
Het |
| Phka1 |
C |
T |
X: 101,629,712 (GRCm39) |
R477H |
probably damaging |
Het |
| Plagl2 |
C |
T |
2: 153,074,574 (GRCm39) |
R109Q |
probably damaging |
Het |
| Prr36 |
T |
A |
8: 4,266,230 (GRCm39) |
I107F |
probably benign |
Het |
| Ptpdc1 |
T |
A |
13: 48,740,080 (GRCm39) |
R450S |
probably damaging |
Het |
| Ptprb |
A |
T |
10: 116,138,179 (GRCm39) |
D361V |
possibly damaging |
Het |
| Rbm44 |
A |
G |
1: 91,096,551 (GRCm39) |
D970G |
probably benign |
Het |
| Scrn2 |
T |
G |
11: 96,921,396 (GRCm39) |
V52G |
probably benign |
Het |
| Sdk1 |
C |
T |
5: 142,197,875 (GRCm39) |
T2176I |
probably benign |
Het |
| Serpina1d |
T |
A |
12: 103,729,993 (GRCm39) |
E396D |
probably benign |
Het |
| Slc38a5 |
A |
C |
X: 8,146,070 (GRCm39) |
Q465P |
probably benign |
Het |
| Slc38a5 |
G |
T |
X: 8,146,071 (GRCm39) |
Q465H |
probably benign |
Het |
| Smarca1 |
T |
C |
X: 46,981,255 (GRCm39) |
T48A |
possibly damaging |
Het |
| Trak2 |
A |
T |
1: 58,962,766 (GRCm39) |
I132N |
probably damaging |
Het |
| Trank1 |
A |
G |
9: 111,194,117 (GRCm39) |
T714A |
probably benign |
Het |
| Trank1 |
T |
C |
9: 111,194,327 (GRCm39) |
S784P |
probably benign |
Het |
| Trp53i13 |
G |
A |
11: 77,399,083 (GRCm39) |
|
probably benign |
Het |
| Trrap |
A |
C |
5: 144,767,831 (GRCm39) |
D2596A |
probably benign |
Het |
| Ttyh1 |
A |
T |
7: 4,127,656 (GRCm39) |
T19S |
probably damaging |
Het |
| Tyk2 |
C |
T |
9: 21,020,660 (GRCm39) |
V947M |
probably damaging |
Het |
| Ugt2b34 |
G |
A |
5: 87,040,689 (GRCm39) |
A411V |
possibly damaging |
Het |
| Virma |
T |
A |
4: 11,518,929 (GRCm39) |
Y725* |
probably null |
Het |
| Vmn1r192 |
A |
G |
13: 22,372,079 (GRCm39) |
L47P |
probably damaging |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,610,555 (GRCm39) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
| Posted On |
2013-11-05 |
Incidental Mutation