Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01419:Hspa12a'

80357

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hspa12a

Ensembl Gene

ENSMUSG00000025092

Gene Name

heat shock protein 12A

Synonyms

Hspa12a, 1700063D12Rik, Gm19925

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.392) question?

Stock #

IGL01419

Quality Score

Status

Chromosome

Chromosomal Location

58784182-58932086 bp(-) (GRCm39)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 58816681 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000066860 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066285]

AlphaFold

Q8K0U4

Predicted Effect

probably null
Transcript: ENSMUST00000066285

SMART Domains

Protein: ENSMUSP00000066860
Gene: ENSMUSG00000025092

Domain	Start	End	E-Value	Type
SCOP:d1bupa1	58	244	4e-14	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	A	T	2: 25,327,526 (GRCm39)	T672S	probably damaging	Het
Adamts14	A	T	10: 61,041,321 (GRCm39)		probably benign	Het
Adgrv1	T	C	13: 81,705,277 (GRCm39)	E791G	probably damaging	Het
Alkbh8	A	G	9: 3,385,354 (GRCm39)	R584G	probably damaging	Het
Apob	A	T	12: 8,052,251 (GRCm39)	I1218F	probably damaging	Het
Atp5f1a	T	C	18: 77,865,233 (GRCm39)	S52P	probably damaging	Het
B4galnt3	A	G	6: 120,192,351 (GRCm39)	S462P	possibly damaging	Het
Bdkrb1	A	G	12: 105,571,040 (GRCm39)	H202R	possibly damaging	Het
Bltp1	T	C	3: 37,102,270 (GRCm39)	S1323P	probably damaging	Het
Cd300lf	T	C	11: 115,017,180 (GRCm39)	K48E	probably benign	Het
Cfhr4	T	C	1: 139,667,382 (GRCm39)		probably null	Het
Chuk	A	T	19: 44,085,420 (GRCm39)	I242K	probably damaging	Het
Csde1	A	G	3: 102,946,086 (GRCm39)	T27A	probably damaging	Het
D930048N14Rik	C	T	11: 51,545,603 (GRCm39)		probably benign	Het
Depdc7	A	T	2: 104,552,455 (GRCm39)	Y451N	possibly damaging	Het
Diaph3	C	A	14: 87,202,989 (GRCm39)	G623*	probably null	Het
Dlc1	T	C	8: 37,317,371 (GRCm39)	T435A	probably benign	Het
Dock8	A	G	19: 25,096,816 (GRCm39)	S575G	probably benign	Het
Fbxw22	T	A	9: 109,210,790 (GRCm39)	Y407F	probably benign	Het
Fzd4	C	A	7: 89,056,943 (GRCm39)	A330E	probably damaging	Het
Gm17415	A	G	1: 93,349,672 (GRCm39)		probably benign	Het
Gnat1	C	T	9: 107,556,633 (GRCm39)		probably null	Het
Gtf3c4	T	C	2: 28,725,081 (GRCm39)	Y76C	probably damaging	Het
Heatr5b	G	A	17: 79,103,939 (GRCm39)	H1079Y	probably benign	Het
Helz	T	G	11: 107,577,340 (GRCm39)	I1897S	unknown	Het
Kcne1	G	T	16: 92,145,534 (GRCm39)	F103L	probably benign	Het
Lrrc20	A	T	10: 61,383,874 (GRCm39)	S94C	probably damaging	Het
Lrrc8a	A	G	2: 30,147,111 (GRCm39)	T642A	probably benign	Het
Ly6g5b	A	G	17: 35,333,494 (GRCm39)	L106P	probably benign	Het
Lyst	A	G	13: 13,810,423 (GRCm39)	S698G	probably benign	Het
Ndrg1	A	G	15: 66,802,900 (GRCm39)	V334A	probably benign	Het
Neb	A	T	2: 52,116,545 (GRCm39)	Y964*	probably null	Het
Or4c123	T	C	2: 89,126,689 (GRCm39)		probably benign	Het
Or8k3	A	T	2: 86,058,973 (GRCm39)	I114N	possibly damaging	Het
Parp10	A	G	15: 76,125,588 (GRCm39)	F497L	probably damaging	Het
Pdss1	A	G	2: 22,825,589 (GRCm39)	M343V	possibly damaging	Het
Phactr3	C	T	2: 177,920,855 (GRCm39)	T231I	probably benign	Het
Plekhh2	A	T	17: 84,890,980 (GRCm39)		probably benign	Het
Ppp1r12c	A	C	7: 4,489,351 (GRCm39)		probably null	Het
Prdm2	G	T	4: 142,860,218 (GRCm39)	P1024H	probably damaging	Het
Prkacb	A	T	3: 146,461,448 (GRCm39)	M1K	probably null	Het
Prkdc	C	A	16: 15,653,030 (GRCm39)	P3835Q	probably damaging	Het
Rps27a	T	C	11: 29,496,353 (GRCm39)	T87A	probably benign	Het
Ryr2	T	A	13: 11,814,723 (GRCm39)	E683V	possibly damaging	Het
Sbk2	A	G	7: 4,960,528 (GRCm39)	L214P	probably damaging	Het
Sema4g	A	G	19: 44,985,835 (GRCm39)	S250G	probably benign	Het
Slc27a6	T	A	18: 58,742,281 (GRCm39)	D498E	probably benign	Het
Tarbp1	T	C	8: 127,154,894 (GRCm39)	D1410G	probably benign	Het
Tas2r134	T	A	2: 51,517,759 (GRCm39)	Y79*	probably null	Het
Tie1	T	C	4: 118,333,295 (GRCm39)	D857G	probably damaging	Het
Tnk2	A	G	16: 32,499,498 (GRCm39)	N432S	probably damaging	Het
Tubg2	C	A	11: 101,049,883 (GRCm39)	D176E	probably benign	Het
Ugt2b34	A	T	5: 87,039,264 (GRCm39)	W466R	probably damaging	Het
Usp47	T	A	7: 111,687,118 (GRCm39)	M692K	possibly damaging	Het
Vmn2r106	T	C	17: 20,499,807 (GRCm39)	K143E	probably benign	Het
Vmn2r118	G	A	17: 55,900,000 (GRCm39)	L635F	probably benign	Het
Vmn2r16	C	T	5: 109,510,267 (GRCm39)		probably benign	Het
Vmn2r76	A	T	7: 85,874,910 (GRCm39)	M689K	probably benign	Het
Xkr6	T	C	14: 64,056,325 (GRCm39)	Y79H	probably benign	Het
Zdhhc6	A	G	19: 55,298,186 (GRCm39)	F224L	probably benign	Het
Zfp493	T	G	13: 67,934,921 (GRCm39)	I291M	probably benign	Het

Other mutations in Hspa12a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01516:Hspa12a	APN	19	58,816,108 (GRCm39)	missense	probably benign	0.00
IGL01766:Hspa12a	APN	19	58,787,899 (GRCm39)	missense	probably damaging	0.99
IGL01986:Hspa12a	APN	19	58,787,834 (GRCm39)	missense	probably benign	0.30
IGL02138:Hspa12a	APN	19	58,816,730 (GRCm39)	missense	probably benign	0.45
IGL02170:Hspa12a	APN	19	58,793,113 (GRCm39)	missense	probably benign	0.01
IGL02576:Hspa12a	APN	19	58,787,842 (GRCm39)	missense	possibly damaging	0.56
IGL02623:Hspa12a	APN	19	58,797,983 (GRCm39)	missense	probably benign	0.01
IGL02890:Hspa12a	APN	19	58,809,431 (GRCm39)	critical splice donor site	probably null
IGL03209:Hspa12a	APN	19	58,810,493 (GRCm39)	splice site	probably null
IGL03343:Hspa12a	APN	19	58,787,828 (GRCm39)	missense	probably benign	0.00
R0040:Hspa12a	UTSW	19	58,788,056 (GRCm39)	missense	probably benign	0.10
R0090:Hspa12a	UTSW	19	58,787,941 (GRCm39)	missense	probably benign	0.00
R2139:Hspa12a	UTSW	19	58,787,914 (GRCm39)	missense	probably benign
R4031:Hspa12a	UTSW	19	58,789,289 (GRCm39)	missense	probably benign	0.17
R4686:Hspa12a	UTSW	19	58,788,181 (GRCm39)	missense	possibly damaging	0.90
R4914:Hspa12a	UTSW	19	58,787,884 (GRCm39)	missense	probably damaging	1.00
R5046:Hspa12a	UTSW	19	58,787,977 (GRCm39)	missense	probably damaging	1.00
R5580:Hspa12a	UTSW	19	58,788,092 (GRCm39)	missense	probably benign	0.11
R5615:Hspa12a	UTSW	19	58,793,082 (GRCm39)	missense	possibly damaging	0.56
R5781:Hspa12a	UTSW	19	58,810,518 (GRCm39)	missense	probably damaging	0.99
R6777:Hspa12a	UTSW	19	58,810,519 (GRCm39)	missense	probably benign	0.03
R6954:Hspa12a	UTSW	19	58,788,124 (GRCm39)	missense	probably benign	0.05
R7038:Hspa12a	UTSW	19	58,793,132 (GRCm39)	missense	probably damaging	1.00
R7151:Hspa12a	UTSW	19	58,810,594 (GRCm39)	missense	probably benign	0.07
R7249:Hspa12a	UTSW	19	58,793,865 (GRCm39)	missense	probably benign	0.27
R7677:Hspa12a	UTSW	19	58,849,317 (GRCm39)	missense	probably benign	0.01
R8110:Hspa12a	UTSW	19	58,809,445 (GRCm39)	missense	possibly damaging	0.86
R8830:Hspa12a	UTSW	19	58,793,895 (GRCm39)	missense	possibly damaging	0.74
R8955:Hspa12a	UTSW	19	58,788,058 (GRCm39)	missense	probably damaging	1.00
R8987:Hspa12a	UTSW	19	58,787,903 (GRCm39)	nonsense	probably null
R9056:Hspa12a	UTSW	19	58,813,720 (GRCm39)	missense	probably damaging	1.00
R9147:Hspa12a	UTSW	19	58,793,890 (GRCm39)	missense	probably damaging	1.00
R9148:Hspa12a	UTSW	19	58,793,890 (GRCm39)	missense	probably damaging	1.00
R9157:Hspa12a	UTSW	19	58,789,292 (GRCm39)	missense	possibly damaging	0.86
R9316:Hspa12a	UTSW	19	58,793,079 (GRCm39)	missense	probably benign	0.22
R9329:Hspa12a	UTSW	19	58,789,298 (GRCm39)	missense	probably benign	0.01
R9370:Hspa12a	UTSW	19	58,813,708 (GRCm39)	missense	probably damaging	1.00
R9486:Hspa12a	UTSW	19	58,797,891 (GRCm39)	missense	probably benign	0.03

Posted On

2013-11-05