Incidental Mutation 'R0885:Lin28b'
ID 81179
Institutional Source Beutler Lab
Gene Symbol Lin28b
Ensembl Gene ENSMUSG00000063804
Gene Name lin-28 homolog B
Synonyms D030047M17Rik, 2810403D23Rik
MMRRC Submission 039052-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0885 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 45252713-45362410 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 45257324 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 218 (G218E)
Ref Sequence ENSEMBL: ENSMUSP00000078361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079390]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000079390
AA Change: G218E

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000078361
Gene: ENSMUSG00000063804
AA Change: G218E

DomainStartEndE-ValueType
CSP 29 100 3.98e-14 SMART
ZnF_C2HC 150 166 2.77e-2 SMART
ZnF_C2HC 172 188 1.79e-1 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 96.9%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal dwarfism in male, but not female, mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020L13Rik T A 7: 29,980,094 (GRCm39) Y46* probably null Het
Adam18 T C 8: 25,141,802 (GRCm39) K256E probably damaging Het
Adam20 T A 8: 41,249,595 (GRCm39) H568Q probably benign Het
Ambp A G 4: 63,069,705 (GRCm39) L107P probably damaging Het
Art1 T C 7: 101,756,541 (GRCm39) F244S probably damaging Het
Asxl2 C A 12: 3,551,458 (GRCm39) L1067I probably damaging Het
Atm T C 9: 53,371,123 (GRCm39) T2242A probably benign Het
Atp2c1 C T 9: 105,298,772 (GRCm39) probably null Het
Bptf A G 11: 106,934,617 (GRCm39) Y2819H probably damaging Het
Caskin1 G A 17: 24,724,668 (GRCm39) R1152H probably damaging Het
Chd7 T A 4: 8,866,432 (GRCm39) L868Q probably damaging Het
Cyp2d40 T C 15: 82,645,116 (GRCm39) E178G unknown Het
Dclk1 G T 3: 55,394,728 (GRCm39) R103S probably damaging Het
Des A G 1: 75,337,374 (GRCm39) T105A probably damaging Het
Ebf3 T C 7: 136,827,613 (GRCm39) T262A probably benign Het
Epha4 A G 1: 77,359,576 (GRCm39) V759A probably damaging Het
Fryl A T 5: 73,246,539 (GRCm39) F1078I probably damaging Het
Il20 T C 1: 130,838,518 (GRCm39) I60V probably benign Het
Kif3c A T 12: 3,415,981 (GRCm39) M1L probably benign Het
Lhfpl5 A T 17: 28,795,011 (GRCm39) I13F probably damaging Het
Lrp2 A T 2: 69,312,697 (GRCm39) N2530K possibly damaging Het
Matn2 T A 15: 34,316,751 (GRCm39) F31Y possibly damaging Het
Mcm6 T C 1: 128,276,670 (GRCm39) N307D probably benign Het
Mmp16 A T 4: 18,054,491 (GRCm39) R332S probably benign Het
Mpdz T A 4: 81,287,829 (GRCm39) T477S probably benign Het
Mrgprb3 C A 7: 48,292,844 (GRCm39) G236W probably damaging Het
Mrpl47 T C 3: 32,784,335 (GRCm39) D145G probably damaging Het
Myo6 T C 9: 80,149,503 (GRCm39) S150P probably damaging Het
Naca C A 10: 127,876,048 (GRCm39) S360* probably null Het
Or2ak6 C T 11: 58,592,913 (GRCm39) P129S possibly damaging Het
Phip C A 9: 82,757,448 (GRCm39) A1575S probably benign Het
Pip4p1 T C 14: 51,167,763 (GRCm39) E54G probably damaging Het
Plxna2 T C 1: 194,326,864 (GRCm39) M266T probably benign Het
Ppp1r16a C T 15: 76,577,869 (GRCm39) Q328* probably null Het
Prag1 T C 8: 36,570,421 (GRCm39) F335L probably benign Het
Prmt2 A G 10: 76,058,399 (GRCm39) Y137H probably damaging Het
Psme3ip1 C A 8: 95,302,407 (GRCm39) C208F probably damaging Het
Ptgds T C 2: 25,357,357 (GRCm39) D184G possibly damaging Het
Ptpn5 T C 7: 46,738,359 (GRCm39) Y241C probably benign Het
Pxdn G A 12: 30,053,401 (GRCm39) V1193M probably benign Het
Raet1e T A 10: 22,057,986 (GRCm39) probably benign Het
Rttn A G 18: 89,001,934 (GRCm39) D282G probably benign Het
Sis G A 3: 72,819,282 (GRCm39) R1425* probably null Het
Slco2a1 G T 9: 102,959,582 (GRCm39) M559I probably damaging Het
Spata4 C T 8: 55,053,879 (GRCm39) A15V probably damaging Het
Spop T C 11: 95,361,453 (GRCm39) S14P probably benign Het
Tcof1 A T 18: 60,968,922 (GRCm39) D230E possibly damaging Het
Tubgcp5 T A 7: 55,455,803 (GRCm39) L277* probably null Het
Ubxn10 A T 4: 138,447,881 (GRCm39) V265E probably damaging Het
Ugt2b36 T A 5: 87,239,848 (GRCm39) Y179F probably benign Het
Wdr37 A C 13: 8,885,288 (GRCm39) probably null Het
Zfp593 A G 4: 133,972,224 (GRCm39) V94A probably benign Het
Other mutations in Lin28b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02598:Lin28b APN 10 45,296,622 (GRCm39) missense possibly damaging 0.57
IGL02819:Lin28b APN 10 45,346,155 (GRCm39) start codon destroyed probably null 0.10
R2407:Lin28b UTSW 10 45,257,183 (GRCm39) missense possibly damaging 0.95
R4962:Lin28b UTSW 10 45,296,736 (GRCm39) missense possibly damaging 0.90
R5523:Lin28b UTSW 10 45,345,164 (GRCm39) nonsense probably null
R7122:Lin28b UTSW 10 45,345,244 (GRCm39) missense probably benign 0.18
R7293:Lin28b UTSW 10 45,295,282 (GRCm39) missense probably benign
R8386:Lin28b UTSW 10 45,345,140 (GRCm39) missense probably damaging 1.00
Z1177:Lin28b UTSW 10 45,296,702 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGTGCTTGCATGAGGTAGACTTCC -3'
(R):5'- TGCTACAACTGTGGTGGTCTCGAC -3'

Sequencing Primer
(F):5'- TGAGGTAGACTTCCCGCCC -3'
(R):5'- TGGTCTCGACCATCATGCTAAAG -3'
Posted On 2013-11-07