Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01419:Or4c123'

80359

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4c123

Ensembl Gene

ENSMUSG00000075094

Gene Name

olfactory receptor family 4 subfamily C member 123

Synonyms

GA_x6K02T2Q125-50741934-50741017, MOR237-1, Olfr1230

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

IGL01419

Quality Score

Status

Chromosome

Chromosomal Location

89126695-89127612 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 89126689 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150310 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099787] [ENSMUST00000216144]

AlphaFold

Q8VG58

Predicted Effect

probably benign
Transcript: ENSMUST00000099787

SMART Domains

Protein: ENSMUSP00000097375
Gene: ENSMUSG00000075094

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	5.7e-44	PFAM
Pfam:7tm_1	39	285	6.8e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216144

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca2	A	T	2: 25,327,526 (GRCm39)	T672S	probably damaging	Het
Adamts14	A	T	10: 61,041,321 (GRCm39)		probably benign	Het
Adgrv1	T	C	13: 81,705,277 (GRCm39)	E791G	probably damaging	Het
Alkbh8	A	G	9: 3,385,354 (GRCm39)	R584G	probably damaging	Het
Apob	A	T	12: 8,052,251 (GRCm39)	I1218F	probably damaging	Het
Atp5f1a	T	C	18: 77,865,233 (GRCm39)	S52P	probably damaging	Het
B4galnt3	A	G	6: 120,192,351 (GRCm39)	S462P	possibly damaging	Het
Bdkrb1	A	G	12: 105,571,040 (GRCm39)	H202R	possibly damaging	Het
Bltp1	T	C	3: 37,102,270 (GRCm39)	S1323P	probably damaging	Het
Cd300lf	T	C	11: 115,017,180 (GRCm39)	K48E	probably benign	Het
Cfhr4	T	C	1: 139,667,382 (GRCm39)		probably null	Het
Chuk	A	T	19: 44,085,420 (GRCm39)	I242K	probably damaging	Het
Csde1	A	G	3: 102,946,086 (GRCm39)	T27A	probably damaging	Het
D930048N14Rik	C	T	11: 51,545,603 (GRCm39)		probably benign	Het
Depdc7	A	T	2: 104,552,455 (GRCm39)	Y451N	possibly damaging	Het
Diaph3	C	A	14: 87,202,989 (GRCm39)	G623*	probably null	Het
Dlc1	T	C	8: 37,317,371 (GRCm39)	T435A	probably benign	Het
Dock8	A	G	19: 25,096,816 (GRCm39)	S575G	probably benign	Het
Fbxw22	T	A	9: 109,210,790 (GRCm39)	Y407F	probably benign	Het
Fzd4	C	A	7: 89,056,943 (GRCm39)	A330E	probably damaging	Het
Gm17415	A	G	1: 93,349,672 (GRCm39)		probably benign	Het
Gnat1	C	T	9: 107,556,633 (GRCm39)		probably null	Het
Gtf3c4	T	C	2: 28,725,081 (GRCm39)	Y76C	probably damaging	Het
Heatr5b	G	A	17: 79,103,939 (GRCm39)	H1079Y	probably benign	Het
Helz	T	G	11: 107,577,340 (GRCm39)	I1897S	unknown	Het
Hspa12a	T	C	19: 58,816,681 (GRCm39)		probably null	Het
Kcne1	G	T	16: 92,145,534 (GRCm39)	F103L	probably benign	Het
Lrrc20	A	T	10: 61,383,874 (GRCm39)	S94C	probably damaging	Het
Lrrc8a	A	G	2: 30,147,111 (GRCm39)	T642A	probably benign	Het
Ly6g5b	A	G	17: 35,333,494 (GRCm39)	L106P	probably benign	Het
Lyst	A	G	13: 13,810,423 (GRCm39)	S698G	probably benign	Het
Ndrg1	A	G	15: 66,802,900 (GRCm39)	V334A	probably benign	Het
Neb	A	T	2: 52,116,545 (GRCm39)	Y964*	probably null	Het
Or8k3	A	T	2: 86,058,973 (GRCm39)	I114N	possibly damaging	Het
Parp10	A	G	15: 76,125,588 (GRCm39)	F497L	probably damaging	Het
Pdss1	A	G	2: 22,825,589 (GRCm39)	M343V	possibly damaging	Het
Phactr3	C	T	2: 177,920,855 (GRCm39)	T231I	probably benign	Het
Plekhh2	A	T	17: 84,890,980 (GRCm39)		probably benign	Het
Ppp1r12c	A	C	7: 4,489,351 (GRCm39)		probably null	Het
Prdm2	G	T	4: 142,860,218 (GRCm39)	P1024H	probably damaging	Het
Prkacb	A	T	3: 146,461,448 (GRCm39)	M1K	probably null	Het
Prkdc	C	A	16: 15,653,030 (GRCm39)	P3835Q	probably damaging	Het
Rps27a	T	C	11: 29,496,353 (GRCm39)	T87A	probably benign	Het
Ryr2	T	A	13: 11,814,723 (GRCm39)	E683V	possibly damaging	Het
Sbk2	A	G	7: 4,960,528 (GRCm39)	L214P	probably damaging	Het
Sema4g	A	G	19: 44,985,835 (GRCm39)	S250G	probably benign	Het
Slc27a6	T	A	18: 58,742,281 (GRCm39)	D498E	probably benign	Het
Tarbp1	T	C	8: 127,154,894 (GRCm39)	D1410G	probably benign	Het
Tas2r134	T	A	2: 51,517,759 (GRCm39)	Y79*	probably null	Het
Tie1	T	C	4: 118,333,295 (GRCm39)	D857G	probably damaging	Het
Tnk2	A	G	16: 32,499,498 (GRCm39)	N432S	probably damaging	Het
Tubg2	C	A	11: 101,049,883 (GRCm39)	D176E	probably benign	Het
Ugt2b34	A	T	5: 87,039,264 (GRCm39)	W466R	probably damaging	Het
Usp47	T	A	7: 111,687,118 (GRCm39)	M692K	possibly damaging	Het
Vmn2r106	T	C	17: 20,499,807 (GRCm39)	K143E	probably benign	Het
Vmn2r118	G	A	17: 55,900,000 (GRCm39)	L635F	probably benign	Het
Vmn2r16	C	T	5: 109,510,267 (GRCm39)		probably benign	Het
Vmn2r76	A	T	7: 85,874,910 (GRCm39)	M689K	probably benign	Het
Xkr6	T	C	14: 64,056,325 (GRCm39)	Y79H	probably benign	Het
Zdhhc6	A	G	19: 55,298,186 (GRCm39)	F224L	probably benign	Het
Zfp493	T	G	13: 67,934,921 (GRCm39)	I291M	probably benign	Het

Other mutations in Or4c123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Or4c123	APN	2	89,126,799 (GRCm39)	missense	probably benign	0.40
IGL01644:Or4c123	APN	2	89,126,976 (GRCm39)	missense	probably benign	0.01
IGL01653:Or4c123	APN	2	89,127,471 (GRCm39)	missense	probably benign	0.08
IGL01674:Or4c123	APN	2	89,127,014 (GRCm39)	missense	probably damaging	1.00
IGL02124:Or4c123	APN	2	89,127,407 (GRCm39)	missense	probably benign	0.01
IGL03053:Or4c123	APN	2	89,126,789 (GRCm39)	missense	probably damaging	0.97
R0504:Or4c123	UTSW	2	89,127,083 (GRCm39)	missense	probably damaging	0.99
R1473:Or4c123	UTSW	2	89,127,250 (GRCm39)	nonsense	probably null
R1742:Or4c123	UTSW	2	89,126,768 (GRCm39)	missense	probably damaging	1.00
R1899:Or4c123	UTSW	2	89,127,014 (GRCm39)	missense	probably damaging	1.00
R1900:Or4c123	UTSW	2	89,127,014 (GRCm39)	missense	probably damaging	1.00
R1945:Or4c123	UTSW	2	89,127,128 (GRCm39)	missense	probably damaging	1.00
R2935:Or4c123	UTSW	2	89,127,604 (GRCm39)	missense	possibly damaging	0.69
R3421:Or4c123	UTSW	2	89,126,897 (GRCm39)	missense	probably benign	0.03
R5185:Or4c123	UTSW	2	89,126,731 (GRCm39)	missense	probably benign
R5377:Or4c123	UTSW	2	89,127,506 (GRCm39)	missense	probably damaging	0.99
R5400:Or4c123	UTSW	2	89,127,257 (GRCm39)	missense	probably damaging	1.00
R6083:Or4c123	UTSW	2	89,127,368 (GRCm39)	missense	probably damaging	1.00
R6086:Or4c123	UTSW	2	89,127,198 (GRCm39)	missense	probably damaging	1.00
R6155:Or4c123	UTSW	2	89,126,765 (GRCm39)	missense	probably damaging	1.00
R6218:Or4c123	UTSW	2	89,127,306 (GRCm39)	missense	probably damaging	0.98
R6361:Or4c123	UTSW	2	89,126,990 (GRCm39)	missense	probably damaging	0.98
R8053:Or4c123	UTSW	2	89,127,540 (GRCm39)	missense	possibly damaging	0.69
R8905:Or4c123	UTSW	2	89,126,801 (GRCm39)	missense	possibly damaging	0.89
Z1176:Or4c123	UTSW	2	89,127,297 (GRCm39)	missense	probably damaging	1.00
Z1177:Or4c123	UTSW	2	89,126,796 (GRCm39)	missense	probably benign	0.19

Posted On

2013-11-05