Incidental Mutation 'R0881:Polr1c'
ID |
80583 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Polr1c
|
Ensembl Gene |
ENSMUSG00000067148 |
Gene Name |
polymerase (RNA) I polypeptide C |
Synonyms |
40kDa, Rpo1-1, RPA40 |
MMRRC Submission |
039048-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R0881 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
46554846-46558971 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 46555539 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 240
(T240A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000084252
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087026]
[ENSMUST00000087031]
[ENSMUST00000095263]
[ENSMUST00000123311]
[ENSMUST00000124655]
[ENSMUST00000142706]
[ENSMUST00000173232]
[ENSMUST00000173349]
|
AlphaFold |
P52432 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087026
AA Change: T240A
PolyPhen 2
Score 0.692 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000084252 Gene: ENSMUSG00000067148 AA Change: T240A
Domain | Start | End | E-Value | Type |
RPOLD
|
60 |
339 |
4.53e-124 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000087031
|
SMART Domains |
Protein: ENSMUSP00000084257 Gene: ENSMUSG00000067150
Domain | Start | End | E-Value | Type |
IBN_N
|
33 |
100 |
6.73e-3 |
SMART |
Pfam:Xpo1
|
109 |
271 |
1.4e-34 |
PFAM |
low complexity region
|
326 |
342 |
N/A |
INTRINSIC |
low complexity region
|
770 |
779 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000095263
|
SMART Domains |
Protein: ENSMUSP00000092897 Gene: ENSMUSG00000071074
Domain | Start | End | E-Value | Type |
low complexity region
|
59 |
75 |
N/A |
INTRINSIC |
transmembrane domain
|
146 |
168 |
N/A |
INTRINSIC |
transmembrane domain
|
183 |
205 |
N/A |
INTRINSIC |
transmembrane domain
|
212 |
234 |
N/A |
INTRINSIC |
transmembrane domain
|
238 |
260 |
N/A |
INTRINSIC |
transmembrane domain
|
272 |
294 |
N/A |
INTRINSIC |
low complexity region
|
320 |
332 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000123311
|
SMART Domains |
Protein: ENSMUSP00000115951 Gene: ENSMUSG00000071074
Domain | Start | End | E-Value | Type |
transmembrane domain
|
51 |
73 |
N/A |
INTRINSIC |
transmembrane domain
|
88 |
110 |
N/A |
INTRINSIC |
transmembrane domain
|
117 |
139 |
N/A |
INTRINSIC |
transmembrane domain
|
143 |
165 |
N/A |
INTRINSIC |
transmembrane domain
|
177 |
199 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124126
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000124655
AA Change: T154A
PolyPhen 2
Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000122026 Gene: ENSMUSG00000067148 AA Change: T154A
Domain | Start | End | E-Value | Type |
RPOLD
|
1 |
253 |
2.14e-93 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000127378
|
SMART Domains |
Protein: ENSMUSP00000114937 Gene: ENSMUSG00000071074
Domain | Start | End | E-Value | Type |
Pfam:Yip1
|
30 |
178 |
4.6e-13 |
PFAM |
low complexity region
|
189 |
201 |
N/A |
INTRINSIC |
|
Predicted Effect |
silent
Transcript: ENSMUST00000142706
|
SMART Domains |
Protein: ENSMUSP00000116998 Gene: ENSMUSG00000067148
Domain | Start | End | E-Value | Type |
RPOLD
|
60 |
255 |
9.13e-47 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151488
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174392
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152583
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000173232
|
SMART Domains |
Protein: ENSMUSP00000133597 Gene: ENSMUSG00000067148
Domain | Start | End | E-Value | Type |
Pfam:RNA_pol_L
|
61 |
100 |
1.7e-11 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000173349
|
SMART Domains |
Protein: ENSMUSP00000133861 Gene: ENSMUSG00000067148
Domain | Start | End | E-Value | Type |
RPOLD
|
42 |
170 |
2.3e-5 |
SMART |
|
Meta Mutation Damage Score |
0.0911 |
Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.9%
- 10x: 97.0%
- 20x: 93.0%
|
Validation Efficiency |
96% (51/53) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 49 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aasdh |
G |
A |
5: 77,024,130 (GRCm39) |
T174M |
probably damaging |
Het |
Abcc9 |
T |
A |
6: 142,592,029 (GRCm39) |
I732F |
probably damaging |
Het |
Adam10 |
T |
C |
9: 70,653,519 (GRCm39) |
S248P |
probably damaging |
Het |
Adam18 |
A |
T |
8: 25,162,159 (GRCm39) |
|
probably benign |
Het |
Angel2 |
G |
A |
1: 190,669,661 (GRCm39) |
E114K |
probably damaging |
Het |
Arhgap29 |
A |
G |
3: 121,808,328 (GRCm39) |
T1169A |
probably damaging |
Het |
Atp13a2 |
T |
A |
4: 140,731,242 (GRCm39) |
M759K |
probably damaging |
Het |
Atxn2l |
A |
G |
7: 126,095,768 (GRCm39) |
S450P |
probably damaging |
Het |
B3glct |
T |
A |
5: 149,663,034 (GRCm39) |
V264E |
probably damaging |
Het |
Bbx |
A |
G |
16: 50,040,963 (GRCm39) |
|
probably benign |
Het |
Bmp3 |
A |
G |
5: 99,020,461 (GRCm39) |
N295D |
possibly damaging |
Het |
C9 |
G |
A |
15: 6,488,349 (GRCm39) |
|
probably benign |
Het |
Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
Cdan1 |
A |
T |
2: 120,551,466 (GRCm39) |
V1039E |
probably damaging |
Het |
Dennd4a |
T |
C |
9: 64,758,665 (GRCm39) |
|
probably null |
Het |
Ext1 |
A |
G |
15: 53,207,879 (GRCm39) |
L294P |
probably benign |
Het |
Fsip2 |
C |
A |
2: 82,816,617 (GRCm39) |
H4117N |
possibly damaging |
Het |
Itga8 |
C |
T |
2: 12,267,003 (GRCm39) |
|
probably null |
Het |
Itln1 |
G |
T |
1: 171,360,949 (GRCm39) |
H48N |
probably benign |
Het |
Kcna5 |
T |
A |
6: 126,511,957 (GRCm39) |
H57L |
probably benign |
Het |
Klhdc4 |
A |
T |
8: 122,526,226 (GRCm39) |
Y304* |
probably null |
Het |
Klhl25 |
A |
G |
7: 75,516,027 (GRCm39) |
Y6C |
probably damaging |
Het |
Lars1 |
C |
T |
18: 42,347,851 (GRCm39) |
V991M |
probably benign |
Het |
Med20 |
T |
C |
17: 47,922,605 (GRCm39) |
M1T |
probably null |
Het |
Mslnl |
A |
T |
17: 25,961,939 (GRCm39) |
H138L |
possibly damaging |
Het |
Mycbp2 |
T |
C |
14: 103,457,449 (GRCm39) |
I1583V |
probably benign |
Het |
Nipbl |
A |
C |
15: 8,337,096 (GRCm39) |
V2093G |
probably damaging |
Het |
Nup98 |
T |
A |
7: 101,809,923 (GRCm39) |
T536S |
probably damaging |
Het |
Opalin |
T |
C |
19: 41,052,420 (GRCm39) |
|
probably null |
Het |
Or1j12 |
T |
G |
2: 36,343,452 (GRCm39) |
L285R |
probably damaging |
Het |
Or51d1 |
T |
A |
7: 102,348,291 (GRCm39) |
V282D |
possibly damaging |
Het |
Or8g26 |
A |
G |
9: 39,095,984 (GRCm39) |
K170R |
probably benign |
Het |
Pgm2 |
A |
T |
5: 64,250,351 (GRCm39) |
T9S |
unknown |
Het |
Piwil2 |
A |
C |
14: 70,646,376 (GRCm39) |
S387A |
probably benign |
Het |
Polr3c |
A |
G |
3: 96,631,163 (GRCm39) |
M118T |
probably damaging |
Het |
Pth1r |
C |
T |
9: 110,560,641 (GRCm39) |
C42Y |
probably damaging |
Het |
Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
Rictor |
A |
T |
15: 6,821,151 (GRCm39) |
M1492L |
probably benign |
Het |
Rrbp1 |
T |
A |
2: 143,795,173 (GRCm39) |
Y1277F |
probably benign |
Het |
Scgb3a2 |
T |
G |
18: 43,897,549 (GRCm39) |
|
probably benign |
Het |
Skint1 |
G |
A |
4: 111,886,054 (GRCm39) |
S327N |
probably benign |
Het |
Steap4 |
A |
T |
5: 8,030,388 (GRCm39) |
S415C |
probably benign |
Het |
Tex48 |
A |
G |
4: 63,530,228 (GRCm39) |
|
probably benign |
Het |
Tox2 |
T |
A |
2: 163,163,365 (GRCm39) |
S502T |
probably benign |
Het |
Usp47 |
T |
A |
7: 111,690,643 (GRCm39) |
I762K |
possibly damaging |
Het |
Vmn2r53 |
T |
C |
7: 12,334,859 (GRCm39) |
H267R |
probably benign |
Het |
Wnt2b |
A |
G |
3: 104,860,513 (GRCm39) |
|
probably benign |
Het |
Xirp1 |
T |
C |
9: 119,847,483 (GRCm39) |
N28D |
possibly damaging |
Het |
Zeb1 |
T |
C |
18: 5,767,138 (GRCm39) |
S550P |
probably benign |
Het |
|
Other mutations in Polr1c |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01412:Polr1c
|
APN |
17 |
46,555,135 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02035:Polr1c
|
APN |
17 |
46,557,085 (GRCm39) |
missense |
possibly damaging |
0.72 |
R0068:Polr1c
|
UTSW |
17 |
46,555,829 (GRCm39) |
missense |
probably benign |
0.00 |
R0457:Polr1c
|
UTSW |
17 |
46,558,689 (GRCm39) |
missense |
probably benign |
0.00 |
R0828:Polr1c
|
UTSW |
17 |
46,555,990 (GRCm39) |
missense |
probably damaging |
0.96 |
R1322:Polr1c
|
UTSW |
17 |
46,555,089 (GRCm39) |
missense |
possibly damaging |
0.74 |
R1518:Polr1c
|
UTSW |
17 |
46,558,821 (GRCm39) |
missense |
possibly damaging |
0.89 |
R3765:Polr1c
|
UTSW |
17 |
46,558,850 (GRCm39) |
missense |
probably damaging |
0.99 |
R4212:Polr1c
|
UTSW |
17 |
46,557,046 (GRCm39) |
missense |
probably damaging |
0.97 |
R4548:Polr1c
|
UTSW |
17 |
46,558,735 (GRCm39) |
splice site |
probably null |
|
R5017:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R5018:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R5039:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R5167:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R5168:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R5971:Polr1c
|
UTSW |
17 |
46,558,635 (GRCm39) |
intron |
probably benign |
|
R6979:Polr1c
|
UTSW |
17 |
46,557,095 (GRCm39) |
missense |
probably damaging |
1.00 |
R7812:Polr1c
|
UTSW |
17 |
46,557,053 (GRCm39) |
missense |
probably damaging |
1.00 |
R7869:Polr1c
|
UTSW |
17 |
46,555,817 (GRCm39) |
missense |
probably benign |
0.00 |
R8025:Polr1c
|
UTSW |
17 |
46,555,974 (GRCm39) |
missense |
probably damaging |
1.00 |
R9186:Polr1c
|
UTSW |
17 |
46,556,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCCGCACAGCCTTCTTGAGTTTC -3'
(R):5'- TGGGCCAGTCTGATTGCAGCAATG -3'
Sequencing Primer
(F):5'- CGGAAGATTTCCCTGCTGAAG -3'
(R):5'- TTGCAGCAATGCAGTCGAAC -3'
|
Posted On |
2013-11-07 |