Incidental Mutation 'R0931:Or10ac1'
ID 80875
Institutional Source Beutler Lab
Gene Symbol Or10ac1
Ensembl Gene ENSMUSG00000071494
Gene Name olfactory receptor family 10 subfamily AC member 1
Synonyms MORO-2, Olfr455, Olfr455-ps1, GA_x6K02T2P3E9-5021913-5022918, EG546896, MOR0-17_p, MOR0-2P
MMRRC Submission 039075-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R0931 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 42515001-42515954 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 42515020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 312 (R312L)
Ref Sequence ENSEMBL: ENSMUSP00000151418 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171307] [ENSMUST00000217978]
AlphaFold A0A0B4J1M2
Predicted Effect probably benign
Transcript: ENSMUST00000171307
AA Change: R312L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000130187
Gene: ENSMUSG00000071494
AA Change: R312L

DomainStartEndE-ValueType
Pfam:7tm_4 32 312 8.4e-41 PFAM
Pfam:7tm_1 42 265 5.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217978
AA Change: R312L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.0%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 G A 4: 86,168,084 (GRCm39) A476T probably benign Het
Ajm1 T C 2: 25,468,501 (GRCm39) E470G possibly damaging Het
Aknad1 T C 3: 108,659,339 (GRCm39) S118P probably damaging Het
Arhgap20 A G 9: 51,728,041 (GRCm39) T85A probably benign Het
Astn2 A G 4: 65,566,530 (GRCm39) L824P probably damaging Het
Ccr1 C A 9: 123,763,827 (GRCm39) K234N probably damaging Het
Cfap46 T C 7: 139,235,757 (GRCm39) R203G probably damaging Het
Col8a1 A G 16: 57,448,931 (GRCm39) I193T unknown Het
Cpa2 T C 6: 30,552,070 (GRCm39) probably benign Het
Crabp1 T C 9: 54,675,717 (GRCm39) L100P possibly damaging Het
Cspp1 A T 1: 10,174,511 (GRCm39) R655W probably damaging Het
Ddx1 A T 12: 13,287,818 (GRCm39) probably benign Het
Dnah7b T G 1: 46,138,772 (GRCm39) probably benign Het
Dzip3 A G 16: 48,771,921 (GRCm39) S583P probably damaging Het
Exosc1 A G 19: 41,921,676 (GRCm39) probably benign Het
Fhip1a A G 3: 85,580,550 (GRCm39) S552P probably benign Het
Gas7 A T 11: 67,543,751 (GRCm39) probably benign Het
Gss A T 2: 155,409,609 (GRCm39) probably benign Het
Hdhd3 G A 4: 62,417,757 (GRCm39) R140* probably null Het
Irx2 T A 13: 72,779,675 (GRCm39) S320T possibly damaging Het
Kcnf1 T C 12: 17,225,142 (GRCm39) S360G possibly damaging Het
Klk1b4 T C 7: 43,860,480 (GRCm39) L166P probably damaging Het
Klri1 A T 6: 129,674,381 (GRCm39) probably benign Het
Mettl27 T C 5: 134,963,285 (GRCm39) probably benign Het
Myrfl T A 10: 116,675,354 (GRCm39) H193L probably benign Het
Nbas C T 12: 13,381,115 (GRCm39) probably benign Het
Or52b2 A T 7: 104,986,736 (GRCm39) Y62* probably null Het
Papolg A G 11: 23,832,257 (GRCm39) I177T probably damaging Het
Pdcd1 A G 1: 93,967,238 (GRCm39) V220A probably benign Het
Psmc1 T C 12: 100,085,341 (GRCm39) L234P probably damaging Het
Rasa2 A T 9: 96,434,457 (GRCm39) M610K possibly damaging Het
Ryr3 A G 2: 112,484,047 (GRCm39) F3930S probably damaging Het
Sacs G A 14: 61,440,944 (GRCm39) V997I probably benign Het
Setdb2 A G 14: 59,660,945 (GRCm39) probably benign Het
Ssu2 C A 6: 112,361,359 (GRCm39) L32F probably damaging Het
Taar1 A T 10: 23,797,181 (GRCm39) N293I probably damaging Het
Ttn A G 2: 76,611,846 (GRCm39) probably benign Het
Vmn2r49 T C 7: 9,720,325 (GRCm39) M389V possibly damaging Het
Wdr7 T C 18: 63,998,371 (GRCm39) V1106A probably benign Het
Zfp324 A G 7: 12,700,185 (GRCm39) I15V probably benign Het
Other mutations in Or10ac1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Or10ac1 APN 6 42,515,113 (GRCm39) missense possibly damaging 0.85
PIT4519001:Or10ac1 UTSW 6 42,515,534 (GRCm39) missense probably damaging 0.98
R1696:Or10ac1 UTSW 6 42,515,537 (GRCm39) missense probably benign 0.04
R1774:Or10ac1 UTSW 6 42,515,453 (GRCm39) missense probably damaging 0.99
R4627:Or10ac1 UTSW 6 42,515,375 (GRCm39) missense possibly damaging 0.46
R4835:Or10ac1 UTSW 6 42,515,770 (GRCm39) missense probably damaging 1.00
R5140:Or10ac1 UTSW 6 42,515,449 (GRCm39) missense probably benign 0.00
R5322:Or10ac1 UTSW 6 42,515,950 (GRCm39) missense probably benign 0.06
R7237:Or10ac1 UTSW 6 42,515,581 (GRCm39) missense probably damaging 1.00
R7399:Or10ac1 UTSW 6 42,515,662 (GRCm39) missense possibly damaging 0.79
R7422:Or10ac1 UTSW 6 42,515,053 (GRCm39) missense possibly damaging 0.72
R7982:Or10ac1 UTSW 6 42,515,225 (GRCm39) missense probably damaging 1.00
R8697:Or10ac1 UTSW 6 42,515,629 (GRCm39) missense probably damaging 1.00
R9120:Or10ac1 UTSW 6 42,515,583 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACTTGGCAGGAATCAAAGGAAGCTC -3'
(R):5'- TGTGCGGCCAAAATCCAGTTACTC -3'

Sequencing Primer
(F):5'- GCTCTCAATGTAGATCAAGGTCTC -3'
(R):5'- AGTTACTCCCCTCGACTGG -3'
Posted On 2013-11-07