Incidental Mutation 'P0026:Zfp354a'
ID8038
Institutional Source Beutler Lab
Gene Symbol Zfp354a
Ensembl Gene ENSMUSG00000020364
Gene Namezinc finger protein 354A
SynonymsTcf17, kid1
MMRRC Submission 038279-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.274) question?
Stock #P0026 (G1)
Quality Score
Status Validated
Chromosome11
Chromosomal Location51059257-51072799 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 51061498 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Arginine at position 85 (G85R)
Ref Sequence ENSEMBL: ENSMUSP00000104750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020628] [ENSMUST00000102766] [ENSMUST00000109119] [ENSMUST00000109122]
Predicted Effect probably null
Transcript: ENSMUST00000020628
AA Change: G86R

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000020628
Gene: ENSMUSG00000020364
AA Change: G86R

DomainStartEndE-ValueType
KRAB 14 74 8.48e-36 SMART
ZnF_C2H2 184 206 1.12e-3 SMART
ZnF_C2H2 212 234 1.38e-3 SMART
ZnF_C2H2 240 262 9.73e-4 SMART
ZnF_C2H2 268 290 1.72e-4 SMART
ZnF_C2H2 321 343 1.47e-3 SMART
ZnF_C2H2 349 371 4.24e-4 SMART
ZnF_C2H2 377 399 2.79e-4 SMART
ZnF_C2H2 405 427 9.58e-3 SMART
ZnF_C2H2 433 455 2.4e-3 SMART
ZnF_C2H2 461 483 1.2e-3 SMART
ZnF_C2H2 489 511 2.99e-4 SMART
ZnF_C2H2 517 539 5.5e-3 SMART
ZnF_C2H2 545 567 9.08e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102766
AA Change: G86R

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000099827
Gene: ENSMUSG00000020364
AA Change: G86R

DomainStartEndE-ValueType
KRAB 14 74 8.48e-36 SMART
ZnF_C2H2 184 206 1.12e-3 SMART
ZnF_C2H2 212 234 1.38e-3 SMART
ZnF_C2H2 240 262 9.73e-4 SMART
ZnF_C2H2 268 290 1.72e-4 SMART
ZnF_C2H2 321 343 1.47e-3 SMART
ZnF_C2H2 349 371 4.24e-4 SMART
ZnF_C2H2 377 399 2.79e-4 SMART
ZnF_C2H2 405 427 9.58e-3 SMART
ZnF_C2H2 433 455 2.4e-3 SMART
ZnF_C2H2 461 483 1.2e-3 SMART
ZnF_C2H2 489 511 2.99e-4 SMART
ZnF_C2H2 517 539 5.5e-3 SMART
ZnF_C2H2 545 567 9.08e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000109119
AA Change: G87R

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000104747
Gene: ENSMUSG00000020364
AA Change: G87R

DomainStartEndE-ValueType
KRAB 14 75 1.67e-34 SMART
ZnF_C2H2 185 207 1.12e-3 SMART
ZnF_C2H2 213 235 1.38e-3 SMART
ZnF_C2H2 241 263 9.73e-4 SMART
ZnF_C2H2 269 291 1.72e-4 SMART
ZnF_C2H2 322 344 1.47e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 2.79e-4 SMART
ZnF_C2H2 406 428 9.58e-3 SMART
ZnF_C2H2 434 456 2.4e-3 SMART
ZnF_C2H2 462 484 1.2e-3 SMART
ZnF_C2H2 490 512 2.99e-4 SMART
ZnF_C2H2 518 540 5.5e-3 SMART
ZnF_C2H2 546 568 9.08e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000109122
AA Change: G85R

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000104750
Gene: ENSMUSG00000020364
AA Change: G85R

DomainStartEndE-ValueType
KRAB 13 73 8.48e-36 SMART
ZnF_C2H2 183 205 1.12e-3 SMART
ZnF_C2H2 211 233 1.38e-3 SMART
ZnF_C2H2 239 261 9.73e-4 SMART
ZnF_C2H2 267 289 1.72e-4 SMART
ZnF_C2H2 320 342 1.47e-3 SMART
ZnF_C2H2 348 370 4.24e-4 SMART
ZnF_C2H2 376 398 2.79e-4 SMART
ZnF_C2H2 404 426 9.58e-3 SMART
ZnF_C2H2 432 454 2.4e-3 SMART
ZnF_C2H2 460 482 1.2e-3 SMART
ZnF_C2H2 488 510 2.99e-4 SMART
ZnF_C2H2 516 538 5.5e-3 SMART
ZnF_C2H2 544 566 9.08e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156914
Meta Mutation Damage Score 0.226 question?
Coding Region Coverage
  • 1x: 85.6%
  • 3x: 78.9%
  • 10x: 59.5%
  • 20x: 38.1%
Validation Efficiency 97% (63/65)
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi2 A G 1: 60,453,723 N182D probably benign Het
Acad10 T C 5: 121,637,352 Y429C probably damaging Het
Aifm3 A T 16: 17,507,117 probably benign Het
Bud13 A G 9: 46,288,358 H339R probably benign Het
Cpa1 T A 6: 30,640,906 M132K probably damaging Het
Dapk1 T A 13: 60,718,149 probably benign Het
Dchs1 A T 7: 105,758,405 N2073K probably damaging Het
Dnah2 A T 11: 69,464,947 N2227K probably damaging Het
Dnpep C T 1: 75,308,685 V468I probably benign Het
Elf3 A G 1: 135,255,973 probably null Het
Fam124a T G 14: 62,606,122 L360V probably damaging Het
Fam20a A T 11: 109,675,841 probably null Het
Fermt3 A G 19: 7,014,424 S140P probably damaging Het
Gm10440 T C 5: 54,356,169 noncoding transcript Het
Il12rb1 A G 8: 70,812,541 D167G probably damaging Het
Ints8 T A 4: 11,225,788 K590* probably null Het
Kcnu1 T C 8: 25,892,122 F500S probably damaging Het
Mrm3 T C 11: 76,247,500 V238A probably damaging Het
Rap1gap2 A G 11: 74,567,210 probably benign Het
Rusc2 T A 4: 43,415,840 V382E possibly damaging Het
Slc9a5 A G 8: 105,355,291 N216S probably damaging Het
Snx7 A T 3: 117,840,023 F63I probably damaging Het
Syne2 A G 12: 75,880,220 probably benign Het
Tenm4 T C 7: 96,874,527 Y1751H probably damaging Het
Trappc9 G A 15: 72,953,082 P366S probably damaging Het
Trim17 A G 11: 58,971,258 D372G possibly damaging Het
Other mutations in Zfp354a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Zfp354a APN 11 51069363 missense probably benign 0.00
IGL00518:Zfp354a APN 11 51070554 missense probably damaging 1.00
IGL01872:Zfp354a APN 11 51069337 missense possibly damaging 0.59
R0063:Zfp354a UTSW 11 51069571 missense probably damaging 1.00
R0063:Zfp354a UTSW 11 51069571 missense probably damaging 1.00
R1013:Zfp354a UTSW 11 51060850 splice site probably benign
R1498:Zfp354a UTSW 11 51070246 missense probably damaging 1.00
R2093:Zfp354a UTSW 11 51069724 missense probably damaging 0.99
R4630:Zfp354a UTSW 11 51070218 missense probably damaging 1.00
R4691:Zfp354a UTSW 11 51070237 missense probably damaging 1.00
R5224:Zfp354a UTSW 11 51070049 missense probably damaging 1.00
R5728:Zfp354a UTSW 11 51070605 missense probably damaging 1.00
R6209:Zfp354a UTSW 11 51060988 critical splice donor site probably null
R6831:Zfp354a UTSW 11 51070554 missense probably damaging 1.00
Posted On2012-11-20