Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01410:Rbm44'

79980

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rbm44

Ensembl Gene

ENSMUSG00000070732

Gene Name

RNA binding motif protein 44

Synonyms

LOC329207

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL01410

Quality Score

Status

Chromosome

Chromosomal Location

91072811-91098517 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 91096551 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 970 (D970G)

Ref Sequence

ENSEMBL: ENSMUSP00000092286 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094698]

AlphaFold

Q3V089

Predicted Effect

probably benign
Transcript: ENSMUST00000094698
AA Change: D970G

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000092286
Gene: ENSMUSG00000070732
AA Change: D970G

Domain	Start	End	E-Value	Type
low complexity region	227	238	N/A	INTRINSIC
low complexity region	444	460	N/A	INTRINSIC
RRM	793	861	8.27e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185229

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191211

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male mice homozygous or heterozygous for a knock-out allele exhibit enhanced fertility with increased litter size. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	A	1: 58,145,184 (GRCm39)		probably null	Het
Aspm	C	T	1: 139,410,182 (GRCm39)	T1359I	probably benign	Het
Atp13a2	A	G	4: 140,719,509 (GRCm39)	D26G	probably benign	Het
Atrnl1	G	A	19: 58,119,536 (GRCm39)	A1343T	probably damaging	Het
Ccsap	A	C	8: 124,585,969 (GRCm39)	S61A	probably damaging	Het
Cdh1	A	T	8: 107,384,485 (GRCm39)	M318L	probably benign	Het
Cfap69	G	A	5: 5,696,979 (GRCm39)	P106S	probably damaging	Het
Cfp	G	A	X: 20,795,963 (GRCm39)	T88I	probably damaging	Het
Chst1	A	T	2: 92,444,475 (GRCm39)	I316F	probably damaging	Het
Col7a1	A	T	9: 108,793,686 (GRCm39)	D1382V	unknown	Het
Cr2	T	A	1: 194,845,542 (GRCm39)	M514L	possibly damaging	Het
Cubn	G	A	2: 13,470,719 (GRCm39)	H558Y	probably benign	Het
Cul9	A	T	17: 46,839,572 (GRCm39)	M802K	probably damaging	Het
Dennd2d	A	T	3: 106,398,542 (GRCm39)	I169L	probably damaging	Het
Dnah11	T	A	12: 118,010,991 (GRCm39)	K162*	probably null	Het
Dnah3	T	A	7: 119,566,943 (GRCm39)	T2428S	possibly damaging	Het
Dock11	T	A	X: 35,301,296 (GRCm39)	H1284Q	probably damaging	Het
Flrt2	T	A	12: 95,745,966 (GRCm39)	D101E	probably damaging	Het
Gabrr2	G	A	4: 33,085,626 (GRCm39)	V349M	probably damaging	Het
Gli2	C	A	1: 118,764,621 (GRCm39)	V1177L	probably benign	Het
Gm16506	A	G	14: 43,961,630 (GRCm39)	Y206H	probably benign	Het
Gm5612	C	T	9: 18,338,869 (GRCm39)		probably benign	Het
Gvin3	C	T	7: 106,202,258 (GRCm39)		noncoding transcript	Het
Heg1	C	T	16: 33,545,936 (GRCm39)	T460I	possibly damaging	Het
Lgals9	T	G	11: 78,863,977 (GRCm39)	D56A	probably damaging	Het
Lpgat1	A	T	1: 191,508,544 (GRCm39)		probably null	Het
Megf6	T	A	4: 154,337,020 (GRCm39)		probably null	Het
Megf8	G	A	7: 25,059,296 (GRCm39)	M2265I	probably benign	Het
Memo1	G	A	17: 74,548,976 (GRCm39)	R121*	probably null	Het
Morc1	T	C	16: 48,432,677 (GRCm39)	V715A	probably benign	Het
Mycbp2	A	T	14: 103,466,928 (GRCm39)		probably null	Het
Ncapg2	T	A	12: 116,388,270 (GRCm39)	V318D	possibly damaging	Het
Ndst1	T	C	18: 60,833,517 (GRCm39)	Y498C	probably damaging	Het
Nod1	C	T	6: 54,921,341 (GRCm39)	A326T	probably damaging	Het
Or2ag15	A	G	7: 106,340,706 (GRCm39)	V145A	probably benign	Het
Or4c11	T	A	2: 88,695,864 (GRCm39)	M305K	probably benign	Het
Peg3	T	C	7: 6,710,624 (GRCm39)	S1533G	probably benign	Het
Pgc	G	T	17: 48,045,165 (GRCm39)	G361V	probably damaging	Het
Phka1	C	T	X: 101,629,712 (GRCm39)	R477H	probably damaging	Het
Plagl2	C	T	2: 153,074,574 (GRCm39)	R109Q	probably damaging	Het
Prr36	T	A	8: 4,266,230 (GRCm39)	I107F	probably benign	Het
Ptpdc1	T	A	13: 48,740,080 (GRCm39)	R450S	probably damaging	Het
Ptprb	A	T	10: 116,138,179 (GRCm39)	D361V	possibly damaging	Het
Scrn2	T	G	11: 96,921,396 (GRCm39)	V52G	probably benign	Het
Sdk1	C	T	5: 142,197,875 (GRCm39)	T2176I	probably benign	Het
Serpina1d	T	A	12: 103,729,993 (GRCm39)	E396D	probably benign	Het
Slc38a5	A	C	X: 8,146,070 (GRCm39)	Q465P	probably benign	Het
Slc38a5	G	T	X: 8,146,071 (GRCm39)	Q465H	probably benign	Het
Smarca1	T	C	X: 46,981,255 (GRCm39)	T48A	possibly damaging	Het
Trak2	A	T	1: 58,962,766 (GRCm39)	I132N	probably damaging	Het
Trank1	A	G	9: 111,194,117 (GRCm39)	T714A	probably benign	Het
Trank1	T	C	9: 111,194,327 (GRCm39)	S784P	probably benign	Het
Trp53i13	G	A	11: 77,399,083 (GRCm39)		probably benign	Het
Trrap	A	C	5: 144,767,831 (GRCm39)	D2596A	probably benign	Het
Ttyh1	A	T	7: 4,127,656 (GRCm39)	T19S	probably damaging	Het
Tyk2	C	T	9: 21,020,660 (GRCm39)	V947M	probably damaging	Het
Ugt2b34	G	A	5: 87,040,689 (GRCm39)	A411V	possibly damaging	Het
Virma	T	A	4: 11,518,929 (GRCm39)	Y725*	probably null	Het
Vmn1r192	A	G	13: 22,372,079 (GRCm39)	L47P	probably damaging	Het
Vmn2r74	T	C	7: 85,610,500 (GRCm39)	D64G	possibly damaging	Het

Other mutations in Rbm44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Rbm44	APN	1	91,084,831 (GRCm39)	missense	probably benign
IGL01089:Rbm44	APN	1	91,096,419 (GRCm39)	missense	possibly damaging	0.61
IGL01339:Rbm44	APN	1	91,096,686 (GRCm39)	missense	probably benign	0.45
IGL01624:Rbm44	APN	1	91,084,380 (GRCm39)	missense	probably damaging	0.96
IGL01963:Rbm44	APN	1	91,090,830 (GRCm39)	missense	probably benign	0.00
IGL02067:Rbm44	APN	1	91,080,567 (GRCm39)	missense	probably damaging	0.98
IGL02513:Rbm44	APN	1	91,083,260 (GRCm39)	missense	possibly damaging	0.63
IGL02804:Rbm44	APN	1	91,077,898 (GRCm39)	intron	probably benign
IGL02806:Rbm44	APN	1	91,080,799 (GRCm39)	missense	possibly damaging	0.79
IGL02887:Rbm44	APN	1	91,080,902 (GRCm39)	missense	probably damaging	1.00
IGL03309:Rbm44	APN	1	91,096,562 (GRCm39)	critical splice donor site	probably null
R0360:Rbm44	UTSW	1	91,080,069 (GRCm39)	missense	probably benign	0.01
R0364:Rbm44	UTSW	1	91,080,069 (GRCm39)	missense	probably benign	0.01
R0647:Rbm44	UTSW	1	91,084,650 (GRCm39)	missense	probably benign	0.00
R1345:Rbm44	UTSW	1	91,080,481 (GRCm39)	missense	probably damaging	0.99
R1352:Rbm44	UTSW	1	91,080,764 (GRCm39)	missense	probably damaging	1.00
R1575:Rbm44	UTSW	1	91,084,565 (GRCm39)	splice site	probably null
R1768:Rbm44	UTSW	1	91,081,679 (GRCm39)	splice site	probably null
R4901:Rbm44	UTSW	1	91,081,050 (GRCm39)	missense	probably benign	0.13
R4913:Rbm44	UTSW	1	91,083,216 (GRCm39)	missense	probably damaging	1.00
R5023:Rbm44	UTSW	1	91,096,820 (GRCm39)	critical splice donor site	probably null
R5569:Rbm44	UTSW	1	91,096,460 (GRCm39)	missense	probably damaging	0.99
R5874:Rbm44	UTSW	1	91,084,562 (GRCm39)	critical splice donor site	probably null
R5981:Rbm44	UTSW	1	91,080,411 (GRCm39)	missense	possibly damaging	0.61
R6441:Rbm44	UTSW	1	91,084,799 (GRCm39)	missense	probably damaging	0.98
R6515:Rbm44	UTSW	1	91,092,860 (GRCm39)	missense	probably damaging	0.96
R7380:Rbm44	UTSW	1	91,079,938 (GRCm39)	missense	possibly damaging	0.77
R7783:Rbm44	UTSW	1	91,096,551 (GRCm39)	missense	probably benign	0.01
R8004:Rbm44	UTSW	1	91,079,880 (GRCm39)	splice site	probably benign
R8678:Rbm44	UTSW	1	91,080,103 (GRCm39)	missense	probably damaging	1.00
R8891:Rbm44	UTSW	1	91,090,136 (GRCm39)	missense	probably benign	0.12
Z1176:Rbm44	UTSW	1	91,081,122 (GRCm39)	missense	probably benign

Posted On

2013-11-05