Incidental Mutation 'R0881:Scgb3a2'
ID 80591
Institutional Source Beutler Lab
Gene Symbol Scgb3a2
Ensembl Gene ENSMUSG00000038791
Gene Name secretoglobin, family 3A, member 2
Synonyms LuLeu1, UGRP1
MMRRC Submission 039048-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R0881 (G1)
Quality Score 177
Status Validated
Chromosome 18
Chromosomal Location 43897354-43900464 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 43897549 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140375 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043803] [ENSMUST00000187157] [ENSMUST00000189750]
AlphaFold Q920H1
Predicted Effect probably benign
Transcript: ENSMUST00000043803
SMART Domains Protein: ENSMUSP00000038872
Gene: ENSMUSG00000038791

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
Pfam:Uteroglobin 30 98 1.3e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158107
Predicted Effect probably benign
Transcript: ENSMUST00000187157
SMART Domains Protein: ENSMUSP00000140476
Gene: ENSMUSG00000038791

DomainStartEndE-ValueType
Pfam:Uteroglobin 27 88 8.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189750
SMART Domains Protein: ENSMUSP00000140375
Gene: ENSMUSG00000038791

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
Pfam:Uteroglobin 27 98 3.2e-20 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.9%
  • 10x: 97.0%
  • 20x: 93.0%
Validation Efficiency 96% (51/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh G A 5: 77,024,130 (GRCm39) T174M probably damaging Het
Abcc9 T A 6: 142,592,029 (GRCm39) I732F probably damaging Het
Adam10 T C 9: 70,653,519 (GRCm39) S248P probably damaging Het
Adam18 A T 8: 25,162,159 (GRCm39) probably benign Het
Angel2 G A 1: 190,669,661 (GRCm39) E114K probably damaging Het
Arhgap29 A G 3: 121,808,328 (GRCm39) T1169A probably damaging Het
Atp13a2 T A 4: 140,731,242 (GRCm39) M759K probably damaging Het
Atxn2l A G 7: 126,095,768 (GRCm39) S450P probably damaging Het
B3glct T A 5: 149,663,034 (GRCm39) V264E probably damaging Het
Bbx A G 16: 50,040,963 (GRCm39) probably benign Het
Bmp3 A G 5: 99,020,461 (GRCm39) N295D possibly damaging Het
C9 G A 15: 6,488,349 (GRCm39) probably benign Het
Cacna1c C T 6: 118,589,586 (GRCm39) R1446H probably damaging Het
Cdan1 A T 2: 120,551,466 (GRCm39) V1039E probably damaging Het
Dennd4a T C 9: 64,758,665 (GRCm39) probably null Het
Ext1 A G 15: 53,207,879 (GRCm39) L294P probably benign Het
Fsip2 C A 2: 82,816,617 (GRCm39) H4117N possibly damaging Het
Itga8 C T 2: 12,267,003 (GRCm39) probably null Het
Itln1 G T 1: 171,360,949 (GRCm39) H48N probably benign Het
Kcna5 T A 6: 126,511,957 (GRCm39) H57L probably benign Het
Klhdc4 A T 8: 122,526,226 (GRCm39) Y304* probably null Het
Klhl25 A G 7: 75,516,027 (GRCm39) Y6C probably damaging Het
Lars1 C T 18: 42,347,851 (GRCm39) V991M probably benign Het
Med20 T C 17: 47,922,605 (GRCm39) M1T probably null Het
Mslnl A T 17: 25,961,939 (GRCm39) H138L possibly damaging Het
Mycbp2 T C 14: 103,457,449 (GRCm39) I1583V probably benign Het
Nipbl A C 15: 8,337,096 (GRCm39) V2093G probably damaging Het
Nup98 T A 7: 101,809,923 (GRCm39) T536S probably damaging Het
Opalin T C 19: 41,052,420 (GRCm39) probably null Het
Or1j12 T G 2: 36,343,452 (GRCm39) L285R probably damaging Het
Or51d1 T A 7: 102,348,291 (GRCm39) V282D possibly damaging Het
Or8g26 A G 9: 39,095,984 (GRCm39) K170R probably benign Het
Pgm2 A T 5: 64,250,351 (GRCm39) T9S unknown Het
Piwil2 A C 14: 70,646,376 (GRCm39) S387A probably benign Het
Polr1c T C 17: 46,555,539 (GRCm39) T240A possibly damaging Het
Polr3c A G 3: 96,631,163 (GRCm39) M118T probably damaging Het
Pth1r C T 9: 110,560,641 (GRCm39) C42Y probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rictor A T 15: 6,821,151 (GRCm39) M1492L probably benign Het
Rrbp1 T A 2: 143,795,173 (GRCm39) Y1277F probably benign Het
Skint1 G A 4: 111,886,054 (GRCm39) S327N probably benign Het
Steap4 A T 5: 8,030,388 (GRCm39) S415C probably benign Het
Tex48 A G 4: 63,530,228 (GRCm39) probably benign Het
Tox2 T A 2: 163,163,365 (GRCm39) S502T probably benign Het
Usp47 T A 7: 111,690,643 (GRCm39) I762K possibly damaging Het
Vmn2r53 T C 7: 12,334,859 (GRCm39) H267R probably benign Het
Wnt2b A G 3: 104,860,513 (GRCm39) probably benign Het
Xirp1 T C 9: 119,847,483 (GRCm39) N28D possibly damaging Het
Zeb1 T C 18: 5,767,138 (GRCm39) S550P probably benign Het
Other mutations in Scgb3a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00696:Scgb3a2 APN 18 43,900,094 (GRCm39) intron probably benign
IGL01112:Scgb3a2 APN 18 43,900,059 (GRCm39) intron probably benign
R1781:Scgb3a2 UTSW 18 43,900,033 (GRCm39) critical splice donor site probably benign
R1857:Scgb3a2 UTSW 18 43,899,900 (GRCm39) missense probably benign 0.03
R4856:Scgb3a2 UTSW 18 43,899,819 (GRCm39) missense probably damaging 1.00
R4886:Scgb3a2 UTSW 18 43,899,819 (GRCm39) missense probably damaging 1.00
R6484:Scgb3a2 UTSW 18 43,899,784 (GRCm39) missense possibly damaging 0.82
R6980:Scgb3a2 UTSW 18 43,897,499 (GRCm39) missense probably damaging 1.00
R9160:Scgb3a2 UTSW 18 43,900,445 (GRCm39) utr 3 prime probably benign
R9405:Scgb3a2 UTSW 18 43,900,129 (GRCm39) missense possibly damaging 0.84
R9556:Scgb3a2 UTSW 18 43,900,039 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGACAGCGAGCAGAACTATTGACAC -3'
(R):5'- ACCCCACTGGAGATTGTAGTACAGC -3'

Sequencing Primer
(F):5'- AGAACTATTGACACCGTGATTTTG -3'
(R):5'- GCCGATGAATGTACCTACTTCAG -3'
Posted On 2013-11-07