Incidental Mutation 'R0965:Or9g4b'
ID 81606
Institutional Source Beutler Lab
Gene Symbol Or9g4b
Ensembl Gene ENSMUSG00000033850
Gene Name olfactory receptor family 9 subfamily G member 4B
Synonyms GA_x6K02T2Q125-47264151-47265089, Olfr1015, MOR213-3
MMRRC Submission 039094-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.262) question?
Stock # R0965 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85615818-85616833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85616643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 263 (S263G)
Ref Sequence ENSEMBL: ENSMUSP00000148957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047870] [ENSMUST00000215945]
AlphaFold Q7TR94
Predicted Effect probably damaging
Transcript: ENSMUST00000047870
AA Change: S263G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000046301
Gene: ENSMUSG00000033850
AA Change: S263G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.5e-49 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214726
Predicted Effect probably damaging
Transcript: ENSMUST00000215945
AA Change: S263G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 AGAGGAGGAGGAGGAGGAGG AGAGGAGGAGGAGGAGG 4: 129,886,209 (GRCm39) probably benign Het
Amacr C T 15: 10,984,891 (GRCm39) R170C probably damaging Het
Bcl2 A T 1: 106,640,021 (GRCm39) L197Q probably benign Het
Brd1 G A 15: 88,601,231 (GRCm39) R468W probably damaging Het
Esco1 A G 18: 10,567,570 (GRCm39) F821L probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Gzma G A 13: 113,234,868 (GRCm39) P38L probably damaging Het
Mcc A G 18: 44,857,593 (GRCm39) L174P probably benign Het
Med19 A G 2: 84,508,793 (GRCm39) E2G probably damaging Het
Muc5b C T 7: 141,417,539 (GRCm39) T3495I possibly damaging Het
Nfatc4 T C 14: 56,064,043 (GRCm39) S107P probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Phf11c T A 14: 59,618,931 (GRCm39) I285F probably damaging Het
Prkdc T C 16: 15,647,580 (GRCm39) V3668A probably benign Het
Rbm20 T C 19: 53,847,832 (GRCm39) F1126S probably damaging Het
Slc7a5 T C 8: 122,633,840 (GRCm39) E169G probably benign Het
Slco1b2 C A 6: 141,631,322 (GRCm39) T652K probably damaging Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Tmem119 A C 5: 113,933,480 (GRCm39) V107G probably damaging Het
Ttn C A 2: 76,629,915 (GRCm39) G14205V probably damaging Het
Zc3h11a T C 1: 133,573,541 (GRCm39) N33S possibly damaging Het
Other mutations in Or9g4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Or9g4b APN 2 85,616,461 (GRCm39) missense probably benign 0.21
IGL01716:Or9g4b APN 2 85,616,487 (GRCm39) missense probably damaging 0.97
IGL03196:Or9g4b APN 2 85,616,365 (GRCm39) missense possibly damaging 0.63
IGL03374:Or9g4b APN 2 85,616,053 (GRCm39) missense probably damaging 1.00
R0329:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0330:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0714:Or9g4b UTSW 2 85,616,743 (GRCm39) missense probably damaging 1.00
R1078:Or9g4b UTSW 2 85,616,437 (GRCm39) missense possibly damaging 0.53
R3826:Or9g4b UTSW 2 85,616,559 (GRCm39) nonsense probably null
R5031:Or9g4b UTSW 2 85,616,062 (GRCm39) nonsense probably null
R5239:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R6120:Or9g4b UTSW 2 85,616,685 (GRCm39) missense probably damaging 1.00
R6177:Or9g4b UTSW 2 85,616,004 (GRCm39) missense probably damaging 0.99
R6726:Or9g4b UTSW 2 85,615,906 (GRCm39) missense possibly damaging 0.51
R6954:Or9g4b UTSW 2 85,616,726 (GRCm39) nonsense probably null
R7766:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R8193:Or9g4b UTSW 2 85,616,305 (GRCm39) missense probably benign 0.34
R8245:Or9g4b UTSW 2 85,616,119 (GRCm39) missense probably benign 0.02
R8339:Or9g4b UTSW 2 85,615,876 (GRCm39) missense probably damaging 0.98
R9272:Or9g4b UTSW 2 85,616,088 (GRCm39) missense probably benign 0.09
Z1176:Or9g4b UTSW 2 85,616,464 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCCGTGTCTATGTGAAAATCCTTTCC -3'
(R):5'- TGTCTATAAGCGAGTTTTGAACAGCCC -3'

Sequencing Primer
(F):5'- AAATCCTTTCCAGTATGGTGGGC -3'
(R):5'- GTCTGCATCAACTTCTTAAAGGCTTC -3'
Posted On 2013-11-08